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Protein

Interleukin-6

Gene

IL6

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Acute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Gene namesi
Name:IL6
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929By similarityAdd
BLAST
Chaini30 – 212183Interleukin-6PRO_0000015591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi72 ↔ 78By similarity
Modified residuei81 – 811PhosphoserineBy similarity
Disulfide bondi101 ↔ 111By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP26893.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024026.

Structurei

3D structure databases

ProteinModelPortaliP26893.
SMRiP26893. Positions 47-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
HOGENOMiHOG000236330.
HOVERGENiHBG000471.
InParanoidiP26893.
KOiK05405.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLSTSAFS PVAFSLGLLL VMATAFPTPE RLEEDAKGDA TSDKMLFTSP
60 70 80 90 100
DKTEELIKYI LGKISAMRKE MCEKYEKCEN SKEVLAENNL NLPKMAEKDG
110 120 130 140 150
CFQSGFNQET CLMRITTGLV EFQIYLDYLQ KEYESNKGNV EAVQISTKAL
160 170 180 190 200
IQTLRQKGKN PDKATTPNPT TNAGLLDKLQ SQNEWMKNTK IILILRSLED
210
FLQFSLRAIR IM
Length:212
Mass (Da):23,953
Last modified:May 27, 2002 - v2
Checksum:i1E736FB230B4FC5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301E → G in AAC37333 (PubMed:1873476).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86722 mRNA. Translation: AAC37333.1.
M80258 mRNA. Translation: AAC27127.1.
AF309651 mRNA. Translation: AAG27730.1.
PIRiI46590.
I46621.
RefSeqiNP_001239358.1. NM_001252429.1.
NP_999564.1. NM_214399.1.
UniGeneiSsc.62.

Genome annotation databases

GeneIDi100628202.
399500.
KEGGissc:100628202.
ssc:399500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86722 mRNA. Translation: AAC37333.1.
M80258 mRNA. Translation: AAC27127.1.
AF309651 mRNA. Translation: AAG27730.1.
PIRiI46590.
I46621.
RefSeqiNP_001239358.1. NM_001252429.1.
NP_999564.1. NM_214399.1.
UniGeneiSsc.62.

3D structure databases

ProteinModelPortaliP26893.
SMRiP26893. Positions 47-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024026.

Proteomic databases

PaxDbiP26893.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100628202.
399500.
KEGGissc:100628202.
ssc:399500.

Organism-specific databases

CTDi100136689.
3569.

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
HOGENOMiHOG000236330.
HOVERGENiHBG000471.
InParanoidiP26893.
KOiK05405.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequence of porcine interleukin 6 cDNA and expression of mRNA in synovial fibroblasts in vitro."
    Richards C., Saklatvala J.
    Cytokine 3:269-276(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression of interleukin-6 in porcine, ovine, and bovine preimplantation conceptuses."
    Mathialagan N., Bixby J.A., Roberts M.R.
    Mol. Reprod. Dev. 32:324-330(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning and expression of interleukin 6 gene from Landrance x Meishan hybrid swine."
    Liu S., Meng M., Gao R.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Landrace X Meishan.
    Tissue: Blood.

Entry informationi

Entry nameiIL6_PIG
AccessioniPrimary (citable) accession number: P26893
Secondary accession number(s): Q95KN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: May 27, 2002
Last modified: November 11, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.