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P26839 (VATA_STAAU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Virginiamycin A acetyltransferase
EC=2.3.1.-
Gene names
Name:vat
Encoded onPlasmid pIP630
OrganismStaphylococcus aureus
Taxonomic identifier1280 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inactivates the A compounds of virginiamycin-like antibiotics, thus providing resistance to these antibiotics.

Sequence similarities

Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainRepeat
   Molecular functionAcyltransferase
Transferase
   Technical term3D-structure
Plasmid
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransferase activity, transferring acyl groups

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Virginiamycin A acetyltransferase
PRO_0000068664

Sites

Active site871 By similarity

Experimental info

Sequence conflict11M → L Ref.2

Secondary structure

1 ......................................... 219
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P26839 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: CDAFD846D0727207

FASTA21924,932
        10         20         30         40         50         60 
MNLNNDHGPD PENILPIKGN RNLQFIKPTI TNENILVGEY SYYDSKRGES FEDQVLYHYE 

        70         80         90        100        110        120 
VIGDKLIIGR FCSIGPGTTF IMNGANHRMD GSTYPFHLFR MGWEKYMPSL KDLPLKGDIE 

       130        140        150        160        170        180 
IGNDVWIGRD VTIMPGVKIG DGAIIAAEAV VTKNVAPYSI VGGNPLKFIR KRFSDGVIEE 

       190        200        210 
WLALQWWNLD MKIINENLPF IINGDIEMLK RKRKLLDDT

« Hide

References

[1]"Sequence of a staphylococcal gene, vat, encoding an acetyltransferase inactivating the A-type compounds of virginiamycin-like antibiotics."
Allignet J., Loncle V., Simenel C., Delpierre M., el Solh N.
Gene 130:91-98(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginiamycin-like antibiotics."
Allignet J., Loncle V., Mazodier P., El Solh N.
Plasmid 20:271-275(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-112.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L07778 Genomic DNA. Translation: AAA26683.1.
M36022 Genomic DNA. No translation available.
PIRJN0822.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4E8LX-ray2.70A/B/C1-219[»]
4HURX-ray2.15A/B/C1-219[»]
4HUSX-ray2.36A/B/C1-219[»]
ProteinModelPortalP26839.
SMRP26839. Positions 8-206.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMSSF51161. Trimer_LpxA_like. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVATA_STAAU
AccessionPrimary (citable) accession number: P26839
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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