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P26842

- CD27_HUMAN

UniProt

P26842 - CD27_HUMAN

Protein

CD27 antigen

Gene

CD27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. transmembrane signaling receptor activity Source: UniProtKB

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: UniProtKB
    2. extrinsic apoptotic signaling pathway Source: BHF-UCL
    3. immunoglobulin mediated immune response Source: UniProtKB
    4. negative regulation of apoptotic process Source: UniProtKB
    5. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC
    6. negative regulation of T cell apoptotic process Source: Ensembl
    7. positive regulation of B cell differentiation Source: UniProtKB
    8. positive regulation of JNK cascade Source: UniProtKB
    9. release of cytoplasmic sequestered NF-kappaB Source: UniProtKB
    10. response to ethanol Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD27 antigen
    Alternative name(s):
    CD27L receptor
    T-cell activation antigen CD27
    T14
    Tumor necrosis factor receptor superfamily member 7
    CD_antigen: CD27
    Gene namesi
    Name:CD27
    Synonyms:TNFRSF7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:11922. CD27.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular region Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Lymphoproliferative syndrome 2 (LPFS2) [MIM:615122]: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531C → Y in LPFS2. 1 Publication
    VAR_069793

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi615122. phenotype.
    Orphaneti238505. Autosomal recessive lymphoproliferative disease.
    PharmGKBiPA162382107.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 260241CD27 antigenPRO_0000034571Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 39PROSITE-ProRule annotation
    Disulfide bondi40 ↔ 53PROSITE-ProRule annotation
    Disulfide bondi43 ↔ 62PROSITE-ProRule annotation
    Disulfide bondi65 ↔ 81PROSITE-ProRule annotation
    Disulfide bondi84 ↔ 96PROSITE-ProRule annotation
    Disulfide bondi87 ↔ 104PROSITE-ProRule annotation
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 117PROSITE-ProRule annotation
    Disulfide bondi112 ↔ 120PROSITE-ProRule annotation
    Glycosylationi127 – 1271O-linked (GalNAc...)1 Publication
    Modified residuei219 – 2191PhosphoserineSequence Analysis

    Post-translational modificationi

    Phosphorylated.
    O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP26842.
    PRIDEiP26842.

    PTM databases

    PhosphoSiteiP26842.

    Miscellaneous databases

    PMAP-CutDBP26842.

    Expressioni

    Tissue specificityi

    Found in most T-lymphocytes.

    Gene expression databases

    BgeeiP26842.
    CleanExiHS_CD27.
    GenevestigatoriP26842.

    Organism-specific databases

    HPAiCAB002420.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with SIVA1 and TRAF2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SIVA1O153043EBI-520729,EBI-520756

    Protein-protein interaction databases

    BioGridi107377. 10 interactions.
    IntActiP26842. 3 interactions.
    STRINGi9606.ENSP00000266557.

    Structurei

    3D structure databases

    ProteinModelPortaliP26842.
    SMRiP26842. Positions 36-122.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 191172ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini213 – 26048CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati26 – 6338TNFR-Cys 1Add
    BLAST
    Repeati64 – 10441TNFR-Cys 2Add
    BLAST
    Repeati105 – 14137TNFR-Cys 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39674.
    HOGENOMiHOG000082545.
    HOVERGENiHBG018200.
    InParanoidiP26842.
    KOiK05144.
    OMAiCPREEEG.
    OrthoDBiEOG7W41CQ.
    PhylomeDBiP26842.
    TreeFamiTF336960.

    Family and domain databases

    InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022328. TNFR_7.
    [Graphical view]
    PfamiPF00020. TNFR_c6. 2 hits.
    [Graphical view]
    PRINTSiPR01960. TNFACTORR7.
    SMARTiSM00208. TNFR. 2 hits.
    [Graphical view]
    PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
    PS50050. TNFR_NGFR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P26842-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV    50
    KDCDQHRKAA QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA 100
    NAECACRNGW QCRDKECTEC DPLPNPSLTA RSSQALSPHP QPTHLPYVSE 150
    MLEARTAGHM QTLADFRQLP ARTLSTHWPP QRSLCSSDFI RILVIFSGMF 200
    LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCHYSCPREE EGSTIPIQED 250
    YRKPEPACSP 260
    Length:260
    Mass (Da):29,137
    Last modified:November 24, 2009 - v2
    Checksum:i43C38B895B2AD4E2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531C → Y in LPFS2. 1 Publication
    VAR_069793
    Natural varianti59 – 591A → T.3 Publications
    Corresponds to variant rs25680 [ dbSNP | Ensembl ].
    VAR_016148
    Natural varianti233 – 2331H → R.5 Publications
    Corresponds to variant rs2532502 [ dbSNP | Ensembl ].
    VAR_052348

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63928 mRNA. Translation: AAA58411.1.
    AK315732 mRNA. Translation: BAG38087.1.
    AY504961 Genomic DNA. Translation: AAR84239.1.
    AC005840 Genomic DNA. No translation available.
    BC012160 mRNA. Translation: AAH12160.1.
    CCDSiCCDS8545.1.
    PIRiA46517.
    RefSeqiNP_001233.1. NM_001242.4.
    UniGeneiHs.355307.

