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P26823

- DNAK_CLOPE

UniProt

P26823 - DNAK_CLOPE

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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein folding Source: InterPro
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPER195102:GJFM-2087-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:CPE2033
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Chaperone protein DnaKPRO_0000078450Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By stress conditions e.g. heat shock By similarity.By similarity

Interactioni

Protein-protein interaction databases

STRINGi195102.CPE2033.

Structurei

3D structure databases

ProteinModelPortaliP26823.
SMRiP26823. Positions 1-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228136.
KOiK04043.
OMAiMNTDNTF.
OrthoDBiEOG6JMMSV.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26823-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKIIGIDLG TTNSCVAVME GGEPVVITNS EGARTTPSVV SFQANGERLV
60 70 80 90 100
GQVAKRQAIT NPDKTIMSIK RHMGTDYKVN IDGKDYTPQE ISAMILQKLK
110 120 130 140 150
ADAEAYLGEK VTEAVITVPA YFNDAERQAT KDAGRIAGLD VKRIINEPTA
160 170 180 190 200
ASLAYGLDKM DSAHKILVYD LGGGTFDVSI LDLGDGVFEV VSTNGDARLG
210 220 230 240 250
GDDFDQRIID YIAEDFKAQN GIDLRQDKMA LQRLKEAAEK AKIELSSSTQ
260 270 280 290 300
TLINLPFITA DATGPKHIDM TLTRAKFNEL THDLVERTIN IMKEALKSGN
310 320 330 340 350
VSLNDIDKVI LVGGSTRIPA VQEAVKNFTG KEPSKGVNPD ECVAMGAAIQ
360 370 380 390 400
AGVLTGDVKD VLLLDVTPLT LGIETLGGVA TPLIERNTTI PARKSQIFST
410 420 430 440 450
AADNQTSVEI HVVQGERQMA ADNKTLGRFT LSGIAPAPRG IPQIEVAFDI
460 470 480 490 500
DANGIVKVSA TDKATGKEAN ITITASTNLS DAEIDKAVKE AEQFAEEDKK
510 520 530 540 550
RKEAIEVKNN AEQTVYQTEK TLNELGDKVS AEEKSEIEAK IEEVKKVKDG
560 570 580 590 600
DDIEAIKKAM EDLTQAFYKV SEKLYQQNGG AQGQGFDPNN MGGANAGAGA
610
TNNNDDNVVD ADFEVQDDK
Length:619
Mass (Da):66,482
Last modified:January 31, 2002 - v2
Checksum:i88990A19444079BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 872YT → LS in CAA44698. (PubMed:1562596)Curated
Sequence conflicti143 – 1431R → T in CAA44698. (PubMed:1562596)Curated
Sequence conflicti218 – 2192AQ → GE in CAA44698. (PubMed:1562596)Curated
Sequence conflicti237 – 2393AAE → GRQ in CAA44698. (PubMed:1562596)Curated
Sequence conflicti398 – 3981F → L in CAA44698. (PubMed:1562596)Curated
Sequence conflicti543 – 5431Missing in CAA44698. (PubMed:1562596)Curated
Sequence conflicti554 – 5541E → Q in CAA44698. (PubMed:1562596)Curated
Sequence conflicti589 – 5902NN → II in CAA44698. (PubMed:1562596)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62915 Genomic DNA. Translation: CAA44698.1.
BA000016 Genomic DNA. Translation: BAB81739.1.
PIRiS22355.
RefSeqiNP_562949.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB81739; BAB81739; BAB81739.
GeneIDi990348.
KEGGicpe:CPE2033.
PATRICi19498035. VBICloPer59675_2107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62915 Genomic DNA. Translation: CAA44698.1 .
BA000016 Genomic DNA. Translation: BAB81739.1 .
PIRi S22355.
RefSeqi NP_562949.1. NC_003366.1.

3D structure databases

ProteinModelPortali P26823.
SMRi P26823. Positions 1-507.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195102.CPE2033.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB81739 ; BAB81739 ; BAB81739 .
GeneIDi 990348.
KEGGi cpe:CPE2033.
PATRICi 19498035. VBICloPer59675_2107.

Phylogenomic databases

eggNOGi COG0443.
HOGENOMi HOG000228136.
KOi K04043.
OMAi MNTDNTF.
OrthoDBi EOG6JMMSV.

Enzyme and pathway databases

BioCyci CPER195102:GJFM-2087-MONOMER.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPi MF_00332. DnaK.
InterProi IPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsi TIGR02350. prok_dnaK. 1 hit.
PROSITEi PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of HSP70 (dnaK) gene from Clostridium perfringens using a general polymerase chain reaction based approach."
    Galley K.A., Singh B., Gupta R.S.
    Biochim. Biophys. Acta 1130:203-208(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.

Entry informationi

Entry nameiDNAK_CLOPE
AccessioniPrimary (citable) accession number: P26823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 31, 2002
Last modified: October 1, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3