Virulence sensor protein BvgS precursor - Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)

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P26762 (BVGS_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 119. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Virulence sensor protein BvgS
EC=2.7.13.3

Gene names

Name:	bvgS
Ordered Locus Names:	BB2995

Organism

Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]

Taxonomic identifier

257310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella ›

Protein attributes

Sequence length	1238 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals By similarity.
Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Probable.
Post-translational modification	Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain By similarity.
Sequence similarities	Contains 1 histidine kinase domain. Contains 1 HPt domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 1 PAS (PER-ARNT-SIM) domain. Contains 1 response regulatory domain.

Ontologies

Keywords
Biological process	Two-component regulatory system Virulence
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro phosphorelay sensor kinase activity Inferred from electronic annotation. Source: InterPro transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 30

Potential

Chain

31 – 1238

1208

Virulence sensor protein BvgS

PRO_0000032368

Regions

Topological domain

33 – 307

275

Cytoplasmic Potential

Transmembrane

308 – 331

Helical; Potential

Topological domain

332 – 541

210

Periplasmic Potential

Transmembrane

542 – 563

Helical; Potential

Topological domain

564 – 1238

675

Cytoplasmic Potential

Domain

580 – 651

PAS

Domain

652 – 708

PAC

Domain

726 – 948

223

Histidine kinase

Domain

974 – 1095

122

Response regulatory

Domain

1133 – 1228

HPt

Amino acid modifications

Modified residue

729

Phosphohistidine; by autocatalysis By similarity

Modified residue

1023

4-aspartylphosphate By similarity

Modified residue

1172

Phosphohistidine By similarity

Experimental info

Sequence conflict

A → T in CAA41252. Ref.1

Sequence conflict

395

M → L in CAA41252. Ref.1

Sequence conflict

651

S → A in CAA41252. Ref.1

Sequence conflict

1008

A → S in CAA41252. Ref.1

Sequence conflict

1067 – 1068

QR → HA in CAA41252. Ref.1

Sequence conflict

1144

L → V in CAA41252. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P26762 [UniParc].

Last modified September 19, 2003. Version 2.
Checksum: 74DCB538B77A0F3E
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FASTA

1,238

134,811

        10         20         30         40         50         60 
MPAPHRLYPR SLICLAQALL AWALLAWAPA QASQELTLVG KAAVPDVEIA LDGDDWRWLA 

        70         80         90        100        110        120 
RKRVLTLGVY APDIPPFDVT YDERYEGLTA DYMAIIAHNL GVQAKVLRYP TREQAVGALE 

       130        140        150        160        170        180 
SGQIDLIGTV NGIEGRLQSL RLSVPYAADH PVLVMPIGAR RAPPADLAGQ RLAVDANYLP 

       190        200        210        220        230        240 
RETLQQAYPQ ATLHYFPSSE QALAAVAYGQ ADVFIGDALT TSHLVSQSYF NDVRVVAPAQ 

       250        260        270        280        290        300 
IVTGGESFGV RADNTRLLRV VNAVLEAIPA SERRSLIYRW GLGSSISLDF ARPAYSAREQ 

       310        320        330        340        350        360 
QWMANHPVVK VAVLNLFAPF TLFRTDEQFG GISAAVLQLL QLRTGLDFQI IGVDTVEELI 

       370        380        390        400        410        420 
AKLRSGEADM AGALFVNAAR ESVLSFSRPY VRNGMVIVTR QDPAAPADAD HLDGRTIAMV 

       430        440        450        460        470        480 
RNSAAIPLLQ QRYPQAKVVT ADNPTEAMLL VADGQADAVV QTQISASYYV NRYFAGKLRI 

       490        500        510        520        530        540 
ASALDLPPAE IALATARGQT ELISILNKAL YSISNDELAS IVSRWRGSDG DPRTWYAYRN 

       550        560        570        580        590        600 
EIYLLIGLGL LSALLFLSWI VYLRRQIRQR KRAERALNDQ LEFMRVLIDG TPNPIYVRDK 

       610        620        630        640        650        660 
EGRMLLCNDA YLDTFGVTAD AVLGKTIPEA NVVGDPALAR EMHEFLLTRM SAEREPRFED 

       670        680        690        700        710        720 
RDVTLHGRTR HVYQWTVPYG DSLGELKGII GGWIDITERA ELLRELHDAK ESADAANRAK 

