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P26809

- POL_MLVFF

UniProt

P26809 - POL_MLVFF

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Protein
Pol polyprotein
Gene
pol
Organism
Friend murine leukemia virus (isolate FB29) (FrMLV)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei32 – 321 By similarity

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-EC
  3. RNA-directed DNA polymerase activity Source: UniProtKB-KW
  4. aspartic-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA integration Source: UniProtKB-KW
  2. DNA recombination Source: UniProtKB-KW
  3. establishment of integrated proviral latency Source: UniProtKB-KW
  4. viral entry into host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

Keywords - Biological processi

DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Pol polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:pol
OrganismiFriend murine leukemia virus (isolate FB29) (FrMLV)
Taxonomic identifieri11797 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostiMus musculus (Mouse) [TaxID: 10090]
ProteomesiUP000008877: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1204IntegrasePRO_0000259730
Chaini1 – 12041204Pol polyprotein
PRO_0000259728Add
BLAST
Chaini1 – 125125Protease
PRO_0000026131Add
BLAST
Chaini126 – ?Reverse transcriptase/ribonuclease HPRO_0000259729

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins.

Structurei

3D structure databases

ProteinModelPortaliP26809.
SMRiP26809. Positions 149-599, 628-793.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 9771Peptidase A2
Add
BLAST
Domaini207 – 398192Reverse transcriptase
Add
BLAST
Domaini640 – 786147RNase H
Add
BLAST
Domaini910 – 1068159Integrase catalytic
Add
BLAST

Sequence similaritiesi

Contains 1 RNase H domain.

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26809-1 [UniParc]FASTAAdd to Basket

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TLDDQGGQGQ EPPPEPRITL RVGGQPVTFL VDTGAQHSVL TQNPGPLSDK     50
SAWVQGATGG KRYRWTTDRR VHLATGKVTH SFLHVPDCPY PLLGRDLLTK 100
LKAQIHFEGS GAQVVGPMGQ PLQVLTLNIE DEYRLHETSK GPDVPLGSTW 150
LSDFPQAWAE TGGMGLAVRQ APLIIPLKAT STPVSIKQYP MSQEARLGIK 200
PHIQRLLDQG ILVPCQSPWN TPLLPVKKPG TNDYRPVQDL REVNKRVEDI 250
HPTVPNPYNL LSGLPPSHQW YTVLDLKDAF FCLRLHPTSQ SLFAFEWRDP 300
EMGISGQLTW TRLPQGFKNS PTLFDEALHR DLADFRIQHP DLILLQYVDD 350
LLLAATSELD CQQGTRALLQ TLGDLGYRAS AKKAQICQKQ VKYLGYLLKE 400
GQRWLTEARK ETVMGQPTPK TPRQLREFLG TAGFCRLWIP GFAEMAAPLY 450
PLTKTGTLFE WGPDQQKAYQ EIKQALLTAP ALGLPDLTKP FELFVDEKQG 500
YAKGVLTQKL GPWRRPVAYL SKKLDPVAAG WPPCLRMVAA IAVLTKDAGK 550
LTMGQPLVIL APHAVEALVK QPPDRWLSNA RMTHYQALLL DTDRVQFGPI 600
VALNPATLLP LPEEGLQHDC LDILAEAHGT RPDLTDQPLP DADHTWYTDG 650
SSFLQEGQRK AGAAVTTETE VVWAKALPAG TSAQRAELIA LTQALKMAEG 700
KKLNVYTDSR YAFATAHIHG EIYRRRGLLT SEGKEIKNKD EILALLKALF 750
LPKRLSIIHC PGHQKGNRAE ARGNRMADQA AREVATRETP ETSTLLIENS 800
APYTHEHFHY TVTDIKDLTK LGATYDDAKK CWVYQGKPVM PDQFTFELLD 850
FLHQLTHLSF SKTKALLERN YCPYYMLNRD RTLKDITETC QACAQVNASK 900
SAVKQGTRVR GHRPGTHWEI DFTEVKPGLY GYKYLLVFID TFSGWVEAFP 950
TKKETAKVVT KKLLEEIFPR FGMPQVLGTD NGPAFVSKVS QTVADLLGVD 1000
WKLHCAYRPQ SSGQVERMNR TIKETLTKLT LATGSRDWVL LLPLALYRAR 1050
NTPGPHGLTP YEILYGAPPP LVNFPDPDMA KVTHNPSLQA HLQALYLVQH 1100
EVWRPLAAAY QEQLDRPVVP HPFRVGDTVW VRRHQTKNLE PRWKGPYTVL 1150
LTTPTALKVD GIAAWIHAAH VKAADTRIEP PSESTWRVQR SQNPLKIRLT 1200
RGTS 1204
Length:1,204
Mass (Da):134,706
Last modified:August 1, 1992 - v1
Checksum:iC046D8501CA7F64A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z11128 Genomic DNA. Translation: CAA77477.1.
PIRiS70393.
RefSeqiNP_040333.1. NC_001362.1.

Genome annotation databases

GeneIDi1491877.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z11128 Genomic DNA. Translation: CAA77477.1 .
PIRi S70393.
RefSeqi NP_040333.1. NC_001362.1.

3D structure databases

ProteinModelPortali P26809.
SMRi P26809. Positions 149-599, 628-793.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1491877.

Family and domain databases

Gene3Di 2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProi IPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view ]
Pfami PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view ]
SUPFAMi SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of Friend murine leukemia virus, strain FB29."
    Perryman S., Nishio J., Chesebro B.
    Nucleic Acids Res. 19:6950-6950(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPOL_MLVFF
AccessioniPrimary (citable) accession number: P26809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Pol polyprotein.

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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