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P26717 (NKG2C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NKG2-C type II integral membrane protein
Alternative name(s):
CD159 antigen-like family member C
NK cell receptor C
NKG2-C-activating NK receptor
CD_antigen=CD159c
Gene names
Name:KLRC2
Synonyms:NKG2C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Subunit structure

Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP. Ref.7

Subcellular location

Membrane; Single-pass type II membrane protein.

Tissue specificity

Natural killer cells.

Polymorphism

Two alleles are known. The sequence shown is that of allele NKG2-C*01.

Sequence similarities

Contains 1 C-type lectin domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TYROBPO439142EBI-3862171,EBI-2214794

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231NKG2-C type II integral membrane protein
PRO_0000046662

Regions

Topological domain1 – 7070Cytoplasmic Potential
Transmembrane71 – 9323Helical; Signal-anchor for type II membrane protein; Potential
Topological domain94 – 231138Extracellular Potential
Domain116 – 229114C-type lectin

Amino acid modifications

Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation1491N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Disulfide bond117 ↔ 128 By similarity
Disulfide bond145 ↔ 227 By similarity
Disulfide bond206 ↔ 219 By similarity

Natural variations

Natural variant21S → N in allele NKG2-C*02. Ref.3
Corresponds to variant rs28403159 [ dbSNP | Ensembl ].
VAR_013404
Natural variant1021S → F in allele NKG2-C*02. Ref.3
VAR_013405

Experimental info

Sequence conflict1611M → I in CAA38651. Ref.1

Secondary structure

... 231
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P26717 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 6B971EECD7542930

FASTA23126,072
        10         20         30         40         50         60 
MSKQRGTFSE VSLAQDPKRQ QRKPKGNKSS ISGTEQEIFQ VELNLQNPSL NHQGIDKIYD 

        70         80         90        100        110        120 
CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN NSSPNTRTQK ARHCGHCPEE 

       130        140        150        160        170        180 
WITYSNSCYY IGKERRTWEE SLLACTSKNS SLLSIDNEEE MKFLASILPS SWIGVFRNSS 

       190        200        210        220        230 
HHPWVTINGL AFKHKIKDSD NAELNCAVLQ VNRLKSAQCG SSMIYHCKHK L 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells."
Houchins J.P., Yabe T., McSherry C., Bach F.H.
J. Exp. Med. 173:1017-1020(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex."
Glienke J., Sobanov Y., Brostjan C., Steffens C., Nguyen C., Lehrach H., Hofer E., Francis F.
Immunogenetics 48:163-173(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Conservation and variation in human and common chimpanzee CD94 and NKG2 genes."
Shum B.P., Flodin L.R., Muir D.G., Rajalingam R., Khakoo S.I., Cleland S., Guethlein L.A., Uhrberg M., Parham P.
J. Immunol. 168:240-252(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-2 AND PHE-102.
[4]Biassoni R.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lymphoid tissue.
[5]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[7]"The structural basis for intramembrane assembly of an activating immunoreceptor complex."
Call M.E., Wucherpfennig K.W., Chou J.J.
Nat. Immunol. 11:1023-1029(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 72-100 IN COMPLEX WITH TYROBP, INTERACTION WITH TYROBP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54869 mRNA. Translation: CAA38651.1.
AJ001684 Genomic DNA. Translation: CAA04922.1.
AF260134 mRNA. Translation: AAF86972.1.
Y13055 mRNA. Translation: CAA73498.1.
AC068775 Genomic DNA. No translation available.
BC093644 mRNA. Translation: AAH93644.1.
BC112039 mRNA. Translation: AAI12040.1.
CCDSCCDS31745.1.
PIRPT0374.
RefSeqNP_002251.2. NM_002260.3.
UniGeneHs.591157.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2L35NMR-A72-100[»]
ProteinModelPortalP26717.
SMRP26717. Positions 72-99, 111-230.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110021. 2 interactions.
IntActP26717. 2 interactions.
STRING9606.ENSP00000371327.

Polymorphism databases

DMDM20141529.

Proteomic databases

PaxDbP26717.
PRIDEP26717.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381902; ENSP00000371327; ENSG00000205809.
GeneID3822.
KEGGhsa:3822.

Organism-specific databases

CTD3822.
GeneCardsGC12M010583.
HGNCHGNC:6375. KLRC2.
MIM602891. gene.
neXtProtNX_P26717.
PharmGKBPA30164.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145472.
HOGENOMHOG000220925.
HOVERGENHBG077044.
InParanoidP26717.
KOK06541.
PhylomeDBP26717.
TreeFamTF336674.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeP26717.
CleanExHS_KLRC2.
GenevestigatorP26717.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP26717.
GeneWikiKLRC2.
GenomeRNAi3822.
NextBio15029.
PROP26717.
SOURCESearch...

Entry information

Entry nameNKG2C_HUMAN
AccessionPrimary (citable) accession number: P26717
Secondary accession number(s): O43802, Q52M74, Q9NR42
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries