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Protein

Interleukin-8

Gene

CXCL8

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-380108. Chemokine receptors bind chemokines.
R-SSC-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-8
Short name:
IL-8
Alternative name(s):
Alveolar macrophage chemotactic factor I
Short name:
AMCF-I
C-X-C motif chemokine 8
Chemokine (C-X-C motif) ligand 8
Gene namesi
Name:CXCL8
Synonyms:IL8
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 252 PublicationsAdd BLAST25
ChainiPRO_000000513426 – 103Interleukin-8Add BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27CitrullineBy similarity1
Disulfide bondi34 ↔ 61By similarity
Disulfide bondi36 ↔ 77By similarity

Post-translational modificationi

Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiP26894.
PRIDEiP26894.

Expressioni

Tissue specificityi

Alveolar macrophages.

Inductioni

By lipopolysaccharide (LPS).

Gene expression databases

BgeeiENSSSCG00000008953.
ExpressionAtlasiP26894. differential.
GenevisibleiP26894. SS.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000026976.

Structurei

3D structure databases

ProteinModelPortaliP26894.
SMRiP26894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J24U. Eukaryota.
ENOG410Z1BP. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP26894.
KOiK10030.
OMAiPTAPWVQ.
OrthoDBiEOG091G13J8.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiView protein in InterPro
IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR028469. Interleukin-8.
IPR036048. Interleukin_8-like_sf.
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF70. PTHR10179:SF70. 1 hit.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00471. SMALL_CYTOKINES_CXC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKLAVAFL AVFLLSAALC EAAVLARVSA ELRCQCINTH STPFHPKFIK
60 70 80 90 100
ELRVIESGPH CENSEIIVKL VNGKEVCLDP KEKWVQKVVQ IFLKRTEKQQ

QQQ
Length:103
Mass (Da):11,633
Last modified:August 1, 1992 - v1
Checksum:i9FE0E350E1928C64
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 34RC → CR AA sequence (PubMed:1850745).Curated2
Sequence conflicti87K → KK in CAA43461 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86923 mRNA. Translation: AAA16616.1.
X61151 mRNA. Translation: CAA43461.1.
M99367 mRNA. Translation: AAA92576.1.
PIRiA39819.
A53096.
RefSeqiNP_999032.1. NM_213867.1.
XP_003362006.1. XM_003361958.3.
UniGeneiSsc.658.

Genome annotation databases

EnsembliENSSSCT00000009807; ENSSSCP00000009554; ENSSSCG00000008953.
GeneIDi396880.
KEGGissc:396880.

Similar proteinsi

Entry informationi

Entry nameiIL8_PIG
AccessioniPrimary (citable) accession number: P26894
Secondary accession number(s): P22951
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 25, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families