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P26717

- NKG2C_HUMAN

UniProt

P26717 - NKG2C_HUMAN

Protein

NKG2-C type II integral membrane protein

Gene

KLRC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. protein binding Source: IntAct
    3. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. cellular defense response Source: ProtInc
    2. innate immune response Source: Reactome
    3. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    Lectin

    Enzyme and pathway databases

    ReactomeiREACT_147694. DAP12 interactions.
    REACT_147814. DAP12 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NKG2-C type II integral membrane protein
    Alternative name(s):
    CD159 antigen-like family member C
    NK cell receptor C
    NKG2-C-activating NK receptor
    CD_antigen: CD159c
    Gene namesi
    Name:KLRC2
    Synonyms:NKG2C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:6375. KLRC2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30164.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 231231NKG2-C type II integral membrane proteinPRO_0000046662Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 128PROSITE-ProRule annotation
    Disulfide bondi145 ↔ 227PROSITE-ProRule annotation
    Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi206 ↔ 219PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP26717.
    PRIDEiP26717.

    Expressioni

    Tissue specificityi

    Natural killer cells.

    Gene expression databases

    BgeeiP26717.
    CleanExiHS_KLRC2.
    GenevestigatoriP26717.

    Interactioni

    Subunit structurei

    Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TYROBPO439142EBI-3862171,EBI-2214794

    Protein-protein interaction databases

    BioGridi110021. 2 interactions.
    IntActiP26717. 2 interactions.
    STRINGi9606.ENSP00000371327.

    Structurei

    Secondary structure

    1
    231
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi76 – 9722

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2L35NMR-A72-100[»]
    ProteinModelPortaliP26717.
    SMRiP26717. Positions 72-99, 111-230.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP26717.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7070CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini94 – 231138ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei71 – 9323Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini116 – 229114C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145472.
    HOGENOMiHOG000220925.
    HOVERGENiHBG077044.
    InParanoidiP26717.
    KOiK06541.
    PhylomeDBiP26717.
    TreeFamiTF336674.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26717-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKQRGTFSE VSLAQDPKRQ QRKPKGNKSS ISGTEQEIFQ VELNLQNPSL    50
    NHQGIDKIYD CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN 100
    NSSPNTRTQK ARHCGHCPEE WITYSNSCYY IGKERRTWEE SLLACTSKNS 150
    SLLSIDNEEE MKFLASILPS SWIGVFRNSS HHPWVTINGL AFKHKIKDSD 200
    NAELNCAVLQ VNRLKSAQCG SSMIYHCKHK L 231
    Length:231
    Mass (Da):26,072
    Last modified:January 23, 2002 - v2
    Checksum:i6B971EECD7542930
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti161 – 1611M → I in CAA38651. (PubMed:2007850)Curated

    Polymorphismi

    Two alleles are known. The sequence shown is that of allele NKG2-C*01.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21S → N in allele NKG2-C*02. 1 Publication
    Corresponds to variant rs28403159 [ dbSNP | Ensembl ].
    VAR_013404
    Natural varianti102 – 1021S → F in allele NKG2-C*02. 1 Publication
    VAR_013405

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54869 mRNA. Translation: CAA38651.1.
    AJ001684 Genomic DNA. Translation: CAA04922.1.
    AF260134 mRNA. Translation: AAF86972.1.
    Y13055 mRNA. Translation: CAA73498.1.
    AC068775 Genomic DNA. No translation available.
    BC093644 mRNA. Translation: AAH93644.1.
    BC112039 mRNA. Translation: AAI12040.1.
    CCDSiCCDS31745.1.
    PIRiPT0374.
    RefSeqiNP_002251.2. NM_002260.3.
    UniGeneiHs.591157.

    Genome annotation databases

    EnsembliENST00000381902; ENSP00000371327; ENSG00000205809.
    GeneIDi3822.
    KEGGihsa:3822.

    Polymorphism databases

    DMDMi20141529.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54869 mRNA. Translation: CAA38651.1 .
    AJ001684 Genomic DNA. Translation: CAA04922.1 .
    AF260134 mRNA. Translation: AAF86972.1 .
    Y13055 mRNA. Translation: CAA73498.1 .
    AC068775 Genomic DNA. No translation available.
    BC093644 mRNA. Translation: AAH93644.1 .
    BC112039 mRNA. Translation: AAI12040.1 .
    CCDSi CCDS31745.1.
    PIRi PT0374.
    RefSeqi NP_002251.2. NM_002260.3.
    UniGenei Hs.591157.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2L35 NMR - A 72-100 [» ]
    ProteinModelPortali P26717.
    SMRi P26717. Positions 72-99, 111-230.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110021. 2 interactions.
    IntActi P26717. 2 interactions.
    STRINGi 9606.ENSP00000371327.

    Polymorphism databases

    DMDMi 20141529.

    Proteomic databases

    PaxDbi P26717.
    PRIDEi P26717.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381902 ; ENSP00000371327 ; ENSG00000205809 .
    GeneIDi 3822.
    KEGGi hsa:3822.

    Organism-specific databases

    CTDi 3822.
    GeneCardsi GC12M010583.
    HGNCi HGNC:6375. KLRC2.
    MIMi 602891. gene.
    neXtProti NX_P26717.
    PharmGKBi PA30164.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145472.
    HOGENOMi HOG000220925.
    HOVERGENi HBG077044.
    InParanoidi P26717.
    KOi K06541.
    PhylomeDBi P26717.
    TreeFami TF336674.

    Enzyme and pathway databases

    Reactomei REACT_147694. DAP12 interactions.
    REACT_147814. DAP12 signaling.

    Miscellaneous databases

    EvolutionaryTracei P26717.
    GeneWikii KLRC2.
    GenomeRNAii 3822.
    NextBioi 15029.
    PROi P26717.
    SOURCEi Search...

    Gene expression databases

    Bgeei P26717.
    CleanExi HS_KLRC2.
    Genevestigatori P26717.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells."
      Houchins J.P., Yabe T., McSherry C., Bach F.H.
      J. Exp. Med. 173:1017-1020(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex."
      Glienke J., Sobanov Y., Brostjan C., Steffens C., Nguyen C., Lehrach H., Hofer E., Francis F.
      Immunogenetics 48:163-173(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes."
      Shum B.P., Flodin L.R., Muir D.G., Rajalingam R., Khakoo S.I., Cleland S., Guethlein L.A., Uhrberg M., Parham P.
      J. Immunol. 168:240-252(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-2 AND PHE-102.
    4. Biassoni R.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lymphoid tissue.
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    7. "The structural basis for intramembrane assembly of an activating immunoreceptor complex."
      Call M.E., Wucherpfennig K.W., Chou J.J.
      Nat. Immunol. 11:1023-1029(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 72-100 IN COMPLEX WITH TYROBP, INTERACTION WITH TYROBP.

    Entry informationi

    Entry nameiNKG2C_HUMAN
    AccessioniPrimary (citable) accession number: P26717
    Secondary accession number(s): O43802, Q52M74, Q9NR42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3