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P26857 (COX2_MARPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Synonyms:COXII
Encoded onMitochondrion
OrganismMarchantia polymorpha (Liverwort) (Marchantia aquatica)
Taxonomic identifier3197 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaMarchantiophytaMarchantiopsidaMarchantiidaeMarchantialesMarchantiaceaeMarchantia

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Cytochrome c oxidase subunit 2
PRO_0000183631

Regions

Topological domain1 – 3939Mitochondrial intermembrane Potential
Transmembrane40 – 6021Helical; Potential
Topological domain61 – 7515Mitochondrial matrix Potential
Transmembrane76 – 10429Helical; Potential
Topological domain105 – 251147Mitochondrial intermembrane Potential

Sites

Metal binding1841Copper A Probable
Metal binding2191Copper A Probable
Metal binding2231Copper A Probable
Metal binding2271Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P26857 [UniParc].

Last modified February 1, 1996. Version 3.
Checksum: 1A6527DB9503278A

FASTA25128,894
        10         20         30         40         50         60 
MNLIWIFPIA FCDAAEPWQL GFQDPATPMM QGIIDLHNDI FFFLIVILIF VLWMLVRALW 

        70         80         90        100        110        120 
HFHYKRNPIP ERIVHGTTIE IIWTIFPSII LMFIAIPSFA LLYSMDEVVD PAITIKAIGH 

       130        140        150        160        170        180 
QWYWTYEYSD YNSSDEQSLT FDSYMIPEDD LELGQLRLLE VDNRVVVPAK THLRMIITSA 

       190        200        210        220        230        240 
DVLHSWAVPS LGVKCDAVPG RLNQTSIFIK REGVYYGQCS ELCGTNHGFM PIVVEAVSLD 

       250 
DYVSWVSNKL D 

« Hide

References

[1]"Gene organization deduced from the complete sequence of liverwort Marchantia polymorpha mitochondrial DNA. A primitive form of plant mitochondrial genome."
Oda K., Yamato K., Ohta E., Nakamura Y., Takemura M., Nozato N., Akashi K., Kanegae T., Ogura Y., Kohchi T., Ohyama K.
J. Mol. Biol. 223:1-7(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M68929 Genomic DNA. Translation: AAC09432.1.
PIRS25950.
RefSeqNP_054434.1. NC_001660.1.

3D structure databases

ProteinModelPortalP26857.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2702479.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_MARPO
AccessionPrimary (citable) accession number: P26857
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families