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Protein

Interleukin-2 receptor subunit alpha

Gene

Il2ra

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.By similarity

GO - Molecular functioni

  • drug binding Source: RGD
  • interleukin-2 binding Source: GO_Central
  • interleukin-2 receptor activity Source: RGD

GO - Biological processi

  • activation-induced cell death of T cells Source: Ensembl
  • inflammatory response to antigenic stimulus Source: RGD
  • negative regulation of defense response to virus Source: RGD
  • negative regulation of immune response Source: RGD
  • negative regulation of inflammatory response Source: Ensembl
  • negative regulation of T cell proliferation Source: Ensembl
  • Notch signaling pathway Source: Ensembl
  • positive regulation of activated T cell proliferation Source: Ensembl
  • positive regulation of T cell differentiation Source: RGD
  • positive regulation of T cell proliferation Source: RGD
  • regulation of T cell homeostatic proliferation Source: Ensembl
  • regulation of T cell tolerance induction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-RNO-114604. GPVI-mediated activation cascade.
R-RNO-392451. G beta:gamma signalling through PI3Kgamma.
R-RNO-451927. Interleukin-2 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-912526. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit alpha
Short name:
IL-2 receptor subunit alpha
Short name:
IL-2-RA
Short name:
IL-2R subunit alpha
Short name:
IL2-RA
Alternative name(s):
CD_antigen: CD25
Gene namesi
Name:Il2ra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi2895. Il2ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 235214ExtracellularSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Topological domaini257 – 26711CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: RGD
  • external side of plasma membrane Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 267246Interleukin-2 receptor subunit alphaPRO_0000011028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 66PROSITE-ProRule annotation
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi49 ↔ 75PROSITE-ProRule annotation
Disulfide bondi51 ↔ 77PROSITE-ProRule annotation
Disulfide bondi120 ↔ 163PROSITE-ProRule annotation
Disulfide bondi147 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP26897.

Expressioni

Gene expression databases

BgeeiENSRNOG00000047647.
GenevisibleiP26897. RN.

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066383.

Structurei

3D structure databases

ProteinModelPortaliP26897.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 7958Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini118 – 18164Sushi 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J24B. Eukaryota.
ENOG41116U7. LUCA.
GeneTreeiENSGT00390000018872.
HOVERGENiHBG052109.
InParanoidiP26897.
KOiK05068.
OMAiCQAELCD.
OrthoDBiEOG091G0NHH.
PhylomeDBiP26897.

Family and domain databases

InterProiIPR015486. IL-2_rcpt_alpha.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR10573. PTHR10573. 1 hit.
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 2 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 2 hits.
PROSITEiPS50923. SUSHI. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPHLLMLGF LSFTIVPGCW AELCLYDPPE VPNATFKALS YKNGTILNCE
60 70 80 90 100
CKRGFRRLNE LVYMACLGNS WSNNCQCTSN SHDNSREQVT PQPEGQKEQQ
110 120 130 140 150
TTDTQKSTQS VYQENLAGHC REPPPWRHED TKRIYHFVEG QIVLYTCIQG
160 170 180 190 200
YKALQRGPAI SICKTVCGEI RWTHPQLTCV DEKEHHQFLA SEESQGSRNS
210 220 230 240 250
FPESEASCPT PNTDFSQLTE ATTTMETFVF TKEYQVAVAS CIFLLLSILL
260
LSGFTWQHRW RKSRRTI
Length:267
Mass (Da):30,557
Last modified:August 1, 1992 - v1
Checksum:i647B92D2E274302C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55049 mRNA. Translation: AAA41428.1.
PIRiA46535.
RefSeqiNP_037295.1. NM_013163.1.
UniGeneiRn.9872.

Genome annotation databases

EnsembliENSRNOT00000073144; ENSRNOP00000066383; ENSRNOG00000047647.
GeneIDi25704.
KEGGirno:25704.
UCSCiRGD:2895. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55049 mRNA. Translation: AAA41428.1.
PIRiA46535.
RefSeqiNP_037295.1. NM_013163.1.
UniGeneiRn.9872.

3D structure databases

ProteinModelPortaliP26897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066383.

Proteomic databases

PaxDbiP26897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073144; ENSRNOP00000066383; ENSRNOG00000047647.
GeneIDi25704.
KEGGirno:25704.
UCSCiRGD:2895. rat.

Organism-specific databases

CTDi3559.
RGDi2895. Il2ra.

Phylogenomic databases

eggNOGiENOG410J24B. Eukaryota.
ENOG41116U7. LUCA.
GeneTreeiENSGT00390000018872.
HOVERGENiHBG052109.
InParanoidiP26897.
KOiK05068.
OMAiCQAELCD.
OrthoDBiEOG091G0NHH.
PhylomeDBiP26897.

Enzyme and pathway databases

ReactomeiR-RNO-114604. GPVI-mediated activation cascade.
R-RNO-392451. G beta:gamma signalling through PI3Kgamma.
R-RNO-451927. Interleukin-2 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-912526. Interleukin receptor SHC signaling.

Miscellaneous databases

PROiP26897.

Gene expression databases

BgeeiENSRNOG00000047647.
GenevisibleiP26897. RN.

Family and domain databases

InterProiIPR015486. IL-2_rcpt_alpha.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR10573. PTHR10573. 1 hit.
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 2 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 2 hits.
PROSITEiPS50923. SUSHI. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL2RA_RAT
AccessioniPrimary (citable) accession number: P26897
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.