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P26762

- BVGS_BORBR

UniProt

P26762 - BVGS_BORBR

Protein

Virulence sensor protein BvgS

Gene

bvgS

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (19 Sep 2003)
      Previous versions | rss
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    Functioni

    Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals By similarity.By similarity

    Catalytic activityi

    ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorelay response regulator activity Source: InterPro
    3. phosphorelay sensor kinase activity Source: InterPro
    4. transporter activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Two-component regulatory system, Virulence

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBBRO257310:BB2995-MONOMER.
    BRENDAi2.7.13.3. 897.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Virulence sensor protein BvgS (EC:2.7.13.3)
    Gene namesi
    Name:bvgS
    Ordered Locus Names:BB2995
    OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
    Taxonomic identifieri257310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001027: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 12381208Virulence sensor protein BvgSPRO_0000032368Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei729 – 7291Phosphohistidine; by autocatalysisPROSITE-ProRule annotation
    Modified residuei1023 – 102314-aspartylphosphatePROSITE-ProRule annotation
    Modified residuei1172 – 11721PhosphohistidinePROSITE-ProRule annotation

    Post-translational modificationi

    Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi257310.BB2995.

    Structurei

    3D structure databases

    ProteinModelPortaliP26762.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 307275CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini332 – 541210PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini564 – 1238675CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei308 – 33124HelicalSequence AnalysisAdd
    BLAST
    Transmembranei542 – 56322HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini580 – 65172PASPROSITE-ProRule annotationAdd
    BLAST
    Domaini652 – 70857PACPROSITE-ProRule annotationAdd
    BLAST
    Domaini726 – 948223Histidine kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini974 – 1095122Response regulatoryPROSITE-ProRule annotationAdd
    BLAST
    Domaini1133 – 122896HPtPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 histidine kinase domain.PROSITE-ProRule annotation
    Contains 1 HPt domain.PROSITE-ProRule annotation
    Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation
    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0642.
    HOGENOMiHOG000269369.
    KOiK07679.
    OMAiAPAHIAT.
    OrthoDBiEOG6G4VQG.

    Family and domain databases

    Gene3Di1.10.287.130. 1 hit.
    1.20.120.160. 1 hit.
    3.30.565.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR003661. EnvZ-like_dim/P.
    IPR003594. HATPase_ATP-bd.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR013767. PAS_fold.
    IPR001638. SBP_bac_3.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR008207. Sig_transdc_His_kin_Hpt_dom.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view]
    PfamiPF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    PF01627. Hpt. 1 hit.
    PF00989. PAS. 1 hit.
    PF00072. Response_reg. 1 hit.
    PF00497. SBP_bac_3. 2 hits.
    [Graphical view]
    PRINTSiPR00344. BCTRLSENSOR.
    SMARTiSM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    SM00073. HPT. 1 hit.
    SM00091. PAS. 1 hit.
    SM00062. PBPb. 2 hits.
    SM00448. REC. 1 hit.
    [Graphical view]
    SUPFAMiSSF47226. SSF47226. 2 hits.
    SSF47384. SSF47384. 1 hit.
    SSF52172. SSF52172. 1 hit.
    SSF55785. SSF55785. 1 hit.
    SSF55874. SSF55874. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50109. HIS_KIN. 1 hit.
    PS50894. HPT. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P26762-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAPHRLYPR SLICLAQALL AWALLAWAPA QASQELTLVG KAAVPDVEIA     50
    LDGDDWRWLA RKRVLTLGVY APDIPPFDVT YDERYEGLTA DYMAIIAHNL 100
    GVQAKVLRYP TREQAVGALE SGQIDLIGTV NGIEGRLQSL RLSVPYAADH 150
    PVLVMPIGAR RAPPADLAGQ RLAVDANYLP RETLQQAYPQ ATLHYFPSSE 200
    QALAAVAYGQ ADVFIGDALT TSHLVSQSYF NDVRVVAPAQ IVTGGESFGV 250
    RADNTRLLRV VNAVLEAIPA SERRSLIYRW GLGSSISLDF ARPAYSAREQ 300
    QWMANHPVVK VAVLNLFAPF TLFRTDEQFG GISAAVLQLL QLRTGLDFQI 350
    IGVDTVEELI AKLRSGEADM AGALFVNAAR ESVLSFSRPY VRNGMVIVTR 400
    QDPAAPADAD HLDGRTIAMV RNSAAIPLLQ QRYPQAKVVT ADNPTEAMLL 450
    VADGQADAVV QTQISASYYV NRYFAGKLRI ASALDLPPAE IALATARGQT 500
    ELISILNKAL YSISNDELAS IVSRWRGSDG DPRTWYAYRN EIYLLIGLGL 550
    LSALLFLSWI VYLRRQIRQR KRAERALNDQ LEFMRVLIDG TPNPIYVRDK 600
    EGRMLLCNDA YLDTFGVTAD AVLGKTIPEA NVVGDPALAR EMHEFLLTRM 650
    SAEREPRFED RDVTLHGRTR HVYQWTVPYG DSLGELKGII GGWIDITERA 700
    ELLRELHDAK ESADAANRAK TTFLATMSHE IRTPMNAIIG MLELALLRPA 750
    DQEPDRQSIQ VAYDSARSLL ELIGDILDIA KIEAGKFDLA PVRTALRALP 800
    EGAIRVFDGL ARQKGIELVL KTDIVGVDDV LIDPLRMKQV LSNLVGNAIK 850
    FTTEGQVVLT VTARPDGEAA HVQFSVSDTG CGISEADQRQ LFKPFSQVGG 900
    SAEAGPAPGT GLGLSISRRL VELMGGTLVM RSAPGVGTTV SVDLRLTMVE 950
    KSAQATPPAA AAQATPSKPQ VSLRVLVVDD HKPNLMLLRQ QLDYLGQRVV 1000
    AADSGEAALA LWHEHAFDVV ITDCNMPGIN GYELARRIRA AEAAPGYGRT 1050
    RCILFGFTAS AQMDEAQRCR AAGMDDCLFK PIGVDALRQR LNEAAARAAL 1100
    PTPPSPQAAA PATHDATPAA FSAESILALT QNDEALIRQL LEELIRTNRA 1150
    DVDQLQKLHQ QADWPKVSDM AHRLAGGARV VDAKAMIDTA LALEKKAQGQ 1200
    AGPSPEIDGM VRTLAAQSAA LETQLRAWLE QRPHQGQP 1238
    Length:1,238
    Mass (Da):134,811
    Last modified:September 19, 2003 - v2
    Checksum:i74DCB538B77A0F3E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501A → T in CAA41252. (PubMed:1791760)Curated
    Sequence conflicti395 – 3951M → L in CAA41252. (PubMed:1791760)Curated
    Sequence conflicti651 – 6511S → A in CAA41252. (PubMed:1791760)Curated
    Sequence conflicti1008 – 10081A → S in CAA41252. (PubMed:1791760)Curated
    Sequence conflicti1067 – 10682QR → HA in CAA41252. (PubMed:1791760)Curated
    Sequence conflicti1144 – 11441L → V in CAA41252. (PubMed:1791760)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58355 Genomic DNA. Translation: CAA41252.1.
    BX640446 Genomic DNA. Translation: CAE33487.1.
    PIRiS17944.
    RefSeqiNP_889531.1. NC_002927.3.

