Reviewed, UniProtKB/Swiss-Prot P26717 (NKG2C_HUMAN)

Names and origin

Protein names

Recommended name:
    NKG2-C type II integral membrane protein
Alternative name(s):
    NKG2-C-activating NK receptor
    NK cell receptor C
    CD159 antigen-like family member C
    CD_antigen=CD159c

Gene names

Name:	KLRC2
Synonyms:	NKG2C

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Subunit structure	Can form disulfide-bonded heterodimer with CD94.
Subcellular location	Membrane; Single-pass type II membrane protein.
Tissue specificity	Natural killer cells.
Polymorphism	Two alleles are known. The sequence shown is that of allele NKG2-C*02.
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane
Ligand	Lectin
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	cellular defense response Ref.2 Traceable author statement. Source: ProtInc signal transduction Ref.1 Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	sugar binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor activity Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	NKG2-C type II integral membrane protein		PRO_0000046662
Regions
	Topological domain	1 – 70	70	Cytoplasmic Potential
	Transmembrane	71 – 93	23	Signal-anchor for type II membrane protein Potential
	Topological domain	94 – 231	138	Extracellular Potential
	Domain	116 – 229	114	C-type lectin
Amino acid modifications
	Glycosylation	100	1	N-linked (GlcNAc...) Potential
	Glycosylation	149	1	N-linked (GlcNAc...) Potential
	Glycosylation	178	1	N-linked (GlcNAc...) Potential
	Disulfide bond	117 ↔ 128		By similarity
	Disulfide bond	145 ↔ 227		By similarity
	Disulfide bond	206 ↔ 219		By similarity
Natural variations
	Natural variant	2	1	S → N in allele NKG2-C*02. Ref.3		VAR_013404
	Natural variant	102	1	S → F in allele NKG2-C*02. Ref.3		VAR_013405
Experimental info
	Sequence conflict	161	1	M → I in CAA38651. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P26717-1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 6B971EECD7542930	FASTA	231	26,072
	10 20 30 40 50 60 MSKQRGTFSE VSLAQDPKRQ QRKPKGNKSS ISGTEQEIFQ VELNLQNPSL NHQGIDKIYD 70 80 90 100 110 120 CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN NSSPNTRTQK ARHCGHCPEE 130 140 150 160 170 180 WITYSNSCYY IGKERRTWEE SLLACTSKNS SLLSIDNEEE MKFLASILPS SWIGVFRNSS 190 200 210 220 230 HHPWVTINGL AFKHKIKDSD NAELNCAVLQ VNRLKSAQCG SSMIYHCKHK L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells." Houchins J.P., Yabe T., McSherry C., Bach F.H. J. Exp. Med. 173:1017-1020(1991) [PubMed: 2007850] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex." Glienke J., Sobanov Y., Brostjan C., Steffens C., Nguyen C., Lehrach H., Hofer E., Francis F. Immunogenetics 48:163-173(1998) [PubMed: 9683661] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Conservation and variation in human and common chimpanzee CD94 and NKG2 genes." Shum B.P., Flodin L.R., Muir D.G., Rajalingam R., Khakoo S.I., Cleland S., Guethlein L.A., Uhrberg M., Parham P. J. Immunol. 168:240-252(2002) [PubMed: 11751968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-2 AND PHE-102.
[4]	Biassoni R. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lymphoid.
[5]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed: 16541075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X54869 mRNA. Translation: CAA38651.1. AJ001684 Genomic DNA. Translation: CAA04922.1. AF260134 mRNA. Translation: AAF86972.1. Y13055 mRNA. Translation: CAA73498.1. AC068775 Genomic DNA. No translation available. BC093644 mRNA. Translation: AAH93644.1. BC112039 mRNA. Translation: AAI12040.1.
IPI	IPI00291660.
PIR	PT0374.
RefSeq	NP_002251.2.
UniGene	Hs.591157
3D structure databases
HSSP	HSSP built from PDB template 1EGG based on UniProtKB P22897.
ModBase	Search...
Proteomic databases
PRIDE	P26717.
Genome annotation databases
Ensembl	ENSG00000205809. Homo sapiens. [Contig view]
GeneID	3822.
KEGG	hsa:3822.
Organism-specific databases
GeneCards	GC12M010474.
HGNC	HGNC:6375. KLRC2.
MIM	602891. gene.
PharmGKB	PA30164.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P26717.
HOVERGEN	P26717.
Gene expression databases
Bgee	P26717.
CleanEx	HS_KLRC2.
GermOnline	ENSG00000205809. Homo sapiens.
Family and domain databases
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR018378. C-type_lectin_CS. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
Pfam	PF00059. Lectin_C. 1 hit. [Graphical view]
SMART	SM00034. CLECT. 1 hit. [Graphical view]
PROSITE	PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	15029.
SOURCE	Search...

Entry information

Entry name

NKG2C_HUMAN

Accession

Primary (citable) accession number: P26717
Secondary accession number(s): O43802, Q52M74, Q9NR42

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	January 23, 2002
Last modified:	May 5, 2009
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)