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P26885

- FKBP2_HUMAN

UniProt

P26885 - FKBP2_HUMAN

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Protein
Peptidyl-prolyl cis-trans isomerase FKBP2
Gene
FKBP2, FKBP13
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

  1. FK506 binding Source: RefGenome
  2. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome
  3. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. chaperone-mediated protein folding Source: RefGenome
  2. protein peptidyl-prolyl isomerization Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP2 (EC:5.2.1.8)
Short name:
PPIase FKBP2
Alternative name(s):
13 kDa FK506-binding protein
Short name:
13 kDa FKBP
Short name:
FKBP-13
FK506-binding protein 2
Short name:
FKBP-2
Immunophilin FKBP13
Rotamase
Gene namesi
Name:FKBP2
Synonyms:FKBP13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:3718. FKBP2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: ProtInc
  2. endoplasmic reticulum membrane Source: RefGenome
  3. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121
Add
BLAST
Chaini22 – 142121Peptidyl-prolyl cis-trans isomerase FKBP2
PRO_0000025506Add
BLAST

Proteomic databases

MaxQBiP26885.
PaxDbiP26885.
PeptideAtlasiP26885.
PRIDEiP26885.

2D gel databases

OGPiP26885.

PTM databases

PhosphoSiteiP26885.

Expressioni

Tissue specificityi

T-cells and thymus.

Gene expression databases

ArrayExpressiP26885.
BgeeiP26885.
CleanExiHS_FKBP2.
GenevestigatoriP26885.

Organism-specific databases

HPAiCAB025561.
HPA049405.

Interactioni

Subunit structurei

Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN4Q9NRR52EBI-719873,EBI-711226

Protein-protein interaction databases

BioGridi108576. 12 interactions.
IntActiP26885. 6 interactions.
MINTiMINT-1421370.
STRINGi9606.ENSP00000310935.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi51 – 599
Beta strandi65 – 695
Turni70 – 734
Beta strandi76 – 794
Beta strandi82 – 854
Helixi87 – 904
Beta strandi101 – 1066
Helixi108 – 1103
Turni111 – 1155
Turni118 – 1203
Beta strandi127 – 13610
Helixi137 – 1393

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PBCX-ray1.80A/B/C/D43-142[»]
4NNRX-ray1.98A/B1-142[»]
ProteinModelPortaliP26885.
SMRiP26885. Positions 43-140.

Miscellaneous databases

EvolutionaryTraceiP26885.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 13789PPIase FKBP-type
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi139 – 1424Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiP26885.
KOiK09569.
OMAiKRVENCT.
OrthoDBiEOG7T1R9S.
PhylomeDBiP26885.
TreeFamiTF105292.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26885-1 [UniParc]FASTAAdd to Basket

« Hide

MRLSWFRVLT VLSICLSAVA TATGAEGKRK LQIGVKKRVD HCPIKSRKGD    50
VLHMHYTGKL EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE 100
KRKLVIPSEL GYGERGAPPK IPGGATLVFE VELLKIERRT EL 142
Length:142
Mass (Da):15,649
Last modified:September 19, 2002 - v2
Checksum:i01024F869BA7B5DA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71R → Q.1 Publication
Corresponds to variant rs4672 [ dbSNP | Ensembl ].
VAR_050623
Natural varianti21 – 222TA → S.
VAR_006410
Natural varianti25 – 251A → T.
VAR_006411
Natural varianti97 – 971C → Y.
VAR_006412

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M65128 mRNA. Translation: AAA58473.1.
M75099 mRNA. Translation: AAA36563.1.
BC003384 mRNA. Translation: AAH03384.1.
BC091475 mRNA. Translation: AAH91475.1.
CCDSiCCDS8063.1.
PIRiJC1365.
RefSeqiNP_001128680.1. NM_001135208.1.
NP_004461.2. NM_004470.3.
NP_476433.1. NM_057092.2.
XP_005273905.1. XM_005273848.2.
XP_006718539.1. XM_006718476.1.
UniGeneiHs.227729.

