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P26770

- ADCY4_RAT

UniProt

P26770 - ADCY4_RAT

Protein

Adenylate cyclase type 4

Gene

Adcy4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Enzyme regulationi

    Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi278 – 2781Magnesium 1PROSITE-ProRule annotation
    Metal bindingi278 – 2781Magnesium 2PROSITE-ProRule annotation
    Metal bindingi279 – 2791Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi322 – 3221Magnesium 1PROSITE-ProRule annotation
    Metal bindingi322 – 3221Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: BHF-UCL
    2. ATP binding Source: UniProtKB-KW
    3. G-protein beta/gamma-subunit complex binding Source: RGD
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cAMP biosynthetic process Source: BHF-UCL
    2. intracellular signal transduction Source: RGD

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 4 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 4
    Adenylate cyclase type IV
    Adenylyl cyclase 4
    Gene namesi
    Name:Adcy4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2034. Adcy4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: BHF-UCL
    3. protein complex Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10641064Adenylate cyclase type 4PRO_0000195692Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi694 – 6941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi701 – 7011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP26770.
    PRIDEiP26770.

    PTM databases

    PhosphoSiteiP26770.

    Expressioni

    Tissue specificityi

    Widely distributed.

    Gene expression databases

    GenevestigatoriP26770.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000059923.

    Structurei

    3D structure databases

    ProteinModelPortaliP26770.
    SMRiP26770. Positions 261-447, 854-1053.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini191 – 582392CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini685 – 70723ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini805 – 1064260CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 5022HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11724HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 13819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei583 – 60422HelicalSequence AnalysisAdd
    BLAST
    Transmembranei608 – 63023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei661 – 68424HelicalSequence AnalysisAdd
    BLAST
    Transmembranei708 – 73326HelicalSequence AnalysisAdd
    BLAST
    Transmembranei741 – 76121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei788 – 80417HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    HOGENOMiHOG000006941.
    HOVERGENiHBG050458.
    InParanoidiP26770.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view]
    PfamiPF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26770-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARLFSPRPP PSEDLFYETY YSLSQQYPLL ILLLVIVLCA IVALPAVAWA     50
    SGRELTSDPS FLTTVLCALG GFSLLLGLAS REQQLQRWTR PLSGLIWAAL 100
    LALGYGFLFT GGVVSAWDQV SFFLFIIFTV YAMLPLGMRD AAAAGVISSL 150
    SHLLVLGLYL GWRPESQRDL LPQLAANAVL FLCGNVVGAY HKALMERALR 200
    ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK AEIMARLQAG 250
    QSSRPENTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE 300
    LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR 350
    AIRKLRVATG VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME 400
    AGGVPGRVHI TGATLALLAG AYAVERADME HRDPYLRELG EPTYLVIDPW 450
    AEEEDEKGTE RGLLSSLEGH TMRPSLLMTR YLESWGAAKP FAHLSHVDSP 500
    ASTSTPLPEK AFSPQWSLDR SRTPRGLHDE LDTGDAKFFQ VIEQLNSQKQ 550
    WKQSKDFNLL TLYFREKEME KQYRLSALPA FKYYAACTFL VFLSNFTIQM 600
    LVTTRPPALA TTYSITFLLF LLLLFVCFSE HLTKCVQKGP KMLHWLPALS 650
    VLVATRPGLR VALGTATILL VFTMAVVSLL FLPVSSDCPF LAPNVSSVAF 700
    NTSWELPASL PLISIPYSMH CCVLGFLSCS LFLHMSFELK LLLLLLWLVA 750
    SCSLFLHSHA WLSDCLIARL YQGSLGSRPG VLKEPKLMGA IYFFIFFFTL 800
    LVLARQNEYY CRLDFLWKKK LRQEREETET MENVLPAHVA PQLIGQNRRN 850
    EDLYHQSYEC VCVLFASIPD FKEFYSESNI NHEGLECLRL LNEIIADFDE 900
    LLSKPKFSGV EKIKTIGSTY MAATGLNATP GQDTQQDAER SCSHLGTMVE 950
    FAVALGSKLG VINKHSFNNF RLRVGLNHGP VVAGVIGAQK PQYDIWGNTV 1000
    NVASRMESTG VLGKIQVTEE TARALQSLGY TCYSRGVIKV KGKGQLCTYF 1050
    LNTDLTRTGS PSAS 1064
    Length:1,064
    Mass (Da):118,799
    Last modified:August 1, 1992 - v1
    Checksum:i5A2A0B895B5A0DA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80633 mRNA. Translation: AAA40665.1.
    PIRiA41542.
    UniGeneiRn.1904.

    Genome annotation databases

    UCSCiRGD:2034. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80633 mRNA. Translation: AAA40665.1 .
    PIRi A41542.
    UniGenei Rn.1904.

    3D structure databases

    ProteinModelPortali P26770.
    SMRi P26770. Positions 261-447, 854-1053.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000059923.

    Chemistry

    BindingDBi P26770.
    ChEMBLi CHEMBL2095179.

    PTM databases

    PhosphoSitei P26770.

    Proteomic databases

    PaxDbi P26770.
    PRIDEi P26770.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:2034. rat.

    Organism-specific databases

    RGDi 2034. Adcy4.

    Phylogenomic databases

    eggNOGi COG2114.
    HOGENOMi HOG000006941.
    HOVERGENi HBG050458.
    InParanoidi P26770.

    Gene expression databases

    Genevestigatori P26770.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view ]
    Pfami PF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a widely distributed (type IV) adenylyl cyclase."
      Gao B., Gilman A.G.
      Proc. Natl. Acad. Sci. U.S.A. 88:10178-10182(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiADCY4_RAT
    AccessioniPrimary (citable) accession number: P26770
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3