Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P26836

- LYS_CLOPE

UniProt

P26836 - LYS_CLOPE

Protein

Probable autolytic lysozyme

Gene

lyc

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (31 Jan 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei13 – 131PROSITE-ProRule annotation
    Active sitei103 – 1031PROSITE-ProRule annotation

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell wall macromolecule catabolic process Source: InterPro
    3. cytolysis Source: UniProtKB-KW
    4. defense response to bacterium Source: UniProtKB-KW
    5. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciCPER195102:GJFM-419-MONOMER.

    Protein family/group databases

    CAZyiGH25. Glycoside Hydrolase Family 25.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable autolytic lysozyme (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase
    Autolysin
    Gene namesi
    Name:lyc
    Ordered Locus Names:CPE0382
    OrganismiClostridium perfringens (strain 13 / Type A)
    Taxonomic identifieri195102 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000818: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Probable autolytic lysozymePRO_0000208265Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi195102.CPE0382.

    Structurei

    3D structure databases

    ProteinModelPortaliP26836.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati230 – 252231Add
    BLAST
    Repeati253 – 272202Add
    BLAST
    Repeati273 – 295233Add
    BLAST
    Repeati296 – 318234Add
    BLAST
    Repeati319 – 342245Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni230 – 3421135 X 23 AA tandem repeatsAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 25 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG3757.
    HOGENOMiHOG000113426.
    KOiK07273.
    OMAiDVETTEG.
    OrthoDBiEOG6SV55S.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR002053. Glyco_hydro_25.
    IPR008270. Glyco_hydro_25_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR018077. Glyco_hydro_fam25_subgr.
    IPR017853. Glycoside_hydrolase_SF.
    IPR003646. SH3-like_bac-type.
    [Graphical view]
    PfamiPF01183. Glyco_hydro_25. 1 hit.
    PF08239. SH3_3. 2 hits.
    [Graphical view]
    SMARTiSM00641. Glyco_25. 1 hit.
    SM00287. SH3b. 2 hits.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00953. GLYCOSYL_HYDROL_F25. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26836-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGRNSNNLK GIDVSNWQGN INFKSVKNEG IEVVYIKATE GDYFKDSYAK    50
    QNYKRAKAEG LKVGFYHFFK PNKNAKRQAK YFIDYLNEIG ATDYDCKLAL 100
    DVETTEGRSA YELTTMCIEF LEEVRKITNR EVVVYTYTSF ANNNLDNRLG 150
    VYPLWIAEYG VKAPKDNRVW SSWIGFQYSD KGNVAGVSGN CDMNEFKEEI 200
    LDVKNNFKLY NATTKNISTY LNIREKGEID SKIIGKIPAG EEFMIKWVDS 250
    NYLGWYLIEY KNITGYVSSK YVEKFQMATT YNVSDFLNVR ERGTTDSKVV 300
    AIIDDGEIFR IDWVDSDYIG WYRITTKYGK NGFVKADFVK KI 342
    Length:342
    Mass (Da):39,558
    Last modified:January 31, 2002 - v2
    Checksum:iEC3B4078A2FB4732
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000016 Genomic DNA. Translation: BAB80088.1.
    M81878 Genomic DNA. Translation: AAA23261.1.
    PIRiS43906.
    RefSeqiNP_561298.1. NC_003366.1.
    WP_011009775.1. NC_003366.1.

    Genome annotation databases

    EnsemblBacteriaiBAB80088; BAB80088; BAB80088.
    GeneIDi988635.
    KEGGicpe:CPE0382.
    PATRICi19494672. VBICloPer59675_0441.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000016 Genomic DNA. Translation: BAB80088.1 .
    M81878 Genomic DNA. Translation: AAA23261.1 .
    PIRi S43906.
    RefSeqi NP_561298.1. NC_003366.1.
    WP_011009775.1. NC_003366.1.

    3D structure databases

    ProteinModelPortali P26836.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 195102.CPE0382.

    Protein family/group databases

    CAZyi GH25. Glycoside Hydrolase Family 25.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB80088 ; BAB80088 ; BAB80088 .
    GeneIDi 988635.
    KEGGi cpe:CPE0382.
    PATRICi 19494672. VBICloPer59675_0441.

    Phylogenomic databases

    eggNOGi COG3757.
    HOGENOMi HOG000113426.
    KOi K07273.
    OMAi DVETTEG.
    OrthoDBi EOG6SV55S.

    Enzyme and pathway databases

    BioCyci CPER195102:GJFM-419-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR002053. Glyco_hydro_25.
    IPR008270. Glyco_hydro_25_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR018077. Glyco_hydro_fam25_subgr.
    IPR017853. Glycoside_hydrolase_SF.
    IPR003646. SH3-like_bac-type.
    [Graphical view ]
    Pfami PF01183. Glyco_hydro_25. 1 hit.
    PF08239. SH3_3. 2 hits.
    [Graphical view ]
    SMARTi SM00641. Glyco_25. 1 hit.
    SM00287. SH3b. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00953. GLYCOSYL_HYDROL_F25. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 13 / Type A.
    2. "Molecular genetic analysis of the nagH gene encoding a hyaluronidase of Clostridium perfringens."
      Canard B., Garnier T., Saint-Joanis B., Cole S.T.
      Mol. Gen. Genet. 243:215-224(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 256-342.
      Strain: CPN50.

    Entry informationi

    Entry nameiLYS_CLOPE
    AccessioniPrimary (citable) accession number: P26836
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: January 31, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3