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Protein

Beta-adrenergic receptor kinase 2

Gene

Grk3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

Catalytic activityi

ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei220ATPPROSITE-ProRule annotation1
Active sitei317Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi197 – 205ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • beta-adrenergic receptor kinase activity Source: RGD
  • D1 dopamine receptor binding Source: RGD
  • G-protein coupled receptor kinase activity Source: RGD
  • protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  • desensitization of G-protein coupled receptor protein signaling pathway Source: RGD
  • inositol phosphate metabolic process Source: RGD
  • intracellular protein transport Source: RGD
  • multicellular organism aging Source: RGD
  • negative regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • protein phosphorylation Source: RGD
  • receptor internalization Source: RGD
  • rhodopsin metabolic process Source: RGD
  • signal transduction Source: InterPro

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.15 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-adrenergic receptor kinase 2 (EC:2.7.11.15)
Short name:
Beta-ARK-2
Alternative name(s):
G-protein-coupled receptor kinase 3Imported
Gene namesi
Name:Grk3Imported
Synonyms:Adrbk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2063 Grk3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856331 – 688Beta-adrenergic receptor kinase 2Add BLAST688

Post-translational modificationi

Ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiP26819

PTM databases

PhosphoSitePlusiP26819

Interactioni

GO - Molecular functioni

  • D1 dopamine receptor binding Source: RGD

Structurei

3D structure databases

ProteinModelPortaliP26819
SMRiP26819
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 175RGSPROSITE-ProRule annotationAdd BLAST122
Domaini191 – 453Protein kinasePROSITE-ProRule annotationAdd BLAST263
Domaini454 – 521AGC-kinase C-terminalAdd BLAST68
Domaini558 – 652PHPROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 190N-terminalAdd BLAST190

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG050559
InParanoidiP26819
KOiK00910
PhylomeDBiP26819

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000239 GPCR_kinase
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016137 RGS
IPR036305 RGS_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR00717 GPCRKINASE
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00315 RGS, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

P26819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLEAVLAD VSYLMAMEKS KATPAARASK KVVLPEPSIR SVMQRYLAER
60 70 80 90 100
NEITFDKIFN QKIGFLLFKD FCLNEIGEAV PQVKFYEEIK EYEKLDNEED
110 120 130 140 150
RLHRSRQMYD AYIMRELLSS THQFSKQAVE HVQSHLSKKQ VTPTLFQPYI
160 170 180 190 200
EEICESLRGD IFQKFMESEK FTRFCQWKNV ELNIHLSMND FSVHRIIGRG
210 220 230 240 250
GFGEVYGCRK ADTGKMYAMK CLDKKRVKMK QGETLALNER IMLSLVSTGD
260 270 280 290 300
CPFIVCMTYA FHTPDKLCFI LDLMNGGDMH YHLSQHGVFS EKEMRFYASE
310 320 330 340 350
IILGLEHMHT CFVVYRDLKP ANILLDEYGH VRISDLGLAC DFSKKKPHAS
360 370 380 390 400
VGTHGYMAPE VLQKGTCYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH
410 420 430 440 450
EIDRMTLTVN VQLPDAFSPE LRSLLEGLLQ RDVSQRLGCY GGGARELKEH
460 470 480 490 500
IFFKGIDWQY VYLRKYPPPL IPPRGEVNAA DAFDIGSFDE EDTKGIKLLD
510 520 530 540 550
CDQDLYKNFP LMISERWQQE VVETIYDAVN AETDKIEARK KAKNKQLCQE
560 570 580 590 600
EDYAMGKDCI MHGYMLKLGN PFLTQWQRRY FYLFPNRLEW RGEGESRQNL
610 620 630 640 650
LTMEQIMSVE ETQIKDRKCI LLRVKGGKQF VLQCESDPEF AQWLKELTCT
660 670 680
FNEAQRLLRR APKFLNKPRA AILEFSKPPL CHRNSSGL
Length:688
Mass (Da):79,887
Last modified:August 1, 1992 - v1
Checksum:iB4A077F4B48DDD3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87855 mRNA Translation: AAA40803.1
PIRiI73628
RefSeqiNP_037029.1, NM_012897.2
UniGeneiRn.9861

Genome annotation databases

GeneIDi25372
KEGGirno:25372

Similar proteinsi

Entry informationi

Entry nameiARBK2_RAT
AccessioniPrimary (citable) accession number: P26819
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health