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P26784

- RL16A_YEAST

UniProt

P26784 - RL16A_YEAST

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Protein

60S ribosomal protein L16-A

Gene
RPL16A, RPL13, RPL21A, YIL133C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: SGD
  2. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-31384-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L16-A
Alternative name(s):
L13a
L21
RP22
YL15
Gene namesi
Name:RPL16A
Synonyms:RPL13, RPL21A
Ordered Locus Names:YIL133C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

SGDiS000001395. RPL16A.

Subcellular locationi

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 19919860S ribosomal protein L16-APRO_0000133791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP26784.
PeptideAtlasiP26784.

Expressioni

Gene expression databases

GenevestigatoriP26784.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).

Protein-protein interaction databases

BioGridi34858. 159 interactions.
IntActiP26784. 36 interactions.
MINTiMINT-2981627.
STRINGi4932.YIL133C.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-M2-147[»]
1S1Ielectron microscopy11.70M2-147[»]
1VW8electron microscopy6.10P1-199[»]
1VWUelectron microscopy6.10P1-199[»]
3IZSelectron microscopy-K1-199[»]
3J65electron microscopy8.70J1-199[»]
3O58X-ray4.00P1-199[»]
3O5HX-ray4.00P1-199[»]
3U5EX-ray3.00O1-199[»]
3U5IX-ray3.00O1-199[»]
4B6Aelectron microscopy8.10O1-199[»]
4BYNelectron microscopy4.30O2-199[»]
4BYUelectron microscopy6.60O2-199[»]
4CUWelectron microscopy3.70O1-199[»]
ProteinModelPortaliP26784.
SMRiP26784. Positions 4-199.

Miscellaneous databases

EvolutionaryTraceiP26784.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000010799.
HOGENOMiHOG000225289.
KOiK02872.
OMAiKTHYNPE.
OrthoDBiEOG70W3RX.

Family and domain databases

Gene3Di3.90.1180.10. 1 hit.
HAMAPiMF_01366. Ribosomal_L13.
InterProiIPR005822. Ribosomal_L13.
IPR023563. Ribosomal_L13_CS.
IPR023564. Ribosomal_L13_dom.
IPR005755. Ribosomal_L13_euk/arc.
[Graphical view]
PANTHERiPTHR11545. PTHR11545. 1 hit.
PTHR11545:SF3. PTHR11545:SF3. 1 hit.
PfamiPF00572. Ribosomal_L13. 1 hit.
[Graphical view]
PIRSFiPIRSF002181. Ribosomal_L13. 1 hit.
SUPFAMiSSF52161. SSF52161. 1 hit.
TIGRFAMsiTIGR01077. L13_A_E. 1 hit.
PROSITEiPS00783. RIBOSOMAL_L13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26784-1 [UniParc]FASTAAdd to Basket

« Hide

MSVEPVVVID GKGHLVGRLA SVVAKQLLNG QKIVVVRAEE LNISGEFFRN    50
KLKYHDFLRK ATAFNKTRGP FHFRAPSRIF YKALRGMVSH KTARGKAALE 100
RLKVFEGIPP PYDKKKRVVV PQALRVLRLK PGRKYTTLGK LSTSVGWKYE 150
DVVAKLEAKR KVSSAEYYAK KRAFTKKVAS ANATAAESDV AKQLAALGY 199
Length:199
Mass (Da):22,201
Last modified:January 23, 2007 - v3
Checksum:iDAB11B0D4A91EF0B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141H → L AA sequence 1 Publication
Sequence conflicti21 – 211S → E AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86145.1.
BK006942 Genomic DNA. Translation: DAA08420.1.
PIRiS48401.
RefSeqiNP_012133.1. NM_001179481.1.

Genome annotation databases

EnsemblFungiiYIL133C; YIL133C; YIL133C.
GeneIDi854673.
KEGGisce:YIL133C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86145.1 .
BK006942 Genomic DNA. Translation: DAA08420.1 .
PIRi S48401.
RefSeqi NP_012133.1. NM_001179481.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K5Y model - M 2-147 [» ]
1S1I electron microscopy 11.70 M 2-147 [» ]
1VW8 electron microscopy 6.10 P 1-199 [» ]
1VWU electron microscopy 6.10 P 1-199 [» ]
3IZS electron microscopy - K 1-199 [» ]
3J65 electron microscopy 8.70 J 1-199 [» ]
3O58 X-ray 4.00 P 1-199 [» ]
3O5H X-ray 4.00 P 1-199 [» ]
3U5E X-ray 3.00 O 1-199 [» ]
3U5I X-ray 3.00 O 1-199 [» ]
4B6A electron microscopy 8.10 O 1-199 [» ]
4BYN electron microscopy 4.30 O 2-199 [» ]
4BYU electron microscopy 6.60 O 2-199 [» ]
4CUW electron microscopy 3.70 O 1-199 [» ]
ProteinModelPortali P26784.
SMRi P26784. Positions 4-199.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34858. 159 interactions.
IntActi P26784. 36 interactions.
MINTi MINT-2981627.
STRINGi 4932.YIL133C.

Proteomic databases

MaxQBi P26784.
PeptideAtlasi P26784.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL133C ; YIL133C ; YIL133C .
GeneIDi 854673.
KEGGi sce:YIL133C.

Organism-specific databases

SGDi S000001395. RPL16A.

Phylogenomic databases

GeneTreei ENSGT00390000010799.
HOGENOMi HOG000225289.
KOi K02872.
OMAi KTHYNPE.
OrthoDBi EOG70W3RX.

Enzyme and pathway databases

BioCyci YEAST:G3O-31384-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Miscellaneous databases

EvolutionaryTracei P26784.
NextBioi 977265.

Gene expression databases

Genevestigatori P26784.

Family and domain databases

Gene3Di 3.90.1180.10. 1 hit.
HAMAPi MF_01366. Ribosomal_L13.
InterProi IPR005822. Ribosomal_L13.
IPR023563. Ribosomal_L13_CS.
IPR023564. Ribosomal_L13_dom.
IPR005755. Ribosomal_L13_euk/arc.
[Graphical view ]
PANTHERi PTHR11545. PTHR11545. 1 hit.
PTHR11545:SF3. PTHR11545:SF3. 1 hit.
Pfami PF00572. Ribosomal_L13. 1 hit.
[Graphical view ]
PIRSFi PIRSF002181. Ribosomal_L13. 1 hit.
SUPFAMi SSF52161. SSF52161. 1 hit.
TIGRFAMsi TIGR01077. L13_A_E. 1 hit.
PROSITEi PS00783. RIBOSOMAL_L13. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae."
    Takakura H., Tsunasawa S., Miyagi M., Warner J.R.
    J. Biol. Chem. 267:5442-5445(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-26, ACETYLATION AT SER-2 BY NATA.
  4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 2-147, ELECTRON MICROSCOPY.
  10. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
    Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
    EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 2-147, ELECTRON MICROSCOPY.
  11. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  12. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL16A_YEAST
AccessioniPrimary (citable) accession number: P26784
Secondary accession number(s): D6VVF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 43300 molecules/cell in log phase SD medium.
There are 2 genes for L16 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

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