Reviewed,
UniProtKB/Swiss-Prot P26842 (CD27_HUMAN)
Last modified
June 16, 2009.
Version 95.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: CD27 antigen Alternative name(s): CD27L receptor T-cell activation antigen CD27 T14 Tumor necrosis factor receptor superfamily member 7 CD_antigen=CD27 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 260 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. |
| Subunit structure | |
| Subcellular location | |
| Tissue specificity | Found in most T-lymphocytes. |
| Post-translational modification | Phosphorylated and O-glycosylated Probable. |
| Sequence similarities | Contains 3 TNFR-Cys repeats. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| SIVA1 | O15304 | 3 | EBI-520729,EBI-520756 | |
| TRAF2 | Q12933 | 2 | EBI-520729,EBI-355744 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Ref.6 | ||||||||
| Chain | 20 – 260 | 241 | CD27 antigen | PRO_0000034571 | |||||||
Regions | |||||||||||
| Topological domain | 20 – 191 | 172 | Extracellular Potential | ||||||||
| Transmembrane | 192 – 212 | 21 | Potential | ||||||||
| Topological domain | 213 – 260 | 48 | Cytoplasmic Potential | ||||||||
| Repeat | 26 – 63 | 38 | TNFR-Cys 1 | ||||||||
| Repeat | 64 – 104 | 41 | TNFR-Cys 2 | ||||||||
| Repeat | 105 – 141 | 37 | TNFR-Cys 3 | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 219 | 1 | Phosphoserine Potential | ||||||||
| Glycosylation | 95 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 27 ↔ 39 | By similarity | |||||||||
| Disulfide bond | 40 ↔ 53 | By similarity | |||||||||
| Disulfide bond | 43 ↔ 62 | By similarity | |||||||||
| Disulfide bond | 65 ↔ 81 | By similarity | |||||||||
| Disulfide bond | 84 ↔ 96 | By similarity | |||||||||
| Disulfide bond | 87 ↔ 104 | By similarity | |||||||||
| Disulfide bond | 106 ↔ 117 | By similarity | |||||||||
| Disulfide bond | 112 ↔ 120 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 59 | 1 | A → T: dbSNP rs25680. Ref.2 Ref.3 Ref.4 | VAR_016148 | |||||||
| Natural variant | 233 | 1 | R → H: dbSNP rs2532502. | VAR_052348 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family." Camerini D., Walz G., Loenen W.A.M., Borst J., Seed B. J. Immunol. 147:3165-3169(1991) [PubMed: 1655907] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Monocyte. |
| [2] | "Genomic organization and chromosomal localization of the human CD27 gene." Loenen W.A., Gravestein L.A., Beumer S., Melief C.J., Hagemeijer A., Borst J. J. Immunol. 149:3937-3943(1992) [PubMed: 1334106] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-59. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-59. Tissue: Thymus. |
| [4] | NIEHS SNPs program Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-59. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell. |
| [6] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-34. |
| [7] | "The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2." Gravestein L.A., Amsen D., Boes M., Calvo C.R., Kruisbeek A.M., Borst J. Eur. J. Immunol. 28:2208-2216(1998) [PubMed: 9692890] [Abstract] Cited for: INTERACTION WITH TRAF2. |
| [8] | "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein." Prasad K.V.S., Ao Z., Yoon Y., Wu M.X., Rizk M., Jacquot S., Schlossman S.F. Proc. Natl. Acad. Sci. U.S.A. 94:6346-6351(1997) [PubMed: 9177220] [Abstract] Cited for: INTERACTION WITH SIVA1. Tissue: Cervix carcinoma and Thymus. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M63928 mRNA. Translation: AAA58411.1. AK315732 mRNA. Translation: BAG38087.1. AY504961 Genomic DNA. Translation: AAR84239.1. BC012160 mRNA. Translation: AAH12160.1. | |
| IPI | IPI00002435. |
| PIR | A46517. |
| RefSeq | NP_001233.1. |
| UniGene | Hs.355307 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NCF based on UniProtKB P19438. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P26842. 2 interactions. |
Proteomic databases | |
| PRIDE | P26842. |
Genome annotation databases | |
| Ensembl | ENSG00000139193. Homo sapiens. [Contig view] |
| GeneID | 939. |
| KEGG | hsa:939. |
Organism-specific databases | |
| GeneCards | GC12P006425. |
| H-InvDB | HIX0010363. |
| HGNC | HGNC:11922. CD27. |
| HPA | CAB002420. |
| MIM | 186711. gene. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P26842. |
Gene expression databases | |
| ArrayExpress | P26842. |
| Bgee | P26842. |
| CleanEx | HS_CD27. |
| GermOnline | ENSG00000139193. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008063. Fas_rcpt. IPR001368. TNFR_Cys_rich_reg. [Graphical view] |
| Pfam | PF00020. TNFR_c6. 2 hits. [Graphical view] |
| PRINTS | PR01680. FASRECEPTOR. |
| ProDom | PD008931. TP2. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00208. TNFR. 2 hits. [Graphical view] |
| PROSITE | PS00652. TNFR_NGFR_1. 1 hit. PS50050. TNFR_NGFR_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 3890. |
| PMAP-CutDB | P26842. |
| SOURCE | Search... |
Entry information
| Entry name | CD27_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P26842 Secondary accession number(s): B2RDZ0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


