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Protein

Virulence sensor protein BvgS

Gene

bvgS

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system, Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 227.

Names & Taxonomyi

Protein namesi
Recommended name:
Virulence sensor protein BvgS (EC:2.7.13.3)
Gene namesi
Name:bvgS
Ordered Locus Names:BB2995
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001027 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 307CytoplasmicSequence analysisAdd BLAST275
Transmembranei308 – 331HelicalSequence analysisAdd BLAST24
Topological domaini332 – 541PeriplasmicSequence analysisAdd BLAST210
Transmembranei542 – 563HelicalSequence analysisAdd BLAST22
Topological domaini564 – 1238CytoplasmicSequence analysisAdd BLAST675

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000003236831 – 1238Virulence sensor protein BvgSAdd BLAST1208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei729Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1
Modified residuei10234-aspartylphosphatePROSITE-ProRule annotation1
Modified residuei1172PhosphohistidinePROSITE-ProRule annotation1

Post-translational modificationi

Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi257310.BB2995.

Structurei

3D structure databases

ProteinModelPortaliP26762.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini580 – 651PASPROSITE-ProRule annotationAdd BLAST72
Domaini652 – 708PACPROSITE-ProRule annotationAdd BLAST57
Domaini726 – 948Histidine kinasePROSITE-ProRule annotationAdd BLAST223
Domaini974 – 1095Response regulatoryPROSITE-ProRule annotationAdd BLAST122
Domaini1133 – 1228HPtPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Contains 1 histidine kinase domain.PROSITE-ProRule annotation
Contains 1 HPt domain.PROSITE-ProRule annotation
Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000269369.
KOiK07679.
OMAiFMRVLID.
OrthoDBiPOG091H03T5.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
1.20.120.160. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013767. PAS_fold.
IPR004358. Sig_transdc_His_kin-like_C.
IPR008207. Sig_transdc_His_kin_Hpt_dom.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR001638. Solute-binding_3/MltF_N.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF01627. Hpt. 1 hit.
PF00989. PAS. 1 hit.
PF00072. Response_reg. 1 hit.
PF00497. SBP_bac_3. 2 hits.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00073. HPT. 1 hit.
SM00091. PAS. 1 hit.
SM00062. PBPb. 2 hits.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47226. SSF47226. 2 hits.
SSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50894. HPT. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPHRLYPR SLICLAQALL AWALLAWAPA QASQELTLVG KAAVPDVEIA
60 70 80 90 100
LDGDDWRWLA RKRVLTLGVY APDIPPFDVT YDERYEGLTA DYMAIIAHNL
110 120 130 140 150
GVQAKVLRYP TREQAVGALE SGQIDLIGTV NGIEGRLQSL RLSVPYAADH
160 170 180 190 200
PVLVMPIGAR RAPPADLAGQ RLAVDANYLP RETLQQAYPQ ATLHYFPSSE
210 220 230 240 250
QALAAVAYGQ ADVFIGDALT TSHLVSQSYF NDVRVVAPAQ IVTGGESFGV
260 270 280 290 300
RADNTRLLRV VNAVLEAIPA SERRSLIYRW GLGSSISLDF ARPAYSAREQ
310 320 330 340 350
QWMANHPVVK VAVLNLFAPF TLFRTDEQFG GISAAVLQLL QLRTGLDFQI
360 370 380 390 400
IGVDTVEELI AKLRSGEADM AGALFVNAAR ESVLSFSRPY VRNGMVIVTR
410 420 430 440 450
QDPAAPADAD HLDGRTIAMV RNSAAIPLLQ QRYPQAKVVT ADNPTEAMLL
460 470 480 490 500
VADGQADAVV QTQISASYYV NRYFAGKLRI ASALDLPPAE IALATARGQT
510 520 530 540 550
ELISILNKAL YSISNDELAS IVSRWRGSDG DPRTWYAYRN EIYLLIGLGL
