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P26823

- DNAK_CLOPE

UniProt

P26823 - DNAK_CLOPE

Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (31 Jan 2002)
      Previous versions | rss
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    Functioni

    Acts as a chaperone.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPER195102:GJFM-2087-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chaperone protein DnaK
    Alternative name(s):
    HSP70
    Heat shock 70 kDa protein
    Heat shock protein 70
    Gene namesi
    Name:dnaK
    Ordered Locus Names:CPE2033
    OrganismiClostridium perfringens (strain 13 / Type A)
    Taxonomic identifieri195102 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000818: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 619619Chaperone protein DnaKPRO_0000078450Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei175 – 1751Phosphothreonine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Inductioni

    By stress conditions e.g. heat shock By similarity.By similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi195102.CPE2033.

    Structurei

    3D structure databases

    ProteinModelPortaliP26823.
    SMRiP26823. Positions 1-507.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Phylogenomic databases

    eggNOGiCOG0443.
    HOGENOMiHOG000228136.
    KOiK04043.
    OMAiMNTDNTF.
    OrthoDBiEOG6JMMSV.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    HAMAPiMF_00332. DnaK.
    InterProiIPR012725. Chaperone_DnaK.
    IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
    PROSITEiPS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26823-1 [UniParc]FASTAAdd to Basket

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    MSKIIGIDLG TTNSCVAVME GGEPVVITNS EGARTTPSVV SFQANGERLV    50
    GQVAKRQAIT NPDKTIMSIK RHMGTDYKVN IDGKDYTPQE ISAMILQKLK 100
    ADAEAYLGEK VTEAVITVPA YFNDAERQAT KDAGRIAGLD VKRIINEPTA 150
    ASLAYGLDKM DSAHKILVYD LGGGTFDVSI LDLGDGVFEV VSTNGDARLG 200
    GDDFDQRIID YIAEDFKAQN GIDLRQDKMA LQRLKEAAEK AKIELSSSTQ 250
    TLINLPFITA DATGPKHIDM TLTRAKFNEL THDLVERTIN IMKEALKSGN 300
    VSLNDIDKVI LVGGSTRIPA VQEAVKNFTG KEPSKGVNPD ECVAMGAAIQ 350
    AGVLTGDVKD VLLLDVTPLT LGIETLGGVA TPLIERNTTI PARKSQIFST 400
    AADNQTSVEI HVVQGERQMA ADNKTLGRFT LSGIAPAPRG IPQIEVAFDI 450
    DANGIVKVSA TDKATGKEAN ITITASTNLS DAEIDKAVKE AEQFAEEDKK 500
    RKEAIEVKNN AEQTVYQTEK TLNELGDKVS AEEKSEIEAK IEEVKKVKDG 550
    DDIEAIKKAM EDLTQAFYKV SEKLYQQNGG AQGQGFDPNN MGGANAGAGA 600
    TNNNDDNVVD ADFEVQDDK 619
    Length:619
    Mass (Da):66,482
    Last modified:January 31, 2002 - v2
    Checksum:i88990A19444079BE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti86 – 872YT → LS in CAA44698. (PubMed:1562596)Curated
    Sequence conflicti143 – 1431R → T in CAA44698. (PubMed:1562596)Curated
    Sequence conflicti218 – 2192AQ → GE in CAA44698. (PubMed:1562596)Curated
    Sequence conflicti237 – 2393AAE → GRQ in CAA44698. (PubMed:1562596)Curated
    Sequence conflicti398 – 3981F → L in CAA44698. (PubMed:1562596)Curated
    Sequence conflicti543 – 5431Missing in CAA44698. (PubMed:1562596)Curated
    Sequence conflicti554 – 5541E → Q in CAA44698. (PubMed:1562596)Curated
    Sequence conflicti589 – 5902NN → II in CAA44698. (PubMed:1562596)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62915 Genomic DNA. Translation: CAA44698.1.
    BA000016 Genomic DNA. Translation: BAB81739.1.
    PIRiS22355.
    RefSeqiNP_562949.1. NC_003366.1.

    Genome annotation databases

    EnsemblBacteriaiBAB81739; BAB81739; BAB81739.
    GeneIDi990348.
    KEGGicpe:CPE2033.
    PATRICi19498035. VBICloPer59675_2107.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62915 Genomic DNA. Translation: CAA44698.1 .
    BA000016 Genomic DNA. Translation: BAB81739.1 .
    PIRi S22355.
    RefSeqi NP_562949.1. NC_003366.1.

    3D structure databases

    ProteinModelPortali P26823.
    SMRi P26823. Positions 1-507.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 195102.CPE2033.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB81739 ; BAB81739 ; BAB81739 .
    GeneIDi 990348.
    KEGGi cpe:CPE2033.
    PATRICi 19498035. VBICloPer59675_2107.

    Phylogenomic databases

    eggNOGi COG0443.
    HOGENOMi HOG000228136.
    KOi K04043.
    OMAi MNTDNTF.
    OrthoDBi EOG6JMMSV.

    Enzyme and pathway databases

    BioCyci CPER195102:GJFM-2087-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    HAMAPi MF_00332. DnaK.
    InterProi IPR012725. Chaperone_DnaK.
    IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    TIGRFAMsi TIGR02350. prok_dnaK. 1 hit.
    PROSITEi PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of HSP70 (dnaK) gene from Clostridium perfringens using a general polymerase chain reaction based approach."
      Galley K.A., Singh B., Gupta R.S.
      Biochim. Biophys. Acta 1130:203-208(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 13 / Type A.

    Entry informationi

    Entry nameiDNAK_CLOPE
    AccessioniPrimary (citable) accession number: P26823
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: January 31, 2002
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3