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P26762 (BVGS_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Virulence sensor protein BvgS

EC=2.7.13.3
Gene names
Name:bvgS
Ordered Locus Names:BB2995
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length1238 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals By similarity.

Catalytic activity

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Subcellular location

Cell inner membrane; Multi-pass membrane protein Probable.

Post-translational modification

Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain By similarity.

Sequence similarities

Contains 1 histidine kinase domain.

Contains 1 HPt domain.

Contains 1 PAC (PAS-associated C-terminal) domain.

Contains 1 PAS (PER-ARNT-SIM) domain.

Contains 1 response regulatory domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 12381208Virulence sensor protein BvgS
PRO_0000032368

Regions

Topological domain33 – 307275Cytoplasmic Potential
Transmembrane308 – 33124Helical; Potential
Topological domain332 – 541210Periplasmic Potential
Transmembrane542 – 56322Helical; Potential
Topological domain564 – 1238675Cytoplasmic Potential
Domain580 – 65172PAS
Domain652 – 70857PAC
Domain726 – 948223Histidine kinase
Domain974 – 1095122Response regulatory
Domain1133 – 122896HPt

Amino acid modifications

Modified residue7291Phosphohistidine; by autocatalysis By similarity
Modified residue102314-aspartylphosphate By similarity
Modified residue11721Phosphohistidine By similarity

Experimental info

Sequence conflict501A → T in CAA41252. Ref.1
Sequence conflict3951M → L in CAA41252. Ref.1
Sequence conflict6511S → A in CAA41252. Ref.1
Sequence conflict10081A → S in CAA41252. Ref.1
Sequence conflict1067 – 10682QR → HA in CAA41252. Ref.1
Sequence conflict11441L → V in CAA41252. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P26762 [UniParc].

Last modified September 19, 2003. Version 2.
Checksum: 74DCB538B77A0F3E

FASTA1,238134,811
        10         20         30         40         50         60 
MPAPHRLYPR SLICLAQALL AWALLAWAPA QASQELTLVG KAAVPDVEIA LDGDDWRWLA 

        70         80         90        100        110        120 
RKRVLTLGVY APDIPPFDVT YDERYEGLTA DYMAIIAHNL GVQAKVLRYP TREQAVGALE 

       130        140        150        160        170        180 
SGQIDLIGTV NGIEGRLQSL RLSVPYAADH PVLVMPIGAR RAPPADLAGQ RLAVDANYLP 

       190        200        210        220        230        240 
RETLQQAYPQ ATLHYFPSSE QALAAVAYGQ ADVFIGDALT TSHLVSQSYF NDVRVVAPAQ 

       250        260        270        280        290        300 
IVTGGESFGV RADNTRLLRV VNAVLEAIPA SERRSLIYRW GLGSSISLDF ARPAYSAREQ 

       310        320        330        340        350        360 
QWMANHPVVK VAVLNLFAPF TLFRTDEQFG GISAAVLQLL QLRTGLDFQI IGVDTVEELI 

       370        380        390        400        410        420 
AKLRSGEADM AGALFVNAAR ESVLSFSRPY VRNGMVIVTR QDPAAPADAD HLDGRTIAMV 

       430        440        450        460        470        480 
RNSAAIPLLQ QRYPQAKVVT ADNPTEAMLL VADGQADAVV QTQISASYYV NRYFAGKLRI 

       490        500        510        520        530        540 
ASALDLPPAE IALATARGQT ELISILNKAL YSISNDELAS IVSRWRGSDG DPRTWYAYRN 

       550        560        570        580        590        600 
EIYLLIGLGL LSALLFLSWI VYLRRQIRQR KRAERALNDQ LEFMRVLIDG TPNPIYVRDK 

       610        620        630        640        650        660 
EGRMLLCNDA YLDTFGVTAD AVLGKTIPEA NVVGDPALAR EMHEFLLTRM SAEREPRFED 

       670        680        690        700        710        720 
RDVTLHGRTR HVYQWTVPYG DSLGELKGII GGWIDITERA ELLRELHDAK ESADAANRAK 

       730        740        750        760        770        780 
TTFLATMSHE IRTPMNAIIG MLELALLRPA DQEPDRQSIQ VAYDSARSLL ELIGDILDIA 

       790        800        810        820        830        840 
KIEAGKFDLA PVRTALRALP EGAIRVFDGL ARQKGIELVL KTDIVGVDDV LIDPLRMKQV 

       850        860        870        880        890        900 
LSNLVGNAIK FTTEGQVVLT VTARPDGEAA HVQFSVSDTG CGISEADQRQ LFKPFSQVGG 

       910        920        930        940        950        960 
SAEAGPAPGT GLGLSISRRL VELMGGTLVM RSAPGVGTTV SVDLRLTMVE KSAQATPPAA 

       970        980        990       1000       1010       1020 
AAQATPSKPQ VSLRVLVVDD HKPNLMLLRQ QLDYLGQRVV AADSGEAALA LWHEHAFDVV 

      1030       1040       1050       1060       1070       1080 
ITDCNMPGIN GYELARRIRA AEAAPGYGRT RCILFGFTAS AQMDEAQRCR AAGMDDCLFK 

      1090       1100       1110       1120       1130       1140 
PIGVDALRQR LNEAAARAAL PTPPSPQAAA PATHDATPAA FSAESILALT QNDEALIRQL 

      1150       1160       1170       1180       1190       1200 
LEELIRTNRA DVDQLQKLHQ QADWPKVSDM AHRLAGGARV VDAKAMIDTA LALEKKAQGQ 

      1210       1220       1230 
AGPSPEIDGM VRTLAAQSAA LETQLRAWLE QRPHQGQP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58355 Genomic DNA. Translation: CAA41252.1.
BX640446 Genomic DNA. Translation: CAE33487.1.
PIRS17944.
RefSeqNP_889531.1. NC_002927.3.

3D structure databases

ProteinModelPortalP26762.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257310.BB2995.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE33487; CAE33487; BB2995.
GeneID2659742.
KEGGbbr:BB2995.
PATRIC21139345. VBIBorBro124907_3041.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0642.
HOGENOMHOG000269369.
KOK07679.
OMAAPAHIAT.
OrthoDBEOG6G4VQG.

Enzyme and pathway databases

BioCycBBRO257310:BB2995-MONOMER.
BRENDA2.7.13.3. 897.

Family and domain databases

Gene3D1.10.287.130. 1 hit.
1.20.120.160. 1 hit.
3.30.565.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR003661. EnvZ-like_dim/P.
IPR003594. HATPase_ATP-bd.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013767. PAS_fold.
IPR001638. SBP_bac_3.
IPR004358. Sig_transdc_His_kin-like_C.
IPR008207. Sig_transdc_His_kin_Hpt_dom.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF01627. Hpt. 1 hit.
PF00989. PAS. 1 hit.
PF00072. Response_reg. 1 hit.
PF00497. SBP_bac_3. 2 hits.
[Graphical view]
PRINTSPR00344. BCTRLSENSOR.
SMARTSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00073. HPT. 1 hit.
SM00091. PAS. 1 hit.
SM00062. PBPb. 2 hits.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMSSF47226. SSF47226. 2 hits.
SSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsTIGR00229. sensory_box. 1 hit.
PROSITEPS50109. HIS_KIN. 1 hit.
PS50894. HPT. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBVGS_BORBR
AccessionPrimary (citable) accession number: P26762
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 19, 2003
Last modified: May 14, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families