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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Marchantia polymorpha (Liverwort) (Marchantia aquatica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi184Copper ACurated1
Metal bindingi219Copper ACurated1
Metal bindingi223Copper ACurated1
Metal bindingi227Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COXII
Encoded oniMitochondrion
OrganismiMarchantia polymorpha (Liverwort) (Marchantia aquatica)
Taxonomic identifieri3197 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaMarchantiophytaMarchantiopsidaMarchantiidaeMarchantialesMarchantiaceaeMarchantia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39Mitochondrial intermembraneSequence analysisAdd BLAST39
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 75Mitochondrial matrixSequence analysisAdd BLAST15
Transmembranei76 – 104HelicalSequence analysisAdd BLAST29
Topological domaini105 – 251Mitochondrial intermembraneSequence analysisAdd BLAST147

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836311 – 251Cytochrome c oxidase subunit 2Add BLAST251

Structurei

3D structure databases

ProteinModelPortaliP26857
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P26857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLIWIFPIA FCDAAEPWQL GFQDPATPMM QGIIDLHNDI FFFLIVILIF
60 70 80 90 100
VLWMLVRALW HFHYKRNPIP ERIVHGTTIE IIWTIFPSII LMFIAIPSFA
110 120 130 140 150
LLYSMDEVVD PAITIKAIGH QWYWTYEYSD YNSSDEQSLT FDSYMIPEDD
160 170 180 190 200
LELGQLRLLE VDNRVVVPAK THLRMIITSA DVLHSWAVPS LGVKCDAVPG
210 220 230 240 250
RLNQTSIFIK REGVYYGQCS ELCGTNHGFM PIVVEAVSLD DYVSWVSNKL

D
Length:251
Mass (Da):28,894
Last modified:February 1, 1996 - v3
Checksum:i1A6527DB9503278A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68929 Genomic DNA Translation: AAC09432.1
PIRiS25950
RefSeqiNP_054434.1, NC_001660.1

Genome annotation databases

GeneIDi2702479

Similar proteinsi

Entry informationi

Entry nameiCOX2_MARPO
AccessioniPrimary (citable) accession number: P26857
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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