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Protein

CD27 antigen

Gene

CD27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors
SIGNORiP26842

Names & Taxonomyi

Protein namesi
Recommended name:
CD27 antigen
Alternative name(s):
CD27L receptor
T-cell activation antigen CD27
T14
Tumor necrosis factor receptor superfamily member 7
CD_antigen: CD27
Gene namesi
Name:CD27
Synonyms:TNFRSF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139193.3
HGNCiHGNC:11922 CD27
MIMi186711 gene
neXtProtiNX_P26842

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 191ExtracellularSequence analysisAdd BLAST172
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 260CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Lymphoproliferative syndrome 2 (LPFS2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.
See also OMIM:615122
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06979353C → Y in LPFS2. 1 PublicationCorresponds to variant dbSNP:rs397514667Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi939
MalaCardsiCD27
MIMi615122 phenotype
OpenTargetsiENSG00000139193
Orphaneti238505 Autosomal recessive lymphoproliferative disease
PharmGKBiPA162382107

Polymorphism and mutation databases

BioMutaiCD27
DMDMi269849546

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000003457120 – 260CD27 antigenAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 39PROSITE-ProRule annotation
Disulfide bondi40 ↔ 53PROSITE-ProRule annotation
Disulfide bondi43 ↔ 62PROSITE-ProRule annotation
Disulfide bondi65 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 96PROSITE-ProRule annotation
Disulfide bondi87 ↔ 104PROSITE-ProRule annotation
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 117PROSITE-ProRule annotation
Disulfide bondi112 ↔ 120PROSITE-ProRule annotation
Glycosylationi127O-linked (GalNAc...) serine1 Publication1
Modified residuei219PhosphoserineSequence analysis1

Post-translational modificationi

Phosphorylated.
O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP26842
PeptideAtlasiP26842
PRIDEiP26842

PTM databases

GlyConnecti800
iPTMnetiP26842
PhosphoSitePlusiP26842
SwissPalmiP26842
UniCarbKBiP26842

Miscellaneous databases

PMAP-CutDBiP26842

Expressioni

Tissue specificityi

Found in most T-lymphocytes.

Gene expression databases

BgeeiENSG00000139193
CleanExiHS_CD27
GenevisibleiP26842 HS

Organism-specific databases

HPAiCAB002420
HPA038936

Interactioni

Subunit structurei

Homodimer. Interacts with SIVA1 and TRAF2.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107377, 32 interactors
ELMiP26842
IntActiP26842, 5 interactors
STRINGi9606.ENSP00000266557

Structurei

Secondary structure

1260
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 34Combined sources4
Turni35 – 37Combined sources3
Beta strandi38 – 41Combined sources4
Beta strandi47 – 51Combined sources5
Beta strandi61 – 64Combined sources4
Turni67 – 69Combined sources3
Beta strandi74 – 76Combined sources3
Beta strandi88 – 94Combined sources7
Beta strandi98 – 100Combined sources3
Beta strandi103 – 105Combined sources3
Beta strandi112 – 114Combined sources3
Beta strandi117 – 120Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5TL5X-ray1.80A21-121[»]
5TLJX-ray3.50X21-121[»]
5TLKX-ray2.70X/Y21-121[»]
ProteinModelPortaliP26842
SMRiP26842
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 63TNFR-Cys 1Add BLAST38
Repeati64 – 104TNFR-Cys 2Add BLAST41
Repeati105 – 141TNFR-Cys 3Add BLAST37

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZUP Eukaryota
ENOG410ZDEA LUCA
GeneTreeiENSGT00510000049297
HOGENOMiHOG000082545
HOVERGENiHBG018200
InParanoidiP26842
KOiK05144
OMAiYSCPREE
OrthoDBiEOG091G0KN1
PhylomeDBiP26842
TreeFamiTF336960

Family and domain databases

CDDicd13408 TNFRSF7, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022328 TNFR_7
IPR034000 TNFRSF7_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01960 TNFACTORR7
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV
60 70 80 90 100
KDCDQHRKAA QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA
110 120 130 140 150
NAECACRNGW QCRDKECTEC DPLPNPSLTA RSSQALSPHP QPTHLPYVSE
160 170 180 190 200
MLEARTAGHM QTLADFRQLP ARTLSTHWPP QRSLCSSDFI RILVIFSGMF
210 220 230 240 250
LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCHYSCPREE EGSTIPIQED
260
YRKPEPACSP
Length:260
Mass (Da):29,137
Last modified:November 24, 2009 - v2
Checksum:i43C38B895B2AD4E2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06979353C → Y in LPFS2. 1 PublicationCorresponds to variant dbSNP:rs397514667Ensembl.1
Natural variantiVAR_01614859A → T3 PublicationsCorresponds to variant dbSNP:rs25680Ensembl.1
Natural variantiVAR_052348233H → R5 PublicationsCorresponds to variant dbSNP:rs2532502Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63928 mRNA Translation: AAA58411.1
AK315732 mRNA Translation: BAG38087.1
AY504961 Genomic DNA Translation: AAR84239.1
AC005840 Genomic DNA No translation available.
BC012160 mRNA Translation: AAH12160.1
CCDSiCCDS8545.1
PIRiA46517
RefSeqiNP_001233.1, NM_001242.4
UniGeneiHs.355307

Genome annotation databases

EnsembliENST00000266557; ENSP00000266557; ENSG00000139193
GeneIDi939
KEGGihsa:939
UCSCiuc001qod.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD27_HUMAN
AccessioniPrimary (citable) accession number: P26842
Secondary accession number(s): B2RDZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 24, 2009
Last modified: April 25, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health