560 570 580 590 600
LSALLFLSWI VYLRRQIRQR KRAERALNDQ LEFMRVLIDG TPNPIYVRDK
610 620 630 640 650
EGRMLLCNDA YLDTFGVTAD AVLGKTIPEA NVVGDPALAR EMHEFLLTRM
660 670 680 690 700
SAEREPRFED RDVTLHGRTR HVYQWTVPYG DSLGELKGII GGWIDITERA
710 720 730 740 750
ELLRELHDAK ESADAANRAK TTFLATMSHE IRTPMNAIIG MLELALLRPA
760 770 780 790 800
DQEPDRQSIQ VAYDSARSLL ELIGDILDIA KIEAGKFDLA PVRTALRALP
810 820 830 840 850
EGAIRVFDGL ARQKGIELVL KTDIVGVDDV LIDPLRMKQV LSNLVGNAIK
860 870 880 890 900
FTTEGQVVLT VTARPDGEAA HVQFSVSDTG CGISEADQRQ LFKPFSQVGG
910 920 930 940 950
SAEAGPAPGT GLGLSISRRL VELMGGTLVM RSAPGVGTTV SVDLRLTMVE
960 970 980 990 1000
KSAQATPPAA AAQATPSKPQ VSLRVLVVDD HKPNLMLLRQ QLDYLGQRVV
1010 1020 1030 1040 1050
AADSGEAALA LWHEHAFDVV ITDCNMPGIN GYELARRIRA AEAAPGYGRT
1060 1070 1080 1090 1100
RCILFGFTAS AQMDEAQRCR AAGMDDCLFK PIGVDALRQR LNEAAARAAL
1110 1120 1130 1140 1150
PTPPSPQAAA PATHDATPAA FSAESILALT QNDEALIRQL LEELIRTNRA
1160 1170 1180 1190 1200
DVDQLQKLHQ QADWPKVSDM AHRLAGGARV VDAKAMIDTA LALEKKAQGQ
1210 1220 1230
AGPSPEIDGM VRTLAAQSAA LETQLRAWLE QRPHQGQP
Length:1,238
Mass (Da):134,811
Last modified:September 19, 2003 - v2
Checksum:i74DCB538B77A0F3E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50A → T in CAA41252 (PubMed:1791760).Curated1
Sequence conflicti395M → L in CAA41252 (PubMed:1791760).Curated1
Sequence conflicti651S → A in CAA41252 (PubMed:1791760).Curated1
Sequence conflicti1008A → S in CAA41252 (PubMed:1791760).Curated1
Sequence conflicti1067 – 1068QR → HA in CAA41252 (PubMed:1791760).Curated2
Sequence conflicti1144L → V in CAA41252 (PubMed:1791760).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58355 Genomic DNA. Translation: CAA41252.1.
BX640446 Genomic DNA. Translation: CAE33487.1.
PIRiS17944.
RefSeqiWP_010926708.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE33487; CAE33487; BB2995.
KEGGibbr:BB2995.
PATRICi21139345. VBIBorBro124907_3041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58355 Genomic DNA. Translation: CAA41252.1.
BX640446 Genomic DNA. Translation: CAE33487.1.
PIRiS17944.
RefSeqiWP_010926708.1. NC_002927.3.

3D structure databases

ProteinModelPortaliP26762.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257310.BB2995.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE33487; CAE33487; BB2995.
KEGGibbr:BB2995.
PATRICi21139345. VBIBorBro124907_3041.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000269369.
KOiK07679.
OMAiFMRVLID.
OrthoDBiPOG091H03T5.

Enzyme and pathway databases

BRENDAi2.7.13.3. 227.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
1.20.120.160. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013767. PAS_fold.
IPR004358. Sig_transdc_His_kin-like_C.
IPR008207. Sig_transdc_His_kin_Hpt_dom.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR001638. Solute-binding_3/MltF_N.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF01627. Hpt. 1 hit.
PF00989. PAS. 1 hit.
PF00072. Response_reg. 1 hit.
PF00497. SBP_bac_3. 2 hits.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00073. HPT. 1 hit.
SM00091. PAS. 1 hit.
SM00062. PBPb. 2 hits.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47226. SSF47226. 2 hits.
SSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50894. HPT. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBVGS_BORBR
AccessioniPrimary (citable) accession number: P26762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 19, 2003
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.