P26825 (CAT1_CLOPF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chloramphenicol acetyltransferase
Short name=CAT
EC=2.3.1.28

Gene names

Name:

catQ

Organism

Clostridium perfringens

Taxonomic identifier

1502 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is an effector of chloramphenicol resistance in bacteria.
Catalytic activity	Acetyl-CoA + chloramphenicol = CoA + chloramphenicol 3-acetate.
Subunit structure	Homotrimer.
Sequence similarities	Belongs to the chloramphenicol acetyltransferase family.

Ontologies

Keywords
Biological process	Antibiotic resistance
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological_process	response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	chloramphenicol O-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Chloramphenicol acetyltransferase		PRO_0000165861
Sites
	Active site	190	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P26825 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 00555D36A843D589	FASTA	219	26,044
	10 20 30 40 50 60 MKFNLIDIED WNRKPYFEHY LNAVRCTYSM TANIEITGLL REIKLKGLKL YPTLIYIITT 70 80 90 100 110 120 VVNRHKEFRT CFDQKGKLGY WDSMNPSYTV FHKDNETFSS IWTEYDENFP RFYYNYLEDI 130 140 150 160 170 180 RNYSDVLNFM PKTGEPANTI NVSSIPWVNF TGFNLNIYND ATYLIPIFTL GKYFQQDNKI 190 200 210 LLPMSVQVHH AVCDGYHISR FFNEAQELAS NYETWLGEK

References

[1]	"Relationship between the Clostridium perfringens catQ gene product and chloramphenicol acetyltransferases from other bacteria." Bannam T.L., Rood J.I. Antimicrob. Agents Chemother. 35:471-476(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CW531.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M55620 Genomic DNA. Translation: AAA23215.1.
PIR	A49793.
3D structure databases
ProteinModelPortal	P26825.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.559.10. 1 hit.
InterPro	IPR023213. CAT-like_dom. IPR018372. Chloramphenicol_AcTrfase_AS. IPR001707. Cmp_AcTrfase. [Graphical view]
Pfam	PF00302. CAT. 1 hit. [Graphical view]
PIRSF	PIRSF000440. CAT. 1 hit.
ProDom	PD002660. Cmp_AcTrfase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM01059. CAT. 1 hit. [Graphical view]
PROSITE	PS00100. CAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAT1_CLOPF

Accession

Primary (citable) accession number: P26825

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program