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P26856

- COX1_MARPO

UniProt

P26856 - COX1_MARPO

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Protein
Cytochrome c oxidase subunit 1
Gene
COX1, COXI
Organism
Marchantia polymorpha (Liverwort) (Marchantia aquatica)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Iron (heme A axial ligand) Inferred
Metal bindingi244 – 2441Copper B Inferred
Metal bindingi248 – 2481Copper B Inferred
Metal bindingi293 – 2931Copper B Inferred
Metal bindingi294 – 2941Copper B Inferred
Metal bindingi379 – 3791Iron (heme A3 axial ligand) Inferred
Metal bindingi381 – 3811Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Synonyms:COXI
Encoded oniMitochondrion
OrganismiMarchantia polymorpha (Liverwort) (Marchantia aquatica)
Taxonomic identifieri3197 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaMarchantiophytaMarchantiopsidaMarchantiidaeMarchantialesMarchantiaceaeMarchantia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921Helical; Reviewed prediction
Add
BLAST
Transmembranei67 – 8721Helical; Reviewed prediction
Add
BLAST
Transmembranei104 – 12421Helical; Reviewed prediction
Add
BLAST
Transmembranei149 – 16921Helical; Reviewed prediction
Add
BLAST
Transmembranei187 – 20721Helical; Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Reviewed prediction
Add
BLAST
Transmembranei270 – 29021Helical; Reviewed prediction
Add
BLAST
Transmembranei313 – 33321Helical; Reviewed prediction
Add
BLAST
Transmembranei341 – 36121Helical; Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Reviewed prediction
Add
BLAST
Transmembranei417 – 43721Helical; Reviewed prediction
Add
BLAST
Transmembranei459 – 47921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. plasma membrane Source: InterPro
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Cytochrome c oxidase subunit 1
PRO_0000183360Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki244 ↔ 2481'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP26856.
SMRiP26856. Positions 4-514.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26856-1 [UniParc]FASTAAdd to Basket

« Hide

MNNFAQRWLF STNHKDIGTL YLIFGAIAGV MGTCFSVLIR MELAQPGNQI    50
LGGNHQLYNV LITAHAFLMI FFMVMPAMIG GFGNWFVPIL IGSPDMAFPR 100
LNNISFWLLP PSLLLLLSSA LVEVGCGSGW TVYPPLSGIT SHSGGSVDLA 150
IFSLHLSGVS SILGSINFIT TIFNMRAPGL TMHRLPLFVW SVLVTAFLLL 200
LSLPVLAGAI TMLLTDRNFN TTFFDPAGGG DPILYQHLFW FFGHPEVYIL 250
ILPGFGIISH IVSTFSRKPV FGYLGMVYAM ISIGVLGFIV WAHHMFTVGL 300
DVDTRAYFTA ATMIIAVPTG IKIFSWIATM WGGSIQYKTP MLFAVGFIFL 350
FTVGGLTGIV LANSGVDIAL HDTYYVVAHF HYVLSMGAVF ALFAGFYYWI 400
GKITGLQYPE TLGQIHFWIT FFGVNLTFFP MHFLGLAGMP RRIPDYPDAY 450
AGWNAFSSFG SYVSVVGIFC FFVVVFLTLT SENKCAPSPW AVEQNSTTLE 500
WMVPSPPAFH TFEELPAIKE SI 522
Length:522
Mass (Da):57,552
Last modified:February 1, 1994 - v2
Checksum:i4B88E16F03A11D01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68929 Genomic DNA. Translation: AAC09451.1.
PIRiS25956.
RefSeqiNP_054454.1. NC_001660.1.

Genome annotation databases

GeneIDi2702483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68929 Genomic DNA. Translation: AAC09451.1 .
PIRi S25956.
RefSeqi NP_054454.1. NC_001660.1.

3D structure databases

ProteinModelPortali P26856.
SMRi P26856. Positions 4-514.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2702483.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene organization deduced from the complete sequence of liverwort Marchantia polymorpha mitochondrial DNA. A primitive form of plant mitochondrial genome."
    Oda K., Yamato K., Ohta E., Nakamura Y., Takemura M., Nozato N., Akashi K., Kanegae T., Ogura Y., Kohchi T., Ohyama K.
    J. Mol. Biol. 223:1-7(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_MARPO
AccessioniPrimary (citable) accession number: P26856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1994
Last modified: September 3, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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