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P26875

- RNT1_TRIHA

UniProt

P26875 - RNT1_TRIHA

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Protein

Guanyl-specific ribonuclease Th1

Gene
N/A
Organism
Trichoderma harzianum (Hypocrea lixii)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in G-P with 2',3'-cyclic phosphate intermediates.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391
Active sitei58 – 581Proton acceptor
Active sitei92 – 921Proton donor

GO - Molecular functioni

  1. endoribonuclease activity Source: InterPro
  2. ribonuclease T1 activity Source: UniProtKB-EC
  3. RNA binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Guanyl-specific ribonuclease Th1 (EC:3.1.27.3)
Short name:
RNase Th1
OrganismiTrichoderma harzianum (Hypocrea lixii)
Taxonomic identifieri5544 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106Guanyl-specific ribonuclease Th1PRO_0000137375Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi5 ↔ 103
Disulfide bondi23 ↔ 84

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP26875.
SMRiP26875. Positions 4-106.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.10.450.30. 1 hit.
InterProiIPR000026. Gua-sp_ribonuclease_N1/T1.
IPR016191. Ribonuclease/ribotoxin.
[Graphical view]
PfamiPF00545. Ribonuclease. 1 hit.
[Graphical view]
SUPFAMiSSF53933. SSF53933. 1 hit.

Sequencei

Sequence statusi: Complete.

P26875-1 [UniParc]FASTAAdd to Basket

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DTATCGKVFY SASAVSAASN AACNYVRAGS TAGGSTYPHV YNNYEGFRFK    50
GLSKPFYEFP ILSSGKTYTG GSPGADRVVI NGQCSIAGII THTGASGNAF 100
VACGGT 106
Length:106
Mass (Da):10,750
Last modified:August 1, 1992 - v1
Checksum:i892A8BFE043AA022
GO

Sequence databases

PIRiJN0428.

Cross-referencesi

Sequence databases

PIRi JN0428.

3D structure databases

ProteinModelPortali P26875.
SMRi P26875. Positions 4-106.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.10.450.30. 1 hit.
InterProi IPR000026. Gua-sp_ribonuclease_N1/T1.
IPR016191. Ribonuclease/ribotoxin.
[Graphical view ]
Pfami PF00545. Ribonuclease. 1 hit.
[Graphical view ]
SUPFAMi SSF53933. SSF53933. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation, analysis of amino acid sequence and crystallization of the extracellular ribonuclease Th1 from Trichoderma harzianum-01."
    Bezborodova S.I., Vasileva-Tonkova E.S., Polyakov K.M., Shlyapnikov S.V.
    Bioorg. Khim. 14:453-466(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Strain: 01.

Entry informationi

Entry nameiRNT1_TRIHA
AccessioniPrimary (citable) accession number: P26875
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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