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P26885

- FKBP2_HUMAN

UniProt

P26885 - FKBP2_HUMAN

Protein

Peptidyl-prolyl cis-trans isomerase FKBP2

Gene

FKBP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Inhibited by both FK506 and rapamycin.

    GO - Molecular functioni

    1. FK506 binding Source: RefGenome
    2. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome
    3. protein binding Source: IntAct

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. protein peptidyl-prolyl isomerization Source: RefGenome

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP2 (EC:5.2.1.8)
    Short name:
    PPIase FKBP2
    Alternative name(s):
    13 kDa FK506-binding protein
    Short name:
    13 kDa FKBP
    Short name:
    FKBP-13
    FK506-binding protein 2
    Short name:
    FKBP-2
    Immunophilin FKBP13
    Rotamase
    Gene namesi
    Name:FKBP2
    Synonyms:FKBP13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:3718. FKBP2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: ProtInc
    2. endoplasmic reticulum membrane Source: RefGenome
    3. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28159.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Add
    BLAST
    Chaini22 – 142121Peptidyl-prolyl cis-trans isomerase FKBP2PRO_0000025506Add
    BLAST

    Proteomic databases

    MaxQBiP26885.
    PaxDbiP26885.
    PeptideAtlasiP26885.
    PRIDEiP26885.

    2D gel databases

    OGPiP26885.

    PTM databases

    PhosphoSiteiP26885.

    Expressioni

    Tissue specificityi

    T-cells and thymus.

    Gene expression databases

    ArrayExpressiP26885.
    BgeeiP26885.
    CleanExiHS_FKBP2.
    GenevestigatoriP26885.

    Organism-specific databases

    HPAiCAB025561.
    HPA049405.

    Interactioni

    Subunit structurei

    Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UBQLN4Q9NRR52EBI-719873,EBI-711226

    Protein-protein interaction databases

    BioGridi108576. 12 interactions.
    IntActiP26885. 6 interactions.
    MINTiMINT-1421370.
    STRINGi9606.ENSP00000310935.

    Structurei

    Secondary structure

    1
    142
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi51 – 599
    Beta strandi65 – 695
    Turni70 – 734
    Beta strandi76 – 794
    Beta strandi82 – 854
    Helixi87 – 904
    Beta strandi101 – 1066
    Helixi108 – 1103
    Turni111 – 1155
    Turni118 – 1203
    Beta strandi127 – 13610
    Helixi137 – 1393

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PBCX-ray1.80A/B/C/D43-142[»]
    4NNRX-ray1.98A/B1-142[»]
    ProteinModelPortaliP26885.
    SMRiP26885. Positions 43-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP26885.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 13789PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi139 – 1424Prevents secretion from ERSequence Analysis

    Sequence similaritiesi

    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000154887.
    HOVERGENiHBG051623.
    InParanoidiP26885.
    KOiK09569.
    OMAiKRVENCT.
    OrthoDBiEOG7T1R9S.
    PhylomeDBiP26885.
    TreeFamiTF105292.

    Family and domain databases

    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P26885-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLSWFRVLT VLSICLSAVA TATGAEGKRK LQIGVKKRVD HCPIKSRKGD    50
    VLHMHYTGKL EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE 100
    KRKLVIPSEL GYGERGAPPK IPGGATLVFE VELLKIERRT EL 142
    Length:142
    Mass (Da):15,649
    Last modified:September 19, 2002 - v2
    Checksum:i01024F869BA7B5DA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71R → Q.1 Publication
    Corresponds to variant rs4672 [ dbSNP | Ensembl ].
    VAR_050623
    Natural varianti21 – 222TA → S.
    VAR_006410
    Natural varianti25 – 251A → T.
    VAR_006411
    Natural varianti97 – 971C → Y.
    VAR_006412

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65128 mRNA. Translation: AAA58473.1.
    M75099 mRNA. Translation: AAA36563.1.
    BC003384 mRNA. Translation: AAH03384.1.
    BC091475 mRNA. Translation: AAH91475.1.
    CCDSiCCDS8063.1.
    PIRiJC1365.
    RefSeqiNP_001128680.1. NM_001135208.1.
    NP_004461.2. NM_004470.3.
    NP_476433.1. NM_057092.2.
    XP_005273905.1. XM_005273848.2.
    XP_006718539.1. XM_006718476.1.
    UniGeneiHs.227729.

    Genome annotation databases

    EnsembliENST00000309366; ENSP00000310935; ENSG00000173486.
    ENST00000394540; ENSP00000378046; ENSG00000173486.
    ENST00000449942; ENSP00000398147; ENSG00000173486.
    GeneIDi2286.
    KEGGihsa:2286.
    UCSCiuc001nyy.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65128 mRNA. Translation: AAA58473.1 .
    M75099 mRNA. Translation: AAA36563.1 .
    BC003384 mRNA. Translation: AAH03384.1 .
    BC091475 mRNA. Translation: AAH91475.1 .
    CCDSi CCDS8063.1.
    PIRi JC1365.
    RefSeqi NP_001128680.1. NM_001135208.1.
    NP_004461.2. NM_004470.3.
    NP_476433.1. NM_057092.2.
    XP_005273905.1. XM_005273848.2.
    XP_006718539.1. XM_006718476.1.
    UniGenei Hs.227729.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PBC X-ray 1.80 A/B/C/D 43-142 [» ]
    4NNR X-ray 1.98 A/B 1-142 [» ]
    ProteinModelPortali P26885.
    SMRi P26885. Positions 43-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108576. 12 interactions.
    IntActi P26885. 6 interactions.
    MINTi MINT-1421370.
    STRINGi 9606.ENSP00000310935.

    PTM databases

    PhosphoSitei P26885.

    2D gel databases

    OGPi P26885.

    Proteomic databases

    MaxQBi P26885.
    PaxDbi P26885.
    PeptideAtlasi P26885.
    PRIDEi P26885.

    Protocols and materials databases

    DNASUi 2286.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309366 ; ENSP00000310935 ; ENSG00000173486 .
    ENST00000394540 ; ENSP00000378046 ; ENSG00000173486 .
    ENST00000449942 ; ENSP00000398147 ; ENSG00000173486 .
    GeneIDi 2286.
    KEGGi hsa:2286.
    UCSCi uc001nyy.3. human.

    Organism-specific databases

    CTDi 2286.
    GeneCardsi GC11P064008.
    HGNCi HGNC:3718. FKBP2.
    HPAi CAB025561.
    HPA049405.
    MIMi 186946. gene.
    neXtProti NX_P26885.
    PharmGKBi PA28159.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000154887.
    HOVERGENi HBG051623.
    InParanoidi P26885.
    KOi K09569.
    OMAi KRVENCT.
    OrthoDBi EOG7T1R9S.
    PhylomeDBi P26885.
    TreeFami TF105292.

    Miscellaneous databases

    ChiTaRSi FKBP2. human.
    EvolutionaryTracei P26885.
    GeneWikii FKBP2.
    GenomeRNAii 2286.
    NextBioi 9289.
    PROi P26885.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P26885.
    Bgeei P26885.
    CleanExi HS_FKBP2.
    Genevestigatori P26885.

    Family and domain databases

    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13."
      Jin Y.-J., Albers M.W., Lane W.S., Bierer B.E., Schreiber S.L., Burakoff S.J.
      Proc. Natl. Acad. Sci. U.S.A. 88:6677-6681(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon carcinoma.
    2. "Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13."
      Dilella A.G., Hawkins A., Craig R.J., Schreiber S.L., Griffin C.A.
      Biochem. Biophys. Res. Commun. 189:819-823(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-7.
      Tissue: Placenta.
    4. "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506."
      Padilla P.I., Chang M.J., Pacheco-Rodriguez G., Adamik R., Moss J., Vaughan M.
      Proc. Natl. Acad. Sci. U.S.A. 100:2322-2327(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARFGEF1.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFKBP2_HUMAN
    AccessioniPrimary (citable) accession number: P26885
    Secondary accession number(s): Q5BJH9, Q9BTS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3