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Reviewed, UniProtKB/Swiss-Prot P26725 (YUR1_YEAST)

Last modified January 19, 2010. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable mannosyltransferase YUR1
    EC=2.4.1.131
Gene names
Name: YUR1
Ordered Locus Names: YJL139C
ORF Names: J0657
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Possible glycosyltransferase involved in N-linked glycosylation.

Catalytic activity

Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein.

Miscellaneous

Present with 6400 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Belongs to the glycosyltransferase 15 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Probable mannosyltransferase YUR1
PRO_0000208250

Regions

Topological domain1 – 33Cytoplasmic Potential
Transmembrane4 – 2421Signal-anchor for type II membrane protein
Topological domain25 – 428404Lumenal Potential
Region25 – 8864Stem region By similarity
Region89 – 428340Catalytic By similarity

Sites

Active site3131Nucleophile Potential

Amino acid modifications

Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation921N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation4141N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
P26725-1 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: E4F1CF97480DB3CA

FASTA42850,836
        10         20         30         40         50         60 
MAKGGSLYIV GIFLPIWTFM IYIFGKELFL IRKYQKIDST YTALSQRVKE QYDTSRRRNY 

        70         80         90        100        110        120 
FPKVKLSRNS YDDYTLNYTR QNDSDSFHLR ENATILMLVR NSELEGALDS MRSLEDRFNN 

       130        140        150        160        170        180 
KYHYDWTFLN DVPFDQDFIE ATTSMASGKT QYALIPPEDW NRPQWINDTL FEERLRVMED 

       190        200        210        220        230        240 
EGVLYGGSKS YRNMCRFNSG FFFRQSILDN YDYYFRVEPN VKYYCDFPYD PFRVMRLKGK 

       250        260        270        280        290        300 
KYGFVISLYE YEETIPTLWD AVEEYLVASE ETILRKEDSA YAFLTDSGLV GKHYPVVEAN 

       310        320        330        340        350        360 
SDYNLCHFWS NFEIGDLNFF RSDEYKHFFE TLDAKGGFYY ERWGDAPVHS IGVSLLLRPD 

       370        380        390        400        410        420 
EIIHFDELGY FHSPFGTCPA SYAVRLDQRC RCKSDDESVI DITPHSCLMR WWKNGSGKYF 


LKEEQDEI

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References

« Hide 'large scale' references
[1]"The Saccharomyces cerevisiae RPB4 gene is tightly linked to the TIF2 gene."
Foreman P.K., Davis R.W., Sachs A.B.
Nucleic Acids Res. 19:2781-2781(1991) [PubMed: 2041753] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI."
Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D.
Yeast 12:787-797(1996) [PubMed: 8813765] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X58099 Genomic DNA. Translation: CAA41111.1.
X87371 Genomic DNA. Translation: CAA60816.1.
Z49414 Genomic DNA. Translation: CAA89434.1.
PIRS36856.
RefSeqNP_012396.1.

3D structure databases

SMRP26725. Positions 89-418.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-2605N.
STRINGP26725.

Protein family/group databases

CAZyGT15. Glycosyltransferase Family 15.

Genome annotation databases

EnsemblYJL139C; YJL139C; YJL139C; Saccharomyces cerevisiae. [Genome view]
GeneID853302.
KEGGsce:YJL139C.
NMPDRfig|4932.3.peg.3361.

Organism-specific databases

CYGDYJL139c.
SGDS000003675. YUR1.

Phylogenomic databases

eggNOGfuNOG05651.
HOGENOMHBG396033.
OMAVINNEIN.
OrthoDBEOG9ZSBKN.
PhylomeDBP26725.

Enzyme and pathway databases

BRENDA2.4.1.131. 250.

Gene expression databases

ArrayExpressP26725.
GenevestigatorP26725.
GermOnlineYJL139C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR002685. Glyco_trans_15.
[Graphical view]
PfamPF01793. Glyco_transf_15. 1 hit.
[Graphical view]
PIRSFPIRSF018153. Glyco_trans_15. 1 hit.
ProtoNetSearch...

Other Resources

NextBio973624.

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Entry information

Entry nameYUR1_YEAST
AccessionPrimary (citable) accession number: P26725
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: January 19, 2010
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents