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P26839

- VATA_STAAU

UniProt

P26839 - VATA_STAAU

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Protein

Virginiamycin A acetyltransferase

Gene

vat

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Inactivates the A compounds of virginiamycin-like antibiotics, thus providing resistance to these antibiotics.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871By similarity

GO - Molecular functioni

  1. transferase activity, transferring acyl groups Source: UniProtKB-KW

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Virginiamycin A acetyltransferase (EC:2.3.1.-)
Gene namesi
Name:vat
Encoded oniPlasmid pIP6300 Publication
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Virginiamycin A acetyltransferasePRO_0000068664Add
BLAST

Structurei

Secondary structure

1
219
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 266Combined sources
Helixi27 – 293Combined sources
Beta strandi35 – 373Combined sources
Beta strandi42 – 443Combined sources
Beta strandi46 – 483Combined sources
Helixi51 – 544Combined sources
Beta strandi55 – 573Combined sources
Turni60 – 623Combined sources
Beta strandi66 – 683Combined sources
Beta strandi79 – 813Combined sources
Helixi83 – 853Combined sources
Helixi96 – 994Combined sources
Helixi103 – 1064Combined sources
Helixi110 – 1123Combined sources
Beta strandi119 – 1213Combined sources
Beta strandi159 – 1624Combined sources
Turni163 – 1664Combined sources
Beta strandi167 – 1737Combined sources
Helixi175 – 18410Combined sources
Helixi186 – 1883Combined sources
Helixi191 – 20313Combined sources
Helixi206 – 21510Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HURX-ray2.15A/B/C1-219[»]
4HUSX-ray2.36A/B/C1-219[»]
4MYOX-ray2.70A/B/C7-219[»]
ProteinModelPortaliP26839.
SMRiP26839. Positions 8-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26839-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLNNDHGPD PENILPIKGN RNLQFIKPTI TNENILVGEY SYYDSKRGES
60 70 80 90 100
FEDQVLYHYE VIGDKLIIGR FCSIGPGTTF IMNGANHRMD GSTYPFHLFR
110 120 130 140 150
MGWEKYMPSL KDLPLKGDIE IGNDVWIGRD VTIMPGVKIG DGAIIAAEAV
160 170 180 190 200
VTKNVAPYSI VGGNPLKFIR KRFSDGVIEE WLALQWWNLD MKIINENLPF
210
IINGDIEMLK RKRKLLDDT
Length:219
Mass (Da):24,932
Last modified:October 1, 1996 - v2
Checksum:iCDAFD846D0727207
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → L(PubMed:3149758)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07778 Genomic DNA. Translation: AAA26683.1.
M36022 Genomic DNA. No translation available.
PIRiJN0822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07778 Genomic DNA. Translation: AAA26683.1 .
M36022 Genomic DNA. No translation available.
PIRi JN0822.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HUR X-ray 2.15 A/B/C 1-219 [» ]
4HUS X-ray 2.36 A/B/C 1-219 [» ]
4MYO X-ray 2.70 A/B/C 7-219 [» ]
ProteinModelPortali P26839.
SMRi P26839. Positions 8-206.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
[Graphical view ]
Pfami PF00132. Hexapep. 1 hit.
[Graphical view ]
SUPFAMi SSF51161. SSF51161. 1 hit.
PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of a staphylococcal gene, vat, encoding an acetyltransferase inactivating the A-type compounds of virginiamycin-like antibiotics."
    Allignet J., Loncle V., Simenel C., Delpierre M., el Solh N.
    Gene 130:91-98(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginiamycin-like antibiotics."
    Allignet J., Loncle V., Mazodier P., El Solh N.
    Plasmid 20:271-275(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-112.

Entry informationi

Entry nameiVATA_STAAU
AccessioniPrimary (citable) accession number: P26839
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3