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P26836

- LYS_CLOPE

UniProt

P26836 - LYS_CLOPE

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Protein

Probable autolytic lysozyme

Gene

lyc

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131PROSITE-ProRule annotation
Active sitei103 – 1031PROSITE-ProRule annotation

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell wall macromolecule catabolic process Source: InterPro
  3. cytolysis Source: UniProtKB-KW
  4. defense response to bacterium Source: UniProtKB-KW
  5. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciCPER195102:GJFM-419-MONOMER.

Protein family/group databases

CAZyiGH25. Glycoside Hydrolase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable autolytic lysozyme (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
Autolysin
Gene namesi
Name:lyc
Ordered Locus Names:CPE0382
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Probable autolytic lysozymePRO_0000208265Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195102.CPE0382.

Structurei

3D structure databases

ProteinModelPortaliP26836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati230 – 252231Add
BLAST
Repeati253 – 272202Add
BLAST
Repeati273 – 295233Add
BLAST
Repeati296 – 318234Add
BLAST
Repeati319 – 342245Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni230 – 3421135 X 23 AA tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 25 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG3757.
HOGENOMiHOG000113426.
KOiK07273.
OMAiDVETTEG.
OrthoDBiEOG6SV55S.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR002053. Glyco_hydro_25.
IPR008270. Glyco_hydro_25_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR018077. Glyco_hydro_fam25_subgr.
IPR017853. Glycoside_hydrolase_SF.
IPR003646. SH3-like_bac-type.
[Graphical view]
PfamiPF01183. Glyco_hydro_25. 1 hit.
PF08239. SH3_3. 2 hits.
[Graphical view]
SMARTiSM00641. Glyco_25. 1 hit.
SM00287. SH3b. 2 hits.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00953. GLYCOSYL_HYDROL_F25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26836-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGRNSNNLK GIDVSNWQGN INFKSVKNEG IEVVYIKATE GDYFKDSYAK
60 70 80 90 100
QNYKRAKAEG LKVGFYHFFK PNKNAKRQAK YFIDYLNEIG ATDYDCKLAL
110 120 130 140 150
DVETTEGRSA YELTTMCIEF LEEVRKITNR EVVVYTYTSF ANNNLDNRLG
160 170 180 190 200
VYPLWIAEYG VKAPKDNRVW SSWIGFQYSD KGNVAGVSGN CDMNEFKEEI
210 220 230 240 250
LDVKNNFKLY NATTKNISTY LNIREKGEID SKIIGKIPAG EEFMIKWVDS
260 270 280 290 300
NYLGWYLIEY KNITGYVSSK YVEKFQMATT YNVSDFLNVR ERGTTDSKVV
310 320 330 340
AIIDDGEIFR IDWVDSDYIG WYRITTKYGK NGFVKADFVK KI
Length:342
Mass (Da):39,558
Last modified:January 31, 2002 - v2
Checksum:iEC3B4078A2FB4732
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB80088.1.
M81878 Genomic DNA. Translation: AAA23261.1.
PIRiS43906.
RefSeqiNP_561298.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB80088; BAB80088; BAB80088.
GeneIDi988635.
KEGGicpe:CPE0382.
PATRICi19494672. VBICloPer59675_0441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB80088.1 .
M81878 Genomic DNA. Translation: AAA23261.1 .
PIRi S43906.
RefSeqi NP_561298.1. NC_003366.1.

3D structure databases

ProteinModelPortali P26836.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195102.CPE0382.

Protein family/group databases

CAZyi GH25. Glycoside Hydrolase Family 25.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB80088 ; BAB80088 ; BAB80088 .
GeneIDi 988635.
KEGGi cpe:CPE0382.
PATRICi 19494672. VBICloPer59675_0441.

Phylogenomic databases

eggNOGi COG3757.
HOGENOMi HOG000113426.
KOi K07273.
OMAi DVETTEG.
OrthoDBi EOG6SV55S.

Enzyme and pathway databases

BioCyci CPER195102:GJFM-419-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR002053. Glyco_hydro_25.
IPR008270. Glyco_hydro_25_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR018077. Glyco_hydro_fam25_subgr.
IPR017853. Glycoside_hydrolase_SF.
IPR003646. SH3-like_bac-type.
[Graphical view ]
Pfami PF01183. Glyco_hydro_25. 1 hit.
PF08239. SH3_3. 2 hits.
[Graphical view ]
SMARTi SM00641. Glyco_25. 1 hit.
SM00287. SH3b. 2 hits.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00953. GLYCOSYL_HYDROL_F25. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.
  2. "Molecular genetic analysis of the nagH gene encoding a hyaluronidase of Clostridium perfringens."
    Canard B., Garnier T., Saint-Joanis B., Cole S.T.
    Mol. Gen. Genet. 243:215-224(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 256-342.
    Strain: CPN50.

Entry informationi

Entry nameiLYS_CLOPE
AccessioniPrimary (citable) accession number: P26836
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 31, 2002
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3