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P26918

- BLAB_AERHY

UniProt

P26918 - BLAB_AERHY

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Protein
Beta-lactamase
Gene
cphA
Organism
Aeromonas hydrophila
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Can hydrolyze carbapenem compounds.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951Zinc 1 By similarity
Metal bindingi97 – 971Zinc 1 By similarity
Metal bindingi99 – 991Zinc 2 By similarity
Metal bindingi174 – 1741Zinc 1 By similarity
Metal bindingi193 – 1931Zinc 2 By similarity
Metal bindingi231 – 2311Zinc 2 By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SABIO-RKP26918.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Gene namesi
Name:cphA
OrganismiAeromonas hydrophila
Taxonomic identifieri644 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

Subcellular locationi

Periplasm Inferred

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 254227Beta-lactamase
PRO_0000016941Add
BLAST

Expressioni

Inductioni

By beta-lactam antibiotics.

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 367
Beta strandi39 – 446
Beta strandi46 – 483
Beta strandi50 – 567
Beta strandi61 – 655
Helixi70 – 8112
Beta strandi88 – 925
Beta strandi94 – 974
Helixi98 – 1014
Helixi104 – 1096
Beta strandi113 – 1175
Helixi118 – 13821
Beta strandi151 – 1566
Beta strandi158 – 1603
Turni161 – 1644
Beta strandi165 – 1684
Beta strandi173 – 1775
Beta strandi180 – 1834
Turni184 – 1874
Beta strandi188 – 1903
Helixi192 – 1943
Beta strandi198 – 2003
Helixi209 – 21911
Beta strandi225 – 2284
Beta strandi230 – 2323
Helixi239 – 25012

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X8GX-ray1.70A28-254[»]
1X8HX-ray1.60A28-254[»]
1X8IX-ray1.90A28-254[»]
2GKLX-ray1.86A28-254[»]
2QDSX-ray1.66A28-254[»]
3F9OX-ray2.03A28-254[»]
3FAIX-ray1.70A28-254[»]
3IOFX-ray1.44A28-254[»]
3IOGX-ray1.41A28-254[»]
3SW3X-ray2.35A28-254[»]
3T9MX-ray2.03A28-254[»]
ProteinModelPortaliP26918.
SMRiP26918. Positions 28-251.

Miscellaneous databases

EvolutionaryTraceiP26918.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26918-1 [UniParc]FASTAAdd to Basket

« Hide

MMKGWMKCGL AGAVVLMASF WGGSVRAAGM SLTQVSGPVY VVEDNYYVQE    50
NSMVYFGAKG VTVVGATWTP DTARELHKLI KRVSRKPVLE VINTNYHTDR 100
AGGNAYWKSI GAKVVSTRQT RDLMKSDWAE IVAFTRKGLP EYPDLPLVLP 150
NVVHDGDFTL QEGKVRAFYA GPAHTPDGIF VYFPDEQVLY GNCILKEKLG 200
NLSFADVKAY PQTLERLKAM KLPIKTVIGG HDSPLHGPEL IDHYEALIKA 250
APQS 254
Length:254
Mass (Da):28,016
Last modified:August 1, 1992 - v1
Checksum:i9D54760E17CF4B50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57102 Genomic DNA. Translation: CAA40386.1.
PIRiS17287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57102 Genomic DNA. Translation: CAA40386.1 .
PIRi S17287.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1X8G X-ray 1.70 A 28-254 [» ]
1X8H X-ray 1.60 A 28-254 [» ]
1X8I X-ray 1.90 A 28-254 [» ]
2GKL X-ray 1.86 A 28-254 [» ]
2QDS X-ray 1.66 A 28-254 [» ]
3F9O X-ray 2.03 A 28-254 [» ]
3FAI X-ray 1.70 A 28-254 [» ]
3IOF X-ray 1.44 A 28-254 [» ]
3IOG X-ray 1.41 A 28-254 [» ]
3SW3 X-ray 2.35 A 28-254 [» ]
3T9M X-ray 2.03 A 28-254 [» ]
ProteinModelPortali P26918.
SMRi P26918. Positions 28-251.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P26918.
ChEMBLi CHEMBL1169593.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P26918.

Miscellaneous databases

EvolutionaryTracei P26918.

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
InterProi IPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view ]
Pfami PF00753. Lactamase_B. 1 hit.
[Graphical view ]
SMARTi SM00849. Lactamase_B. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 1 hit.
PROSITEi PS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-beta-lactamases."
    Massidda O., Rossolini G.M., Satta G.
    J. Bacteriol. 173:4611-4617(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AE036.

Entry informationi

Entry nameiBLAB_AERHY
AccessioniPrimary (citable) accession number: P26918
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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