P26885 (FKBP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP2
Short name=PPIase FKBP2
EC=5.2.1.8

Alternative name(s):
13 kDa FK506-binding protein
Short name=13 kDa FKBP
Short name=FKBP-13
FK506-binding protein 2
Short name=FKBP-2
Immunophilin FKBP13
Rotamase

Gene names

Name:	FKBP2
Synonyms:	FKBP13

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Inhibited by both FK506 and rapamycin.
Subunit structure	Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2. Ref.4
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein Probable.
Tissue specificity	T-cells and thymus.
Sequence similarities	Belongs to the FKBP-type PPIase family. FKBP2 subfamily. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Isomerase Rotamase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FK506 binding Inferred from Biological aspect of Ancestor. Source: RefGenome peptidyl-prolyl cis-trans isomerase activity Inferred from Biological aspect of Ancestor. Source: RefGenome protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
UBQLN4	Q9NRR5	2	EBI-719873,EBI-711226

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

21

Chain

22 – 142

121

Peptidyl-prolyl cis-trans isomerase FKBP2

PRO_0000025506

Regions

Domain

49 – 137

89

PPIase FKBP-type

Motif

139 – 142

4

Prevents secretion from ER Potential

Natural variations

Natural variant

7

1

R → Q. Ref.3
Corresponds to variant rs4672 [ dbSNP | Ensembl ].

VAR_050623

Natural variant

21 – 22

2

TA → S.

VAR_006410

Natural variant

25

1

A → T.

VAR_006411

Natural variant

97

1

C → Y.

VAR_006412

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

142

Helix Strand Turn

Details...

Beta strand

51 – 59

9

Beta strand

65 – 69

5

Turn

70 – 73

4

Beta strand

76 – 79

4

Beta strand

82 – 85

4

Helix

87 – 90

4

Beta strand

101 – 106

6

Helix

108 – 110

3

Turn

111 – 115

5

Turn

118 – 120

3

Beta strand

127 – 136

10

Helix

137 – 139

3

Sequences

	Sequence		Length	Mass (Da)
	P26885 [UniParc]. Last modified September 19, 2002. Version 2. Checksum: 01024F869BA7B5DA	FASTA	142	15,649
	10 20 30 40 50 60 MRLSWFRVLT VLSICLSAVA TATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL 70 80 90 100 110 120 EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK 130 140 IPGGATLVFE VELLKIERRT EL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13." Jin Y.-J., Albers M.W., Lane W.S., Bierer B.E., Schreiber S.L., Burakoff S.J. Proc. Natl. Acad. Sci. U.S.A. 88:6677-6681(1991) [PubMed: 1713687] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon carcinoma.
[2]	"Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13." Dilella A.G., Hawkins A., Craig R.J., Schreiber S.L., Griffin C.A. Biochem. Biophys. Res. Commun. 189:819-823(1992) [PubMed: 1281998] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-7. Tissue: Placenta.
[4]	"Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506." Padilla P.I., Chang M.J., Pacheco-Rodriguez G., Adamik R., Moss J., Vaughan M. Proc. Natl. Acad. Sci. U.S.A. 100:2322-2327(2003) [PubMed: 12606707] [Abstract] Cited for: INTERACTION WITH ARFGEF1.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M65128 mRNA. Translation: AAA58473.1.
M75099 mRNA. Translation: AAA36563.1.
BC003384 mRNA. Translation: AAH03384.1.
BC091475 mRNA. Translation: AAH91475.1.

IPI

IPI00002535.

PIR

JC1365.

RefSeq

NP_001128680.1. NM_001135208.1.
NP_004461.2. NM_004470.3.
NP_476433.1. NM_057092.2.

UniGene

Hs.227729.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2PBC	X-ray	1.80	A/B/C/D	43-142	[»]

ProteinModelPortal

P26885.

SMR

P26885. Positions 43-140.

ModBase

Search...

Protein-protein interaction databases

IntAct

P26885. 5 interactions.

MINT

MINT-1421370.

STRING

P26885.

Polymorphism databases

DMDM

23503054.

2D gel databases

OGP

P26885.

Proteomic databases

PeptideAtlas

P26885.

PRIDE

P26885.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000309366; ENSP00000310935; ENSG00000173486.
ENST00000394540; ENSP00000378046; ENSG00000173486.
ENST00000449942; ENSP00000398147; ENSG00000173486.

GeneID

2286.

KEGG

hsa:2286.

UCSC

uc001nyy.1. human.

Organism-specific databases

CTD

2286.

GeneCards

GC11P064008.

H-InvDB

HIX0009756.

HGNC

HGNC:3718. FKBP2.

HPA

CAB025561.

MIM

186946. gene.

neXtProt

NX_P26885.

PharmGKB

PA28159.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG15335.

HOGENOM

HBG731200.

HOVERGEN

HBG051623.

InParanoid

P26885.

OMA

DVELMKI.

OrthoDB

EOG4Q2DGT.

PhylomeDB

P26885.

Gene expression databases

ArrayExpress

P26885.

Bgee

P26885.

CleanEx

HS_FKBP2.

Genevestigator

P26885.

GermOnline

ENSG00000173486. Homo sapiens.

Family and domain databases

InterPro

IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]

KO

K09569.

PANTHER

PTHR10516. PPIase_FKBP. 1 hit.

Pfam

PF00254. FKBP_C. 1 hit.
[Graphical view]

PROSITE

PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

9289.

SOURCE

Search...

Entry information

Entry name

FKBP2_HUMAN

Accession

Primary (citable) accession number: P26885
Secondary accession number(s): Q5BJH9, Q9BTS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	September 19, 2002
Last modified:	January 25, 2012
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.