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P26839

- VATA_STAAU

UniProt

P26839 - VATA_STAAU

Protein

Virginiamycin A acetyltransferase

Gene

vat

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Inactivates the A compounds of virginiamycin-like antibiotics, thus providing resistance to these antibiotics.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei87 – 871By similarity

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups Source: UniProtKB-KW

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Virginiamycin A acetyltransferase (EC:2.3.1.-)
    Gene namesi
    Name:vat
    Encoded oniPlasmid pIP6300 Publication
    OrganismiStaphylococcus aureus
    Taxonomic identifieri1280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219Virginiamycin A acetyltransferasePRO_0000068664Add
    BLAST

    Structurei

    Secondary structure

    1
    219
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi21 – 266
    Helixi27 – 293
    Beta strandi35 – 373
    Beta strandi42 – 443
    Beta strandi46 – 483
    Helixi51 – 544
    Beta strandi55 – 573
    Turni60 – 623
    Beta strandi66 – 683
    Beta strandi79 – 813
    Helixi83 – 853
    Helixi96 – 994
    Helixi103 – 1064
    Helixi110 – 1123
    Beta strandi119 – 1213
    Beta strandi159 – 1624
    Turni163 – 1664
    Beta strandi167 – 1737
    Helixi175 – 18410
    Helixi186 – 1883
    Helixi191 – 20313
    Helixi206 – 21510

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HURX-ray2.15A/B/C1-219[»]
    4HUSX-ray2.36A/B/C1-219[»]
    4MYOX-ray2.70A/B/C7-219[»]
    ProteinModelPortaliP26839.
    SMRiP26839. Positions 8-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PfamiPF00132. Hexapep. 1 hit.
    [Graphical view]
    SUPFAMiSSF51161. SSF51161. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26839-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLNNDHGPD PENILPIKGN RNLQFIKPTI TNENILVGEY SYYDSKRGES    50
    FEDQVLYHYE VIGDKLIIGR FCSIGPGTTF IMNGANHRMD GSTYPFHLFR 100
    MGWEKYMPSL KDLPLKGDIE IGNDVWIGRD VTIMPGVKIG DGAIIAAEAV 150
    VTKNVAPYSI VGGNPLKFIR KRFSDGVIEE WLALQWWNLD MKIINENLPF 200
    IINGDIEMLK RKRKLLDDT 219
    Length:219
    Mass (Da):24,932
    Last modified:October 1, 1996 - v2
    Checksum:iCDAFD846D0727207
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 11M → L(PubMed:3149758)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07778 Genomic DNA. Translation: AAA26683.1.
    M36022 Genomic DNA. No translation available.
    PIRiJN0822.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07778 Genomic DNA. Translation: AAA26683.1 .
    M36022 Genomic DNA. No translation available.
    PIRi JN0822.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HUR X-ray 2.15 A/B/C 1-219 [» ]
    4HUS X-ray 2.36 A/B/C 1-219 [» ]
    4MYO X-ray 2.70 A/B/C 7-219 [» ]
    ProteinModelPortali P26839.
    SMRi P26839. Positions 8-206.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    Pfami PF00132. Hexapep. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51161. SSF51161. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a staphylococcal gene, vat, encoding an acetyltransferase inactivating the A-type compounds of virginiamycin-like antibiotics."
      Allignet J., Loncle V., Simenel C., Delpierre M., el Solh N.
      Gene 130:91-98(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginiamycin-like antibiotics."
      Allignet J., Loncle V., Mazodier P., El Solh N.
      Plasmid 20:271-275(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-112.

    Entry informationi

    Entry nameiVATA_STAAU
    AccessioniPrimary (citable) accession number: P26839
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 62 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Plasmid

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3