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Protein

Virginiamycin A acetyltransferase

Gene

vat

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inactivates the A compounds of virginiamycin-like antibiotics, thus providing resistance to these antibiotics.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Virginiamycin A acetyltransferase (EC:2.3.1.-)
Gene namesi
Name:vat
Encoded oniPlasmid pIP6300 Publication
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686641 – 219Virginiamycin A acetyltransferaseAdd BLAST219

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 26Combined sources6
Helixi27 – 29Combined sources3
Beta strandi35 – 37Combined sources3
Beta strandi42 – 44Combined sources3
Beta strandi46 – 48Combined sources3
Helixi51 – 54Combined sources4
Beta strandi55 – 57Combined sources3
Turni60 – 62Combined sources3
Beta strandi66 – 68Combined sources3
Beta strandi79 – 81Combined sources3
Helixi83 – 85Combined sources3
Helixi96 – 99Combined sources4
Helixi103 – 106Combined sources4
Helixi110 – 112Combined sources3
Beta strandi119 – 121Combined sources3
Beta strandi159 – 162Combined sources4
Turni163 – 166Combined sources4
Beta strandi167 – 173Combined sources7
Helixi175 – 184Combined sources10
Helixi186 – 188Combined sources3
Helixi191 – 203Combined sources13
Helixi206 – 215Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HURX-ray2.15A/B/C1-219[»]
4HUSX-ray2.36A/B/C1-219[»]
4MYOX-ray2.70A/B/C7-219[»]
ProteinModelPortaliP26839.
SMRiP26839.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK18234.

Family and domain databases

InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLNNDHGPD PENILPIKGN RNLQFIKPTI TNENILVGEY SYYDSKRGES
60 70 80 90 100
FEDQVLYHYE VIGDKLIIGR FCSIGPGTTF IMNGANHRMD GSTYPFHLFR
110 120 130 140 150
MGWEKYMPSL KDLPLKGDIE IGNDVWIGRD VTIMPGVKIG DGAIIAAEAV
160 170 180 190 200
VTKNVAPYSI VGGNPLKFIR KRFSDGVIEE WLALQWWNLD MKIINENLPF
210
IINGDIEMLK RKRKLLDDT
Length:219
Mass (Da):24,932
Last modified:October 1, 1996 - v2
Checksum:iCDAFD846D0727207
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → L (PubMed:3149758).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07778 Genomic DNA. Translation: AAA26683.1.
M36022 Genomic DNA. No translation available.
PIRiJN0822.
RefSeqiWP_032489635.1. NG_048537.1.

Genome annotation databases

KEGGiag:AAA26683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07778 Genomic DNA. Translation: AAA26683.1.
M36022 Genomic DNA. No translation available.
PIRiJN0822.
RefSeqiWP_032489635.1. NG_048537.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HURX-ray2.15A/B/C1-219[»]
4HUSX-ray2.36A/B/C1-219[»]
4MYOX-ray2.70A/B/C7-219[»]
ProteinModelPortaliP26839.
SMRiP26839.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAA26683.

Phylogenomic databases

KOiK18234.

Family and domain databases

InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVATA_STAAU
AccessioniPrimary (citable) accession number: P26839
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.