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Protein

Somatostatin

Gene

SST

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Somatostatin inhibits the release of somatotropin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin
Cleaved into the following 2 chains:
Gene namesi
Name:SST
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Propeptidei25 – 8864By similarityPRO_0000033080Add
BLAST
Peptidei89 – 11628Somatostatin-28PRO_0000033081Add
BLAST
Peptidei103 – 11614Somatostatin-14PRO_0000033082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi105 ↔ 116By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP26917.
PRIDEiP26917.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023020.

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ5. Eukaryota.
ENOG4111WUI. LUCA.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP26917.
KOiK05237.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSCRLQCAL AALSIVLALG GVTGAPSDPR LRQFLQKSLA AAAGKQELAK
60 70 80 90 100
YFLAELLSEP NQTEIDALEP EDLSQAAEQD EMRLELQRSA NSNPAMAPRE
110
RKAGCKNFFW KTFTSC
Length:116
Mass (Da):12,689
Last modified:August 1, 1992 - v1
Checksum:iC18F17E64A371D8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31217 mRNA. Translation: AAA30744.1.
U97077 Genomic DNA. Translation: AAB58056.1.
DQ156121 Genomic DNA. Translation: AAZ81422.1.
BC103253 mRNA. Translation: AAI03254.1.
PIRiA40929. RIBOS1.
RefSeqiNP_776385.1. NM_173960.1.
UniGeneiBt.49664.

Genome annotation databases

GeneIDi280932.
KEGGibta:280932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31217 mRNA. Translation: AAA30744.1.
U97077 Genomic DNA. Translation: AAB58056.1.
DQ156121 Genomic DNA. Translation: AAZ81422.1.
BC103253 mRNA. Translation: AAI03254.1.
PIRiA40929. RIBOS1.
RefSeqiNP_776385.1. NM_173960.1.
UniGeneiBt.49664.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023020.

Proteomic databases

PaxDbiP26917.
PRIDEiP26917.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280932.
KEGGibta:280932.

Organism-specific databases

CTDi6750.

Phylogenomic databases

eggNOGiENOG410IXQ5. Eukaryota.
ENOG4111WUI. LUCA.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP26917.
KOiK05237.

Miscellaneous databases

NextBioi20805049.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of the bovine somatostatin gene."
    Furu L.M., Kazmer G.W., Strausbaugh L., Zinn S.A.
    J. Anim. Sci. 77:492-493(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Holstein.
  3. Morsci N.S., Schnabel R.D., Taylor J.F.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiSMS_BOVIN
AccessioniPrimary (citable) accession number: P26917
Secondary accession number(s): Q3Y5Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 11, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.