Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

10 kDa heat shock protein, mitochondrial

Gene

Hspe1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
10 kDa heat shock protein, mitochondrial
Short name:
Hsp10
Alternative name(s):
10 kDa chaperonin
Chaperonin 10
Short name:
CPN10
Gene namesi
Name:Hspe1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2844. Hspe1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: RGD
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 10210110 kDa heat shock protein, mitochondrialPRO_0000174919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei8 – 81N6-acetyllysineBy similarity
Modified residuei28 – 281N6-succinyllysineBy similarity
Modified residuei40 – 401N6-acetyllysine; alternateBy similarity
Modified residuei40 – 401N6-malonyllysine; alternateBy similarity
Modified residuei40 – 401N6-succinyllysine; alternateBy similarity
Modified residuei54 – 541N6-malonyllysine; alternateBy similarity
Modified residuei54 – 541N6-succinyllysine; alternateBy similarity
Modified residuei56 – 561N6-acetyllysine; alternateBy similarity
Modified residuei56 – 561N6-malonyllysine; alternateBy similarity
Modified residuei56 – 561N6-succinyllysine; alternateBy similarity
Modified residuei66 – 661N6-acetyllysine; alternateBy similarity
Modified residuei66 – 661N6-succinyllysine; alternateBy similarity
Modified residuei70 – 701N6-acetyllysine; alternateBy similarity
Modified residuei70 – 701N6-succinyllysine; alternateBy similarity
Modified residuei79 – 791PhosphothreonineBy similarity
Modified residuei80 – 801N6-acetyllysine; alternateBy similarity
Modified residuei80 – 801N6-succinyllysine; alternateBy similarity
Modified residuei86 – 861N6-acetyllysine; alternateBy similarity
Modified residuei86 – 861N6-succinyllysine; alternateBy similarity
Modified residuei99 – 991N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP26772.
PRIDEiP26772.

PTM databases

iPTMnetiP26772.
PhosphoSiteiP26772.
SwissPalmiP26772.

Expressioni

Inductioni

By stress.

Gene expression databases

BgeeiENSRNOG00000014868.

Interactioni

Subunit structurei

Homohexamer.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP26772. 1 interaction.
MINTiMINT-4564857.
STRINGi10116.ENSRNOP00000020066.

Structurei

3D structure databases

ProteinModelPortaliP26772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GroES chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG1641. Eukaryota.
COG0234. LUCA.
HOGENOMiHOG000133897.
HOVERGENiHBG000385.
InParanoidiP26772.
PhylomeDBiP26772.
TreeFamiTF313814.

Family and domain databases

CDDicd00320. cpn10. 1 hit.
Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10. 1 hit.
InterProiIPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQAFRKFL PLFDRVLVER SAAETVTKGG IMLPEKSQGK VLQATVVAVG
60 70 80 90 100
SGGKGKGGEI QPVSVKVGDK VLLPEYGGTK VVLDDKDYFL FRDGDILGKY

VD
Length:102
Mass (Da):10,902
Last modified:January 23, 2007 - v3
Checksum:i1F2AE41369AEDB78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71429 mRNA. Translation: CAA50560.1.
BC058492 mRNA. Translation: AAH58492.1.
PIRiS41750.
UniGeneiRn.106093.

Genome annotation databases

UCSCiRGD:2844. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71429 mRNA. Translation: CAA50560.1.
BC058492 mRNA. Translation: AAH58492.1.
PIRiS41750.
UniGeneiRn.106093.

3D structure databases

ProteinModelPortaliP26772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP26772. 1 interaction.
MINTiMINT-4564857.
STRINGi10116.ENSRNOP00000020066.

PTM databases

iPTMnetiP26772.
PhosphoSiteiP26772.
SwissPalmiP26772.

Proteomic databases

PaxDbiP26772.
PRIDEiP26772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2844. rat.

Organism-specific databases

RGDi2844. Hspe1.

Phylogenomic databases

eggNOGiKOG1641. Eukaryota.
COG0234. LUCA.
HOGENOMiHOG000133897.
HOVERGENiHBG000385.
InParanoidiP26772.
PhylomeDBiP26772.
TreeFamiTF313814.

Miscellaneous databases

PROiP26772.

Gene expression databases

BgeeiENSRNOG00000014868.

Family and domain databases

CDDicd00320. cpn10. 1 hit.
Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10. 1 hit.
InterProiIPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH10_RAT
AccessioniPrimary (citable) accession number: P26772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.