Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Elongation factor 2

Gene

fusA

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 358GTPBy similarity
Nucleotide bindingi94 – 985GTPBy similarity
Nucleotide bindingi148 – 1514GTPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 2
Short name:
EF-2
Gene namesi
Name:fusA
Synonyms:fus
Ordered Locus Names:Ta0446
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Elongation factor 2PRO_0000091050Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei598 – 5981DiphthamideBy similarity

Proteomic databases

PRIDEiP26752.

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0446.

Structurei

3D structure databases

ProteinModelPortaliP26752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 228210tr-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01559. Archaea.
COG0480. LUCA.
HOGENOMiHOG000231589.
KOiK03234.
OMAiFTGHVTR.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_A. EF_G_EF_2_A. 1 hit.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004543. Transl_elong_EFG/EF2_arc.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00490. aEF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRKEDNIEK ALKIVEHTEL IRNIGIVAHI DHGKTTLSDN LIAGAGMMSE
60 70 80 90 100
ELAGKQLVLD YDEQEQARGI TINAAVASMV HTFQGKEYLI NLIDTPGHVD
110 120 130 140 150
FGGDVTRAMR AVDGVIVVVD SVEGVMPQTE TVIRQALREH VKPVLFINKI
160 170 180 190 200
DRLINELRLN SDEMQKRFTK IITDVNRLIS KYAPQQFTKE WQVSVQDGRV
210 220 230 240 250
AFGSAYNNWA ISIPAMAETK ITFKDIVEYV KNGKQKELAQ KNQLHKIILN
260 270 280 290 300
MVIRHLPDPK TAQSYRIKQI WKGDLDSEIG KAMINCDYKG PVAMMVTKII
310 320 330 340 350
IDPHAGEIAI GRLFSGTVKK GTDLYISGAG KGKVQTLAMM VGPDRIPVDE
360 370 380 390 400
ITAGNIAAIV GLKGAIAGAT VSSLENMVPF EPMIHYSEPV VTLAIEAKHT
410 420 430 440 450
ADLPRLIEVL RDISKADPSI QVDINQETGE HLISGMGELH LDVTLYRIKN
460 470 480 490 500
DYKVEVETSD PIVVYRETVE KKGGPFEGKS PNKHNRFYFE VEPLKPEVIQ
510 520 530 540 550
AIEDGDIPQG SKFKDKKALV ELLVSKGIDR DEAKGLVCVE GTNMMFDVTR
560 570 580 590 600
GIQYLDETME LLIEAFVEVM NRGPLANEKV FGVKARLVDA KLHEDSIHRG
610 620 630 640 650
PAQVIPAGRN SIYGAMCEAK RVLLEPVQRV FINVPQEEMG AAINEIQQRR
660 670 680 690 700
GIIEDMKQEG DEISLTAKVP VAGMFGFASA IRGATGGKVL WSFENAGYQK
710 720 730
VPPELQDSIV RSIRERKGLR QEPYDADYYA SM
Length:732
Mass (Da):81,217
Last modified:December 1, 2000 - v2
Checksum:iC69D533CC852A1F4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti730 – 7301A → D in CAA40171 (PubMed:2044939).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56840 Genomic DNA. Translation: CAA40171.1.
AL445064 Genomic DNA. Translation: CAC11588.1.
PIRiS36089.
RefSeqiWP_010900873.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11588; CAC11588; CAC11588.
GeneIDi1456055.
KEGGitac:Ta0446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56840 Genomic DNA. Translation: CAA40171.1.
AL445064 Genomic DNA. Translation: CAC11588.1.
PIRiS36089.
RefSeqiWP_010900873.1. NC_002578.1.

3D structure databases

ProteinModelPortaliP26752.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta0446.

Proteomic databases

PRIDEiP26752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC11588; CAC11588; CAC11588.
GeneIDi1456055.
KEGGitac:Ta0446.

Phylogenomic databases

eggNOGiarCOG01559. Archaea.
COG0480. LUCA.
HOGENOMiHOG000231589.
KOiK03234.
OMAiFTGHVTR.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_A. EF_G_EF_2_A. 1 hit.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004543. Transl_elong_EFG/EF2_arc.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00490. aEF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEF2_THEAC
AccessioniPrimary (citable) accession number: P26752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 1, 2000
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.