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Protein

Probable mannosyltransferase YUR1

Gene

YUR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible glycosyltransferase involved in N-linked glycosylation. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

Miscellaneous

Present with 6400 molecules/cell in log phase SD medium.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei313NucleophileSequence analysis1

GO - Molecular functioni

  • alpha-1,2-mannosyltransferase activity Source: GO_Central
  • mannosyltransferase activity Source: SGD

GO - Biological processi

  • cell wall mannoprotein biosynthetic process Source: SGD
  • protein N-linked glycosylation Source: SGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:YJL139C-MONOMER
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT15 Glycosyltransferase Family 15

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannosyltransferase YUR1 (EC:2.4.1.-)
Gene namesi
Name:YUR1
Ordered Locus Names:YJL139C
ORF Names:J0657
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL139C
SGDiS000003675 YUR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3CytoplasmicSequence analysis3
Transmembranei4 – 24Helical; Signal-anchor for type II membrane proteinAdd BLAST21
Topological domaini25 – 428LumenalSequence analysisAdd BLAST404

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002082501 – 428Probable mannosyltransferase YUR1Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi414N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP26725
PaxDbiP26725
PRIDEiP26725

Interactioni

Protein-protein interaction databases

BioGridi33618, 146 interactors
DIPiDIP-2605N
IntActiP26725, 2 interactors
MINTiP26725
STRINGi4932.YJL139C

Structurei

3D structure databases

ProteinModelPortaliP26725
SMRiP26725
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 88Stem regionBy similarityAdd BLAST64
Regioni89 – 428CatalyticBy similarityAdd BLAST340

Sequence similaritiesi

Belongs to the glycosyltransferase 15 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000000831
HOGENOMiHOG000160667
InParanoidiP26725
KOiK03854
OrthoDBiEOG092C3H4I

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR002685 Glyco_trans_15
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR31121 PTHR31121, 1 hit
PfamiView protein in Pfam
PF01793 Glyco_transf_15, 1 hit
PIRSFiPIRSF018153 Glyco_trans_15, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

P26725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKGGSLYIV GIFLPIWTFM IYIFGKELFL IRKYQKIDST YTALSQRVKE
60 70 80 90 100
QYDTSRRRNY FPKVKLSRNS YDDYTLNYTR QNDSDSFHLR ENATILMLVR
110 120 130 140 150
NSELEGALDS MRSLEDRFNN KYHYDWTFLN DVPFDQDFIE ATTSMASGKT
160 170 180 190 200
QYALIPPEDW NRPQWINDTL FEERLRVMED EGVLYGGSKS YRNMCRFNSG
210 220 230 240 250
FFFRQSILDN YDYYFRVEPN VKYYCDFPYD PFRVMRLKGK KYGFVISLYE
260 270 280 290 300
YEETIPTLWD AVEEYLVASE ETILRKEDSA YAFLTDSGLV GKHYPVVEAN
310 320 330 340 350
SDYNLCHFWS NFEIGDLNFF RSDEYKHFFE TLDAKGGFYY ERWGDAPVHS
360 370 380 390 400
IGVSLLLRPD EIIHFDELGY FHSPFGTCPA SYAVRLDQRC RCKSDDESVI
410 420
DITPHSCLMR WWKNGSGKYF LKEEQDEI
Length:428
Mass (Da):50,836
Last modified:August 1, 1992 - v1
Checksum:iE4F1CF97480DB3CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58099 Genomic DNA Translation: CAA41111.1
X87371 Genomic DNA Translation: CAA60816.1
Z49414 Genomic DNA Translation: CAA89434.1
BK006943 Genomic DNA Translation: DAA08661.1
PIRiS36856
RefSeqiNP_012396.1, NM_001181572.1

Genome annotation databases

EnsemblFungiiYJL139C; YJL139C; YJL139C
GeneIDi853302
KEGGisce:YJL139C

Similar proteinsi

Entry informationi

Entry nameiYUR1_YEAST
AccessioniPrimary (citable) accession number: P26725
Secondary accession number(s): D6VW45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: March 28, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health