       730        740        750        760        770        780 
TTFLATMSHE IRTPMNAIIG MLELALLRPA DQEPDRQSIQ VAYDSARSLL ELIGDILDIA 

       790        800        810        820        830        840 
KIEAGKFDLA PVRTALRALP EGAIRVFDGL ARQKGIELVL KTDIVGVDDV LIDPLRMKQV 

       850        860        870        880        890        900 
LSNLVGNAIK FTTEGQVVLT VTARPDGEAA HVQFSVSDTG CGISEADQRQ LFKPFSQVGG 

       910        920        930        940        950        960 
SAEAGPAPGT GLGLSISRRL VELMGGTLVM RSAPGVGTTV SVDLRLTMVE KSAQATPPAA 

       970        980        990       1000       1010       1020 
AAQATPSKPQ VSLRVLVVDD HKPNLMLLRQ QLDYLGQRVV AADSGEAALA LWHEHAFDVV 

      1030       1040       1050       1060       1070       1080 
ITDCNMPGIN GYELARRIRA AEAAPGYGRT RCILFGFTAS AQMDEAQRCR AAGMDDCLFK 

      1090       1100       1110       1120       1130       1140 
PIGVDALRQR LNEAAARAAL PTPPSPQAAA PATHDATPAA FSAESILALT QNDEALIRQL 

      1150       1160       1170       1180       1190       1200 
LEELIRTNRA DVDQLQKLHQ QADWPKVSDM AHRLAGGARV VDAKAMIDTA LALEKKAQGQ 

      1210       1220       1230 
AGPSPEIDGM VRTLAAQSAA LETQLRAWLE QRPHQGQP

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural and genetic analysis of the bvg locus in Bordetella species." Arico B., Scarlato V., Monack D.M., Falkow S., Rappuoli R. Mol. Microbiol. 5:2481-2491(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 7865.
[2]	"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X58355 Genomic DNA. Translation: CAA41252.1. BX640446 Genomic DNA. Translation: CAE33487.1.
PIR	S17944.
RefSeq	NP_889531.1. NC_002927.3.
3D structure databases
ProteinModelPortal	P26762.
ModBase	Search...
Protein-protein interaction databases
STRING	257310.BB2995.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE33487; CAE33487; BB2995.
GeneID	2659742.
KEGG	bbr:BB2995.
PATRIC	21139345. VBIBorBro124907_3041.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0642.
HOGENOM	HOG000269369.
KO	K07679.
OMA	SFAEAFI.
ProtClustDB	CLSK920529.
Enzyme and pathway databases
BioCyc	BBRO257310:BB2995-MONOMER.
BRENDA	2.7.13.3. 897.
Family and domain databases
Gene3D	1.10.287.130. 1 hit. 1.20.120.160. 1 hit. 3.30.565.10. 1 hit.
InterPro	IPR011006. CheY-like_superfamily. IPR003594. HATPase_ATP-bd. IPR000014. PAS. IPR000700. PAS-assoc_C. IPR013767. PAS_fold. IPR001638. SBP_bac_3. IPR004358. Sig_transdc_His_kin-like_C. IPR008207. Sig_transdc_His_kin_Hpt_dom. IPR003661. Sig_transdc_His_kin_sub1_dim/P. IPR005467. Sig_transdc_His_kinase_core. IPR009082. Sig_transdc_His_kinase_dimeric. IPR001789. Sig_transdc_resp-reg_receiver. [Graphical view]
Pfam	PF02518. HATPase_c. 1 hit. PF00512. HisKA. 1 hit. PF01627. Hpt. 1 hit. PF00989. PAS. 1 hit. PF00072. Response_reg. 1 hit. PF00497. SBP_bac_3. 2 hits. [Graphical view]
PRINTS	PR00344. BCTRLSENSOR.
SMART	SM00387. HATPase_c. 1 hit. SM00388. HisKA. 1 hit. SM00073. HPT. 1 hit. SM00091. PAS. 1 hit. SM00062. PBPb. 2 hits. SM00448. REC. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF52172. CheY_like. 1 hit. SSF47384. His_kin_homodim. 1 hit. SSF47226. Hpt. 1 hit.
TIGRFAMs	TIGR00229. sensory_box. 1 hit.
PROSITE	PS50109. HIS_KIN. 1 hit. PS50894. HPT. 1 hit. PS50113. PAC. 1 hit. PS50112. PAS. 1 hit. PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BVGS_BORBR

Accession

Primary (citable) accession number: P26762

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	September 19, 2003
Last modified:	May 1, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents