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Protein

Peptidyl-prolyl cis-trans isomerase FKBP1A

Gene

Fkbp1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).By similarity

Enzyme regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

  • activin binding Source: MGI
  • drug binding Source: MGI
  • enzyme binding Source: Ensembl
  • FK506 binding Source: MGI
  • Hsp70 protein binding Source: Ensembl
  • ion channel binding Source: BHF-UCL
  • peptidyl-prolyl cis-trans isomerase activity Source: MGI
  • protein homodimerization activity Source: MGI
  • signal transducer activity Source: MGI
  • SMAD binding Source: MGI
  • type I transforming growth factor beta receptor binding Source: Ensembl

GO - Biological processi

  • amyloid fibril formation Source: MGI
  • chaperone-mediated protein folding Source: GO_Central
  • cytokine-mediated signaling pathway Source: MGI
  • heart morphogenesis Source: BHF-UCL
  • heart trabecula formation Source: BHF-UCL
  • muscle contraction Source: MGI
  • negative regulation of phosphoprotein phosphatase activity Source: MGI
  • negative regulation of protein phosphorylation Source: MGI
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • positive regulation of protein binding Source: MGI
  • positive regulation of protein ubiquitination Source: MGI
  • protein peptidyl-prolyl isomerization Source: MGI
  • regulation of activin receptor signaling pathway Source: MGI
  • regulation of amyloid precursor protein catabolic process Source: MGI
  • regulation of immune response Source: MGI
  • regulation of protein localization Source: MGI
  • regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
  • release of sequestered calcium ion into cytosol Source: MGI
  • response to caffeine Source: MGI
  • response to iron ion Source: Ensembl
  • SMAD protein complex assembly Source: MGI
  • supramolecular fiber organization Source: MGI
  • T cell proliferation Source: MGI
  • ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-MMU-2173789. TGF-beta receptor signaling activates SMADs.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP1A (EC:5.2.1.8By similarity)
Short name:
PPIase FKBP1A
Alternative name(s):
12 kDa FK506-binding protein
Short name:
12 kDa FKBP
Short name:
FKBP-12
Calstabin-1
FK506-binding protein 1A
Short name:
FKBP-1A
Immunophilin FKBP12
Rotamase
Gene namesi
Name:Fkbp1a
Synonyms:Fkbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95541. Fkbp1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000752901 – 108Peptidyl-prolyl cis-trans isomerase FKBP1AAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysine; alternateCombined sources1
Modified residuei53N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP26883.
MaxQBiP26883.
PaxDbiP26883.
PeptideAtlasiP26883.
PRIDEiP26883.

PTM databases

iPTMnetiP26883.
PhosphoSitePlusiP26883.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032966.
CleanExiMM_FKBP1A.
ExpressionAtlasiP26883. baseline and differential.
GenevisibleiP26883. MM.

Interactioni

Subunit structurei

Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation (By similarity). Interacts with ACVR1B and SMAD7 (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (PubMed:18268335). Interacts directly with RYR2 and RYR3 (By similarity). Interacts directly with RYR1 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Ryr1E9PZQ02EBI-6379901,EBI-642079

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199682. 3 interactors.
DIPiDIP-29707N.
IntActiP26883. 4 interactors.
MINTiMINT-4095099.
STRINGi10090.ENSMUSP00000037206.

Structurei

3D structure databases

ProteinModelPortaliP26883.
SMRiP26883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 108PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0544. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiP26883.
KOiK09568.
OMAiRVIAGWD.
TreeFamiTF105291.

Family and domain databases

InterProiView protein in InterPro
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiView protein in Pfam
PF00254. FKBP_C. 1 hit.
PROSITEiView protein in PROSITE
PS50059. FKBP_PPIASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P26883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFT
60 70 80 90 100
LGKQEVIRGW EEGVAQMSVG QRAKLIISSD YAYGATGHPG IIPPHATLVF

DVELLKLE
Length:108
Mass (Da):11,923
Last modified:January 23, 2007 - v2
Checksum:i8C265ED5803F6987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60203 mRNA. Translation: CAA42762.1.
U65100, U65098, U65099 Genomic DNA. Translation: AAB17554.1.
AF483488 mRNA. Translation: AAL90762.1.
AF483489 mRNA. Translation: AAL90763.1.
AK002777 mRNA. Translation: BAB22351.1.
AK010693 mRNA. Translation: BAB27125.1.
AK019362 mRNA. Translation: BAB31680.1.
AK154751 mRNA. Translation: BAE32804.1.
AK168333 mRNA. Translation: BAE40271.1.
AK169186 mRNA. Translation: BAE40963.1.
AK169242 mRNA. Translation: BAE41008.1.
BC004671 mRNA. Translation: AAH04671.1.
CCDSiCCDS16869.1.
PIRiJH0528.
RefSeqiNP_001289006.1. NM_001302077.1.
NP_001289007.1. NM_001302078.1.
NP_001289008.1. NM_001302079.1.
NP_001289009.1. NM_001302080.1.
NP_032045.1. NM_008019.3.
UniGeneiMm.278458.

Genome annotation databases

EnsembliENSMUST00000044011; ENSMUSP00000037206; ENSMUSG00000032966.
GeneIDi14225.
KEGGimmu:14225.
UCSCiuc008ndy.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiFKB1A_MOUSE
AccessioniPrimary (citable) accession number: P26883
Secondary accession number(s): Q545E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families