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P26842

- CD27_HUMAN

UniProt

P26842 - CD27_HUMAN

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Protein

CD27 antigen

Gene
CD27, TNFRSF7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  1. cell surface receptor signaling pathway Source: UniProtKB
  2. extrinsic apoptotic signaling pathway Source: BHF-UCL
  3. immunoglobulin mediated immune response Source: UniProtKB
  4. negative regulation of apoptotic process Source: UniProtKB
  5. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC
  6. negative regulation of T cell apoptotic process Source: Ensembl
  7. positive regulation of B cell differentiation Source: UniProtKB
  8. positive regulation of JNK cascade Source: UniProtKB
  9. release of cytoplasmic sequestered NF-kappaB Source: UniProtKB
  10. response to ethanol Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
CD27 antigen
Alternative name(s):
CD27L receptor
T-cell activation antigen CD27
T14
Tumor necrosis factor receptor superfamily member 7
CD_antigen: CD27
Gene namesi
Name:CD27
Synonyms:TNFRSF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:11922. CD27.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 191172Extracellular Reviewed predictionAdd
BLAST
Transmembranei192 – 21221Helical; Reviewed predictionAdd
BLAST
Topological domaini213 – 26048Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular region Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Lymphoproliferative syndrome 2 (LPFS2) [MIM:615122]: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531C → Y in LPFS2. 1 Publication
VAR_069793

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi615122. phenotype.
Orphaneti238505. Autosomal recessive lymphoproliferative disease.
PharmGKBiPA162382107.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 260241CD27 antigenPRO_0000034571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 39 By similarity
Disulfide bondi40 ↔ 53 By similarity
Disulfide bondi43 ↔ 62 By similarity
Disulfide bondi65 ↔ 81 By similarity
Disulfide bondi84 ↔ 96 By similarity
Disulfide bondi87 ↔ 104 By similarity
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi106 ↔ 117 By similarity
Disulfide bondi112 ↔ 120 By similarity
Glycosylationi127 – 1271O-linked (GalNAc...)1 Publication
Modified residuei219 – 2191Phosphoserine Reviewed prediction

Post-translational modificationi

Phosphorylated.
O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP26842.
PRIDEiP26842.

PTM databases

PhosphoSiteiP26842.

Miscellaneous databases

PMAP-CutDBP26842.

Expressioni

Tissue specificityi

Found in most T-lymphocytes.

Gene expression databases

BgeeiP26842.
CleanExiHS_CD27.
GenevestigatoriP26842.

Organism-specific databases

HPAiCAB002420.

Interactioni

Subunit structurei

Homodimer. Interacts with SIVA1 and TRAF2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SIVA1O153043EBI-520729,EBI-520756

Protein-protein interaction databases

BioGridi107377. 9 interactions.
IntActiP26842. 3 interactions.
STRINGi9606.ENSP00000266557.

Structurei

3D structure databases

ProteinModelPortaliP26842.
SMRiP26842. Positions 36-122.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 6338TNFR-Cys 1Add
BLAST
Repeati64 – 10441TNFR-Cys 2Add
BLAST
Repeati105 – 14137TNFR-Cys 3Add
BLAST

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39674.
HOGENOMiHOG000082545.
HOVERGENiHBG018200.
InParanoidiP26842.
KOiK05144.
OMAiCPREEEG.
OrthoDBiEOG7W41CQ.
PhylomeDBiP26842.
TreeFamiTF336960.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022328. TNFR_7.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01960. TNFACTORR7.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26842-1 [UniParc]FASTAAdd to Basket

« Hide

MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV    50
KDCDQHRKAA QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA 100
NAECACRNGW QCRDKECTEC DPLPNPSLTA RSSQALSPHP QPTHLPYVSE 150
MLEARTAGHM QTLADFRQLP ARTLSTHWPP QRSLCSSDFI RILVIFSGMF 200
LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCHYSCPREE EGSTIPIQED 250
YRKPEPACSP 260
Length:260
Mass (Da):29,137
Last modified:November 24, 2009 - v2
Checksum:i43C38B895B2AD4E2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531C → Y in LPFS2. 1 Publication
VAR_069793
Natural varianti59 – 591A → T.3 Publications
Corresponds to variant rs25680 [ dbSNP | Ensembl ].
VAR_016148
Natural varianti233 – 2331H → R.5 Publications
Corresponds to variant rs2532502 [ dbSNP | Ensembl ].
VAR_052348

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63928 mRNA. Translation: AAA58411.1.
AK315732 mRNA. Translation: BAG38087.1.
AY504961 Genomic DNA. Translation: AAR84239.1.
AC005840 Genomic DNA. No translation available.
BC012160 mRNA. Translation: AAH12160.1.
CCDSiCCDS8545.1.
PIRiA46517.
RefSeqiNP_001233.1. NM_001242.4.
UniGeneiHs.355307.