Genome annotation databases

EnsembliENST00000309366; ENSP00000310935; ENSG00000173486.
ENST00000394540; ENSP00000378046; ENSG00000173486.
ENST00000449942; ENSP00000398147; ENSG00000173486.
GeneIDi2286.
KEGGihsa:2286.
UCSCiuc001nyy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M65128 mRNA. Translation: AAA58473.1 .
M75099 mRNA. Translation: AAA36563.1 .
BC003384 mRNA. Translation: AAH03384.1 .
BC091475 mRNA. Translation: AAH91475.1 .
CCDSi CCDS8063.1.
PIRi JC1365.
RefSeqi NP_001128680.1. NM_001135208.1.
NP_004461.2. NM_004470.3.
NP_476433.1. NM_057092.2.
XP_005273905.1. XM_005273848.2.
XP_006718539.1. XM_006718476.1.
UniGenei Hs.227729.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PBC X-ray 1.80 A/B/C/D 43-142 [» ]
4NNR X-ray 1.98 A/B 1-142 [» ]
ProteinModelPortali P26885.
SMRi P26885. Positions 43-140.
ModBasei Search...

Protein-protein interaction databases

BioGridi 108576. 12 interactions.
IntActi P26885. 6 interactions.
MINTi MINT-1421370.
STRINGi 9606.ENSP00000310935.

PTM databases

PhosphoSitei P26885.

2D gel databases

OGPi P26885.

Proteomic databases

MaxQBi P26885.
PaxDbi P26885.
PeptideAtlasi P26885.
PRIDEi P26885.

Protocols and materials databases

DNASUi 2286.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309366 ; ENSP00000310935 ; ENSG00000173486 .
ENST00000394540 ; ENSP00000378046 ; ENSG00000173486 .
ENST00000449942 ; ENSP00000398147 ; ENSG00000173486 .
GeneIDi 2286.
KEGGi hsa:2286.
UCSCi uc001nyy.3. human.

Organism-specific databases

CTDi 2286.
GeneCardsi GC11P064008.
HGNCi HGNC:3718. FKBP2.
HPAi CAB025561.
HPA049405.
MIMi 186946. gene.
neXtProti NX_P26885.
PharmGKBi PA28159.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0545.
HOGENOMi HOG000154887.
HOVERGENi HBG051623.
InParanoidi P26885.
KOi K09569.
OMAi KRVENCT.
OrthoDBi EOG7T1R9S.
PhylomeDBi P26885.
TreeFami TF105292.

Miscellaneous databases

ChiTaRSi FKBP2. human.
EvolutionaryTracei P26885.
GeneWikii FKBP2.
GenomeRNAii 2286.
NextBioi 9289.
PROi P26885.
SOURCEi Search...

Gene expression databases

ArrayExpressi P26885.
Bgeei P26885.
CleanExi HS_FKBP2.
Genevestigatori P26885.

Family and domain databases

InterProi IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13."
    Jin Y.-J., Albers M.W., Lane W.S., Bierer B.E., Schreiber S.L., Burakoff S.J.
    Proc. Natl. Acad. Sci. U.S.A. 88:6677-6681(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon carcinoma.
  2. "Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13."
    Dilella A.G., Hawkins A., Craig R.J., Schreiber S.L., Griffin C.A.
    Biochem. Biophys. Res. Commun. 189:819-823(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-7.
    Tissue: Placenta.
  4. "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506."
    Padilla P.I., Chang M.J., Pacheco-Rodriguez G., Adamik R., Moss J., Vaughan M.
    Proc. Natl. Acad. Sci. U.S.A. 100:2322-2327(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARFGEF1.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFKBP2_HUMAN
AccessioniPrimary (citable) accession number: P26885
Secondary accession number(s): Q5BJH9, Q9BTS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 19, 2002
Last modified: September 3, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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