Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase FKBP2

Gene

FKBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

  1. FK506 binding Source: GO_Central
  2. peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

  1. chaperone-mediated protein folding Source: GO_Central
  2. protein peptidyl-prolyl isomerization Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP2 (EC:5.2.1.8)
Short name:
PPIase FKBP2
Alternative name(s):
13 kDa FK506-binding protein
Short name:
13 kDa FKBP
Short name:
FKBP-13
FK506-binding protein 2
Short name:
FKBP-2
Immunophilin FKBP13
Rotamase
Gene namesi
Name:FKBP2
Synonyms:FKBP13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:3718. FKBP2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: ProtInc
  2. endoplasmic reticulum membrane Source: GO_Central
  3. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 142121Peptidyl-prolyl cis-trans isomerase FKBP2PRO_0000025506Add
BLAST

Proteomic databases

MaxQBiP26885.
PaxDbiP26885.
PeptideAtlasiP26885.
PRIDEiP26885.

2D gel databases

OGPiP26885.

PTM databases

PhosphoSiteiP26885.

Expressioni

Tissue specificityi

T-cells and thymus.

Gene expression databases

BgeeiP26885.
CleanExiHS_FKBP2.
ExpressionAtlasiP26885. baseline and differential.
GenevestigatoriP26885.

Organism-specific databases

HPAiCAB025561.
HPA049405.

Interactioni

Subunit structurei

Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN4Q9NRR52EBI-719873,EBI-711226

Protein-protein interaction databases

BioGridi108576. 15 interactions.
IntActiP26885. 6 interactions.
MINTiMINT-1421370.
STRINGi9606.ENSP00000310935.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi51 – 599Combined sources
Beta strandi65 – 695Combined sources
Turni70 – 734Combined sources
Beta strandi76 – 794Combined sources
Beta strandi82 – 854Combined sources
Helixi87 – 904Combined sources
Beta strandi101 – 1066Combined sources
Helixi108 – 1103Combined sources
Turni111 – 1155Combined sources
Turni118 – 1203Combined sources
Beta strandi127 – 13610Combined sources
Helixi137 – 1393Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PBCX-ray1.80A/B/C/D43-142[»]
4NNRX-ray1.98A/B1-142[»]
ProteinModelPortaliP26885.
SMRiP26885. Positions 43-140.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26885.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 13789PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi139 – 1424Prevents secretion from ERSequence Analysis

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiP26885.
KOiK09569.
OMAiDVELMKI.
OrthoDBiEOG7T1R9S.
PhylomeDBiP26885.
TreeFamiTF105292.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSWFRVLT VLSICLSAVA TATGAEGKRK LQIGVKKRVD HCPIKSRKGD
60 70 80 90 100
VLHMHYTGKL EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE
110 120 130 140
KRKLVIPSEL GYGERGAPPK IPGGATLVFE VELLKIERRT EL
Length:142
Mass (Da):15,649
Last modified:September 19, 2002 - v2
Checksum:i01024F869BA7B5DA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71R → Q.1 Publication
Corresponds to variant rs4672 [ dbSNP | Ensembl ].
VAR_050623
Natural varianti21 – 222TA → S.
VAR_006410
Natural varianti25 – 251A → T.
VAR_006411
Natural varianti97 – 971C → Y.
VAR_006412

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65128 mRNA. Translation: AAA58473.1.
M75099 mRNA. Translation: AAA36563.1.
BC003384 mRNA. Translation: AAH03384.1.
BC091475 mRNA. Translation: AAH91475.1.
CCDSiCCDS8063.1.
PIRiJC1365.
RefSeqiNP_001128680.1. NM_001135208.1.
NP_004461.2. NM_004470.3.
NP_476433.1. NM_057092.2.
XP_005273905.1. XM_005273848.2.
XP_006718539.1. XM_006718476.1.
UniGeneiHs.227729.

Genome annotation databases

EnsembliENST00000309366; ENSP00000310935; ENSG00000173486.
ENST00000394540; ENSP00000378046; ENSG00000173486.
ENST00000449942; ENSP00000398147; ENSG00000173486.
GeneIDi2286.
KEGGihsa:2286.
UCSCiuc001nyy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65128 mRNA. Translation: AAA58473.1.
M75099 mRNA. Translation: AAA36563.1.
BC003384 mRNA. Translation: AAH03384.1.
BC091475 mRNA. Translation: AAH91475.1.
CCDSiCCDS8063.1.
PIRiJC1365.
RefSeqiNP_001128680.1. NM_001135208.1.
NP_004461.2. NM_004470.3.
NP_476433.1. NM_057092.2.
XP_005273905.1. XM_005273848.2.
XP_006718539.1. XM_006718476.1.
UniGeneiHs.227729.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PBCX-ray1.80A/B/C/D43-142[»]
4NNRX-ray1.98A/B1-142[»]
ProteinModelPortaliP26885.
SMRiP26885. Positions 43-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108576. 15 interactions.
IntActiP26885. 6 interactions.
MINTiMINT-1421370.
STRINGi9606.ENSP00000310935.

PTM databases

PhosphoSiteiP26885.

2D gel databases

OGPiP26885.

Proteomic databases

MaxQBiP26885.
PaxDbiP26885.
PeptideAtlasiP26885.
PRIDEiP26885.

Protocols and materials databases

DNASUi2286.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309366; ENSP00000310935; ENSG00000173486.
ENST00000394540; ENSP00000378046; ENSG00000173486.
ENST00000449942; ENSP00000398147; ENSG00000173486.
GeneIDi2286.
KEGGihsa:2286.
UCSCiuc001nyy.3. human.

Organism-specific databases

CTDi2286.
GeneCardsiGC11P064008.
HGNCiHGNC:3718. FKBP2.
HPAiCAB025561.
HPA049405.
MIMi186946. gene.
neXtProtiNX_P26885.
PharmGKBiPA28159.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiP26885.
KOiK09569.
OMAiDVELMKI.
OrthoDBiEOG7T1R9S.
PhylomeDBiP26885.
TreeFamiTF105292.

Miscellaneous databases

ChiTaRSiFKBP2. human.
EvolutionaryTraceiP26885.
GeneWikiiFKBP2.
GenomeRNAii2286.
NextBioi9289.
PROiP26885.
SOURCEiSearch...

Gene expression databases

BgeeiP26885.
CleanExiHS_FKBP2.
ExpressionAtlasiP26885. baseline and differential.
GenevestigatoriP26885.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13."
    Jin Y.-J., Albers M.W., Lane W.S., Bierer B.E., Schreiber S.L., Burakoff S.J.
    Proc. Natl. Acad. Sci. U.S.A. 88:6677-6681(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon carcinoma.
  2. "Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13."
    Dilella A.G., Hawkins A., Craig R.J., Schreiber S.L., Griffin C.A.
    Biochem. Biophys. Res. Commun. 189:819-823(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-7.
    Tissue: Placenta.
  4. "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506."
    Padilla P.I., Chang M.J., Pacheco-Rodriguez G., Adamik R., Moss J., Vaughan M.
    Proc. Natl. Acad. Sci. U.S.A. 100:2322-2327(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARFGEF1.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFKBP2_HUMAN
AccessioniPrimary (citable) accession number: P26885
Secondary accession number(s): Q5BJH9, Q9BTS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 19, 2002
Last modified: March 4, 2015
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.