P26717 (NKG2C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NKG2-C type II integral membrane protein

Alternative name(s):
CD159 antigen-like family member C
NK cell receptor C
NKG2-C-activating NK receptor
CD_antigen=CD159c

Gene names

Name:	KLRC2
Synonyms:	NKG2C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Subunit structure	Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP. Ref.7
Subcellular location	Membrane; Single-pass type II membrane protein.
Tissue specificity	Natural killer cells.
Polymorphism	Two alleles are known. The sequence shown is that of allele NKG2-C*01.
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Lectin
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular defense response Traceable author statement Ref.2. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement PubMed 8436421. Source: ProtInc
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro transmembrane signaling receptor activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TYROBP	O43914	2	EBI-3862171,EBI-2214794

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 231

231

NKG2-C type II integral membrane protein

PRO_0000046662

Regions

Topological domain

1 – 70

70

Cytoplasmic Potential

Transmembrane

71 – 93

23

Helical; Signal-anchor for type II membrane protein; Potential

Topological domain

94 – 231

138

Extracellular Potential

Domain

116 – 229

114

C-type lectin

Amino acid modifications

Glycosylation

100

1

N-linked (GlcNAc...) Potential

Glycosylation

149

1

N-linked (GlcNAc...) Potential

Glycosylation

178

1

N-linked (GlcNAc...) Potential

Disulfide bond

117 ↔ 128

By similarity

Disulfide bond

145 ↔ 227

By similarity

Disulfide bond

206 ↔ 219

By similarity

Natural variations

Natural variant

2

1

S → N in allele NKG2-C*02. Ref.3
Corresponds to variant rs28403159 [ dbSNP | Ensembl ].

VAR_013404

Natural variant

102

1

S → F in allele NKG2-C*02. Ref.3

VAR_013405

Experimental info

Sequence conflict

161

1

M → I in CAA38651. Ref.1

Secondary structure

1

.

.

.

231

Helix Strand Turn

Details...

Helix

76 – 97

22

Sequences

	Sequence		Length	Mass (Da)
	P26717 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 6B971EECD7542930	FASTA	231	26,072
	10 20 30 40 50 60 MSKQRGTFSE VSLAQDPKRQ QRKPKGNKSS ISGTEQEIFQ VELNLQNPSL NHQGIDKIYD 70 80 90 100 110 120 CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN NSSPNTRTQK ARHCGHCPEE 130 140 150 160 170 180 WITYSNSCYY IGKERRTWEE SLLACTSKNS SLLSIDNEEE MKFLASILPS SWIGVFRNSS 190 200 210 220 230 HHPWVTINGL AFKHKIKDSD NAELNCAVLQ VNRLKSAQCG SSMIYHCKHK L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells." Houchins J.P., Yabe T., McSherry C., Bach F.H. J. Exp. Med. 173:1017-1020(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex." Glienke J., Sobanov Y., Brostjan C., Steffens C., Nguyen C., Lehrach H., Hofer E., Francis F. Immunogenetics 48:163-173(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Conservation and variation in human and common chimpanzee CD94 and NKG2 genes." Shum B.P., Flodin L.R., Muir D.G., Rajalingam R., Khakoo S.I., Cleland S., Guethlein L.A., Uhrberg M., Parham P. J. Immunol. 168:240-252(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-2 AND PHE-102.
[4]	Biassoni R. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lymphoid tissue.
[5]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[7]	"The structural basis for intramembrane assembly of an activating immunoreceptor complex." Call M.E., Wucherpfennig K.W., Chou J.J. Nat. Immunol. 11:1023-1029(2010) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 72-100 IN COMPLEX WITH TYROBP, INTERACTION WITH TYROBP.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X54869 mRNA. Translation: CAA38651.1.
AJ001684 Genomic DNA. Translation: CAA04922.1.
AF260134 mRNA. Translation: AAF86972.1.
Y13055 mRNA. Translation: CAA73498.1.
AC068775 Genomic DNA. No translation available.
BC093644 mRNA. Translation: AAH93644.1.
BC112039 mRNA. Translation: AAI12040.1.

IPI

IPI00291660.

PIR

PT0374.

RefSeq

NP_002251.2. NM_002260.3.

UniGene

Hs.591157.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2L35	NMR	-	A	72-100	[»]

ProteinModelPortal

P26717.

ModBase

Search...

Protein-protein interaction databases

IntAct

P26717. 2 interactions.

STRING

9606.ENSP00000371327.

Polymorphism databases

DMDM

20141529.

Proteomic databases

PaxDb

P26717.

PRIDE

P26717.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000381902; ENSP00000371327; ENSG00000205809.

GeneID

3822.

KEGG

hsa:3822.

Organism-specific databases

CTD

3822.

GeneCards

GC12M010583.

HGNC

HGNC:6375. KLRC2.

MIM

602891. gene.

neXtProt

NX_P26717.

PharmGKB

PA30164.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG145472.

HOGENOM

HOG000220925.

HOVERGEN

HBG077044.

InParanoid

P26717.

KO

K06541.

OrthoDB

EOG4HQDK7.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P26717.

Bgee

P26717.

CleanEx

HS_KLRC2.

Genevestigator

P26717.

GermOnline

ENSG00000205809. Homo sapiens.

Family and domain databases

Gene3D

3.10.100.10. 1 hit.

InterPro

IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]

Pfam

PF00059. Lectin_C. 1 hit.
[Graphical view]

SMART

SM00034. CLECT. 1 hit.
[Graphical view]

SUPFAM

SSF56436. C-type_lectin_fold. 1 hit.

PROSITE

PS00615. C_TYPE_LECTIN_1. False negative.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P26717.

GenomeRNAi

3822.

NextBio

15029.

SOURCE

Search...

Entry information

Entry name

NKG2C_HUMAN

Accession

Primary (citable) accession number: P26717
Secondary accession number(s): O43802, Q52M74, Q9NR42

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	January 23, 2002
Last modified:	May 1, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.