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Protein

Interleukin-2 receptor subunit alpha

Gene

Il2ra

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.By similarity

GO - Molecular functioni

  • drug binding Source: RGD
  • interleukin-2 binding Source: GO_Central
  • interleukin-2 receptor activity Source: Ensembl

GO - Biological processi

  • activation-induced cell death of T cells Source: Ensembl
  • inflammatory response to antigenic stimulus Source: RGD
  • negative regulation of defense response to virus Source: RGD
  • negative regulation of immune response Source: RGD
  • negative regulation of inflammatory response Source: Ensembl
  • negative regulation of T cell proliferation Source: Ensembl
  • Notch signaling pathway Source: Ensembl
  • positive regulation of activated T cell proliferation Source: Ensembl
  • positive regulation of T cell differentiation Source: RGD
  • positive regulation of T cell proliferation Source: RGD
  • regulation of T cell homeostatic proliferation Source: Ensembl
  • regulation of T cell tolerance induction Source: Ensembl

Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

ReactomeiR-RNO-392451 G beta:gamma signalling through PI3Kgamma
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-9020558 Interleukin-2 signaling
R-RNO-912526 Interleukin receptor SHC signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit alpha
Short name:
IL-2 receptor subunit alpha
Short name:
IL-2-RA
Short name:
IL-2R subunit alpha
Short name:
IL2-RA
Alternative name(s):
CD_antigen: CD25
Gene namesi
Name:Il2ra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi2895 Il2ra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 235ExtracellularSequence analysisAdd BLAST214
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 267CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001102822 – 267Interleukin-2 receptor subunit alphaAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 66PROSITE-ProRule annotation
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi49 ↔ 75PROSITE-ProRule annotation
Disulfide bondi51 ↔ 77PROSITE-ProRule annotation
Disulfide bondi120 ↔ 163PROSITE-ProRule annotation
Disulfide bondi147 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP26897

Expressioni

Gene expression databases

BgeeiENSRNOG00000047647
GenevisibleiP26897 RN

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066383

Structurei

3D structure databases

ProteinModelPortaliP26897
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 79Sushi 1PROSITE-ProRule annotationAdd BLAST58
Domaini118 – 181Sushi 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J24B Eukaryota
ENOG41116U7 LUCA
GeneTreeiENSGT00390000018872
HOVERGENiHBG052109
InParanoidiP26897
KOiK05068
OMAiTILNCEC
OrthoDBiEOG091G0NHH
PhylomeDBiP26897

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR015486 IL-2_rcpt_alpha
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10573 PTHR10573, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPHLLMLGF LSFTIVPGCW AELCLYDPPE VPNATFKALS YKNGTILNCE
60 70 80 90 100
CKRGFRRLNE LVYMACLGNS WSNNCQCTSN SHDNSREQVT PQPEGQKEQQ
110 120 130 140 150
TTDTQKSTQS VYQENLAGHC REPPPWRHED TKRIYHFVEG QIVLYTCIQG
160 170 180 190 200
YKALQRGPAI SICKTVCGEI RWTHPQLTCV DEKEHHQFLA SEESQGSRNS
210 220 230 240 250
FPESEASCPT PNTDFSQLTE ATTTMETFVF TKEYQVAVAS CIFLLLSILL
260
LSGFTWQHRW RKSRRTI
Length:267
Mass (Da):30,557
Last modified:August 1, 1992 - v1
Checksum:i647B92D2E274302C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55049 mRNA Translation: AAA41428.1
PIRiA46535
RefSeqiNP_037295.1, NM_013163.1
UniGeneiRn.9872

Genome annotation databases

EnsembliENSRNOT00000073144; ENSRNOP00000066383; ENSRNOG00000047647
GeneIDi25704
KEGGirno:25704
UCSCiRGD:2895 rat

Similar proteinsi

Entry informationi

Entry nameiIL2RA_RAT
AccessioniPrimary (citable) accession number: P26897
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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