Reviewed, UniProtKB/Swiss-Prot P26715 (NKG2A_HUMAN)

Names and origin

Protein names

Recommended name:
    NKG2-A/NKG2-B type II integral membrane protein
Alternative name(s):
    NKG2-A/B-activating NK receptor
    NK cell receptor A
    CD159 antigen-like family member A
    CD_antigen=CD159a

Gene names

Name:	KLRC1
Synonyms:	NKG2A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Subunit structure	Can form disulfide-bonded heterodimer with CD94.
Subcellular location	Membrane; Single-pass type II membrane protein.
Tissue specificity	Natural killer cells.
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal-anchor Transmembrane
Ligand	Lectin
Molecular function	Receptor
PTM	Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cell surface receptor linked signal transduction Ref.1 Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	sugar binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform NKG2-A (identifier: P26715-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform NKG2-B (identifier: P26715-2)

The sequence of this isoform differs from the canonical sequence as follows:
     96-113: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 233

233

NKG2-A/NKG2-B type II integral membrane protein

PRO_0000046659

Regions

Topological domain

1 – 70

70

Cytoplasmic Potential

Transmembrane

71 – 93

23

Signal-anchor for type II membrane protein Potential

Topological domain

94 – 233

140

Extracellular Potential

Domain

118 – 231

114

C-type lectin

Amino acid modifications

Glycosylation

102

1

N-linked (GlcNAc...) Potential

Glycosylation

103

1

N-linked (GlcNAc...) Potential

Glycosylation

151

1

N-linked (GlcNAc...) Potential

Glycosylation

180

1

N-linked (GlcNAc...) Potential

Disulfide bond

119 ↔ 130

By similarity

Disulfide bond

147 ↔ 229

By similarity

Disulfide bond

208 ↔ 221

By similarity

Natural variations

Alternative sequence

96 – 113

18

Missing in isoform NKG2-B.

VSP_003062

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

233

Helix Strand Turn

Details...

Beta strand

124 – 138

15

Helix

140 – 149

10

Beta strand

152 – 154

3

Helix

160 – 169

10

Beta strand

171 – 178

8

Beta strand

191 – 193

3

Beta strand

208 – 219

12

Beta strand

225 – 230

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform NKG2-A [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 1654BD7958C81A84	FASTA	233	26,287
	10 20 30 40 50 60 MDNQGVIYSD LNLPPNPKRQ QRKPKGNKSS ILATEQEITY AELNLQKASQ DFQGNDKTYH 70 80 90 100 110 120 CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSTLIQR HNNSSLNTRT QKARHCGHCP 130 140 150 160 170 180 EEWITYSNSC YYIGKERRTW EESLLACTSK NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN 190 200 210 220 230 SSHHPWVTMN GLAFKHEIKD SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKL
	Isoform NKG2-B [UniParc]. Checksum: FEFF8FCFC4BAD243		215	24,223
	10 20 30 40 50 60 MDNQGVIYSD LNLPPNPKRQ QRKPKGNKSS ILATEQEITY AELNLQKASQ DFQGNDKTYH 70 80 90 100 110 120 CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSRHCGH CPEEWITYSN SCYYIGKERR 130 140 150 160 170 180 TWEESLLACT SKNSSLLSID NEEEMKFLSI ISPSSWIGVF RNSSHHPWVT MNGLAFKHEI 190 200 210 KDSDNAELNC AVLQVNRLKS AQCGSSIIYH CKHKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells." Houchins J.P., Yabe T., McSherry C., Bach F.H. J. Exp. Med. 173:1017-1020(1991) [PubMed: 2007850] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS NKG2-A AND NKG2-B).
[2]	"Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene." Plougastel B., Jones T., Trowsdale J. Immunogenetics 44:286-291(1996) [PubMed: 8753859] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS NKG2-A AND NKG2-B).
[3]	"Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes." Plougastel B., Trowsdale J. Genomics 49:193-199(1998) [PubMed: 9598306] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS NKG2-A AND NKG2-B).
[4]	"Identification and characterization of the NKG2A gene from large granular lymphocytic leukemia (LGL) cells." Kothapalli R., Kusmartseva I., Loughran T.P. Jr. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS NKG2-A AND NKG2-B). Tissue: Blood and Kidney.
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

NKG-2A

Cross-references

Sequence databases

EMBLGenBankDDBJ

X54867 mRNA. Translation: CAA38649.1.
X54868 mRNA. Translation: CAA38650.1.
U54786 , U54783, U54784, U54785 Genomic DNA. Translation: AAB17133.1.
AF023840 Genomic DNA. Translation: AAC17488.1.
AF461812 mRNA. Translation: AAL65234.1.
BC012550 mRNA. Translation: AAH12550.1.
BC053840 mRNA. Translation: AAH53840.1.

PIR

PT0372.

RefSeq

NP_002250.1.
NP_015567.1.
NP_998822.1.
NP_998823.1.

UniGene

Hs.512576

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BDW	X-ray	2.50	B/D	113-232	[»]
3CDG	X-ray	3.40	F/K	113-232	[»]
3CII	X-ray	4.41	H/J	113-232	[»]

ModBase

Search...

PTM databases

PhosphoSite

P26715.

Genome annotation databases

Ensembl

ENSG00000134545. Homo sapiens. [Contig view]

GeneID

3821.

KEGG

hsa:3821.

Organism-specific databases

H-InvDB

HIX0017878.

HGNC

HGNC:6374. KLRC1.

MIM

161555. gene.

PharmGKB

PA30163.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

P26715.

HOVERGEN

P26715.

Enzyme and pathway databases

Reactome

REACT_6900. Signaling in Immune System.

Gene expression databases

CleanEx

HS_KLRC1.

GermOnline

ENSG00000134545. Homo sapiens.

Family and domain databases

InterPro

IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
[Graphical view]

Gene3D

G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.

Pfam

PF00059. Lectin_C. 1 hit.
[Graphical view]

SMART

SM00034. CLECT. 1 hit.
[Graphical view]

PROSITE

PS00615. C_TYPE_LECTIN_1. False negative.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

LinkHub

P26715.

NextBio

15019.

SOURCE

Search...

Entry information

Entry name

NKG2A_HUMAN

Accession

Primary (citable) accession number: P26715

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	November 25, 2008
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)