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Protein

Elongation factor 2

Gene

fusA

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 35GTPBy similarity8
Nucleotide bindingi94 – 98GTPBy similarity5
Nucleotide bindingi148 – 151GTPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTACI273075:G1GT7-476-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 2
Short name:
EF-2
Gene namesi
Name:fusA
Synonyms:fus
Ordered Locus Names:Ta0446
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000910501 – 732Elongation factor 2Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei598DiphthamideBy similarity1

Interactioni

Protein-protein interaction databases

STRINGi273075.Ta0446

Structurei

3D structure databases

ProteinModelPortaliP26752
SMRiP26752
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 228tr-type GAdd BLAST210

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01559 Archaea
COG0480 LUCA
HOGENOMiHOG000231589
KOiK03234
OMAiEHLISGM
OrthoDBiPOG093Z00HF

Family and domain databases

Gene3Di3.30.230.10, 2 hits
HAMAPiMF_00054_A EF_G_EF_2_A, 1 hit
InterProiView protein in InterPro
IPR035647 EFG_III/V
IPR000640 EFG_V-like
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR004543 Transl_elong_EFG/EF2_arc
IPR005517 Transl_elong_EFG/EF2_IV
PfamiView protein in Pfam
PF00679 EFG_C, 1 hit
PF03764 EFG_IV, 1 hit
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PRINTSiPR00315 ELONGATNFCT
SMARTiView protein in SMART
SM00838 EFG_C, 1 hit
SM00889 EFG_IV, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
SSF52540 SSF52540, 1 hit
SSF54211 SSF54211, 1 hit
SSF54980 SSF54980, 2 hits
TIGRFAMsiTIGR00490 aEF-2, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P26752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRKEDNIEK ALKIVEHTEL IRNIGIVAHI DHGKTTLSDN LIAGAGMMSE
60 70 80 90 100
ELAGKQLVLD YDEQEQARGI TINAAVASMV HTFQGKEYLI NLIDTPGHVD
110 120 130 140 150
FGGDVTRAMR AVDGVIVVVD SVEGVMPQTE TVIRQALREH VKPVLFINKI
160 170 180 190 200
DRLINELRLN SDEMQKRFTK IITDVNRLIS KYAPQQFTKE WQVSVQDGRV
210 220 230 240 250
AFGSAYNNWA ISIPAMAETK ITFKDIVEYV KNGKQKELAQ KNQLHKIILN
260 270 280 290 300
MVIRHLPDPK TAQSYRIKQI WKGDLDSEIG KAMINCDYKG PVAMMVTKII
310 320 330 340 350
IDPHAGEIAI GRLFSGTVKK GTDLYISGAG KGKVQTLAMM VGPDRIPVDE
360 370 380 390 400
ITAGNIAAIV GLKGAIAGAT VSSLENMVPF EPMIHYSEPV VTLAIEAKHT
410 420 430 440 450
ADLPRLIEVL RDISKADPSI QVDINQETGE HLISGMGELH LDVTLYRIKN
460 470 480 490 500
DYKVEVETSD PIVVYRETVE KKGGPFEGKS PNKHNRFYFE VEPLKPEVIQ
510 520 530 540 550
AIEDGDIPQG SKFKDKKALV ELLVSKGIDR DEAKGLVCVE GTNMMFDVTR
560 570 580 590 600
GIQYLDETME LLIEAFVEVM NRGPLANEKV FGVKARLVDA KLHEDSIHRG
610 620 630 640 650
PAQVIPAGRN SIYGAMCEAK RVLLEPVQRV FINVPQEEMG AAINEIQQRR
660 670 680 690 700
GIIEDMKQEG DEISLTAKVP VAGMFGFASA IRGATGGKVL WSFENAGYQK
710 720 730
VPPELQDSIV RSIRERKGLR QEPYDADYYA SM
Length:732
Mass (Da):81,217
Last modified:December 1, 2000 - v2
Checksum:iC69D533CC852A1F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti730A → D in CAA40171 (PubMed:2044939).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56840 Genomic DNA Translation: CAA40171.1
AL445064 Genomic DNA Translation: CAC11588.1
PIRiS36089
RefSeqiWP_010900873.1, NC_002578.1

Genome annotation databases

EnsemblBacteriaiCAC11588; CAC11588; CAC11588
GeneIDi1456055
KEGGitac:Ta0446

Similar proteinsi

Entry informationi

Entry nameiEF2_THEAC
AccessioniPrimary (citable) accession number: P26752
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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