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P26836 (LYS_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable autolytic lysozyme

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase
Autolysin
Gene names
Name:lyc
Ordered Locus Names:CPE0382
OrganismClostridium perfringens (strain 13 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier195102 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sequence similarities

Belongs to the glycosyl hydrolase 25 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Probable autolytic lysozyme
PRO_0000208265

Regions

Repeat230 – 252231
Repeat253 – 272202
Repeat273 – 295233
Repeat296 – 318234
Repeat319 – 342245
Region230 – 3421135 X 23 AA tandem repeats

Sites

Active site131 By similarity
Active site1031 By similarity

Sequences

Sequence LengthMass (Da)Tools
P26836 [UniParc].

Last modified January 31, 2002. Version 2.
Checksum: EC3B4078A2FB4732

FASTA34239,558
        10         20         30         40         50         60 
MEGRNSNNLK GIDVSNWQGN INFKSVKNEG IEVVYIKATE GDYFKDSYAK QNYKRAKAEG 

        70         80         90        100        110        120 
LKVGFYHFFK PNKNAKRQAK YFIDYLNEIG ATDYDCKLAL DVETTEGRSA YELTTMCIEF 

       130        140        150        160        170        180 
LEEVRKITNR EVVVYTYTSF ANNNLDNRLG VYPLWIAEYG VKAPKDNRVW SSWIGFQYSD 

       190        200        210        220        230        240 
KGNVAGVSGN CDMNEFKEEI LDVKNNFKLY NATTKNISTY LNIREKGEID SKIIGKIPAG 

       250        260        270        280        290        300 
EEFMIKWVDS NYLGWYLIEY KNITGYVSSK YVEKFQMATT YNVSDFLNVR ERGTTDSKVV 

       310        320        330        340 
AIIDDGEIFR IDWVDSDYIG WYRITTKYGK NGFVKADFVK KI 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater."
Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.
Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13 / Type A.
[2]"Molecular genetic analysis of the nagH gene encoding a hyaluronidase of Clostridium perfringens."
Canard B., Garnier T., Saint-Joanis B., Cole S.T.
Mol. Gen. Genet. 243:215-224(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 256-342.
Strain: CPN50.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000016 Genomic DNA. Translation: BAB80088.1.
M81878 Genomic DNA. Translation: AAA23261.1.
PIRS43906.
RefSeqNP_561298.1. NC_003366.1.

3D structure databases

ProteinModelPortalP26836.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING195102.CPE0382.

Protein family/group databases

CAZyGH25. Glycoside Hydrolase Family 25.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB80088; BAB80088; BAB80088.
GeneID988635.
KEGGcpe:CPE0382.
PATRIC19494672. VBICloPer59675_0441.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3757.
HOGENOMHOG000113426.
KOK07273.
OMADVETTEG.
OrthoDBEOG6SV55S.
ProtClustDBCLSK566944.

Enzyme and pathway databases

BioCycCPER195102:GJFM-419-MONOMER.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR002053. Glyco_hydro_25.
IPR008270. Glyco_hydro_25_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR018077. Glyco_hydro_fam25_subgr.
IPR017853. Glycoside_hydrolase_SF.
IPR003646. SH3-like_bac-type.
[Graphical view]
PfamPF01183. Glyco_hydro_25. 1 hit.
PF08239. SH3_3. 2 hits.
[Graphical view]
SMARTSM00641. Glyco_25. 1 hit.
SM00287. SH3b. 2 hits.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00953. GLYCOSYL_HYDROL_F25. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYS_CLOPE
AccessionPrimary (citable) accession number: P26836
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 31, 2002
Last modified: November 13, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries