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Protein

Protein INO2

Gene

INO2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positive regulatory factor required for depression of the coregulated phospholipid biosynthetic enzymes. Also involved in the expression of ITR1.

Miscellaneous

Present with 784 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • phospholipid biosynthetic process Source: SGD
  • positive regulation of transcription by RNA polymerase II Source: SGD
  • transcription by RNA polymerase II Source: GOC

Keywordsi

Molecular functionActivator, DNA-binding
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29723-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein INO2
Gene namesi
Name:INO2
Synonyms:DIE1, SCS1
Ordered Locus Names:YDR123C
ORF Names:YD9727.18C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR123C
SGDiS000002530 INO2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272531 – 304Protein INO2Add BLAST304

Proteomic databases

PaxDbiP26798
PRIDEiP26798

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
INO4P139022EBI-9262,EBI-9270

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32179, 448 interactors
DIPiDIP-680N
IntActiP26798, 3 interactors
MINTiP26798
STRINGi4932.YDR123C

Structurei

3D structure databases

ProteinModelPortaliP26798
SMRiP26798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini236 – 290bHLHPROSITE-ProRule annotationAdd BLAST55

Phylogenomic databases

InParanoidiP26798
KOiK09102
OMAiMSAHIHE
OrthoDBiEOG092C5RPX

Family and domain databases

CDDicd00083 HLH, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P26798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQATGNELL GILDLDNDID FETAYQMLSS NFDDQMSAHI HENTFSATSP
60 70 80 90 100
PLLTHELGII PNVATVQPSH VETIPADNQT HHAPLHTHAH YLNHNPHQPS
110 120 130 140 150
MGFDQALGLK LSPSSSGLLS TNESNAIEQF LDNLISQDMM SSNASMNSES
160 170 180 190 200
HLHIRSPKKQ HRYTELNQRY PETHPHSNTG ELPTNTADVP TEFTTREGPH
210 220 230 240 250
QPIGNDHYNP PPFSVPEIRI PDSDIPANIE DDPVKVRKWK HVQMEKIRRI
260 270 280 290 300
NTKEAFERLI KSVRTPPKEN GKRIPKHILL TCVMNDIKSI RSANEALQHI

LDDS
Length:304
Mass (Da):34,234
Last modified:August 1, 1992 - v1
Checksum:iADF0F0D745A12CE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66066 Genomic DNA Translation: CAA46866.1
D90460 Genomic DNA Translation: BAA14424.1
Z48758 Genomic DNA Translation: CAA88676.1
AY557685 Genomic DNA Translation: AAS56011.1
BK006938 Genomic DNA Translation: DAA11969.1
PIRiS21570
RefSeqiNP_010408.1, NM_001180431.1

Genome annotation databases

EnsemblFungiiYDR123C; YDR123C; YDR123C
GeneIDi851701
KEGGisce:YDR123C

Similar proteinsi

Entry informationi

Entry nameiINO2_YEAST
AccessioniPrimary (citable) accession number: P26798
Secondary accession number(s): D6VSA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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