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P26918

- BLAB_AERHY

UniProt

P26918 - BLAB_AERHY

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Protein

Beta-lactamase

Gene

cphA

Organism
Aeromonas hydrophila
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Can hydrolyze carbapenem compounds.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951Zinc 1By similarity
Metal bindingi97 – 971Zinc 1By similarity
Metal bindingi99 – 991Zinc 2By similarity
Metal bindingi174 – 1741Zinc 1By similarity
Metal bindingi193 – 1931Zinc 2By similarity
Metal bindingi231 – 2311Zinc 2By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SABIO-RKP26918.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Gene namesi
Name:cphA
OrganismiAeromonas hydrophila
Taxonomic identifieri644 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

Subcellular locationi

Periplasm Curated

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 254227Beta-lactamasePRO_0000016941Add
BLAST

Expressioni

Inductioni

By beta-lactam antibiotics.

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1
254
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 367Combined sources
Beta strandi39 – 446Combined sources
Beta strandi46 – 483Combined sources
Beta strandi50 – 567Combined sources
Beta strandi61 – 655Combined sources
Helixi70 – 8112Combined sources
Beta strandi88 – 925Combined sources
Beta strandi94 – 974Combined sources
Helixi98 – 1014Combined sources
Helixi104 – 1096Combined sources
Beta strandi113 – 1175Combined sources
Helixi118 – 13821Combined sources
Beta strandi151 – 1566Combined sources
Beta strandi158 – 1603Combined sources
Turni161 – 1644Combined sources
Beta strandi165 – 1684Combined sources
Beta strandi173 – 1775Combined sources
Beta strandi180 – 1834Combined sources
Turni184 – 1874Combined sources
Beta strandi188 – 1903Combined sources
Helixi192 – 1943Combined sources
Beta strandi198 – 2003Combined sources
Helixi209 – 21911Combined sources
Beta strandi225 – 2284Combined sources
Beta strandi230 – 2323Combined sources
Helixi239 – 25012Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X8GX-ray1.70A28-254[»]
1X8HX-ray1.60A28-254[»]
1X8IX-ray1.90A28-254[»]
2GKLX-ray1.86A28-254[»]
2QDSX-ray1.66A28-254[»]
3F9OX-ray2.03A28-254[»]
3FAIX-ray1.70A28-254[»]
3IOFX-ray1.44A28-254[»]
3IOGX-ray1.41A28-254[»]
3SW3X-ray2.35A28-254[»]
3T9MX-ray2.03A28-254[»]
ProteinModelPortaliP26918.
SMRiP26918. Positions 28-251.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26918.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26918-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMKGWMKCGL AGAVVLMASF WGGSVRAAGM SLTQVSGPVY VVEDNYYVQE
60 70 80 90 100
NSMVYFGAKG VTVVGATWTP DTARELHKLI KRVSRKPVLE VINTNYHTDR
110 120 130 140 150
AGGNAYWKSI GAKVVSTRQT RDLMKSDWAE IVAFTRKGLP EYPDLPLVLP
160 170 180 190 200
NVVHDGDFTL QEGKVRAFYA GPAHTPDGIF VYFPDEQVLY GNCILKEKLG
210 220 230 240 250
NLSFADVKAY PQTLERLKAM KLPIKTVIGG HDSPLHGPEL IDHYEALIKA

APQS
Length:254
Mass (Da):28,016
Last modified:August 1, 1992 - v1
Checksum:i9D54760E17CF4B50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57102 Genomic DNA. Translation: CAA40386.1.
PIRiS17287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57102 Genomic DNA. Translation: CAA40386.1 .
PIRi S17287.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1X8G X-ray 1.70 A 28-254 [» ]
1X8H X-ray 1.60 A 28-254 [» ]
1X8I X-ray 1.90 A 28-254 [» ]
2GKL X-ray 1.86 A 28-254 [» ]
2QDS X-ray 1.66 A 28-254 [» ]
3F9O X-ray 2.03 A 28-254 [» ]
3FAI X-ray 1.70 A 28-254 [» ]
3IOF X-ray 1.44 A 28-254 [» ]
3IOG X-ray 1.41 A 28-254 [» ]
3SW3 X-ray 2.35 A 28-254 [» ]
3T9M X-ray 2.03 A 28-254 [» ]
ProteinModelPortali P26918.
SMRi P26918. Positions 28-251.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P26918.
ChEMBLi CHEMBL1169593.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P26918.

Miscellaneous databases

EvolutionaryTracei P26918.

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
InterProi IPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view ]
Pfami PF00753. Lactamase_B. 1 hit.
[Graphical view ]
SMARTi SM00849. Lactamase_B. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 1 hit.
PROSITEi PS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-beta-lactamases."
    Massidda O., Rossolini G.M., Satta G.
    J. Bacteriol. 173:4611-4617(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AE036.

Entry informationi

Entry nameiBLAB_AERHY
AccessioniPrimary (citable) accession number: P26918
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3