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Protein

Interleukin-8

Gene

CXCL8

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-SSC-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-SSC-375276. Peptide ligand-binding receptors.
R-SSC-380108. Chemokine receptors bind chemokines.
R-SSC-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-8
Short name:
IL-8
Alternative name(s):
Alveolar macrophage chemotactic factor I
Short name:
AMCF-I
C-X-C motif chemokine 8
Chemokine (C-X-C motif) ligand 8
Gene namesi
Name:CXCL8
Synonyms:IL8
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25252 PublicationsAdd
BLAST
Chaini26 – 10378Interleukin-8PRO_0000005134Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271CitrullineBy similarity
Disulfide bondi34 ↔ 61By similarity
Disulfide bondi36 ↔ 77By similarity

Post-translational modificationi

Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiP26894.

Expressioni

Tissue specificityi

Alveolar macrophages.

Inductioni

By lipopolysaccharide (LPS).

Gene expression databases

BgeeiENSSSCG00000008953.
ExpressionAtlasiP26894. differential.
GenevisibleiP26894. SS.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000026976.

Structurei

3D structure databases

ProteinModelPortaliP26894.
SMRiP26894. Positions 31-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J24U. Eukaryota.
ENOG410Z1BP. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP26894.
KOiK10030.
OMAiWVQKVVE.
OrthoDBiEOG091G13J8.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR028469. Interleukin-8.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF15. PTHR10179:SF15. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKLAVAFL AVFLLSAALC EAAVLARVSA ELRCQCINTH STPFHPKFIK
60 70 80 90 100
ELRVIESGPH CENSEIIVKL VNGKEVCLDP KEKWVQKVVQ IFLKRTEKQQ

QQQ
Length:103
Mass (Da):11,633
Last modified:August 1, 1992 - v1
Checksum:i9FE0E350E1928C64
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 342RC → CR AA sequence (PubMed:1850745).Curated
Sequence conflicti87 – 871K → KK in CAA43461 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86923 mRNA. Translation: AAA16616.1.
X61151 mRNA. Translation: CAA43461.1.
M99367 mRNA. Translation: AAA92576.1.
PIRiA39819.
A53096.
RefSeqiNP_999032.1. NM_213867.1.
XP_003362006.1. XM_003361958.3.
UniGeneiSsc.658.

Genome annotation databases

EnsembliENSSSCT00000009807; ENSSSCP00000009554; ENSSSCG00000008953.
ENSSSCT00000023198; ENSSSCP00000026976; ENSSSCG00000027291.
GeneIDi100620730.
396880.
KEGGissc:100620730.
ssc:396880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86923 mRNA. Translation: AAA16616.1.
X61151 mRNA. Translation: CAA43461.1.
M99367 mRNA. Translation: AAA92576.1.
PIRiA39819.
A53096.
RefSeqiNP_999032.1. NM_213867.1.
XP_003362006.1. XM_003361958.3.
UniGeneiSsc.658.

3D structure databases

ProteinModelPortaliP26894.
SMRiP26894. Positions 31-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000026976.

Proteomic databases

PaxDbiP26894.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000009807; ENSSSCP00000009554; ENSSSCG00000008953.
ENSSSCT00000023198; ENSSSCP00000026976; ENSSSCG00000027291.
GeneIDi100620730.
396880.
KEGGissc:100620730.
ssc:396880.

Organism-specific databases

CTDi3576.

Phylogenomic databases

eggNOGiENOG410J24U. Eukaryota.
ENOG410Z1BP. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP26894.
KOiK10030.
OMAiWVQKVVE.
OrthoDBiEOG091G13J8.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-SSC-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-SSC-375276. Peptide ligand-binding receptors.
R-SSC-380108. Chemokine receptors bind chemokines.
R-SSC-418594. G alpha (i) signalling events.

Gene expression databases

BgeeiENSSSCG00000008953.
ExpressionAtlasiP26894. differential.
GenevisibleiP26894. SS.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR028469. Interleukin-8.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF15. PTHR10179:SF15. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL8_PIG
AccessioniPrimary (citable) accession number: P26894
Secondary accession number(s): P22951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.