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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140SubstrateBy similarity1
Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 35NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
ORF Names:GE19037
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000002282 Componentsi: Chromosome 2L, Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0013162. Dyak\Adh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000545012 – 256Alcohol dehydrogenaseAdd BLAST255

Expressioni

Gene expression databases

BgeeiFBgn0013162.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi7245.FBpp0264047.

Structurei

3D structure databases

ProteinModelPortaliP26719.
SMRiP26719.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4169. Eukaryota.
COG1028. LUCA.
KOiK00001.
OMAiWSKHWDS.
OrthoDBiEOG091G0OC9.
PhylomeDBiP26719.

Family and domain databases

InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTLTNKNV VFVAGLGGIG LDTSKELVKR DLKNLVILDR IENPAAIAEL
60 70 80 90 100
KAINPKVTVT FYPYDVTVPI AETTKLLKTI FAQLKTIDVL INGAGILDDH
110 120 130 140 150
QIERTIAVNY TGLVNTTTAI LDFWDKRKGG PGGIICNIGS VTGFNAIYQV
160 170 180 190 200
PVYSGTKAAV VNFTSSLAKL APITGVTAYT VNPGITRTTL VHKFNSWLDV
210 220 230 240 250
EPQVAEKLLA HPTQPSLACA QNFVKAIELN QNGAIWKLDL GTLEAIQWSK

HWDSGI
Length:256
Mass (Da):27,716
Last modified:January 23, 2007 - v2
Checksum:i2BA1ED90A9D275D5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti211H → Q in strain: Gif-sur-Yvette stock 115. 1
Natural varianti213T → N in strain: Gif-sur-Yvette stock 115. 1
Natural varianti233G → R in strain: Gif-sur-Yvette stock 115. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57365 Genomic DNA. Translation: CAA40639.1.
X57366 Genomic DNA. Translation: CAA40640.1.
X57367 Genomic DNA. Translation: CAA40641.1.
X57368 Genomic DNA. Translation: CAA40642.1.
X57369 Genomic DNA. Translation: CAA40643.1.
X57370 Genomic DNA. Translation: CAA40644.1.
X57371 Genomic DNA. Translation: CAA40645.1.
X57372 Genomic DNA. Translation: CAA40646.1.
X57373 Genomic DNA. Translation: CAA40647.1.
X57374 Genomic DNA. Translation: CAA40648.1.
X57375 Genomic DNA. Translation: CAA40649.1.
X57376 Genomic DNA. Translation: CAA40650.1.
X54120 Genomic DNA. Translation: CAA38063.1.
CM000157 Genomic DNA. Translation: EDW89018.1.
PIRiS18277.
S18278.
S18279.
S18280.
S18281.
S18282.
S18284.
S18287.
S20718.
RefSeqiXP_002089306.1. XM_002089270.2.

Genome annotation databases

EnsemblMetazoaiFBtr0265555; FBpp0264047; FBgn0013162.
GeneIDi6528253.
KEGGidya:Dyak_GE19037.

Similar proteinsi

Entry informationi

Entry nameiADH_DROYA
AccessioniPrimary (citable) accession number: P26719
Secondary accession number(s): B4P0U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families