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Protein

Vegetative catalase

Gene

katA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.2 Publications

Catalytic activityi

2 H2O2 = O2 + 2 H2O.1 Publication

Cofactori

heme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54PROSITE-ProRule annotationBy similarity1
Active sitei127By similarity1
Metal bindingi337Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU08820-MONOMER

Protein family/group databases

PeroxiBasei4082 BsKat01_168

Names & Taxonomyi

Protein namesi
Recommended name:
Vegetative catalase1 Publication (EC:1.11.1.61 Publication)
Gene namesi
Name:katA1 Publication
Synonyms:kat, kat-19
Ordered Locus Names:BSU08820
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Insertion mutant shows increased sensitivity to H202, reduced catalase expression and an absence of induced protection of the cell.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00000849752 – 483Vegetative catalaseAdd BLAST482

Proteomic databases

PaxDbiP26901
PRIDEiP26901

Expressioni

Developmental stagei

Elevated levels of expression during entry into the stationary phase of the growth cycle.1 Publication

Inductioni

By hydrogen peroxide.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100004888

Structurei

3D structure databases

ProteinModelPortaliP26901
SMRiP26901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiCOG0753 LUCA
HOGENOMiHOG000087852
InParanoidiP26901
KOiK03781
OMAiHADFGRM
PhylomeDBiP26901

Family and domain databases

Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNKLTTSW GAPVGDNQNS MTAGSRGPTL IQDVHLLEKL AHFNRERVPE
60 70 80 90 100
RVVHAKGAGA HGYFEVTNDV TKYTKAAFLS EVGKRTPLFI RFSTVAGELG
110 120 130 140 150
SADTVRDPRG FAVKFYTEEG NYDIVGNNTP VFFIRDAIKF PDFIHTQKRD
160 170 180 190 200
PKTHLKNPTA VWDFWSLSPE SLHQVTILMS DRGIPATLRH MHGFGSHTFK
210 220 230 240 250
WTNAEGEGVW IKYHFKTEQG VKNLDVNTAA KIAGENPDYH TEDLFNAIEN
260 270 280 290 300
GDYPAWKLYV QIMPLEDANT YRFDPFDVTK VWSQKDYPLI EVGRMVLDRN
310 320 330 340 350
PENYFAEVEQ ATFSPGTLVP GIDVSPDKML QGRLFAYHDA HRYRVGANHQ
360 370 380 390 400
ALPINRARNK VNNYQRDGQM RFDDNGGGSV YYEPNSFGGP KESPEDKQAA
410 420 430 440 450
YPVQGIADSV SYDHYDHYTQ AGDLYRLMSE DERTRLVENI VNAMKPVEKE
460 470 480
EIKLRQIEHF YKADPEYGKR VAEGLGLPIK KDS
Length:483
Mass (Da):54,791
Last modified:June 16, 2009 - v5
Checksum:i63BC1F23B6A39E16
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206G → P in AAA22402 (PubMed:1756979).Curated1
Sequence conflicti373D → G in CAB04807 (PubMed:9202460).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80796 Genomic DNA Translation: AAA22402.1
Z82044 Genomic DNA Translation: CAB04807.1
AL009126 Genomic DNA Translation: CAB12710.2
PIRiJH0532
RefSeqiNP_388762.2, NC_000964.3
WP_003245322.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB12710; CAB12710; BSU08820
GeneIDi939240
KEGGibsu:BSU08820
PATRICifig|224308.179.peg.952

Similar proteinsi

Entry informationi

Entry nameiCATA_BACSU
AccessioniPrimary (citable) accession number: P26901
Secondary accession number(s): P77838
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: June 16, 2009
Last modified: May 23, 2018
This is version 130 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

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