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P26798 (INO2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein INO2
Gene names
Name:INO2
Synonyms:DIE1, SCS1
Ordered Locus Names:YDR123C
ORF Names:YD9727.18C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Positive regulatory factor required for depression of the coregulated phospholipid biosynthetic enzymes. Also involved in the expression of ITR1.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein By similarity.

Subcellular location

Nucleus Probable.

Miscellaneous

Present with 784 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

INO4P139022EBI-9262,EBI-9270

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Protein INO2
PRO_0000127253

Regions

Domain236 – 29055bHLH

Sequences

Sequence LengthMass (Da)Tools
P26798 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: ADF0F0D745A12CE8

FASTA30434,234
        10         20         30         40         50         60 
MQQATGNELL GILDLDNDID FETAYQMLSS NFDDQMSAHI HENTFSATSP PLLTHELGII 

        70         80         90        100        110        120 
PNVATVQPSH VETIPADNQT HHAPLHTHAH YLNHNPHQPS MGFDQALGLK LSPSSSGLLS 

       130        140        150        160        170        180 
TNESNAIEQF LDNLISQDMM SSNASMNSES HLHIRSPKKQ HRYTELNQRY PETHPHSNTG 

       190        200        210        220        230        240 
ELPTNTADVP TEFTTREGPH QPIGNDHYNP PPFSVPEIRI PDSDIPANIE DDPVKVRKWK 

       250        260        270        280        290        300 
HVQMEKIRRI NTKEAFERLI KSVRTPPKEN GKRIPKHILL TCVMNDIKSI RSANEALQHI 


LDDS 

« Hide

References

« Hide 'large scale' references
[1]"The INO2 gene of Saccharomyces cerevisiae encodes a helix-loop-helix protein that is required for activation of phospholipid synthesis."
Nikoloff D.M., McGraw P., Henry S.A.
Nucleic Acids Res. 20:3253-3253(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning and characterization of the SCS1 gene required for the expression of genes in yeast phospholipid synthesis."
Hosaka K., Nikawa J., Kodaki T., Yamashita S.
J. Biochem. 115:131-136(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"Functional characterization of the INO2 gene of Saccharomyces cerevisiae. A positive regulator of phospholipid biosynthesis."
Nikoloff D.M., Henry S.A.
J. Biol. Chem. 269:7402-7411(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[7]"Isolation and characterization of genes that promote the expression of inositol transporter gene ITR1 in Saccharomyces cerevisiae."
Nikawa J., Hosaka K.
Mol. Microbiol. 16:301-308(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X66066 Genomic DNA. Translation: CAA46866.1.
D90460 Genomic DNA. Translation: BAA14424.1.
Z48758 Genomic DNA. Translation: CAA88676.1.
AY557685 Genomic DNA. Translation: AAS56011.1.
BK006938 Genomic DNA. Translation: DAA11969.1.
PIRS21570.
RefSeqNP_010408.1. NM_001180431.1.

3D structure databases

ProteinModelPortalP26798.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32179. 162 interactions.
DIPDIP-680N.
IntActP26798. 3 interactions.
MINTMINT-410234.
STRING4932.YDR123C.

Proteomic databases

PaxDbP26798.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR123C; YDR123C; YDR123C.
GeneID851701.
KEGGsce:YDR123C.

Organism-specific databases

CYGDYDR123c.
SGDS000002530. INO2.

Phylogenomic databases

eggNOGNOG42426.
KOK09102.
OrthoDBEOG7HXD47.

Enzyme and pathway databases

BioCycYEAST:G3O-29723-MONOMER.

Gene expression databases

GenevestigatorP26798.

Family and domain databases

InterProIPR011598. bHLH_dom.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio969374.

Entry information

Entry nameINO2_YEAST
AccessionPrimary (citable) accession number: P26798
Secondary accession number(s): D6VSA9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: June 11, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families