    Genome annotation databases

    EnsemblBacteriaiCAE33487; CAE33487; BB2995.
    GeneIDi2659742.
    KEGGibbr:BB2995.
    PATRICi21139345. VBIBorBro124907_3041.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58355 Genomic DNA. Translation: CAA41252.1 .
    BX640446 Genomic DNA. Translation: CAE33487.1 .
    PIRi S17944.
    RefSeqi NP_889531.1. NC_002927.3.

    3D structure databases

    ProteinModelPortali P26762.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257310.BB2995.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE33487 ; CAE33487 ; BB2995 .
    GeneIDi 2659742.
    KEGGi bbr:BB2995.
    PATRICi 21139345. VBIBorBro124907_3041.

    Phylogenomic databases

    eggNOGi COG0642.
    HOGENOMi HOG000269369.
    KOi K07679.
    OMAi APAHIAT.
    OrthoDBi EOG6G4VQG.

    Enzyme and pathway databases

    BioCyci BBRO257310:BB2995-MONOMER.
    BRENDAi 2.7.13.3. 897.

    Family and domain databases

    Gene3Di 1.10.287.130. 1 hit.
    1.20.120.160. 1 hit.
    3.30.565.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR003661. EnvZ-like_dim/P.
    IPR003594. HATPase_ATP-bd.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR013767. PAS_fold.
    IPR001638. SBP_bac_3.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR008207. Sig_transdc_His_kin_Hpt_dom.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view ]
    Pfami PF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    PF01627. Hpt. 1 hit.
    PF00989. PAS. 1 hit.
    PF00072. Response_reg. 1 hit.
    PF00497. SBP_bac_3. 2 hits.
    [Graphical view ]
    PRINTSi PR00344. BCTRLSENSOR.
    SMARTi SM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    SM00073. HPT. 1 hit.
    SM00091. PAS. 1 hit.
    SM00062. PBPb. 2 hits.
    SM00448. REC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47226. SSF47226. 2 hits.
    SSF47384. SSF47384. 1 hit.
    SSF52172. SSF52172. 1 hit.
    SSF55785. SSF55785. 1 hit.
    SSF55874. SSF55874. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50109. HIS_KIN. 1 hit.
    PS50894. HPT. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural and genetic analysis of the bvg locus in Bordetella species."
      Arico B., Scarlato V., Monack D.M., Falkow S., Rappuoli R.
      Mol. Microbiol. 5:2481-2491(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 7865.
    2. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
      Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
      , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
      Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-588 / NCTC 13252 / RB50.

    Entry informationi

    Entry nameiBVGS_BORBR
    AccessioniPrimary (citable) accession number: P26762
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: September 19, 2003
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3