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Protein

CD27 antigen

Gene

CD27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139193-MONOMER.
ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.
SIGNORiP26842.

Names & Taxonomyi

Protein namesi
Recommended name:
CD27 antigen
Alternative name(s):
CD27L receptor
T-cell activation antigen CD27
T14
Tumor necrosis factor receptor superfamily member 7
CD_antigen: CD27
Gene namesi
Name:CD27
Synonyms:TNFRSF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:11922. CD27.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 191ExtracellularSequence analysisAdd BLAST172
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 260CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • neuron projection Source: GO_Central
  • nucleus Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Lymphoproliferative syndrome 2 (LPFS2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.
See also OMIM:615122
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06979353C → Y in LPFS2. 1 PublicationCorresponds to variant rs397514667dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi939.
MalaCardsiCD27.
MIMi615122. phenotype.
OpenTargetsiENSG00000139193.
Orphaneti238505. Autosomal recessive lymphoproliferative disease.
PharmGKBiPA162382107.

Polymorphism and mutation databases

BioMutaiCD27.
DMDMi269849546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000003457120 – 260CD27 antigenAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 39PROSITE-ProRule annotation
Disulfide bondi40 ↔ 53PROSITE-ProRule annotation
Disulfide bondi43 ↔ 62PROSITE-ProRule annotation
Disulfide bondi65 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 96PROSITE-ProRule annotation
Disulfide bondi87 ↔ 104PROSITE-ProRule annotation
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 117PROSITE-ProRule annotation
Disulfide bondi112 ↔ 120PROSITE-ProRule annotation
Glycosylationi127O-linked (GalNAc...)1 Publication1
Modified residuei219PhosphoserineSequence analysis1

Post-translational modificationi

Phosphorylated.
O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP26842.
PeptideAtlasiP26842.
PRIDEiP26842.

PTM databases

iPTMnetiP26842.
PhosphoSitePlusiP26842.
SwissPalmiP26842.
UniCarbKBiP26842.

Miscellaneous databases

PMAP-CutDBP26842.

Expressioni

Tissue specificityi

Found in most T-lymphocytes.

Gene expression databases

BgeeiENSG00000139193.
CleanExiHS_CD27.
GenevisibleiP26842. HS.

Organism-specific databases

HPAiCAB002420.
HPA038936.

Interactioni

Subunit structurei

Homodimer. Interacts with SIVA1 and TRAF2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SIVA1O153043EBI-520729,EBI-520756

Protein-protein interaction databases

BioGridi107377. 31 interactors.
IntActiP26842. 4 interactors.
STRINGi9606.ENSP00000266557.

Structurei

3D structure databases

ProteinModelPortaliP26842.
SMRiP26842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 63TNFR-Cys 1Add BLAST38
Repeati64 – 104TNFR-Cys 2Add BLAST41
Repeati105 – 141TNFR-Cys 3Add BLAST37

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZUP. Eukaryota.
ENOG410ZDEA. LUCA.
GeneTreeiENSGT00510000049297.
HOGENOMiHOG000082545.
HOVERGENiHBG018200.
InParanoidiP26842.
KOiK05144.
OMAiYSCPREE.
OrthoDBiEOG091G0KN1.
PhylomeDBiP26842.
TreeFamiTF336960.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022328. TNFR_7.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01960. TNFACTORR7.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV
60 70 80 90 100
KDCDQHRKAA QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA
110 120 130 140 150
NAECACRNGW QCRDKECTEC DPLPNPSLTA RSSQALSPHP QPTHLPYVSE
160 170 180 190 200
MLEARTAGHM QTLADFRQLP ARTLSTHWPP QRSLCSSDFI RILVIFSGMF
210 220 230 240 250
LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCHYSCPREE EGSTIPIQED
260
YRKPEPACSP
Length:260
Mass (Da):29,137
Last modified:November 24, 2009 - v2
Checksum:i43C38B895B2AD4E2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06979353C → Y in LPFS2. 1 PublicationCorresponds to variant rs397514667dbSNPEnsembl.1
Natural variantiVAR_01614859A → T.3 PublicationsCorresponds to variant rs25680dbSNPEnsembl.1
Natural variantiVAR_052348233H → R.5 PublicationsCorresponds to variant rs2532502dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63928 mRNA. Translation: AAA58411.1.
AK315732 mRNA. Translation: BAG38087.1.
AY504961 Genomic DNA. Translation: AAR84239.1.
AC005840 Genomic DNA. No translation available.
BC012160 mRNA. Translation: AAH12160.1.
CCDSiCCDS8545.1.
PIRiA46517.
RefSeqiNP_001233.1. NM_001242.4.
UniGeneiHs.355307.

Genome annotation databases

EnsembliENST00000266557; ENSP00000266557; ENSG00000139193.
GeneIDi939.
KEGGihsa:939.
UCSCiuc001qod.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63928 mRNA. Translation: AAA58411.1.
AK315732 mRNA. Translation: BAG38087.1.
AY504961 Genomic DNA. Translation: AAR84239.1.
AC005840 Genomic DNA. No translation available.
BC012160 mRNA. Translation: AAH12160.1.
CCDSiCCDS8545.1.
PIRiA46517.
RefSeqiNP_001233.1. NM_001242.4.
UniGeneiHs.355307.

3D structure databases

ProteinModelPortaliP26842.
SMRiP26842.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107377. 31 interactors.
IntActiP26842. 4 interactors.
STRINGi9606.ENSP00000266557.

PTM databases

iPTMnetiP26842.
PhosphoSitePlusiP26842.
SwissPalmiP26842.
UniCarbKBiP26842.

Polymorphism and mutation databases

BioMutaiCD27.
DMDMi269849546.

Proteomic databases

PaxDbiP26842.
PeptideAtlasiP26842.
PRIDEiP26842.

Protocols and materials databases

DNASUi939.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266557; ENSP00000266557; ENSG00000139193.
GeneIDi939.
KEGGihsa:939.
UCSCiuc001qod.4. human.

Organism-specific databases

CTDi939.
DisGeNETi939.
GeneCardsiCD27.
HGNCiHGNC:11922. CD27.
HPAiCAB002420.
HPA038936.
MalaCardsiCD27.
MIMi186711. gene.
615122. phenotype.
neXtProtiNX_P26842.
OpenTargetsiENSG00000139193.
Orphaneti238505. Autosomal recessive lymphoproliferative disease.
PharmGKBiPA162382107.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZUP. Eukaryota.
ENOG410ZDEA. LUCA.
GeneTreeiENSGT00510000049297.
HOGENOMiHOG000082545.
HOVERGENiHBG018200.
InParanoidiP26842.
KOiK05144.
OMAiYSCPREE.
OrthoDBiEOG091G0KN1.
PhylomeDBiP26842.
TreeFamiTF336960.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139193-MONOMER.
ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.
SIGNORiP26842.

Miscellaneous databases

ChiTaRSiCD27. human.
GeneWikiiCD27.
GenomeRNAii939.
PMAP-CutDBP26842.
PROiP26842.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139193.
CleanExiHS_CD27.
GenevisibleiP26842. HS.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022328. TNFR_7.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01960. TNFACTORR7.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD27_HUMAN
AccessioniPrimary (citable) accession number: P26842
Secondary accession number(s): B2RDZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.