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P26810

- POL_MLVF5

UniProt

P26810 - POL_MLVF5

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Protein
Pol polyprotein
Gene
pol
Organism
Friend murine leukemia virus (isolate 57) (FrMLV)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei32 – 321 By similarity

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-EC
  3. RNA-directed DNA polymerase activity Source: UniProtKB-KW
  4. aspartic-type endopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA integration Source: UniProtKB-KW
  2. DNA recombination Source: UniProtKB-KW
  3. establishment of integrated proviral latency Source: UniProtKB-KW
  4. viral entry into host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

Keywords - Biological processi

DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Pol polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:pol
OrganismiFriend murine leukemia virus (isolate 57) (FrMLV)
Taxonomic identifieri11796 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostiMus musculus (Mouse) [TaxID: 10090]
ProteomesiUP000007776: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1204IntegrasePRO_0000259727
Chaini1 – 12041204Pol polyprotein
PRO_0000259725Add
BLAST
Chaini1 – 125125Protease
PRO_0000026130Add
BLAST
Chaini126 – ?Reverse transcriptase/ribonuclease HPRO_0000259726

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins.

Structurei

3D structure databases

ProteinModelPortaliP26810.
SMRiP26810. Positions 149-599, 628-793.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 9771Peptidase A2
Add
BLAST
Domaini207 – 398192Reverse transcriptase
Add
BLAST
Domaini640 – 786147RNase H
Add
BLAST
Domaini910 – 1068159Integrase catalytic
Add
BLAST

Sequence similaritiesi

Contains 1 RNase H domain.

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26810-1 [UniParc]FASTAAdd to Basket

« Hide

TLDDQGGQGQ EPPPEPRITL KVGGQPVTFL VDTGAQHSVL TQNPGPLSDK     50
SAWVQGATGG KRYRWTTDRR VHLATGKVTH SFLHVPDCPY PLLGRHLLTK 100
LKAQIHFEGS GAQVVGPMGQ PLQVLTLNIE DEYRLHETSK GPDVPLGSTW 150
LSDFPQAWAE TGGMGLAFRQ APLIISLKAT STPVSIKQYP MSQEARLGIK 200
PHIQRLLDQG ILVPCQSPWN TPLLPVKKPG TNDYRPVQDL REVNKRVEDI 250
HPTVPNPYNL LSGLPPSHQW YTVLDLKDAF FCLRLHPTSQ SLFAFEWKDP 300
EMGISGQLTW TRLPQGFKNS PTLFDEALHR DLADFRIQHP DLILLQYVDD 350
LLLAATSELD CQQGTRALLQ TLGDLGYRAS AKKAQICQKQ VKYLGYLLKE 400
GQRWLTEARK ETVMGQPTPK TPRQLREFLG TAGLCRLWIP GFAEMAAPLY 450
PLTKTGTLFK WGPDQQKAYQ EIKQALLTAP ALGLPDLTKP FELFVDEKQG 500
YAKGVLTQKL GPWRRPVAYL SKKLDPVAAG WPPCLRMVAA IAVLTKDVGK 550
LTMGQPLVIL APHAVEALVK QPPDRWLSNA RMTHYQALLL DTDRVQFGPI 600
VALNPATLLP LPEEGLQHDC LDILAEAHGT RPDLTDQPLP DADHTWYTDG 650
SSFLQEGQRR AGAAVTTETE VIWAKALPAG TSAQRAELIA LTQALKMAAG 700
KKLNVYTDSR YAFATAHIHG EIYRRRGLLT SEGKEIKNKD EILALLKALF 750
LPKRLSIIHC PGHQKGNHAE ARGNRMADQA AREVATRETP ETSTLLIENS 800
APYTREHFHY TVTDIKDLTK LGATYDDAKK CWVYQGKPVM PDQFTFELLD 850
FLHQLTHLSF SKTKALLERS YSPSYMLNRD RTLKDITETC KACAQVNASK 900
SAVKQGTRVR GHRPGTHWEI DFTEVKPGLY GYKYLLVFVD TFSGWVEAFP 950
TKKETAKVVT KKLLEEIFPR FGMPQVLGTD NGPAFVSKVS QTVADLLGVD 1000
WKLHCAYRPQ SSGQVERMNR TIKETLTKLT LATGSRDWVL LLPLALYRAR 1050
NTPGPHGLTP YEILYGAPPP LVNFPDPDMA KVTHNPSLQA HLQALYLVQH 1100
EVWRPLAAAY QEQLDRPVVP HPFRVGDTVW VRRHQTKNLE PRWKGPYTVL 1150
LTTPTALKVD GIAAWIHAAH VKAADTRIEP PAESTWRVQR SQNPLKIRLT 1200
RGTS 1204
Length:1,204
Mass (Da):134,538
Last modified:August 1, 1992 - v1
Checksum:iB96839B992B8E898
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02794 Genomic RNA. No translation available.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02794 Genomic RNA. No translation available.

3D structure databases

ProteinModelPortali P26810.
SMRi P26810. Positions 149-599, 628-793.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProi IPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view ]
Pfami PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view ]
SUPFAMi SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Friedrich R.W., Koch W., von Maydell-Livonius U., Schrewe H., Zimmermann W.
    Submitted (SEP-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiPOL_MLVF5
AccessioniPrimary (citable) accession number: P26810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Pol polyprotein.

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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