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P26857

- COX2_MARPO

UniProt

P26857 - COX2_MARPO

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Protein
Cytochrome c oxidase subunit 2
Gene
COX2, COXII
Organism
Marchantia polymorpha (Liverwort) (Marchantia aquatica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi184 – 1841Copper A Inferred
Metal bindingi219 – 2191Copper A Inferred
Metal bindingi223 – 2231Copper A Inferred
Metal bindingi227 – 2271Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COXII
Encoded oniMitochondrion
OrganismiMarchantia polymorpha (Liverwort) (Marchantia aquatica)
Taxonomic identifieri3197 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaMarchantiophytaMarchantiopsidaMarchantiidaeMarchantialesMarchantiaceaeMarchantia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei40 – 6021Helical; Reviewed prediction
Add
BLAST
Topological domaini61 – 7515Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei76 – 10429Helical; Reviewed prediction
Add
BLAST
Topological domaini105 – 251147Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Cytochrome c oxidase subunit 2
PRO_0000183631Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP26857.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26857-1 [UniParc]FASTAAdd to Basket

« Hide

MNLIWIFPIA FCDAAEPWQL GFQDPATPMM QGIIDLHNDI FFFLIVILIF    50
VLWMLVRALW HFHYKRNPIP ERIVHGTTIE IIWTIFPSII LMFIAIPSFA 100
LLYSMDEVVD PAITIKAIGH QWYWTYEYSD YNSSDEQSLT FDSYMIPEDD 150
LELGQLRLLE VDNRVVVPAK THLRMIITSA DVLHSWAVPS LGVKCDAVPG 200
RLNQTSIFIK REGVYYGQCS ELCGTNHGFM PIVVEAVSLD DYVSWVSNKL 250
D 251
Length:251
Mass (Da):28,894
Last modified:February 1, 1996 - v3
Checksum:i1A6527DB9503278A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68929 Genomic DNA. Translation: AAC09432.1.
PIRiS25950.
RefSeqiNP_054434.1. NC_001660.1.

Genome annotation databases

GeneIDi2702479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68929 Genomic DNA. Translation: AAC09432.1 .
PIRi S25950.
RefSeqi NP_054434.1. NC_001660.1.

3D structure databases

ProteinModelPortali P26857.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2702479.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene organization deduced from the complete sequence of liverwort Marchantia polymorpha mitochondrial DNA. A primitive form of plant mitochondrial genome."
    Oda K., Yamato K., Ohta E., Nakamura Y., Takemura M., Nozato N., Akashi K., Kanegae T., Ogura Y., Kohchi T., Ohyama K.
    J. Mol. Biol. 223:1-7(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX2_MARPO
AccessioniPrimary (citable) accession number: P26857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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