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Protein

CCAAT/enhancer-binding protein gamma

Gene

Cebpg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (PubMed:1377818). Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter (By similarity).By similarity1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • double-stranded DNA binding Source: RGD
  • protein heterodimerization activity Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending Source: RGD
  • sequence-specific DNA binding Source: UniProtKB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: Ensembl
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein gamma
Short name:
C/EBP gamma
Gene namesi
Name:Cebpg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2330. Cebpg.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleoplasm Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766301 – 150CCAAT/enhancer-binding protein gammaAdd BLAST150

Proteomic databases

PaxDbiP26801.
PRIDEiP26801.

PTM databases

iPTMnetiP26801.
PhosphoSitePlusiP26801.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021144.
ExpressionAtlasiP26801. baseline and differential.
GenevisibleiP26801. RN.

Interactioni

Subunit structurei

Binds DNA as a dimer and can form stable heterodimers with CEBPA and CEBPB (PubMed:1377818). Interacts with ZNF638; this interaction increases transcriptional activation (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi247340. 3 interactors.
STRINGi10116.ENSRNOP00000028703.

Structurei

3D structure databases

ProteinModelPortaliP26801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 125bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni66 – 93Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni97 – 118Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISXZ. Eukaryota.
ENOG41128ZN. LUCA.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000057291.
HOVERGENiHBG050880.
InParanoidiP26801.
KOiK10049.
OMAiADNVQPS.
OrthoDBiEOG091G11FC.
PhylomeDBiP26801.
TreeFamiTF105009.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLSQPAST AGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVPPSK
60 70 80 90 100
QSKKSSPMDR NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE
110 120 130 140 150
NERLEAKIKL LTKELSVLKD LFLEHAHNLA DNVQPISTET TVANSDNTGQ
Length:150
Mass (Da):16,388
Last modified:October 1, 1996 - v2
Checksum:iB7B1686652E52326
GO

Sequence cautioni

The sequence CAA45745 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64403 mRNA. Translation: CAA45745.1. Different initiation.
PIRiS26300.
RefSeqiNP_036963.1. NM_012831.1.
UniGeneiRn.10332.

Genome annotation databases

EnsembliENSRNOT00000028703; ENSRNOP00000028703; ENSRNOG00000021144.
GeneIDi25301.
KEGGirno:25301.
UCSCiRGD:2330. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64403 mRNA. Translation: CAA45745.1. Different initiation.
PIRiS26300.
RefSeqiNP_036963.1. NM_012831.1.
UniGeneiRn.10332.

3D structure databases

ProteinModelPortaliP26801.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247340. 3 interactors.
STRINGi10116.ENSRNOP00000028703.

PTM databases

iPTMnetiP26801.
PhosphoSitePlusiP26801.

Proteomic databases

PaxDbiP26801.
PRIDEiP26801.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028703; ENSRNOP00000028703; ENSRNOG00000021144.
GeneIDi25301.
KEGGirno:25301.
UCSCiRGD:2330. rat.

Organism-specific databases

CTDi1054.
RGDi2330. Cebpg.

Phylogenomic databases

eggNOGiENOG410ISXZ. Eukaryota.
ENOG41128ZN. LUCA.
GeneTreeiENSGT00530000063192.
HOGENOMiHOG000057291.
HOVERGENiHBG050880.
InParanoidiP26801.
KOiK10049.
OMAiADNVQPS.
OrthoDBiEOG091G11FC.
PhylomeDBiP26801.
TreeFamiTF105009.

Miscellaneous databases

PROiP26801.

Gene expression databases

BgeeiENSRNOG00000021144.
ExpressionAtlasiP26801. baseline and differential.
GenevisibleiP26801. RN.

Family and domain databases

InterProiIPR004827. bZIP.
IPR031106. C/EBP.
[Graphical view]
PANTHERiPTHR23334. PTHR23334. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEBPG_RAT
AccessioniPrimary (citable) accession number: P26801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.