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Protein

Interleukin-2 receptor subunit alpha

Gene

IL2RA

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit alpha
Short name:
IL-2 receptor subunit alpha
Short name:
IL-2-RA
Short name:
IL-2R subunit alpha
Short name:
IL2-RA
Alternative name(s):
CD_antigen: CD25
Gene namesi
Name:IL2RA
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 243ExtracellularSequence analysisAdd BLAST222
Transmembranei244 – 262HelicalSequence analysisAdd BLAST19
Topological domaini263 – 275CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001102922 – 275Interleukin-2 receptor subunit alphaAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 64PROSITE-ProRule annotation
Disulfide bondi49 ↔ 77PROSITE-ProRule annotation
Disulfide bondi51 ↔ 79PROSITE-ProRule annotation
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi123 ↔ 168PROSITE-ProRule annotation
Disulfide bondi152 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP26898.

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP26898.
SMRiP26898.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 81Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini121 – 186Sushi 2PROSITE-ProRule annotationAdd BLAST66

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052109.
KOiK05068.

Family and domain databases

CDDicd00033. CCP. 1 hit.
InterProiView protein in InterPro
IPR015486. IL-2_rcpt_alpha.
IPR000436. Sushi_SCR_CCP_dom.
PANTHERiPTHR10573. PTHR10573. 1 hit.
PfamiView protein in Pfam
PF00084. Sushi. 1 hit.
SMARTiView protein in SMART
SM00032. CCP. 2 hits.
SUPFAMiSSF57535. SSF57535. 2 hits.
PROSITEiView protein in PROSITE
PS50923. SUSHI. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSLLMWRF FVFIVVPGCV TEACHDDPPS LRNAMFKVLR YEVGTMINCD
60 70 80 90 100
CKAGFRRVSA VMRCVGDSSH SAWNNRCFCN STSPAKNPVK PVTPGSEEQR
110 120 130 140 150
ERKPTDAQSQ TQPPEQADLP GHCEEPPPWE HEREPLKRVY HFTLGQTVHY
160 170 180 190 200
QCAQGFRALH TGPAESTCTM IHGEMRWTRP RLKCISEGAN SQAPDEAEPP
210 220 230 240 250
ESTEAPPGSG TFLTTRMAGT TDFQKPTDVV ATLDTFIFTT EYQIAVAGCI
260 270
LLLSSILLLS CLTWQRRWKK NRRTI
Length:275
Mass (Da):30,904
Last modified:August 1, 1992 - v1
Checksum:i1101A2DE5AC5A088
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166S → T in CAA42723 (PubMed:1572550).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11560 mRNA. Translation: CAA77652.1.
X60149 mRNA. Translation: CAA42723.1.
PIRiJC1113.
RefSeqiNP_001009415.1. NM_001009415.1.
UniGeneiOar.435.

Genome annotation databases

GeneIDi443435.
KEGGioas:443435.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIL2RA_SHEEP
AccessioniPrimary (citable) accession number: P26898
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 5, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome