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P26817

- ARBK1_RAT

UniProt

P26817 - ARBK1_RAT

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Protein

Beta-adrenergic receptor kinase 1

Gene
Adrbk1, Grk2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.

Catalytic activityi

ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei220 – 2201ATP By similarity
Active sitei317 – 3171Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi197 – 2059ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. beta-adrenergic receptor kinase activity Source: RGD
  3. G-protein coupled receptor kinase activity Source: RGD
  4. protein binding Source: RGD

GO - Biological processi

  1. aging Source: RGD
  2. desensitization of G-protein coupled receptor protein signaling pathway Source: BHF-UCL
  3. follicle-stimulating hormone signaling pathway Source: RGD
  4. G-protein coupled receptor signaling pathway Source: RGD
  5. negative regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  6. positive regulation of catecholamine secretion Source: BHF-UCL
  7. protein phosphorylation Source: RGD
  8. response to hydrogen peroxide Source: RGD
  9. response to organic cyclic compound Source: RGD
  10. response to oxidative stress Source: RGD
  11. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.15. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-adrenergic receptor kinase 1 (EC:2.7.11.15)
Short name:
Beta-ARK-1
Alternative name(s):
G-protein-coupled receptor kinase 2
Gene namesi
Name:Adrbk1
Synonyms:Grk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2062. Adrbk1.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: RGD
  2. axon Source: RGD
  3. basolateral plasma membrane Source: RGD
  4. caveola Source: RGD
  5. cytoplasm Source: RGD
  6. dendritic shaft Source: RGD
  7. dendritic spine Source: RGD
  8. synapse Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Beta-adrenergic receptor kinase 1PRO_0000085630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei670 – 6701Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP26817.

PTM databases

PhosphoSiteiP26817.

Expressioni

Gene expression databases

GenevestigatoriP26817.

Interactioni

Subunit structurei

Interacts with GIT1. Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1 By similarity.

Protein-protein interaction databases

BioGridi247278. 2 interactions.
STRINGi10116.ENSRNOP00000025847.

Structurei

3D structure databases

ProteinModelPortaliP26817.
SMRiP26817. Positions 28-667.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 175122RGSAdd
BLAST
Domaini191 – 453263Protein kinaseAdd
BLAST
Domaini454 – 52168AGC-kinase C-terminalAdd
BLAST
Domaini558 – 65295PHAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 190190N-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 RGS domain.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000006742.
HOVERGENiHBG050559.
InParanoidiP26817.
KOiK00910.
PhylomeDBiP26817.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00233. PH. 1 hit.
SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26817-1 [UniParc]FASTAAdd to Basket

« Hide

MADLEAVLAD VSYLMAMEKS KATPAARASK KILLPEPSIR SVMQKYLEDR    50
GEVTFEKIFS QKLGYLLFRD FYLNHLEEAK PLVEFYEEIE KYEKLETEEE 100
RVVRSREIFD SYIMKELLAC SHPFSKNATE HVQGHLVKKQ VPPDLFQPYI 150
EEICQNLRGD VFHKFIESDK FTRFCQWKNV ELNIHLTMND FSVHRIIGRG 200
GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER IMLSLVSTGD 250
CPFIVCMSYA FHTPDKLSFI LDLMNGGDLH YHLSQHGVFS EADMRFYAAE 300
IILGLEHMHN RFVVYRDLKP ANILLDEHGH VRISDLGLAC DFSKKKPHAS 350
VGTHGYMAPE VLQKGVAYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH 400
EIDRMTLTMA VELPDSFSPE LRSLLEGLLQ RDVNRRLGCL GRGAQEIKES 450
PFFRSLDWQM VFLQKYPPPL IPPRGEVNAA DAFDIGSFDE EDTKGIKLLD 500
SDQELYRNFP LTISERWQQE VAETVFDTIN AETDRLEARK KAKNKQLGHE 550
EDYALGKDCI MHGYMSKMGN PFLTQWQRRY FYLFPNRLEW RGEDEAPQSL 600
LTMEEIQSVE ETQIKERKCL LLKIRGGKQF VLQCDSDPEL VQWKKELRDA 650
YREAQQLVQR VPKMKNKPRS PVVELSKVPL IQRGSANGL 689
Length:689
Mass (Da):79,785
Last modified:August 1, 1992 - v1
Checksum:i426A3335ACEB5A34
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 252PA → RR in AAB24228. 1 Publication
Sequence conflicti46 – 461Y → N in AAB24228. 1 Publication
Sequence conflicti72 – 721Y → C in AAB24228. 1 Publication
Sequence conflicti90 – 901E → K in AAB24228. 1 Publication
Sequence conflicti249 – 2491G → V in AAB24228. 1 Publication
Sequence conflicti270 – 2701I → S in AAB24228. 1 Publication
Sequence conflicti296 – 2961F → Y in AAB24228. 1 Publication
Sequence conflicti447 – 4471I → V in AAB24228. 1 Publication
Sequence conflicti594 – 5941D → G in AAB24228. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M87854 mRNA. Translation: AAA40802.1.
S48813 mRNA. Translation: AAB24228.1.
PIRiI56531.
RefSeqiNP_036908.1. NM_012776.1.
UniGeneiRn.13010.

Genome annotation databases

GeneIDi25238.
KEGGirno:25238.
UCSCiRGD:2062. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M87854 mRNA. Translation: AAA40802.1 .
S48813 mRNA. Translation: AAB24228.1 .
PIRi I56531.
RefSeqi NP_036908.1. NM_012776.1.
UniGenei Rn.13010.

3D structure databases

ProteinModelPortali P26817.
SMRi P26817. Positions 28-667.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247278. 2 interactions.
STRINGi 10116.ENSRNOP00000025847.

PTM databases

PhosphoSitei P26817.

Proteomic databases

PRIDEi P26817.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25238.
KEGGi rno:25238.
UCSCi RGD:2062. rat.

Organism-specific databases

CTDi 156.
RGDi 2062. Adrbk1.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000006742.
HOVERGENi HBG050559.
InParanoidi P26817.
KOi K00910.
PhylomeDBi P26817.

Enzyme and pathway databases

BRENDAi 2.7.11.15. 5301.

Miscellaneous databases

NextBioi 605815.
PROi P26817.

Gene expression databases

Genevestigatori P26817.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR00717. GPCRKINASE.
SMARTi SM00233. PH. 1 hit.
SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain."
    Arriza J.L., Dawson T.M., Simerly R.B., Martin L.J., Caron M.G., Snyder S.H., Lefkowitz R.J.
    J. Neurosci. 12:4045-4055(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Localization of mRNA for beta-adrenergic receptor kinase in the brain of adult rats."
    Owada Y., Watanabe M., Kondo H.
    Neurosci. Lett. 144:9-13(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiARBK1_RAT
AccessioniPrimary (citable) accession number: P26817
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 3, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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