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Protein

Interleukin-6

Gene

IL6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Acute phase

Enzyme and pathway databases

ReactomeiR-BTA-1059683. Interleukin-6 signaling.
R-BTA-110056. MAPK3 (ERK1) activation.
R-BTA-112411. MAPK1 (ERK2) activation.
R-BTA-2559582. Senescence-Associated Secretory Phenotype (SASP).

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Gene namesi
Name:IL6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • extracellular space Source: AgBase
  • interleukin-6 receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000001557330 – 208Interleukin-6Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi72 ↔ 78By similarity
Modified residuei81PhosphoserineBy similarity1
Disulfide bondi101 ↔ 111By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP26892.
PRIDEiP26892.

Expressioni

Gene expression databases

BgeeiENSBTAG00000014921.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019865.

Structurei

3D structure databases

ProteinModelPortaliP26892.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
GeneTreeiENSGT00390000000878.
HOGENOMiHOG000236330.
HOVERGENiHBG000471.
InParanoidiP26892.
KOiK05405.
OMAiFNQETCL.
OrthoDBiEOG091G0NW5.
TreeFamiTF335984.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSRFTSAFT PFAVSLGLLL VMTSAFPTPG PLGEDFKNDT TPGRLLLTTP
60 70 80 90 100
EKTEALIKRM VDKISAMRKE ICEKNDECES SKETLAENKL NLPKMEEKDG
110 120 130 140 150
CFQSGFNQAI CLIRTTAGLL EYQIYLDYLQ NEYEGNQENV RDLRKNIRTL
160 170 180 190 200
IQILKQKIAD LITTPATNTD LLEKMQSSNE WVKNAKIILI LRNLENFLQF

SLRAIRMK
Length:208
Mass (Da):23,759
Last modified:August 1, 1992 - v1
Checksum:iA0F000B9BA2EC341
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57317 mRNA. Translation: CAA40572.1.
EU276071 mRNA. Translation: ABX72069.1.
BC123577 mRNA. Translation: AAI23578.1.
PIRiA56610.
RefSeqiNP_776348.1. NM_173923.2.
UniGeneiBt.3686.

Genome annotation databases

EnsembliENSBTAT00000019865; ENSBTAP00000019865; ENSBTAG00000014921.
GeneIDi280826.
KEGGibta:280826.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57317 mRNA. Translation: CAA40572.1.
EU276071 mRNA. Translation: ABX72069.1.
BC123577 mRNA. Translation: AAI23578.1.
PIRiA56610.
RefSeqiNP_776348.1. NM_173923.2.
UniGeneiBt.3686.

3D structure databases

ProteinModelPortaliP26892.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019865.

Proteomic databases

PaxDbiP26892.
PRIDEiP26892.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019865; ENSBTAP00000019865; ENSBTAG00000014921.
GeneIDi280826.
KEGGibta:280826.

Organism-specific databases

CTDi3569.

Phylogenomic databases

eggNOGiENOG410IW11. Eukaryota.
ENOG4112BXV. LUCA.
GeneTreeiENSGT00390000000878.
HOGENOMiHOG000236330.
HOVERGENiHBG000471.
InParanoidiP26892.
KOiK05405.
OMAiFNQETCL.
OrthoDBiEOG091G0NW5.
TreeFamiTF335984.

Enzyme and pathway databases

ReactomeiR-BTA-1059683. Interleukin-6 signaling.
R-BTA-110056. MAPK3 (ERK1) activation.
R-BTA-112411. MAPK1 (ERK2) activation.
R-BTA-2559582. Senescence-Associated Secretory Phenotype (SASP).

Gene expression databases

BgeeiENSBTAG00000014921.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL6_BOVIN
AccessioniPrimary (citable) accession number: P26892
Secondary accession number(s): A9QWQ9, Q08DT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.