    Genome annotation databases

    EnsembliENST00000266557; ENSP00000266557; ENSG00000139193.
    GeneIDi939.
    KEGGihsa:939.
    UCSCiuc001qod.3. human.

    Polymorphism databases

    DMDMi269849546.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63928 mRNA. Translation: AAA58411.1 .
    AK315732 mRNA. Translation: BAG38087.1 .
    AY504961 Genomic DNA. Translation: AAR84239.1 .
    AC005840 Genomic DNA. No translation available.
    BC012160 mRNA. Translation: AAH12160.1 .
    CCDSi CCDS8545.1.
    PIRi A46517.
    RefSeqi NP_001233.1. NM_001242.4.
    UniGenei Hs.355307.

    3D structure databases

    ProteinModelPortali P26842.
    SMRi P26842. Positions 36-122.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107377. 10 interactions.
    IntActi P26842. 3 interactions.
    STRINGi 9606.ENSP00000266557.

    Chemistry

    GuidetoPHARMACOLOGYi 1876.

    PTM databases

    PhosphoSitei P26842.

    Polymorphism databases

    DMDMi 269849546.

    Proteomic databases

    PaxDbi P26842.
    PRIDEi P26842.

    Protocols and materials databases

    DNASUi 939.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266557 ; ENSP00000266557 ; ENSG00000139193 .
    GeneIDi 939.
    KEGGi hsa:939.
    UCSCi uc001qod.3. human.

    Organism-specific databases

    CTDi 939.
    GeneCardsi GC12P006554.
    HGNCi HGNC:11922. CD27.
    HPAi CAB002420.
    MIMi 186711. gene.
    615122. phenotype.
    neXtProti NX_P26842.
    Orphaneti 238505. Autosomal recessive lymphoproliferative disease.
    PharmGKBi PA162382107.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39674.
    HOGENOMi HOG000082545.
    HOVERGENi HBG018200.
    InParanoidi P26842.
    KOi K05144.
    OMAi CPREEEG.
    OrthoDBi EOG7W41CQ.
    PhylomeDBi P26842.
    TreeFami TF336960.

    Miscellaneous databases

    ChiTaRSi CD27. human.
    GeneWikii CD27.
    GenomeRNAii 939.
    NextBioi 3890.
    PMAP-CutDB P26842.
    PROi P26842.
    SOURCEi Search...

    Gene expression databases

    Bgeei P26842.
    CleanExi HS_CD27.
    Genevestigatori P26842.

    Family and domain databases

    InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022328. TNFR_7.
    [Graphical view ]
    Pfami PF00020. TNFR_c6. 2 hits.
    [Graphical view ]
    PRINTSi PR01960. TNFACTORR7.
    SMARTi SM00208. TNFR. 2 hits.
    [Graphical view ]
    PROSITEi PS00652. TNFR_NGFR_1. 1 hit.
    PS50050. TNFR_NGFR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family."
      Camerini D., Walz G., Loenen W.A.M., Borst J., Seed B.
      J. Immunol. 147:3165-3169(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-233.
      Tissue: Monocyte.
    2. "Genomic organization and chromosomal localization of the human CD27 gene."
      Loenen W.A., Gravestein L.A., Beumer S., Melief C.J., Hagemeijer A., Borst J.
      J. Immunol. 149:3937-3943(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-59 AND ARG-233.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-59 AND ARG-233.
      Tissue: Thymus.
    4. NIEHS SNPs program
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-59 AND ARG-233.
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-233.
      Tissue: B-cell.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-34.
    8. "The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2."
      Gravestein L.A., Amsen D., Boes M., Calvo C.R., Kruisbeek A.M., Borst J.
      Eur. J. Immunol. 28:2208-2216(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF2.
    9. "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein."
      Prasad K.V.S., Ao Z., Yoon Y., Wu M.X., Rizk M., Jacquot S., Schlossman S.F.
      Proc. Natl. Acad. Sci. U.S.A. 94:6346-6351(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SIVA1.
      Tissue: Cervix carcinoma and Thymus.
    10. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
      Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
      Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT SER-127, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
    11. Cited for: INVOLVEMENT IN LPFS2.
    12. "Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27."
      Salzer E., Daschkey S., Choo S., Gombert M., Santos-Valente E., Ginzel S., Schwendinger M., Haas O.A., Fritsch G., Pickl W.F., Foerster-Waldl E., Borkhardt A., Boztug K., Bienemann K., Seidel M.G.
      Haematologica 98:473-478(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LPFS2 TYR-53.

    Entry informationi

    Entry nameiCD27_HUMAN
    AccessioniPrimary (citable) accession number: P26842
    Secondary accession number(s): B2RDZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3