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P26885 (FKBP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase FKBP2

Short name=PPIase FKBP2
EC=5.2.1.8
Alternative name(s):
13 kDa FK506-binding protein
Short name=13 kDa FKBP
Short name=FKBP-13
FK506-binding protein 2
Short name=FKBP-2
Immunophilin FKBP13
Rotamase
Gene names
Name:FKBP2
Synonyms:FKBP13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by both FK506 and rapamycin.

Subunit structure

Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2. Ref.4

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein Probable.

Tissue specificity

T-cells and thymus.

Sequence similarities

Belongs to the FKBP-type PPIase family. FKBP2 subfamily.

Contains 1 PPIase FKBP-type domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

UBQLN4Q9NRR52EBI-719873,EBI-711226

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121
Chain22 – 142121Peptidyl-prolyl cis-trans isomerase FKBP2
PRO_0000025506

Regions

Domain49 – 13789PPIase FKBP-type
Motif139 – 1424Prevents secretion from ER Potential

Natural variations

Natural variant71R → Q. Ref.3
Corresponds to variant rs4672 [ dbSNP | Ensembl ].
VAR_050623
Natural variant21 – 222TA → S.
VAR_006410
Natural variant251A → T.
VAR_006411
Natural variant971C → Y.
VAR_006412

Secondary structure

...................... 142
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P26885 [UniParc].

Last modified September 19, 2002. Version 2.
Checksum: 01024F869BA7B5DA

FASTA14215,649
        10         20         30         40         50         60 
MRLSWFRVLT VLSICLSAVA TATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL 

        70         80         90        100        110        120 
EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK 

       130        140 
IPGGATLVFE VELLKIERRT EL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13."
Jin Y.-J., Albers M.W., Lane W.S., Bierer B.E., Schreiber S.L., Burakoff S.J.
Proc. Natl. Acad. Sci. U.S.A. 88:6677-6681(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Colon carcinoma.
[2]"Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13."
Dilella A.G., Hawkins A., Craig R.J., Schreiber S.L., Griffin C.A.
Biochem. Biophys. Res. Commun. 189:819-823(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-7.
Tissue: Placenta.
[4]"Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506."
Padilla P.I., Chang M.J., Pacheco-Rodriguez G., Adamik R., Moss J., Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 100:2322-2327(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ARFGEF1.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M65128 mRNA. Translation: AAA58473.1.
M75099 mRNA. Translation: AAA36563.1.
BC003384 mRNA. Translation: AAH03384.1.
BC091475 mRNA. Translation: AAH91475.1.
CCDSCCDS8063.1.
PIRJC1365.
RefSeqNP_001128680.1. NM_001135208.1.
NP_004461.2. NM_004470.3.
NP_476433.1. NM_057092.2.
XP_005273905.1. XM_005273848.2.
XP_006718539.1. XM_006718476.1.
UniGeneHs.227729.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2PBCX-ray1.80A/B/C/D43-142[»]
4NNRX-ray1.98A/B1-142[»]
ProteinModelPortalP26885.
SMRP26885. Positions 43-140.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108576. 12 interactions.
IntActP26885. 6 interactions.
MINTMINT-1421370.
STRING9606.ENSP00000310935.

PTM databases

PhosphoSiteP26885.

2D gel databases

OGPP26885.

Proteomic databases

MaxQBP26885.
PaxDbP26885.
PeptideAtlasP26885.
PRIDEP26885.

Protocols and materials databases

DNASU2286.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309366; ENSP00000310935; ENSG00000173486.
ENST00000394540; ENSP00000378046; ENSG00000173486.
ENST00000449942; ENSP00000398147; ENSG00000173486.
GeneID2286.
KEGGhsa:2286.
UCSCuc001nyy.3. human.

Organism-specific databases

CTD2286.
GeneCardsGC11P064008.
HGNCHGNC:3718. FKBP2.
HPACAB025561.
HPA049405.
MIM186946. gene.
neXtProtNX_P26885.
PharmGKBPA28159.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0545.
HOGENOMHOG000154887.
HOVERGENHBG051623.
InParanoidP26885.
KOK09569.
OMAKRVENCT.
OrthoDBEOG7T1R9S.
PhylomeDBP26885.
TreeFamTF105292.

Gene expression databases

ArrayExpressP26885.
BgeeP26885.
CleanExHS_FKBP2.
GenevestigatorP26885.

Family and domain databases

InterProIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFKBP2. human.
EvolutionaryTraceP26885.
GeneWikiFKBP2.
GenomeRNAi2286.
NextBio9289.
PROP26885.
SOURCESearch...

Entry information

Entry nameFKBP2_HUMAN
AccessionPrimary (citable) accession number: P26885
Secondary accession number(s): Q5BJH9, Q9BTS7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 19, 2002
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM