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P26842 (CD27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 145. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD27 antigen
Alternative name(s):
CD27L receptor
T-cell activation antigen CD27
T14
Tumor necrosis factor receptor superfamily member 7
CD_antigen=CD27
Gene names
Name:CD27
Synonyms:TNFRSF7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Subunit structure

Homodimer. Interacts with SIVA1 and TRAF2. Ref.8 Ref.9

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Found in most T-lymphocytes.

Post-translational modification

Phosphorylated.

O-glycosylated with core 1 or possibly core 8 glycans. Ref.10

Involvement in disease

Lymphoproliferative syndrome 2 (LPFS2) [MIM:615122]: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11 Ref.12

Sequence similarities

Contains 3 TNFR-Cys repeats.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DiseaseDisease mutation
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcell surface receptor signaling pathway

Non-traceable author statement PubMed 14556986. Source: UniProtKB

extrinsic apoptotic signaling pathway

Inferred from direct assay Ref.9. Source: BHF-UCL

immunoglobulin mediated immune response

Non-traceable author statement PubMed 14556986. Source: UniProtKB

negative regulation of T cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from direct assay PubMed 12324477. Source: UniProtKB

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from direct assay PubMed 12324477. Source: GOC

positive regulation of B cell differentiation

Non-traceable author statement PubMed 10809378. Source: UniProtKB

positive regulation of JNK cascade

Inferred from sequence or structural similarity. Source: UniProtKB

release of cytoplasmic sequestered NF-kappaB

Non-traceable author statement PubMed 12324477. Source: UniProtKB

response to ethanol

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular region

Non-traceable author statement PubMed 12624711. Source: UniProtKB

integral component of plasma membrane

Non-traceable author statement PubMed 12324477. Source: UniProtKB

   Molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process

Inferred from direct assay PubMed 12324477. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 12324477. Source: UniProtKB

transmembrane signaling receptor activity

Non-traceable author statement PubMed 14556986. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SIVA1O153043EBI-520729,EBI-520756

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.7
Chain20 – 260241CD27 antigen
PRO_0000034571

Regions

Topological domain20 – 191172Extracellular Potential
Transmembrane192 – 21221Helical; Potential
Topological domain213 – 26048Cytoplasmic Potential
Repeat26 – 6338TNFR-Cys 1
Repeat64 – 10441TNFR-Cys 2
Repeat105 – 14137TNFR-Cys 3

Amino acid modifications

Modified residue2191Phosphoserine Potential
Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation1271O-linked (GalNAc...) Ref.10
Disulfide bond27 ↔ 39 By similarity
Disulfide bond40 ↔ 53 By similarity
Disulfide bond43 ↔ 62 By similarity
Disulfide bond65 ↔ 81 By similarity
Disulfide bond84 ↔ 96 By similarity
Disulfide bond87 ↔ 104 By similarity
Disulfide bond106 ↔ 117 By similarity
Disulfide bond112 ↔ 120 By similarity

Natural variations

Natural variant531C → Y in LPFS2. Ref.12
VAR_069793
Natural variant591A → T. Ref.2 Ref.3 Ref.4
Corresponds to variant rs25680 [ dbSNP | Ensembl ].
VAR_016148
Natural variant2331H → R. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6
Corresponds to variant rs2532502 [ dbSNP | Ensembl ].
VAR_052348

Sequences

Sequence LengthMass (Da)Tools
P26842 [UniParc].

Last modified November 24, 2009. Version 2.
Checksum: 43C38B895B2AD4E2

FASTA26029,137
        10         20         30         40         50         60 
MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV KDCDQHRKAA 

        70         80         90        100        110        120 
QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA NAECACRNGW QCRDKECTEC 

       130        140        150        160        170        180 
DPLPNPSLTA RSSQALSPHP QPTHLPYVSE MLEARTAGHM QTLADFRQLP ARTLSTHWPP 

       190        200        210        220        230        240 
QRSLCSSDFI RILVIFSGMF LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCHYSCPREE 

       250        260 
EGSTIPIQED YRKPEPACSP 

« Hide

References

« Hide 'large scale' references
[1]"The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family."
Camerini D., Walz G., Loenen W.A.M., Borst J., Seed B.
J. Immunol. 147:3165-3169(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-233.
Tissue: Monocyte.
[2]"Genomic organization and chromosomal localization of the human CD27 gene."
Loenen W.A., Gravestein L.A., Beumer S., Melief C.J., Hagemeijer A., Borst J.
J. Immunol. 149:3937-3943(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-59 AND ARG-233.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-59 AND ARG-233.
Tissue: Thymus.
[4]NIEHS SNPs program
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-59 AND ARG-233.
[5]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-233.
Tissue: B-cell.
[7]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-34.
[8]"The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2."
Gravestein L.A., Amsen D., Boes M., Calvo C.R., Kruisbeek A.M., Borst J.
Eur. J. Immunol. 28:2208-2216(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRAF2.
[9]"CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein."
Prasad K.V.S., Ao Z., Yoon Y., Wu M.X., Rizk M., Jacquot S., Schlossman S.F.
Proc. Natl. Acad. Sci. U.S.A. 94:6346-6351(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SIVA1.
Tissue: Cervix carcinoma and Thymus.
[10]"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT SER-127, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
[11]"CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia."
van Montfrans J.M., Hoepelman A.I., Otto S., van Gijn M., van de Corput L., de Weger R.A., Monaco-Shawver L., Banerjee P.P., Sanders E.A., Jol-van der Zijde C.M., Betts M.R., Orange J.S., Bloem A.C., Tesselaar K.
J. Allergy Clin. Immunol. 129:787-793(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN LPFS2.
[12]"Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27."
Salzer E., Daschkey S., Choo S., Gombert M., Santos-Valente E., Ginzel S., Schwendinger M., Haas O.A., Fritsch G., Pickl W.F., Foerster-Waldl E., Borkhardt A., Boztug K., Bienemann K., Seidel M.G.
Haematologica 98:473-478(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LPFS2 TYR-53.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M63928 mRNA. Translation: AAA58411.1.
AK315732 mRNA. Translation: BAG38087.1.
AY504961 Genomic DNA. Translation: AAR84239.1.
AC005840 Genomic DNA. No translation available.
BC012160 mRNA. Translation: AAH12160.1.
CCDSCCDS8545.1.
PIRA46517.
RefSeqNP_001233.1. NM_001242.4.
UniGeneHs.355307.

3D structure databases

ProteinModelPortalP26842.
SMRP26842. Positions 36-122.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107377. 9 interactions.
IntActP26842. 3 interactions.
STRING9606.ENSP00000266557.

Chemistry

GuidetoPHARMACOLOGY1876.

PTM databases

PhosphoSiteP26842.

Polymorphism databases

DMDM269849546.

Proteomic databases

PaxDbP26842.
PRIDEP26842.

Protocols and materials databases

DNASU939.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266557; ENSP00000266557; ENSG00000139193.
GeneID939.
KEGGhsa:939.
UCSCuc001qod.3. human.

Organism-specific databases

CTD939.
GeneCardsGC12P006554.
HGNCHGNC:11922. CD27.
HPACAB002420.
MIM186711. gene.
615122. phenotype.
neXtProtNX_P26842.
Orphanet238505. Autosomal recessive lymphoproliferative disease.
PharmGKBPA162382107.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39674.
HOGENOMHOG000082545.
HOVERGENHBG018200.
InParanoidP26842.
KOK05144.
OMACPREEEG.
OrthoDBEOG7W41CQ.
PhylomeDBP26842.
TreeFamTF336960.

Gene expression databases

BgeeP26842.
CleanExHS_CD27.
GenevestigatorP26842.

Family and domain databases

InterProIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022328. TNFR_7.
[Graphical view]
PfamPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSPR01960. TNFACTORR7.
SMARTSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCD27. human.
GeneWikiCD27.
GenomeRNAi939.
NextBio3890.
PMAP-CutDBP26842.
PROP26842.
SOURCESearch...

Entry information

Entry nameCD27_HUMAN
AccessionPrimary (citable) accession number: P26842
Secondary accession number(s): B2RDZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 24, 2009
Last modified: July 9, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries