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P26770

- ADCY4_RAT

UniProt

P26770 - ADCY4_RAT

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Protein
Adenylate cyclase type 4
Gene
Adcy4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulationi

Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi278 – 2781Magnesium 1 By similarity
Metal bindingi278 – 2781Magnesium 2 By similarity
Metal bindingi279 – 2791Magnesium 2; via carbonyl oxygen By similarity
Metal bindingi322 – 3221Magnesium 1 By similarity
Metal bindingi322 – 3221Magnesium 2 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. G-protein beta/gamma-subunit complex binding Source: RGD
  3. adenylate cyclase activity Source: BHF-UCL
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cAMP biosynthetic process Source: BHF-UCL
  2. intracellular signal transduction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 4 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 4
Adenylate cyclase type IV
Adenylyl cyclase 4
Gene namesi
Name:Adcy4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2034. Adcy4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei29 – 5022Helical; Reviewed prediction
Add
BLAST
Transmembranei61 – 8020Helical; Reviewed prediction
Add
BLAST
Transmembranei94 – 11724Helical; Reviewed prediction
Add
BLAST
Transmembranei120 – 13819Helical; Reviewed prediction
Add
BLAST
Transmembranei141 – 16222Helical; Reviewed prediction
Add
BLAST
Transmembranei170 – 19021Helical; Reviewed prediction
Add
BLAST
Topological domaini191 – 582392Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei583 – 60422Helical; Reviewed prediction
Add
BLAST
Transmembranei608 – 63023Helical; Reviewed prediction
Add
BLAST
Transmembranei661 – 68424Helical; Reviewed prediction
Add
BLAST
Topological domaini685 – 70723Extracellular Reviewed prediction
Add
BLAST
Transmembranei708 – 73326Helical; Reviewed prediction
Add
BLAST
Transmembranei741 – 76121Helical; Reviewed prediction
Add
BLAST
Transmembranei788 – 80417Helical; Reviewed prediction
Add
BLAST
Topological domaini805 – 1064260Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: BHF-UCL
  3. protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10641064Adenylate cyclase type 4
PRO_0000195692Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi694 – 6941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi701 – 7011N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP26770.
PRIDEiP26770.

PTM databases

PhosphoSiteiP26770.

Expressioni

Tissue specificityi

Widely distributed.

Gene expression databases

GenevestigatoriP26770.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059923.

Structurei

3D structure databases

ProteinModelPortaliP26770.
SMRiP26770. Positions 261-447, 854-1053.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiP26770.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26770-1 [UniParc]FASTAAdd to Basket

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MARLFSPRPP PSEDLFYETY YSLSQQYPLL ILLLVIVLCA IVALPAVAWA     50
SGRELTSDPS FLTTVLCALG GFSLLLGLAS REQQLQRWTR PLSGLIWAAL 100
LALGYGFLFT GGVVSAWDQV SFFLFIIFTV YAMLPLGMRD AAAAGVISSL 150
SHLLVLGLYL GWRPESQRDL LPQLAANAVL FLCGNVVGAY HKALMERALR 200
ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK AEIMARLQAG 250
QSSRPENTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE 300
LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR 350
AIRKLRVATG VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME 400
AGGVPGRVHI TGATLALLAG AYAVERADME HRDPYLRELG EPTYLVIDPW 450
AEEEDEKGTE RGLLSSLEGH TMRPSLLMTR YLESWGAAKP FAHLSHVDSP 500
ASTSTPLPEK AFSPQWSLDR SRTPRGLHDE LDTGDAKFFQ VIEQLNSQKQ 550
WKQSKDFNLL TLYFREKEME KQYRLSALPA FKYYAACTFL VFLSNFTIQM 600
LVTTRPPALA TTYSITFLLF LLLLFVCFSE HLTKCVQKGP KMLHWLPALS 650
VLVATRPGLR VALGTATILL VFTMAVVSLL FLPVSSDCPF LAPNVSSVAF 700
NTSWELPASL PLISIPYSMH CCVLGFLSCS LFLHMSFELK LLLLLLWLVA 750
SCSLFLHSHA WLSDCLIARL YQGSLGSRPG VLKEPKLMGA IYFFIFFFTL 800
LVLARQNEYY CRLDFLWKKK LRQEREETET MENVLPAHVA PQLIGQNRRN 850
EDLYHQSYEC VCVLFASIPD FKEFYSESNI NHEGLECLRL LNEIIADFDE 900
LLSKPKFSGV EKIKTIGSTY MAATGLNATP GQDTQQDAER SCSHLGTMVE 950
FAVALGSKLG VINKHSFNNF RLRVGLNHGP VVAGVIGAQK PQYDIWGNTV 1000
NVASRMESTG VLGKIQVTEE TARALQSLGY TCYSRGVIKV KGKGQLCTYF 1050
LNTDLTRTGS PSAS 1064
Length:1,064
Mass (Da):118,799
Last modified:August 1, 1992 - v1
Checksum:i5A2A0B895B5A0DA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M80633 mRNA. Translation: AAA40665.1.
PIRiA41542.
UniGeneiRn.1904.

Genome annotation databases

UCSCiRGD:2034. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M80633 mRNA. Translation: AAA40665.1 .
PIRi A41542.
UniGenei Rn.1904.

3D structure databases

ProteinModelPortali P26770.
SMRi P26770. Positions 261-447, 854-1053.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000059923.

Chemistry

BindingDBi P26770.
ChEMBLi CHEMBL2095179.

PTM databases

PhosphoSitei P26770.

Proteomic databases

PaxDbi P26770.
PRIDEi P26770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2034. rat.

Organism-specific databases

RGDi 2034. Adcy4.

Phylogenomic databases

eggNOGi COG2114.
HOGENOMi HOG000006941.
HOVERGENi HBG050458.
InParanoidi P26770.

Gene expression databases

Genevestigatori P26770.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view ]
Pfami PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of a widely distributed (type IV) adenylyl cyclase."
    Gao B., Gilman A.G.
    Proc. Natl. Acad. Sci. U.S.A. 88:10178-10182(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiADCY4_RAT
AccessioniPrimary (citable) accession number: P26770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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