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P26762

- BVGS_BORBR

UniProt

P26762 - BVGS_BORBR

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Protein
Virulence sensor protein BvgS
Gene
bvgS, BB2995
Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals By similarity.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorelay response regulator activity Source: InterPro
  3. phosphorelay sensor kinase activity Source: InterPro
  4. transporter activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system, Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBRO257310:BB2995-MONOMER.
BRENDAi2.7.13.3. 897.

Names & Taxonomyi

Protein namesi
Recommended name:
Virulence sensor protein BvgS (EC:2.7.13.3)
Gene namesi
Name:bvgS
Ordered Locus Names:BB2995
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001027: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 307275Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei308 – 33124Helical; Reviewed prediction
Add
BLAST
Topological domaini332 – 541210Periplasmic Reviewed prediction
Add
BLAST
Transmembranei542 – 56322Helical; Reviewed prediction
Add
BLAST
Topological domaini564 – 1238675Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 12381208Virulence sensor protein BvgS
PRO_0000032368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei729 – 7291Phosphohistidine; by autocatalysis By similarity
Modified residuei1023 – 102314-aspartylphosphate By similarity
Modified residuei1172 – 11721Phosphohistidine By similarity

Post-translational modificationi

Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi257310.BB2995.

Structurei

3D structure databases

ProteinModelPortaliP26762.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini580 – 65172PAS
Add
BLAST
Domaini652 – 70857PAC
Add
BLAST
Domaini726 – 948223Histidine kinase
Add
BLAST
Domaini974 – 1095122Response regulatory
Add
BLAST
Domaini1133 – 122896HPt
Add
BLAST

Sequence similaritiesi

Contains 1 HPt domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0642.
HOGENOMiHOG000269369.
KOiK07679.
OMAiAPAHIAT.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
1.20.120.160. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR003661. EnvZ-like_dim/P.
IPR003594. HATPase_ATP-bd.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013767. PAS_fold.
IPR001638. SBP_bac_3.
IPR004358. Sig_transdc_His_kin-like_C.
IPR008207. Sig_transdc_His_kin_Hpt_dom.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF01627. Hpt. 1 hit.
PF00989. PAS. 1 hit.
PF00072. Response_reg. 1 hit.
PF00497. SBP_bac_3. 2 hits.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00073. HPT. 1 hit.
SM00091. PAS. 1 hit.
SM00062. PBPb. 2 hits.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47226. SSF47226. 2 hits.
SSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50894. HPT. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26762-1 [UniParc]FASTAAdd to Basket

« Hide

MPAPHRLYPR SLICLAQALL AWALLAWAPA QASQELTLVG KAAVPDVEIA     50
LDGDDWRWLA RKRVLTLGVY APDIPPFDVT YDERYEGLTA DYMAIIAHNL 100
GVQAKVLRYP TREQAVGALE SGQIDLIGTV NGIEGRLQSL RLSVPYAADH 150
PVLVMPIGAR RAPPADLAGQ RLAVDANYLP RETLQQAYPQ ATLHYFPSSE 200
QALAAVAYGQ ADVFIGDALT TSHLVSQSYF NDVRVVAPAQ IVTGGESFGV 250
RADNTRLLRV VNAVLEAIPA SERRSLIYRW GLGSSISLDF ARPAYSAREQ 300
QWMANHPVVK VAVLNLFAPF TLFRTDEQFG GISAAVLQLL QLRTGLDFQI 350
IGVDTVEELI AKLRSGEADM AGALFVNAAR ESVLSFSRPY VRNGMVIVTR 400
QDPAAPADAD HLDGRTIAMV RNSAAIPLLQ QRYPQAKVVT ADNPTEAMLL 450
VADGQADAVV QTQISASYYV NRYFAGKLRI ASALDLPPAE IALATARGQT 500
ELISILNKAL YSISNDELAS IVSRWRGSDG DPRTWYAYRN EIYLLIGLGL 550
LSALLFLSWI VYLRRQIRQR KRAERALNDQ LEFMRVLIDG TPNPIYVRDK 600
EGRMLLCNDA YLDTFGVTAD AVLGKTIPEA NVVGDPALAR EMHEFLLTRM 650
SAEREPRFED RDVTLHGRTR HVYQWTVPYG DSLGELKGII GGWIDITERA 700
ELLRELHDAK ESADAANRAK TTFLATMSHE IRTPMNAIIG MLELALLRPA 750
DQEPDRQSIQ VAYDSARSLL ELIGDILDIA KIEAGKFDLA PVRTALRALP 800
EGAIRVFDGL ARQKGIELVL KTDIVGVDDV LIDPLRMKQV LSNLVGNAIK 850
FTTEGQVVLT VTARPDGEAA HVQFSVSDTG CGISEADQRQ LFKPFSQVGG 900
SAEAGPAPGT GLGLSISRRL VELMGGTLVM RSAPGVGTTV SVDLRLTMVE 950
KSAQATPPAA AAQATPSKPQ VSLRVLVVDD HKPNLMLLRQ QLDYLGQRVV 1000
AADSGEAALA LWHEHAFDVV ITDCNMPGIN GYELARRIRA AEAAPGYGRT 1050
RCILFGFTAS AQMDEAQRCR AAGMDDCLFK PIGVDALRQR LNEAAARAAL 1100
PTPPSPQAAA PATHDATPAA FSAESILALT QNDEALIRQL LEELIRTNRA 1150
DVDQLQKLHQ QADWPKVSDM AHRLAGGARV VDAKAMIDTA LALEKKAQGQ 1200
AGPSPEIDGM VRTLAAQSAA LETQLRAWLE QRPHQGQP 1238
Length:1,238
Mass (Da):134,811
Last modified:September 19, 2003 - v2
Checksum:i74DCB538B77A0F3E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501A → T in CAA41252. 1 Publication
Sequence conflicti395 – 3951M → L in CAA41252. 1 Publication
Sequence conflicti651 – 6511S → A in CAA41252. 1 Publication
Sequence conflicti1008 – 10081A → S in CAA41252. 1 Publication
Sequence conflicti1067 – 10682QR → HA in CAA41252. 1 Publication
Sequence conflicti1144 – 11441L → V in CAA41252. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58355 Genomic DNA. Translation: CAA41252.1.
BX640446 Genomic DNA. Translation: CAE33487.1.
PIRiS17944.
RefSeqiNP_889531.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE33487; CAE33487; BB2995.
GeneIDi2659742.
KEGGibbr:BB2995.
PATRICi21139345. VBIBorBro124907_3041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58355 Genomic DNA. Translation: CAA41252.1 .
BX640446 Genomic DNA. Translation: CAE33487.1 .
PIRi S17944.
RefSeqi NP_889531.1. NC_002927.3.

3D structure databases

ProteinModelPortali P26762.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257310.BB2995.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE33487 ; CAE33487 ; BB2995 .
GeneIDi 2659742.
KEGGi bbr:BB2995.
PATRICi 21139345. VBIBorBro124907_3041.

Phylogenomic databases

eggNOGi COG0642.
HOGENOMi HOG000269369.
KOi K07679.
OMAi APAHIAT.
OrthoDBi EOG6G4VQG.

Enzyme and pathway databases

BioCyci BBRO257310:BB2995-MONOMER.
BRENDAi 2.7.13.3. 897.

Family and domain databases

Gene3Di 1.10.287.130. 1 hit.
1.20.120.160. 1 hit.
3.30.565.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR003661. EnvZ-like_dim/P.
IPR003594. HATPase_ATP-bd.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR013767. PAS_fold.
IPR001638. SBP_bac_3.
IPR004358. Sig_transdc_His_kin-like_C.
IPR008207. Sig_transdc_His_kin_Hpt_dom.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view ]
Pfami PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF01627. Hpt. 1 hit.
PF00989. PAS. 1 hit.
PF00072. Response_reg. 1 hit.
PF00497. SBP_bac_3. 2 hits.
[Graphical view ]
PRINTSi PR00344. BCTRLSENSOR.
SMARTi SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00073. HPT. 1 hit.
SM00091. PAS. 1 hit.
SM00062. PBPb. 2 hits.
SM00448. REC. 1 hit.
[Graphical view ]
SUPFAMi SSF47226. SSF47226. 2 hits.
SSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50109. HIS_KIN. 1 hit.
PS50894. HPT. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and genetic analysis of the bvg locus in Bordetella species."
    Arico B., Scarlato V., Monack D.M., Falkow S., Rappuoli R.
    Mol. Microbiol. 5:2481-2491(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 7865.
  2. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Entry informationi

Entry nameiBVGS_BORBR
AccessioniPrimary (citable) accession number: P26762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 19, 2003
Last modified: May 14, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi