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P26823 (DNAK_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene names
Name:dnaK
Ordered Locus Names:CPE2033
OrganismClostridium perfringens (strain 13 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier195102 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length619 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as a chaperone By similarity. HAMAP-Rule MF_00332

Induction

By stress conditions e.g. heat shock By similarity. HAMAP-Rule MF_00332

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Biological processStress response
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: InterPro

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 619619Chaperone protein DnaK HAMAP-Rule MF_00332
PRO_0000078450

Amino acid modifications

Modified residue1751Phosphothreonine; by autocatalysis By similarity

Experimental info

Sequence conflict86 – 872YT → LS in CAA44698. Ref.1
Sequence conflict1431R → T in CAA44698. Ref.1
Sequence conflict218 – 2192AQ → GE in CAA44698. Ref.1
Sequence conflict237 – 2393AAE → GRQ in CAA44698. Ref.1
Sequence conflict3981F → L in CAA44698. Ref.1
Sequence conflict5431Missing in CAA44698. Ref.1
Sequence conflict5541E → Q in CAA44698. Ref.1
Sequence conflict589 – 5902NN → II in CAA44698. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P26823 [UniParc].

Last modified January 31, 2002. Version 2.
Checksum: 88990A19444079BE

FASTA61966,482
        10         20         30         40         50         60 
MSKIIGIDLG TTNSCVAVME GGEPVVITNS EGARTTPSVV SFQANGERLV GQVAKRQAIT 

        70         80         90        100        110        120 
NPDKTIMSIK RHMGTDYKVN IDGKDYTPQE ISAMILQKLK ADAEAYLGEK VTEAVITVPA 

       130        140        150        160        170        180 
YFNDAERQAT KDAGRIAGLD VKRIINEPTA ASLAYGLDKM DSAHKILVYD LGGGTFDVSI 

       190        200        210        220        230        240 
LDLGDGVFEV VSTNGDARLG GDDFDQRIID YIAEDFKAQN GIDLRQDKMA LQRLKEAAEK 

       250        260        270        280        290        300 
AKIELSSSTQ TLINLPFITA DATGPKHIDM TLTRAKFNEL THDLVERTIN IMKEALKSGN 

       310        320        330        340        350        360 
VSLNDIDKVI LVGGSTRIPA VQEAVKNFTG KEPSKGVNPD ECVAMGAAIQ AGVLTGDVKD 

       370        380        390        400        410        420 
VLLLDVTPLT LGIETLGGVA TPLIERNTTI PARKSQIFST AADNQTSVEI HVVQGERQMA 

       430        440        450        460        470        480 
ADNKTLGRFT LSGIAPAPRG IPQIEVAFDI DANGIVKVSA TDKATGKEAN ITITASTNLS 

       490        500        510        520        530        540 
DAEIDKAVKE AEQFAEEDKK RKEAIEVKNN AEQTVYQTEK TLNELGDKVS AEEKSEIEAK 

       550        560        570        580        590        600 
IEEVKKVKDG DDIEAIKKAM EDLTQAFYKV SEKLYQQNGG AQGQGFDPNN MGGANAGAGA 

       610 
TNNNDDNVVD ADFEVQDDK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of HSP70 (dnaK) gene from Clostridium perfringens using a general polymerase chain reaction based approach."
Galley K.A., Singh B., Gupta R.S.
Biochim. Biophys. Acta 1130:203-208(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater."
Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.
Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13 / Type A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62915 Genomic DNA. Translation: CAA44698.1.
BA000016 Genomic DNA. Translation: BAB81739.1.
PIRS22355.
RefSeqNP_562949.1. NC_003366.1.

3D structure databases

ProteinModelPortalP26823.
SMRP26823. Positions 1-507.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING195102.CPE2033.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB81739; BAB81739; BAB81739.
GeneID990348.
KEGGcpe:CPE2033.
PATRIC19498035. VBICloPer59675_2107.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0443.
HOGENOMHOG000228136.
KOK04043.
OMAMITKNTT.
OrthoDBEOG6JMMSV.
ProtClustDBPRK00290.

Enzyme and pathway databases

BioCycCPER195102:GJFM-2087-MONOMER.

Family and domain databases

HAMAPMF_00332. DnaK.
InterProIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
TIGRFAMsTIGR02350. prok_dnaK. 1 hit.
PROSITEPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNAK_CLOPE
AccessionPrimary (citable) accession number: P26823
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 31, 2002
Last modified: February 19, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families