Skip Header

Contribute Send feedback
Read comments (?) or add your own

P26901 (CATA_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vegetative catalase
EC=1.11.1.6
Gene names
Name:katA
Synonyms:kat, kat-19
Ordered Locus Names:BSU08820
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activity

2 H2O2 = O2 + 2 H2O.

Cofactor

Heme group.

Subcellular location

Cytoplasm Probable.

Developmental stage

Elevated levels of expression during entry into the stationary phase of the growth cycle.

Induction

By hydrogen peroxide.

Sequence similarities

Belongs to the catalase family.

Ontologies

Keywords
   Biological processHydrogen peroxide
   Cellular componentCytoplasm
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncatalase activity

Inferred from electronic annotation. Source: EC

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5 Ref.6 Ref.7
Chain2 – 483482Vegetative catalase
PRO_0000084975

Sites

Active site541 By similarity
Active site1271 By similarity
Metal binding3371Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict2061G → P in AAA22402. Ref.1
Sequence conflict3731D → G in CAB04807. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P26901 [UniParc].

Last modified June 16, 2009. Version 5.
Checksum: 63BC1F23B6A39E16

FASTA48354,791
        10         20         30         40         50         60 
MSSNKLTTSW GAPVGDNQNS MTAGSRGPTL IQDVHLLEKL AHFNRERVPE RVVHAKGAGA 

        70         80         90        100        110        120 
HGYFEVTNDV TKYTKAAFLS EVGKRTPLFI RFSTVAGELG SADTVRDPRG FAVKFYTEEG 

       130        140        150        160        170        180 
NYDIVGNNTP VFFIRDAIKF PDFIHTQKRD PKTHLKNPTA VWDFWSLSPE SLHQVTILMS 

       190        200        210        220        230        240 
DRGIPATLRH MHGFGSHTFK WTNAEGEGVW IKYHFKTEQG VKNLDVNTAA KIAGENPDYH 

       250        260        270        280        290        300 
TEDLFNAIEN GDYPAWKLYV QIMPLEDANT YRFDPFDVTK VWSQKDYPLI EVGRMVLDRN 

       310        320        330        340        350        360 
PENYFAEVEQ ATFSPGTLVP GIDVSPDKML QGRLFAYHDA HRYRVGANHQ ALPINRARNK 

       370        380        390        400        410        420 
VNNYQRDGQM RFDDNGGGSV YYEPNSFGGP KESPEDKQAA YPVQGIADSV SYDHYDHYTQ 

       430        440        450        460        470        480 
AGDLYRLMSE DERTRLVENI VNAMKPVEKE EIKLRQIEHF YKADPEYGKR VAEGLGLPIK 


KDS

« Hide

References

« Hide 'large scale' references
[1]"The isolation, cloning and identification of a vegetative catalase gene from Bacillus subtilis."
Bol D.K., Yasbin R.E.
Gene 109:31-37(1991) [PubMed: 1756979] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / YB886 / BG214.
[2]"The Bacillus subtilis 168 chromosome from sspE to katA."
Cummings N.J., Connerton I.F.
Microbiology 143:1855-1859(1997) [PubMed: 9202460] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[4]"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
Microbiology 155:1758-1775(2009) [PubMed: 19383706] [Abstract]
Cited for: SEQUENCE REVISION TO 373.
[5]"Isolation and characterization of a hydrogen peroxide resistant mutant of Bacillus subtilis."
Hartford O.M., Dowds B.C.A.
Microbiology 140:297-304(1994) [PubMed: 8180695] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-19.
Strain: 168 / YB886 / BG214.
[6]"Proteome analysis of Bacillus subtilis extracellular proteins: a two-dimensional protein electrophoretic study."
Hirose I., Sano K., Shioda I., Kumano M., Nakamura K., Yamane K.
Microbiology 146:65-75(2000) [PubMed: 10658653] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-11.
Strain: 168.
[7]Bano S., Qader S.A.U., Aman A., Azhar A.
Submitted (AUG-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-11.
Strain: KIBGE-HAS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M80796 Genomic DNA. Translation: AAA22402.1.
Z82044 Genomic DNA. Translation: CAB04807.1.
AL009126 Genomic DNA. Translation: CAB12710.2.
PIRJH0532.
RefSeqNP_388762.2. NC_000964.3.

3D structure databases

ProteinModelPortalP26901.
SMRP26901. Positions 6-475.
ModBaseSearch...

Protein family/group databases

PeroxiBase4082. BsKat01_168.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000004087; EBBACP00000004087; EBBACG00000004079.
GeneID939240.
GenomeReviewsGene locus BSU08820 in contig AL009126_GR.
KEGGbsu:BSU08820.
NMPDRfig|224308.1.peg.881.
PATRIC18973456. VBIBacSub10457_0923.

Organism-specific databases

GenoListBSU08820. [Micado]

Phylogenomic databases

GeneTreeEBGT00050000002743.
HOGENOMHBG339355.
PhylomeDBP26901.
ProtClustDBCLSK886919.

Enzyme and pathway databases

BioCycBSUB:BSU08820-MONOMER.

Family and domain databases

InterProIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
Gene3DG3DSA:2.40.180.10. Catalase_N. 1 hit.
KOK03781.
PANTHERPTHR11465. Catalase. 1 hit.
PfamPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSPR00067. CATALASE.
SMARTSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMSSF56634. Catalase_N. 1 hit.
PROSITEPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCATA_BACSU
AccessionPrimary (citable) accession number: P26901
Secondary accession number(s): P77838
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: June 16, 2009
Last modified: January 25, 2012
This is version 96 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents