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P26856

- COX1_MARPO

UniProt

P26856 - COX1_MARPO

Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Marchantia polymorpha (Liverwort) (Marchantia aquatica)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi65 – 651Iron (heme A axial ligand)Curated
    Metal bindingi244 – 2441Copper BCurated
    Metal bindingi248 – 2481Copper BCurated
    Metal bindingi293 – 2931Copper BCurated
    Metal bindingi294 – 2941Copper BCurated
    Metal bindingi379 – 3791Iron (heme A3 axial ligand)Curated
    Metal bindingi381 – 3811Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COX1
    Synonyms:COXI
    Encoded oniMitochondrion
    OrganismiMarchantia polymorpha (Liverwort) (Marchantia aquatica)
    Taxonomic identifieri3197 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaMarchantiophytaMarchantiopsidaMarchantiidaeMarchantialesMarchantiaceaeMarchantia

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. plasma membrane Source: InterPro
    4. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Cytochrome c oxidase subunit 1PRO_0000183360Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki244 ↔ 2481'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP26856.
    SMRiP26856. Positions 4-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei313 – 33321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei341 – 36121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei459 – 47921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26856-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNFAQRWLF STNHKDIGTL YLIFGAIAGV MGTCFSVLIR MELAQPGNQI    50
    LGGNHQLYNV LITAHAFLMI FFMVMPAMIG GFGNWFVPIL IGSPDMAFPR 100
    LNNISFWLLP PSLLLLLSSA LVEVGCGSGW TVYPPLSGIT SHSGGSVDLA 150
    IFSLHLSGVS SILGSINFIT TIFNMRAPGL TMHRLPLFVW SVLVTAFLLL 200
    LSLPVLAGAI TMLLTDRNFN TTFFDPAGGG DPILYQHLFW FFGHPEVYIL 250
    ILPGFGIISH IVSTFSRKPV FGYLGMVYAM ISIGVLGFIV WAHHMFTVGL 300
    DVDTRAYFTA ATMIIAVPTG IKIFSWIATM WGGSIQYKTP MLFAVGFIFL 350
    FTVGGLTGIV LANSGVDIAL HDTYYVVAHF HYVLSMGAVF ALFAGFYYWI 400
    GKITGLQYPE TLGQIHFWIT FFGVNLTFFP MHFLGLAGMP RRIPDYPDAY 450
    AGWNAFSSFG SYVSVVGIFC FFVVVFLTLT SENKCAPSPW AVEQNSTTLE 500
    WMVPSPPAFH TFEELPAIKE SI 522
    Length:522
    Mass (Da):57,552
    Last modified:February 1, 1994 - v2
    Checksum:i4B88E16F03A11D01
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68929 Genomic DNA. Translation: AAC09451.1.
    PIRiS25956.
    RefSeqiNP_054454.1. NC_001660.1.

    Genome annotation databases

    GeneIDi2702483.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68929 Genomic DNA. Translation: AAC09451.1 .
    PIRi S25956.
    RefSeqi NP_054454.1. NC_001660.1.

    3D structure databases

    ProteinModelPortali P26856.
    SMRi P26856. Positions 4-514.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2702483.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene organization deduced from the complete sequence of liverwort Marchantia polymorpha mitochondrial DNA. A primitive form of plant mitochondrial genome."
      Oda K., Yamato K., Ohta E., Nakamura Y., Takemura M., Nozato N., Akashi K., Kanegae T., Ogura Y., Kohchi T., Ohyama K.
      J. Mol. Biol. 223:1-7(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX1_MARPO
    AccessioniPrimary (citable) accession number: P26856
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3