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P26875

- RNT1_TRIHA

UniProt

P26875 - RNT1_TRIHA

Protein

Guanyl-specific ribonuclease Th1

Gene
N/A
Organism
Trichoderma harzianum (Hypocrea lixii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    Two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in G-P with 2',3'-cyclic phosphate intermediates.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei39 – 391By similarity
    Active sitei58 – 581Proton acceptorBy similarity
    Active sitei92 – 921Proton donorBy similarity

    GO - Molecular functioni

    1. endoribonuclease activity Source: InterPro
    2. ribonuclease T1 activity Source: UniProtKB-EC
    3. RNA binding Source: InterPro

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanyl-specific ribonuclease Th1 (EC:3.1.27.3)
    Short name:
    RNase Th1
    OrganismiTrichoderma harzianum (Hypocrea lixii)
    Taxonomic identifieri5544 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 106106Guanyl-specific ribonuclease Th1PRO_0000137375Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi5 ↔ 103By similarity
    Disulfide bondi23 ↔ 84Curated

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliP26875.
    SMRiP26875. Positions 4-106.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribonuclease N1/T1 family.Curated

    Family and domain databases

    Gene3Di3.10.450.30. 1 hit.
    InterProiIPR000026. Gua-sp_ribonuclease_N1/T1.
    IPR016191. Ribonuclease/ribotoxin.
    [Graphical view]
    PfamiPF00545. Ribonuclease. 1 hit.
    [Graphical view]
    SUPFAMiSSF53933. SSF53933. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P26875-1 [UniParc]FASTAAdd to Basket

    « Hide

    DTATCGKVFY SASAVSAASN AACNYVRAGS TAGGSTYPHV YNNYEGFRFK    50
    GLSKPFYEFP ILSSGKTYTG GSPGADRVVI NGQCSIAGII THTGASGNAF 100
    VACGGT 106
    Length:106
    Mass (Da):10,750
    Last modified:August 1, 1992 - v1
    Checksum:i892A8BFE043AA022
    GO

    Sequence databases

    PIRiJN0428.

    Cross-referencesi

    Sequence databases

    PIRi JN0428.

    3D structure databases

    ProteinModelPortali P26875.
    SMRi P26875. Positions 4-106.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.10.450.30. 1 hit.
    InterProi IPR000026. Gua-sp_ribonuclease_N1/T1.
    IPR016191. Ribonuclease/ribotoxin.
    [Graphical view ]
    Pfami PF00545. Ribonuclease. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53933. SSF53933. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, analysis of amino acid sequence and crystallization of the extracellular ribonuclease Th1 from Trichoderma harzianum-01."
      Bezborodova S.I., Vasileva-Tonkova E.S., Polyakov K.M., Shlyapnikov S.V.
      Bioorg. Khim. 14:453-466(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Strain: 01.

    Entry informationi

    Entry nameiRNT1_TRIHA
    AccessioniPrimary (citable) accession number: P26875
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3