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P26839

- VATA_STAAU

UniProt

P26839 - VATA_STAAU

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Protein
Virginiamycin A acetyltransferase
Gene
vat
Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Inactivates the A compounds of virginiamycin-like antibiotics, thus providing resistance to these antibiotics.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871 By similarity

GO - Molecular functioni

  1. transferase activity, transferring acyl groups Source: UniProtKB-KW

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Virginiamycin A acetyltransferase (EC:2.3.1.-)
Gene namesi
Name:vat
Encoded oniPlasmid pIP6300 Publication
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Virginiamycin A acetyltransferase
PRO_0000068664Add
BLAST

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 266
Helixi27 – 293
Beta strandi35 – 373
Beta strandi42 – 443
Beta strandi46 – 483
Helixi51 – 544
Beta strandi55 – 573
Turni60 – 623
Beta strandi66 – 683
Beta strandi79 – 813
Helixi83 – 853
Helixi96 – 994
Helixi103 – 1064
Helixi110 – 1123
Beta strandi119 – 1213
Beta strandi159 – 1624
Turni163 – 1664
Beta strandi167 – 1737
Helixi175 – 18410
Helixi186 – 1883
Helixi191 – 20313
Helixi206 – 21510

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HURX-ray2.15A/B/C1-219[»]
4HUSX-ray2.36A/B/C1-219[»]
4MYOX-ray2.70A/B/C7-219[»]
ProteinModelPortaliP26839.
SMRiP26839. Positions 8-206.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26839-1 [UniParc]FASTAAdd to Basket

« Hide

MNLNNDHGPD PENILPIKGN RNLQFIKPTI TNENILVGEY SYYDSKRGES    50
FEDQVLYHYE VIGDKLIIGR FCSIGPGTTF IMNGANHRMD GSTYPFHLFR 100
MGWEKYMPSL KDLPLKGDIE IGNDVWIGRD VTIMPGVKIG DGAIIAAEAV 150
VTKNVAPYSI VGGNPLKFIR KRFSDGVIEE WLALQWWNLD MKIINENLPF 200
IINGDIEMLK RKRKLLDDT 219
Length:219
Mass (Da):24,932
Last modified:October 1, 1996 - v2
Checksum:iCDAFD846D0727207
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → L1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07778 Genomic DNA. Translation: AAA26683.1.
M36022 Genomic DNA. No translation available.
PIRiJN0822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07778 Genomic DNA. Translation: AAA26683.1 .
M36022 Genomic DNA. No translation available.
PIRi JN0822.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HUR X-ray 2.15 A/B/C 1-219 [» ]
4HUS X-ray 2.36 A/B/C 1-219 [» ]
4MYO X-ray 2.70 A/B/C 7-219 [» ]
ProteinModelPortali P26839.
SMRi P26839. Positions 8-206.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
[Graphical view ]
Pfami PF00132. Hexapep. 1 hit.
[Graphical view ]
SUPFAMi SSF51161. SSF51161. 1 hit.
PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of a staphylococcal gene, vat, encoding an acetyltransferase inactivating the A-type compounds of virginiamycin-like antibiotics."
    Allignet J., Loncle V., Simenel C., Delpierre M., el Solh N.
    Gene 130:91-98(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginiamycin-like antibiotics."
    Allignet J., Loncle V., Mazodier P., El Solh N.
    Plasmid 20:271-275(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-112.

Entry informationi

Entry nameiVATA_STAAU
AccessioniPrimary (citable) accession number: P26839
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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