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Protein

Peptidyl-prolyl cis-trans isomerase FKBP2

Gene

FKBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

  • FK506 binding Source: ProtInc
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciZFISH:HS10674-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP2 (EC:5.2.1.8)
Short name:
PPIase FKBP2
Alternative name(s):
13 kDa FK506-binding protein
Short name:
13 kDa FKBP
Short name:
FKBP-13
FK506-binding protein 2
Short name:
FKBP-2
Immunophilin FKBP13
Rotamase
Gene namesi
Name:FKBP2
Synonyms:FKBP13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:3718. FKBP2.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: ProtInc
  • endoplasmic reticulum membrane Source: GO_Central
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2286.
OpenTargetsiENSG00000173486.
PharmGKBiPA28159.

Polymorphism and mutation databases

BioMutaiFKBP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000002550622 – 142Peptidyl-prolyl cis-trans isomerase FKBP2Add BLAST121

Proteomic databases

EPDiP26885.
PaxDbiP26885.
PeptideAtlasiP26885.
PRIDEiP26885.
TopDownProteomicsiP26885.

2D gel databases

OGPiP26885.

PTM databases

iPTMnetiP26885.
PhosphoSitePlusiP26885.

Expressioni

Tissue specificityi

T-cells and thymus.

Gene expression databases

BgeeiENSG00000173486.
CleanExiHS_FKBP2.
ExpressionAtlasiP26885. baseline and differential.
GenevisibleiP26885. HS.

Organism-specific databases

HPAiCAB025561.
HPA049405.

Interactioni

Subunit structurei

Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX03EBI-719873,EBI-741480
UBQLN1Q9UMX0-23EBI-719873,EBI-10173939
UBQLN4Q9NRR52EBI-719873,EBI-711226

Protein-protein interaction databases

BioGridi108576. 47 interactors.
IntActiP26885. 9 interactors.
MINTiMINT-1421370.
STRINGi9606.ENSP00000310935.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi51 – 59Combined sources9
Beta strandi65 – 69Combined sources5
Turni70 – 73Combined sources4
Beta strandi76 – 79Combined sources4
Beta strandi82 – 85Combined sources4
Helixi87 – 90Combined sources4
Beta strandi101 – 106Combined sources6
Helixi108 – 110Combined sources3
Turni111 – 115Combined sources5
Turni118 – 120Combined sources3
Beta strandi127 – 136Combined sources10
Helixi137 – 139Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PBCX-ray1.80A/B/C/D43-142[»]
4NNRX-ray1.98A/B1-142[»]
ProteinModelPortaliP26885.
SMRiP26885.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26885.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 137PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi139 – 142Prevents secretion from ERSequence analysis4

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiP26885.
KOiK09569.
OMAiQGLMGMC.
OrthoDBiEOG091G02W1.
PhylomeDBiP26885.
TreeFamiTF105292.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSWFRVLT VLSICLSAVA TATGAEGKRK LQIGVKKRVD HCPIKSRKGD
60 70 80 90 100
VLHMHYTGKL EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE
110 120 130 140
KRKLVIPSEL GYGERGAPPK IPGGATLVFE VELLKIERRT EL
Length:142
Mass (Da):15,649
Last modified:September 19, 2002 - v2
Checksum:i01024F869BA7B5DA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0506237R → Q.1 PublicationCorresponds to variant rs4672dbSNPEnsembl.1
Natural variantiVAR_00641021 – 22TA → S.2
Natural variantiVAR_00641125A → T.1
Natural variantiVAR_00641297C → Y.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65128 mRNA. Translation: AAA58473.1.
M75099 mRNA. Translation: AAA36563.1.
BC003384 mRNA. Translation: AAH03384.1.
BC091475 mRNA. Translation: AAH91475.1.
CCDSiCCDS8063.1.
PIRiJC1365.
RefSeqiNP_001128680.1. NM_001135208.1.
NP_004461.2. NM_004470.3.
NP_476433.1. NM_057092.2.
XP_005273905.1. XM_005273848.3.
UniGeneiHs.227729.

Genome annotation databases

EnsembliENST00000309366; ENSP00000310935; ENSG00000173486.
ENST00000394540; ENSP00000378046; ENSG00000173486.
ENST00000449942; ENSP00000398147; ENSG00000173486.
GeneIDi2286.
KEGGihsa:2286.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65128 mRNA. Translation: AAA58473.1.
M75099 mRNA. Translation: AAA36563.1.
BC003384 mRNA. Translation: AAH03384.1.
BC091475 mRNA. Translation: AAH91475.1.
CCDSiCCDS8063.1.
PIRiJC1365.
RefSeqiNP_001128680.1. NM_001135208.1.
NP_004461.2. NM_004470.3.
NP_476433.1. NM_057092.2.
XP_005273905.1. XM_005273848.3.
UniGeneiHs.227729.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PBCX-ray1.80A/B/C/D43-142[»]
4NNRX-ray1.98A/B1-142[»]
ProteinModelPortaliP26885.
SMRiP26885.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108576. 47 interactors.
IntActiP26885. 9 interactors.
MINTiMINT-1421370.
STRINGi9606.ENSP00000310935.

PTM databases

iPTMnetiP26885.
PhosphoSitePlusiP26885.

Polymorphism and mutation databases

BioMutaiFKBP2.

2D gel databases

OGPiP26885.

Proteomic databases

EPDiP26885.
PaxDbiP26885.
PeptideAtlasiP26885.
PRIDEiP26885.
TopDownProteomicsiP26885.

Protocols and materials databases

DNASUi2286.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309366; ENSP00000310935; ENSG00000173486.
ENST00000394540; ENSP00000378046; ENSG00000173486.
ENST00000449942; ENSP00000398147; ENSG00000173486.
GeneIDi2286.
KEGGihsa:2286.

Organism-specific databases

CTDi2286.
DisGeNETi2286.
GeneCardsiFKBP2.
HGNCiHGNC:3718. FKBP2.
HPAiCAB025561.
HPA049405.
MIMi186946. gene.
neXtProtiNX_P26885.
OpenTargetsiENSG00000173486.
PharmGKBiPA28159.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiP26885.
KOiK09569.
OMAiQGLMGMC.
OrthoDBiEOG091G02W1.
PhylomeDBiP26885.
TreeFamiTF105292.

Enzyme and pathway databases

BioCyciZFISH:HS10674-MONOMER.

Miscellaneous databases

ChiTaRSiFKBP2. human.
EvolutionaryTraceiP26885.
GeneWikiiFKBP2.
GenomeRNAii2286.
PROiP26885.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173486.
CleanExiHS_FKBP2.
ExpressionAtlasiP26885. baseline and differential.
GenevisibleiP26885. HS.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP2_HUMAN
AccessioniPrimary (citable) accession number: P26885
Secondary accession number(s): Q5BJH9, Q9BTS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 19, 2002
Last modified: November 30, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.