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P26808

- POL_MLVFP

UniProt

P26808 - POL_MLVFP

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Protein

Pol polyprotein

Gene
pol
Organism
Friend murine leukemia virus (isolate PVC-211) (FrMLV)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei32 – 321 By similarity

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed DNA polymerase activity Source: UniProtKB-KW
  4. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA integration Source: UniProtKB-KW
  2. DNA recombination Source: UniProtKB-KW
  3. establishment of integrated proviral latency Source: UniProtKB-KW
  4. viral entry into host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

Keywords - Biological processi

DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Pol polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:pol
OrganismiFriend murine leukemia virus (isolate PVC-211) (FrMLV)
Taxonomic identifieri11798 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostiMus musculus (Mouse) [TaxID: 10090]
ProteomesiUP000007777: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1204IntegrasePRO_0000259733
Chaini1 – 12041204Pol polyproteinPRO_0000259731Add
BLAST
Chaini1 – 125125ProteasePRO_0000026132Add
BLAST
Chaini126 – ?Reverse transcriptase/ribonuclease HPRO_0000259732

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins.

Structurei

3D structure databases

ProteinModelPortaliP26808.
SMRiP26808. Positions 149-599, 628-793.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 9771Peptidase A2Add
BLAST
Domaini207 – 398192Reverse transcriptaseAdd
BLAST
Domaini640 – 786147RNase HAdd
BLAST
Domaini910 – 1068159Integrase catalyticAdd
BLAST

Sequence similaritiesi

Contains 1 RNase H domain.

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26808-1 [UniParc]FASTAAdd to Basket

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TLDDQGGQGQ EPPPEPRITL KVGGQPVTFL VDTGAQHSVL TQNPGPLSDK     50
SAWVQGATGG KRYRWTTDRR VHLATGKVTH SFLHVPDCPY PLLGRDLLTK 100
LKAQIHFEGS GAQVVGPMGQ PLQVLTLNIE DEYRLHETSK GPDVPLGSTW 150
LSDFPQAWAE TGGMGLAVRQ APLIIPLRAA STPVSIKQYP MSREARLGIK 200
PHIQRLLDQG ILVPCQSPWN TPLLPVKKPG TNDYRPVQDL REVNKRVEDI 250
HPTVPNPYNL LSGLPPSHQW YTVLDLKDAF FCLRLHPTSQ SLFAFEWRDP 300
EMGISGQLTW TRLPQGFKNS PTLFDEALHR DLADFRIQHP DLILLQYVDD 350
LLLAATSELD CQQGTRALLQ TLGDLGYRAS AKKAQICQKQ VKYLGYLLKE 400
GQRWLTEARK ETVMGQPTPK TPRQLREFLG TAGFCRLWIP GFAEMAAPLY 450
PLTKTGTLFK WGPDQQKAYQ EIKQALLTAP ALGLPDLTKP FELFVDEKQG 500
YAKGVLTQKL GPWRRPVAYL SKKLDPVAAG WPPCLRMVAA IAVLTKDAGK 550
LTMGQPLVIL APHAVEALVK QPPDRWLSNA RMTHYQALLL DTDRVQFGPI 600
VTLNPATLLP LPEEGLQHDC LDILAEAHGT RPDLTDQPLP DADHTWYTDG 650
SSFLQEGQRK AGAAVTTETE VIWAKALPAG TSAQRAELIA LTQALKMAEG 700
KKLNVYTDSR YAFATAHIHG EIYRRRGLLT SEGKEIKNKE EILALLKALF 750
LPKRLSIIHC PGHQKGNRAE ARGNRMADQA AREVATRETP ETSTLLIENS 800
APYTREHFHY TVTDIKDLTK LGATYDNAQK CWVYQGKPVM PDQFTFELLD 850
FLHQLTHLSF SKTKALLERS YSPYYMLNRD RTLKDITETC KACAQVNASK 900
SAVKQGTRVR GHRPGTHWEI DFTEVKPGLY GYKYLLVFVD TFSGWVEAFP 950
TKKETAKVVT KKLLEEIFPR FGMPQVLGTD NGPAFVSKVS QTVADLLGVD 1000
WKLHCAYRPQ SSGQVERMNR TIKETLTKLT LATGSRDWVL LLPLALYRAR 1050
NTPGPHGLTP YEILYGAPPP LVNFPDPDMA KVTHNPSLQA HLQALYLVQH 1100
EVWRPLAAAY QEQLDRPVVP HPFRVGDTVW VRRHQTKNLE PRWKGPYTVL 1150
LTTPTALKVD GIAAWIHAAH VKAADTKIEP PSESTWRVQR SQNPLKIRLT 1200
RGTS 1204
Length:1,204
Mass (Da):134,694
Last modified:August 1, 1992 - v1
Checksum:i8091F5C314D9798D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M93134 Genomic RNA. Translation: AAA46477.1.
PIRiS35475.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M93134 Genomic RNA. Translation: AAA46477.1 .
PIRi S35475.

3D structure databases

ProteinModelPortali P26808.
SMRi P26808. Positions 149-599, 628-793.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProi IPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view ]
Pfami PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view ]
SUPFAMi SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of a neuropathogenic variant of Friend murine leukemia virus PVC-211."
    Remington M.P., Hoffman P.M., Ruscetti S.K., Masuda M.
    Nucleic Acids Res. 20:3249-3249(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiPOL_MLVFP
AccessioniPrimary (citable) accession number: P26808
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Pol polyprotein.

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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