Genome annotation databases

EnsembliENST00000266557; ENSP00000266557; ENSG00000139193.
GeneIDi939.
KEGGihsa:939.
UCSCiuc001qod.3. human.

Polymorphism databases

DMDMi269849546.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63928 mRNA. Translation: AAA58411.1 .
AK315732 mRNA. Translation: BAG38087.1 .
AY504961 Genomic DNA. Translation: AAR84239.1 .
AC005840 Genomic DNA. No translation available.
BC012160 mRNA. Translation: AAH12160.1 .
CCDSi CCDS8545.1.
PIRi A46517.
RefSeqi NP_001233.1. NM_001242.4.
UniGenei Hs.355307.

3D structure databases

ProteinModelPortali P26842.
SMRi P26842. Positions 36-122.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107377. 9 interactions.
IntActi P26842. 3 interactions.
STRINGi 9606.ENSP00000266557.

Chemistry

GuidetoPHARMACOLOGYi 1876.

PTM databases

PhosphoSitei P26842.

Polymorphism databases

DMDMi 269849546.

Proteomic databases

PaxDbi P26842.
PRIDEi P26842.

Protocols and materials databases

DNASUi 939.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266557 ; ENSP00000266557 ; ENSG00000139193 .
GeneIDi 939.
KEGGi hsa:939.
UCSCi uc001qod.3. human.

Organism-specific databases

CTDi 939.
GeneCardsi GC12P006554.
HGNCi HGNC:11922. CD27.
HPAi CAB002420.
MIMi 186711. gene.
615122. phenotype.
neXtProti NX_P26842.
Orphaneti 238505. Autosomal recessive lymphoproliferative disease.
PharmGKBi PA162382107.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39674.
HOGENOMi HOG000082545.
HOVERGENi HBG018200.
InParanoidi P26842.
KOi K05144.
OMAi CPREEEG.
OrthoDBi EOG7W41CQ.
PhylomeDBi P26842.
TreeFami TF336960.

Miscellaneous databases

ChiTaRSi CD27. human.
GeneWikii CD27.
GenomeRNAii 939.
NextBioi 3890.
PMAP-CutDB P26842.
PROi P26842.
SOURCEi Search...

Gene expression databases

Bgeei P26842.
CleanExi HS_CD27.
Genevestigatori P26842.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022328. TNFR_7.
[Graphical view ]
Pfami PF00020. TNFR_c6. 2 hits.
[Graphical view ]
PRINTSi PR01960. TNFACTORR7.
SMARTi SM00208. TNFR. 2 hits.
[Graphical view ]
PROSITEi PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family."
    Camerini D., Walz G., Loenen W.A.M., Borst J., Seed B.
    J. Immunol. 147:3165-3169(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-233.
    Tissue: Monocyte.
  2. "Genomic organization and chromosomal localization of the human CD27 gene."
    Loenen W.A., Gravestein L.A., Beumer S., Melief C.J., Hagemeijer A., Borst J.
    J. Immunol. 149:3937-3943(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-59 AND ARG-233.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-59 AND ARG-233.
    Tissue: Thymus.
  4. NIEHS SNPs program
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-59 AND ARG-233.
  5. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-233.
    Tissue: B-cell.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-34.
  8. "The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2."
    Gravestein L.A., Amsen D., Boes M., Calvo C.R., Kruisbeek A.M., Borst J.
    Eur. J. Immunol. 28:2208-2216(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF2.
  9. "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein."
    Prasad K.V.S., Ao Z., Yoon Y., Wu M.X., Rizk M., Jacquot S., Schlossman S.F.
    Proc. Natl. Acad. Sci. U.S.A. 94:6346-6351(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SIVA1.
    Tissue: Cervix carcinoma and Thymus.
  10. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
    Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT SER-127, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
  11. Cited for: INVOLVEMENT IN LPFS2.
  12. "Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27."
    Salzer E., Daschkey S., Choo S., Gombert M., Santos-Valente E., Ginzel S., Schwendinger M., Haas O.A., Fritsch G., Pickl W.F., Foerster-Waldl E., Borkhardt A., Boztug K., Bienemann K., Seidel M.G.
    Haematologica 98:473-478(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LPFS2 TYR-53.

Entry informationi

Entry nameiCD27_HUMAN
AccessioniPrimary (citable) accession number: P26842
Secondary accession number(s): B2RDZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 24, 2009
Last modified: September 3, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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