CD27 antigen precursor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P26842 (CD27_HUMAN)

Last modified June 16, 2009. Version 95. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    CD27 antigen
Alternative name(s):
    CD27L receptor
    T-cell activation antigen CD27
    T14
    Tumor necrosis factor receptor superfamily member 7
    CD_antigen=CD27

Gene names

Name:	CD27
Synonyms:	TNFRSF7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Subunit structure	Homodimer. Interacts with SIVA1 and TRAF2. Ref.7 Ref.8
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Found in most T-lymphocytes.
Post-translational modification	Phosphorylated and O-glycosylated Probable.
Sequence similarities	Contains 3 TNFR-Cys repeats.

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Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	anti-apoptosis Inferred from direct assay. Source: UniProtKB apoptosis Inferred from electronic annotation. Source: UniProtKB-KW cell surface receptor linked signal transduction Non-traceable author statement. Source: UniProtKB immunoglobulin mediated immune response Non-traceable author statement. Source: UniProtKB induction of apoptosis Ref.8 Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of B cell differentiation Non-traceable author statement. Source: UniProtKB positive regulation of JNK cascade Inferred from sequence or structural similarity. Source: UniProtKB release of cytoplasmic sequestered NF-kappaB Non-traceable author statement. Source: UniProtKB
Cellular component	extracellular region Non-traceable author statement. Source: UniProtKB integral to plasma membrane Non-traceable author statement. Source: UniProtKB
Molecular function	caspase inhibitor activity Inferred from direct assay. Source: UniProtKB protein binding Ref.7 Ref.8 Inferred from physical interaction. Source: UniProtKB transmembrane receptor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
SIVA1	O15304	3	EBI-520729,EBI-520756
TRAF2	Q12933	2	EBI-520729,EBI-355744

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

Ref.6

Chain

20 – 260

241

CD27 antigen

PRO_0000034571

Regions

Topological domain

20 – 191

172

Extracellular Potential

Transmembrane

192 – 212

Potential

Topological domain

213 – 260

Cytoplasmic Potential

Repeat

26 – 63

TNFR-Cys 1

Repeat

64 – 104

TNFR-Cys 2

Repeat

105 – 141

TNFR-Cys 3

Amino acid modifications

Modified residue

219

Phosphoserine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

27 ↔ 39

By similarity

Disulfide bond

40 ↔ 53

By similarity

Disulfide bond

43 ↔ 62

By similarity

Disulfide bond

65 ↔ 81

By similarity

Disulfide bond

84 ↔ 96

By similarity

Disulfide bond

87 ↔ 104

By similarity

Disulfide bond

106 ↔ 117

By similarity

Disulfide bond

112 ↔ 120

By similarity

Natural variations

Natural variant

A → T: dbSNP rs25680. Ref.2 Ref.3 Ref.4

VAR_016148

Natural variant

233

R → H: dbSNP rs2532502.

VAR_052348

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Sequences

Sequence

Length

Mass (Da)

Tools

P26842-1 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 43C38B92FA90D4E2
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FASTA

260

29,156

        10         20         30         40         50         60 
MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV KDCDQHRKAA 

        70         80         90        100        110        120 
QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA NAECACRNGW QCRDKECTEC 

       130        140        150        160        170        180 
DPLPNPSLTA RSSQALSPHP QPTHLPYVSE MLEARTAGHM QTLADFRQLP ARTLSTHWPP 

       190        200        210        220        230        240 
QRSLCSSDFI RILVIFSGMF LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCRYSCPREE 

       250        260 
EGSTIPIQED YRKPEPACSP

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family." Camerini D., Walz G., Loenen W.A.M., Borst J., Seed B. J. Immunol. 147:3165-3169(1991) [PubMed: 1655907] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Monocyte.
[2]	"Genomic organization and chromosomal localization of the human CD27 gene." Loenen W.A., Gravestein L.A., Beumer S., Melief C.J., Hagemeijer A., Borst J. J. Immunol. 149:3937-3943(1992) [PubMed: 1334106] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-59.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-59. Tissue: Thymus.
[4]	NIEHS SNPs program Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-59.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell.
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-34.
[7]	"The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2." Gravestein L.A., Amsen D., Boes M., Calvo C.R., Kruisbeek A.M., Borst J. Eur. J. Immunol. 28:2208-2216(1998) [PubMed: 9692890] [Abstract] Cited for: INTERACTION WITH TRAF2.
[8]	"CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein." Prasad K.V.S., Ao Z., Yoon Y., Wu M.X., Rizk M., Jacquot S., Schlossman S.F. Proc. Natl. Acad. Sci. U.S.A. 94:6346-6351(1997) [PubMed: 9177220] [Abstract] Cited for: INTERACTION WITH SIVA1. Tissue: Cervix carcinoma and Thymus.
+	Additional computationally mapped references.

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Web resources

NIEHS-SNPs

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Cross-references

Sequence databases
	M63928 mRNA. Translation: AAA58411.1. AK315732 mRNA. Translation: BAG38087.1. AY504961 Genomic DNA. Translation: AAR84239.1. BC012160 mRNA. Translation: AAH12160.1.
IPI	IPI00002435.
PIR	A46517.
RefSeq	NP_001233.1.
UniGene	Hs.355307
3D structure databases
HSSP	HSSP built from PDB template 1NCF based on UniProtKB P19438.
ModBase	Search...
Protein-protein interaction databases
IntAct	P26842. 2 interactions.
Proteomic databases
PRIDE	P26842.
Genome annotation databases
Ensembl	ENSG00000139193. Homo sapiens. [Contig view]
GeneID	939.
KEGG	hsa:939.
Organism-specific databases
GeneCards	GC12P006425.
H-InvDB	HIX0010363.
HGNC	HGNC:11922. CD27.
HPA	CAB002420.
MIM	186711. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P26842.
Gene expression databases
ArrayExpress	P26842.
Bgee	P26842.
CleanEx	HS_CD27.
GermOnline	ENSG00000139193. Homo sapiens.
Family and domain databases
InterPro	IPR008063. Fas_rcpt. IPR001368. TNFR_Cys_rich_reg. [Graphical view]
Pfam	PF00020. TNFR_c6. 2 hits. [Graphical view]
PRINTS	PR01680. FASRECEPTOR.
ProDom	PD008931. TP2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00208. TNFR. 2 hits. [Graphical view]
PROSITE	PS00652. TNFR_NGFR_1. 1 hit. PS50050. TNFR_NGFR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	3890.
PMAP-CutDB	P26842.
SOURCE	Search...

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Entry information

Entry name

CD27_HUMAN

Accession

Primary (citable) accession number: P26842
Secondary accession number(s): B2RDZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	June 16, 2009
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents