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Protein

Interleukin-2 receptor subunit beta

Gene

Il2rb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

GO - Molecular functioni

  • interleukin-2 binding Source: RGD
  • interleukin-2 receptor activity Source: RGD

GO - Biological processi

  • cytokine-mediated signaling pathway Source: RGD
  • natural killer cell activation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit beta
Short name:
IL-2 receptor subunit beta
Short name:
IL-2R subunit beta
Short name:
IL-2RB
Alternative name(s):
High affinity IL-2 receptor subunit beta
p70-75
CD_antigen: CD122
Gene namesi
Name:Il2rb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2896. Il2rb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 239213ExtracellularSequence analysisAdd
BLAST
Transmembranei240 – 26728HelicalSequence analysisAdd
BLAST
Topological domaini268 – 537270CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 537511Interleukin-2 receptor subunit betaPRO_0000010880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 46By similarity
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi74 ↔ 86By similarity
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP26896.
PRIDEiP26896.

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation (By similarity).By similarity

GO - Molecular functioni

  • interleukin-2 binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064699.

Structurei

3D structure databases

ProteinModelPortaliP26896.
SMRiP26896. Positions 32-233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini135 – 235101Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi221 – 2255WSXWS motif
Motifi280 – 2889Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5H. Eukaryota.
ENOG410YXT9. LUCA.
HOVERGENiHBG052110.
InParanoidiP26896.
KOiK05069.
PhylomeDBiP26896.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVDLSWRL PLYILLLLLA TTWVSAAVND CSHLKCFYNS RANVSCMWSP
60 70 80 90 100
EEALNVTSCH IHAKSDMRHW NKTCELTPVR QASWACNLIL GPLPDSQSLT
110 120 130 140 150
SVDLLSLSVV CWEEKGWRRV KTCTFHPFDN LRLIAPHSLQ VLHIETRRCN
160 170 180 190 200
ISWEVSQVSH YVNPYLEFEA RRRLLDRSWE DASVFSLKQR QQWIFLETLT
210 220 230 240 250
PDTSYELQVR VIAQRGKTRT WSPWSQPMAF RTRPADPKEI FPLPWLRCLL
260 270 280 290 300
LVLGCFFGFL SCVCVLVKCR YLGPWLKTLL KCHIPDPSEF FSQLSSQHGG
310 320 330 340 350
DLQKWLSSPV PQSFFSPTGS APEISPLEVL DRDSKTMQML LFQKEKASSP
360 370 380 390 400
SPSGHSQASC FTNQGYFFFH LSNALEIESC QVYFTYDPCM EEDVEEDGPR
410 420 430 440 450
LPEESPLPPL LPFTGEQDDY CAFPPRDDLL LFSPSMSTPN TAYGNSITPE
460 470 480 490 500
ERPPLSLQEG LPSLASPDLM GLQHPLELEL GDDGEGMSTN SSGQQASVPE
510 520 530
AALMGTTKTE ARPVLTLNTD AYLSLQELQA QDSAHLI
Length:537
Mass (Da):60,657
Last modified:August 1, 1992 - v1
Checksum:i9C744A24F3361968
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55050 mRNA. Translation: AAA41429.1.
PIRiB46535.
RefSeqiNP_037327.1. NM_013195.1.
UniGeneiRn.5832.

Genome annotation databases

GeneIDi25746.
KEGGirno:25746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55050 mRNA. Translation: AAA41429.1.
PIRiB46535.
RefSeqiNP_037327.1. NM_013195.1.
UniGeneiRn.5832.

3D structure databases

ProteinModelPortaliP26896.
SMRiP26896. Positions 32-233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064699.

Proteomic databases

PaxDbiP26896.
PRIDEiP26896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25746.
KEGGirno:25746.

Organism-specific databases

CTDi3560.
RGDi2896. Il2rb.

Phylogenomic databases

eggNOGiENOG410II5H. Eukaryota.
ENOG410YXT9. LUCA.
HOVERGENiHBG052110.
InParanoidiP26896.
KOiK05069.
PhylomeDBiP26896.

Miscellaneous databases

PROiP26896.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL2RB_RAT
AccessioniPrimary (citable) accession number: P26896
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.