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P26717

- NKG2C_HUMAN

UniProt

P26717 - NKG2C_HUMAN

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Protein
NKG2-C type II integral membrane protein
Gene
KLRC2, NKG2C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. protein binding Source: IntAct
  3. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. cellular defense response Source: ProtInc
  2. innate immune response Source: Reactome
  3. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiREACT_147694. DAP12 interactions.
REACT_147814. DAP12 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
NKG2-C type II integral membrane protein
Alternative name(s):
CD159 antigen-like family member C
NK cell receptor C
NKG2-C-activating NK receptor
CD_antigen: CD159c
Gene namesi
Name:KLRC2
Synonyms:NKG2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6375. KLRC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7070Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei71 – 9323Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini94 – 231138Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30164.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231NKG2-C type II integral membrane protein
PRO_0000046662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi117 ↔ 128 By similarity
Disulfide bondi145 ↔ 227 By similarity
Glycosylationi149 – 1491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi206 ↔ 219 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP26717.
PRIDEiP26717.

Expressioni

Tissue specificityi

Natural killer cells.

Gene expression databases

BgeeiP26717.
CleanExiHS_KLRC2.
GenevestigatoriP26717.

Interactioni

Subunit structurei

Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TYROBPO439142EBI-3862171,EBI-2214794

Protein-protein interaction databases

BioGridi110021. 2 interactions.
IntActiP26717. 2 interactions.
STRINGi9606.ENSP00000371327.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi76 – 9722

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L35NMR-A72-100[»]
ProteinModelPortaliP26717.
SMRiP26717. Positions 72-99, 111-230.

Miscellaneous databases

EvolutionaryTraceiP26717.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 229114C-type lectin
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145472.
HOGENOMiHOG000220925.
HOVERGENiHBG077044.
InParanoidiP26717.
KOiK06541.
PhylomeDBiP26717.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26717-1 [UniParc]FASTAAdd to Basket

« Hide

MSKQRGTFSE VSLAQDPKRQ QRKPKGNKSS ISGTEQEIFQ VELNLQNPSL    50
NHQGIDKIYD CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN 100
NSSPNTRTQK ARHCGHCPEE WITYSNSCYY IGKERRTWEE SLLACTSKNS 150
SLLSIDNEEE MKFLASILPS SWIGVFRNSS HHPWVTINGL AFKHKIKDSD 200
NAELNCAVLQ VNRLKSAQCG SSMIYHCKHK L 231
Length:231
Mass (Da):26,072
Last modified:January 23, 2002 - v2
Checksum:i6B971EECD7542930
GO

Polymorphismi

Two alleles are known. The sequence shown is that of allele NKG2-C*01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21S → N in allele NKG2-C*02. 1 Publication
Corresponds to variant rs28403159 [ dbSNP | Ensembl ].
VAR_013404
Natural varianti102 – 1021S → F in allele NKG2-C*02. 1 Publication
VAR_013405

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611M → I in CAA38651. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54869 mRNA. Translation: CAA38651.1.
AJ001684 Genomic DNA. Translation: CAA04922.1.
AF260134 mRNA. Translation: AAF86972.1.
Y13055 mRNA. Translation: CAA73498.1.
AC068775 Genomic DNA. No translation available.
BC093644 mRNA. Translation: AAH93644.1.
BC112039 mRNA. Translation: AAI12040.1.
CCDSiCCDS31745.1.
PIRiPT0374.
RefSeqiNP_002251.2. NM_002260.3.
UniGeneiHs.591157.

Genome annotation databases

EnsembliENST00000381902; ENSP00000371327; ENSG00000205809.
GeneIDi3822.
KEGGihsa:3822.

Polymorphism databases

DMDMi20141529.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54869 mRNA. Translation: CAA38651.1 .
AJ001684 Genomic DNA. Translation: CAA04922.1 .
AF260134 mRNA. Translation: AAF86972.1 .
Y13055 mRNA. Translation: CAA73498.1 .
AC068775 Genomic DNA. No translation available.
BC093644 mRNA. Translation: AAH93644.1 .
BC112039 mRNA. Translation: AAI12040.1 .
CCDSi CCDS31745.1.
PIRi PT0374.
RefSeqi NP_002251.2. NM_002260.3.
UniGenei Hs.591157.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2L35 NMR - A 72-100 [» ]
ProteinModelPortali P26717.
SMRi P26717. Positions 72-99, 111-230.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110021. 2 interactions.
IntActi P26717. 2 interactions.
STRINGi 9606.ENSP00000371327.

Polymorphism databases

DMDMi 20141529.

Proteomic databases

PaxDbi P26717.
PRIDEi P26717.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381902 ; ENSP00000371327 ; ENSG00000205809 .
GeneIDi 3822.
KEGGi hsa:3822.

Organism-specific databases

CTDi 3822.
GeneCardsi GC12M010583.
HGNCi HGNC:6375. KLRC2.
MIMi 602891. gene.
neXtProti NX_P26717.
PharmGKBi PA30164.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145472.
HOGENOMi HOG000220925.
HOVERGENi HBG077044.
InParanoidi P26717.
KOi K06541.
PhylomeDBi P26717.
TreeFami TF336674.

Enzyme and pathway databases

Reactomei REACT_147694. DAP12 interactions.
REACT_147814. DAP12 signaling.

Miscellaneous databases

EvolutionaryTracei P26717.
GeneWikii KLRC2.
GenomeRNAii 3822.
NextBioi 15029.
PROi P26717.
SOURCEi Search...

Gene expression databases

Bgeei P26717.
CleanExi HS_KLRC2.
Genevestigatori P26717.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells."
    Houchins J.P., Yabe T., McSherry C., Bach F.H.
    J. Exp. Med. 173:1017-1020(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex."
    Glienke J., Sobanov Y., Brostjan C., Steffens C., Nguyen C., Lehrach H., Hofer E., Francis F.
    Immunogenetics 48:163-173(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes."
    Shum B.P., Flodin L.R., Muir D.G., Rajalingam R., Khakoo S.I., Cleland S., Guethlein L.A., Uhrberg M., Parham P.
    J. Immunol. 168:240-252(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASN-2 AND PHE-102.
  4. Biassoni R.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lymphoid tissue.
  5. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  7. "The structural basis for intramembrane assembly of an activating immunoreceptor complex."
    Call M.E., Wucherpfennig K.W., Chou J.J.
    Nat. Immunol. 11:1023-1029(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 72-100 IN COMPLEX WITH TYROBP, INTERACTION WITH TYROBP.

Entry informationi

Entry nameiNKG2C_HUMAN
AccessioniPrimary (citable) accession number: P26717
Secondary accession number(s): O43802, Q52M74, Q9NR42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2002
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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