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Protein

NKG2-A/NKG2-B type II integral membrane protein

Gene

KLRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • MHC class I protein complex binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc
  • regulation of immune response Source: Reactome

Keywordsi

Molecular functionReceptor
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SIGNORiP26715

Names & Taxonomyi

Protein namesi
Recommended name:
NKG2-A/NKG2-B type II integral membrane protein
Alternative name(s):
CD159 antigen-like family member A
NK cell receptor A
NKG2-A/B-activating NK receptor
CD_antigen: CD159a
Gene namesi
Name:KLRC1
Synonyms:NKG2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000134545.13
HGNCiHGNC:6374 KLRC1
MIMi161555 gene
neXtProtiNX_P26715

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 70CytoplasmicSequence analysisAdd BLAST70
Transmembranei71 – 93Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini94 – 233ExtracellularSequence analysisAdd BLAST140

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3821
OpenTargetsiENSG00000134545
PharmGKBiPA30163

Chemistry databases

GuidetoPHARMACOLOGYi2849

Polymorphism and mutation databases

BioMutaiKLRC1
DMDMi317373399

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466591 – 233NKG2-A/NKG2-B type II integral membrane proteinAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi116Interchain (with C-59 in KLRD1)
Disulfide bondi119 ↔ 130
Disulfide bondi147 ↔ 229
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi208 ↔ 221

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP26715
PaxDbiP26715
PeptideAtlasiP26715
PRIDEiP26715

PTM databases

iPTMnetiP26715
PhosphoSitePlusiP26715

Expressioni

Tissue specificityi

Natural killer cells.

Gene expression databases

BgeeiENSG00000134545
CleanExiHS_KLRC1
ExpressionAtlasiP26715 baseline and differential
GenevisibleiP26715 HS

Organism-specific databases

HPAiHPA058052

Interactioni

Subunit structurei

Can form disulfide-bonded heterodimer with CD94.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110020, 3 interactors
ELMiP26715
IntActiP26715, 43 interactors
STRINGi9606.ENSP00000352064

Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi117 – 119Combined sources3
Beta strandi124 – 138Combined sources15
Helixi140 – 149Combined sources10
Beta strandi152 – 154Combined sources3
Helixi160 – 169Combined sources10
Beta strandi171 – 178Combined sources8
Beta strandi191 – 193Combined sources3
Beta strandi208 – 219Combined sources12
Beta strandi225 – 230Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMXNMR-B1-15[»]
2YU7NMR-B33-47[»]
3BDWX-ray2.50B/D113-232[»]
3CDGX-ray3.40F/K113-232[»]
3CIIX-ray4.41H/J113-232[»]
ProteinModelPortaliP26715
SMRiP26715
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26715

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 231C-type lectinPROSITE-ProRule annotationAdd BLAST114

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWW4 Eukaryota
ENOG410ZFTY LUCA
GeneTreeiENSGT00730000110282
HOGENOMiHOG000220925
HOVERGENiHBG077044
InParanoidiP26715
KOiK06541
OMAiTYNCKHK
OrthoDBiEOG091G0I60
PhylomeDBiP26715
TreeFamiTF336674

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform NKG2-A (identifier: P26715-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNQGVIYSD LNLPPNPKRQ QRKPKGNKNS ILATEQEITY AELNLQKASQ
60 70 80 90 100
DFQGNDKTYH CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSTLIQR
110 120 130 140 150
HNNSSLNTRT QKARHCGHCP EEWITYSNSC YYIGKERRTW EESLLACTSK
160 170 180 190 200
NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN SSHHPWVTMN GLAFKHEIKD
210 220 230
SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKL
Length:233
Mass (Da):26,314
Last modified:January 11, 2011 - v2
Checksum:i93879A5C8D110C62
GO
Isoform NKG2-B (identifier: P26715-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-113: Missing.

Show »
Length:215
Mass (Da):24,250
Checksum:iFEEE7322C85B2EAE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05012029N → S5 PublicationsCorresponds to variant dbSNP:rs2253849Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00306296 – 113Missing in isoform NKG2-B. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54867 mRNA Translation: CAA38649.1
X54868 mRNA Translation: CAA38650.1
U54786
, U54783, U54784, U54785 Genomic DNA Translation: AAB17133.1
AF023840 Genomic DNA Translation: AAC17488.1
AF461812 mRNA Translation: AAL65234.1
AC068775 Genomic DNA No translation available.
BC012550 mRNA Translation: AAH12550.1
BC053840 mRNA Translation: AAH53840.1
CCDSiCCDS8625.1 [P26715-1]
CCDS8626.1 [P26715-2]
PIRiPT0372
RefSeqiNP_002250.1, NM_002259.4
NP_015567.1, NM_007328.3
NP_998822.1, NM_213657.2
NP_998823.1, NM_213658.2
UniGeneiHs.512576

Genome annotation databases

EnsembliENST00000347831; ENSP00000256965; ENSG00000134545 [P26715-2]
ENST00000359151; ENSP00000352064; ENSG00000134545 [P26715-1]
ENST00000408006; ENSP00000385304; ENSG00000134545 [P26715-2]
ENST00000544822; ENSP00000438038; ENSG00000134545 [P26715-1]
GeneIDi3821
KEGGihsa:3821
UCSCiuc001qyl.5 human [P26715-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNKG2A_HUMAN
AccessioniPrimary (citable) accession number: P26715
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 11, 2011
Last modified: November 22, 2017
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health