Reviewed, UniProtKB/Swiss-Prot P26722 (HIS2_AZOBR)

Names and origin

Protein names

Recommended name:
    Phosphoribosyl-ATP pyrophosphatase
      Short name=PRA-PH
    EC=3.6.1.31

Gene names

Name:

hisE

Organism

Azospirillum brasilense

Taxonomic identifier

192 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Azospirillum

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 111	111	Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020		PRO_0000136341

Sequences

	Sequence		Length	Mass (Da)
	P26722-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: EA8BDE3A36864500	FASTA	111	11,946
	10 20 30 40 50 60 MAEDKISAAV LDRLYATVQA RKGADPETSY TAKLFHRGTA KIAQKVGEEA VETVIEAVRG 70 80 90 100 110 DKAAMASESA DLLYHLMVLW ADAGLEPAAV WEKLAQREGT SGIAEKNARK S

References

[1]

"Cloning of histidine genes of Azospirillum brasilense: organization of the ABFH gene cluster and nucleotide sequence of the hisB gene." Fani R., Bazzicalupo M., Damiani G., Bianchi A., Schipani C., Sgaramella V., Polsinelli M. Mol. Gen. Genet. 216:224-229(1989) [PubMed: 2664449] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sp6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X61207 Genomic DNA. Translation: CAA43520.1.
PIR	S16803.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.6.1.31. 1315.
Family and domain databases
HAMAP	MF_01020. [Tree]
InterPro	IPR008179. PRib-ATP_pyrophosphohydrolase. [Graphical view]
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
ProDom	PD002611. Pra_PH/CH. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03188. histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS2_AZOBR

Accession

Primary (citable) accession number: P26722

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)