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P26770 (ADCY4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenylate cyclase type 4

EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase 4
Adenylate cyclase type IV
Adenylyl cyclase 4
Gene names
Name:Adcy4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1064 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulation

Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Widely distributed.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10641064Adenylate cyclase type 4
PRO_0000195692

Regions

Topological domain1 – 2828Cytoplasmic Potential
Transmembrane29 – 5022Helical; Potential
Transmembrane61 – 8020Helical; Potential
Transmembrane94 – 11724Helical; Potential
Transmembrane120 – 13819Helical; Potential
Transmembrane141 – 16222Helical; Potential
Transmembrane170 – 19021Helical; Potential
Topological domain191 – 582392Cytoplasmic Potential
Transmembrane583 – 60422Helical; Potential
Transmembrane608 – 63023Helical; Potential
Transmembrane661 – 68424Helical; Potential
Topological domain685 – 70723Extracellular Potential
Transmembrane708 – 73326Helical; Potential
Transmembrane741 – 76121Helical; Potential
Transmembrane788 – 80417Helical; Potential
Topological domain805 – 1064260Cytoplasmic Potential

Sites

Metal binding2781Magnesium 1 By similarity
Metal binding2781Magnesium 2 By similarity
Metal binding2791Magnesium 2; via carbonyl oxygen By similarity
Metal binding3221Magnesium 1 By similarity
Metal binding3221Magnesium 2 By similarity

Amino acid modifications

Glycosylation6941N-linked (GlcNAc...) Potential
Glycosylation7011N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P26770 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 5A2A0B895B5A0DA8

FASTA1,064118,799
        10         20         30         40         50         60 
MARLFSPRPP PSEDLFYETY YSLSQQYPLL ILLLVIVLCA IVALPAVAWA SGRELTSDPS 

        70         80         90        100        110        120 
FLTTVLCALG GFSLLLGLAS REQQLQRWTR PLSGLIWAAL LALGYGFLFT GGVVSAWDQV 

       130        140        150        160        170        180 
SFFLFIIFTV YAMLPLGMRD AAAAGVISSL SHLLVLGLYL GWRPESQRDL LPQLAANAVL 

       190        200        210        220        230        240 
FLCGNVVGAY HKALMERALR ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK 

       250        260        270        280        290        300 
AEIMARLQAG QSSRPENTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE 

       310        320        330        340        350        360 
LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR AIRKLRVATG 

       370        380        390        400        410        420 
VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME AGGVPGRVHI TGATLALLAG 

       430        440        450        460        470        480 
AYAVERADME HRDPYLRELG EPTYLVIDPW AEEEDEKGTE RGLLSSLEGH TMRPSLLMTR 

       490        500        510        520        530        540 
YLESWGAAKP FAHLSHVDSP ASTSTPLPEK AFSPQWSLDR SRTPRGLHDE LDTGDAKFFQ 

       550        560        570        580        590        600 
VIEQLNSQKQ WKQSKDFNLL TLYFREKEME KQYRLSALPA FKYYAACTFL VFLSNFTIQM 

       610        620        630        640        650        660 
LVTTRPPALA TTYSITFLLF LLLLFVCFSE HLTKCVQKGP KMLHWLPALS VLVATRPGLR 

       670        680        690        700        710        720 
VALGTATILL VFTMAVVSLL FLPVSSDCPF LAPNVSSVAF NTSWELPASL PLISIPYSMH 

       730        740        750        760        770        780 
CCVLGFLSCS LFLHMSFELK LLLLLLWLVA SCSLFLHSHA WLSDCLIARL YQGSLGSRPG 

       790        800        810        820        830        840 
VLKEPKLMGA IYFFIFFFTL LVLARQNEYY CRLDFLWKKK LRQEREETET MENVLPAHVA 

       850        860        870        880        890        900 
PQLIGQNRRN EDLYHQSYEC VCVLFASIPD FKEFYSESNI NHEGLECLRL LNEIIADFDE 

       910        920        930        940        950        960 
LLSKPKFSGV EKIKTIGSTY MAATGLNATP GQDTQQDAER SCSHLGTMVE FAVALGSKLG 

       970        980        990       1000       1010       1020 
VINKHSFNNF RLRVGLNHGP VVAGVIGAQK PQYDIWGNTV NVASRMESTG VLGKIQVTEE 

      1030       1040       1050       1060 
TARALQSLGY TCYSRGVIKV KGKGQLCTYF LNTDLTRTGS PSAS 

« Hide

References

[1]"Cloning and expression of a widely distributed (type IV) adenylyl cyclase."
Gao B., Gilman A.G.
Proc. Natl. Acad. Sci. U.S.A. 88:10178-10182(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M80633 mRNA. Translation: AAA40665.1.
PIRA41542.
UniGeneRn.1904.

3D structure databases

ProteinModelPortalP26770.
SMRP26770. Positions 261-447, 854-1053.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000059923.

Chemistry

BindingDBP26770.
ChEMBLCHEMBL2095179.

PTM databases

PhosphoSiteP26770.

Proteomic databases

PaxDbP26770.
PRIDEP26770.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:2034. rat.

Organism-specific databases

RGD2034. Adcy4.

Phylogenomic databases

eggNOGCOG2114.
HOGENOMHOG000006941.
HOVERGENHBG050458.
InParanoidP26770.

Gene expression databases

GenevestigatorP26770.

Family and domain databases

Gene3D3.30.70.1230. 2 hits.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view]
PfamPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMSSF55073. SSF55073. 2 hits.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADCY4_RAT
AccessionPrimary (citable) accession number: P26770
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families