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P26715

- NKG2A_HUMAN

UniProt

P26715 - NKG2A_HUMAN

Protein

NKG2-A/NKG2-B type II integral membrane protein

Gene

KLRC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc
    2. regulation of immune response Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    Lectin

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NKG2-A/NKG2-B type II integral membrane protein
    Alternative name(s):
    CD159 antigen-like family member A
    NK cell receptor A
    NKG2-A/B-activating NK receptor
    CD_antigen: CD159a
    Gene namesi
    Name:KLRC1
    Synonyms:NKG2A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:6374. KLRC1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30163.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233NKG2-A/NKG2-B type II integral membrane proteinPRO_0000046659Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi116 – 116Interchain (with C-59 in KLRD1)
    Disulfide bondi119 ↔ 130
    Disulfide bondi147 ↔ 229
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi208 ↔ 221

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP26715.
    PRIDEiP26715.

    PTM databases

    PhosphoSiteiP26715.

    Expressioni

    Tissue specificityi

    Natural killer cells.

    Gene expression databases

    ArrayExpressiP26715.
    BgeeiP26715.
    CleanExiHS_KLRC1.
    GenevestigatoriP26715.

    Interactioni

    Subunit structurei

    Can form disulfide-bonded heterodimer with CD94.3 Publications

    Protein-protein interaction databases

    BioGridi110020. 1 interaction.
    STRINGi9606.ENSP00000352064.

    Structurei

    Secondary structure

    1
    233
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi117 – 1193
    Beta strandi124 – 13815
    Helixi140 – 14910
    Beta strandi152 – 1543
    Helixi160 – 16910
    Beta strandi171 – 1788
    Beta strandi191 – 1933
    Beta strandi208 – 21912
    Beta strandi225 – 2306

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2RMXNMR-B1-15[»]
    2YU7NMR-B33-47[»]
    3BDWX-ray2.50B/D113-232[»]
    3CDGX-ray3.40F/K113-232[»]
    3CIIX-ray4.41H/J113-232[»]
    ProteinModelPortaliP26715.
    SMRiP26715. Positions 113-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP26715.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7070CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini94 – 233140ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei71 – 9323Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini118 – 231114C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146673.
    HOGENOMiHOG000220925.
    HOVERGENiHBG077044.
    InParanoidiP26715.
    KOiK06541.
    OMAiTEQEIIY.
    PhylomeDBiP26715.
    TreeFamiTF336674.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform NKG2-A (identifier: P26715-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDNQGVIYSD LNLPPNPKRQ QRKPKGNKNS ILATEQEITY AELNLQKASQ    50
    DFQGNDKTYH CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSTLIQR 100
    HNNSSLNTRT QKARHCGHCP EEWITYSNSC YYIGKERRTW EESLLACTSK 150
    NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN SSHHPWVTMN GLAFKHEIKD 200
    SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKL 233
    Length:233
    Mass (Da):26,314
    Last modified:January 11, 2011 - v2
    Checksum:i93879A5C8D110C62
    GO
    Isoform NKG2-B (identifier: P26715-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         96-113: Missing.

    Show »
    Length:215
    Mass (Da):24,250
    Checksum:iFEEE7322C85B2EAE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291N → S.5 Publications
    Corresponds to variant rs2253849 [ dbSNP | Ensembl ].
    VAR_050120

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei96 – 11318Missing in isoform NKG2-B. 2 PublicationsVSP_003062Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54867 mRNA. Translation: CAA38649.1.
    X54868 mRNA. Translation: CAA38650.1.
    U54786
    , U54783, U54784, U54785 Genomic DNA. Translation: AAB17133.1.
    AF023840 Genomic DNA. Translation: AAC17488.1.
    AF461812 mRNA. Translation: AAL65234.1.
    AC068775 Genomic DNA. No translation available.
    BC012550 mRNA. Translation: AAH12550.1.
    BC053840 mRNA. Translation: AAH53840.1.
    CCDSiCCDS8625.1. [P26715-1]
    CCDS8626.1. [P26715-2]
    PIRiPT0372.
    RefSeqiNP_002250.1. NM_002259.4.
    NP_015567.1. NM_007328.3.
    NP_998822.1. NM_213657.2.
    NP_998823.1. NM_213658.2.
    UniGeneiHs.512576.

    Genome annotation databases

    EnsembliENST00000347831; ENSP00000256965; ENSG00000134545. [P26715-2]
    ENST00000359151; ENSP00000352064; ENSG00000134545. [P26715-1]
    ENST00000408006; ENSP00000385304; ENSG00000134545. [P26715-2]
    ENST00000544822; ENSP00000438038; ENSG00000134545. [P26715-1]
    GeneIDi3821.
    KEGGihsa:3821.
    UCSCiuc001qyl.3. human. [P26715-1]
    uc001qym.3. human. [P26715-2]

    Polymorphism databases

    DMDMi317373399.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    NKG-2A

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54867 mRNA. Translation: CAA38649.1 .
    X54868 mRNA. Translation: CAA38650.1 .
    U54786
    , U54783 , U54784 , U54785 Genomic DNA. Translation: AAB17133.1 .
    AF023840 Genomic DNA. Translation: AAC17488.1 .
    AF461812 mRNA. Translation: AAL65234.1 .
    AC068775 Genomic DNA. No translation available.
    BC012550 mRNA. Translation: AAH12550.1 .
    BC053840 mRNA. Translation: AAH53840.1 .
    CCDSi CCDS8625.1. [P26715-1 ]
    CCDS8626.1. [P26715-2 ]
    PIRi PT0372.
    RefSeqi NP_002250.1. NM_002259.4.
    NP_015567.1. NM_007328.3.
    NP_998822.1. NM_213657.2.
    NP_998823.1. NM_213658.2.
    UniGenei Hs.512576.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2RMX NMR - B 1-15 [» ]
    2YU7 NMR - B 33-47 [» ]
    3BDW X-ray 2.50 B/D 113-232 [» ]
    3CDG X-ray 3.40 F/K 113-232 [» ]
    3CII X-ray 4.41 H/J 113-232 [» ]
    ProteinModelPortali P26715.
    SMRi P26715. Positions 113-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110020. 1 interaction.
    STRINGi 9606.ENSP00000352064.

    PTM databases

    PhosphoSitei P26715.

    Polymorphism databases

    DMDMi 317373399.

    Proteomic databases

    PaxDbi P26715.
    PRIDEi P26715.

    Protocols and materials databases

    DNASUi 3821.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000347831 ; ENSP00000256965 ; ENSG00000134545 . [P26715-2 ]
    ENST00000359151 ; ENSP00000352064 ; ENSG00000134545 . [P26715-1 ]
    ENST00000408006 ; ENSP00000385304 ; ENSG00000134545 . [P26715-2 ]
    ENST00000544822 ; ENSP00000438038 ; ENSG00000134545 . [P26715-1 ]
    GeneIDi 3821.
    KEGGi hsa:3821.
    UCSCi uc001qyl.3. human. [P26715-1 ]
    uc001qym.3. human. [P26715-2 ]

    Organism-specific databases

    CTDi 3821.
    GeneCardsi GC12M010598.
    HGNCi HGNC:6374. KLRC1.
    MIMi 161555. gene.
    neXtProti NX_P26715.
    PharmGKBi PA30163.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146673.
    HOGENOMi HOG000220925.
    HOVERGENi HBG077044.
    InParanoidi P26715.
    KOi K06541.
    OMAi TEQEIIY.
    PhylomeDBi P26715.
    TreeFami TF336674.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    EvolutionaryTracei P26715.
    GenomeRNAii 3821.
    NextBioi 15019.
    PROi P26715.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P26715.
    Bgeei P26715.
    CleanExi HS_KLRC1.
    Genevestigatori P26715.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells."
      Houchins J.P., Yabe T., McSherry C., Bach F.H.
      J. Exp. Med. 173:1017-1020(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS NKG2-A AND NKG2-B), VARIANT SER-29.
    2. "Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene."
      Plougastel B., Jones T., Trowsdale J.
      Immunogenetics 44:286-291(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS NKG2-A AND NKG2-B), VARIANT SER-29.
    3. "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes."
      Plougastel B., Trowsdale J.
      Genomics 49:193-199(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS NKG2-A AND NKG2-B), VARIANT SER-29.
    4. "Identification and characterization of the NKG2A gene from large granular lymphocytic leukemia (LGL) cells."
      Kothapalli R., Kusmartseva I., Loughran T.P. Jr.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-29.
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS NKG2-A AND NKG2-B), VARIANT SER-29.
      Tissue: Blood and Kidney.
    7. "The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition."
      Sullivan L.C., Clements C.S., Beddoe T., Johnson D., Hoare H.L., Lin J., Huyton T., Hopkins E.J., Reid H.H., Wilce M.C., Kabat J., Borrego F., Coligan J.E., Rossjohn J., Brooks A.G.
      Immunity 27:900-911(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 113-232 IN COMPLEX WITH KLRD1, SUBUNIT, DISULFIDE BONDS.
    8. "CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence."
      Petrie E.J., Clements C.S., Lin J., Sullivan L.C., Johnson D., Huyton T., Heroux A., Hoare H.L., Beddoe T., Reid H.H., Wilce M.C., Brooks A.G., Rossjohn J.
      J. Exp. Med. 205:725-735(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF 113-232 IN COMPLEX WITH KLRD1, SUBUNIT, DISULFIDE BONDS.
    9. Cited for: X-RAY CRYSTALLOGRAPHY (4.41 ANGSTROMS) OF 113-232 IN COMPLEX WITH KLRD1, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiNKG2A_HUMAN
    AccessioniPrimary (citable) accession number: P26715
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3