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P26715 (NKG2A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NKG2-A/NKG2-B type II integral membrane protein
Alternative name(s):
CD159 antigen-like family member A
NK cell receptor A
NKG2-A/B-activating NK receptor
CD_antigen=CD159a
Gene names
Name:KLRC1
Synonyms:NKG2A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Subunit structure

Can form disulfide-bonded heterodimer with CD94. Ref.7 Ref.8 Ref.9

Subcellular location

Membrane; Single-pass type II membrane protein.

Tissue specificity

Natural killer cells.

Sequence similarities

Contains 1 C-type lectin domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform NKG2-A (identifier: P26715-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform NKG2-B (identifier: P26715-2)

The sequence of this isoform differs from the canonical sequence as follows:
     96-113: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 233233NKG2-A/NKG2-B type II integral membrane protein
PRO_0000046659

Regions

Topological domain1 – 7070Cytoplasmic Potential
Transmembrane71 – 9323Helical; Signal-anchor for type II membrane protein; Potential
Topological domain94 – 233140Extracellular Potential
Domain118 – 231114C-type lectin

Amino acid modifications

Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1511N-linked (GlcNAc...) Potential
Glycosylation1801N-linked (GlcNAc...) Potential
Disulfide bond116Interchain (with C-59 in KLRD1) Ref.7 Ref.8 Ref.9
Disulfide bond119 ↔ 130 Ref.7 Ref.8 Ref.9
Disulfide bond147 ↔ 229 Ref.7 Ref.8 Ref.9
Disulfide bond208 ↔ 221 Ref.7 Ref.8 Ref.9

Natural variations

Alternative sequence96 – 11318Missing in isoform NKG2-B.
VSP_003062
Natural variant291N → S. Ref.1 Ref.2 Ref.3 Ref.4 Ref.6
Corresponds to variant rs2253849 [ dbSNP | Ensembl ].
VAR_050120

Secondary structure

................... 233
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform NKG2-A [UniParc].

Last modified January 11, 2011. Version 2.
Checksum: 93879A5C8D110C62

FASTA23326,314
        10         20         30         40         50         60 
MDNQGVIYSD LNLPPNPKRQ QRKPKGNKNS ILATEQEITY AELNLQKASQ DFQGNDKTYH 

        70         80         90        100        110        120 
CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSTLIQR HNNSSLNTRT QKARHCGHCP 

       130        140        150        160        170        180 
EEWITYSNSC YYIGKERRTW EESLLACTSK NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN 

       190        200        210        220        230 
SSHHPWVTMN GLAFKHEIKD SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKL 

« Hide

Isoform NKG2-B [UniParc].

Checksum: FEEE7322C85B2EAE
Show »

FASTA21524,250

References

« Hide 'large scale' references
[1]"DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells."
Houchins J.P., Yabe T., McSherry C., Bach F.H.
J. Exp. Med. 173:1017-1020(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS NKG2-A AND NKG2-B), VARIANT SER-29.
[2]"Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene."
Plougastel B., Jones T., Trowsdale J.
Immunogenetics 44:286-291(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS NKG2-A AND NKG2-B), VARIANT SER-29.
[3]"Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes."
Plougastel B., Trowsdale J.
Genomics 49:193-199(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS NKG2-A AND NKG2-B), VARIANT SER-29.
[4]"Identification and characterization of the NKG2A gene from large granular lymphocytic leukemia (LGL) cells."
Kothapalli R., Kusmartseva I., Loughran T.P. Jr.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-29.
[5]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS NKG2-A AND NKG2-B), VARIANT SER-29.
Tissue: Blood and Kidney.
[7]"The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition."
Sullivan L.C., Clements C.S., Beddoe T., Johnson D., Hoare H.L., Lin J., Huyton T., Hopkins E.J., Reid H.H., Wilce M.C., Kabat J., Borrego F., Coligan J.E., Rossjohn J., Brooks A.G.
Immunity 27:900-911(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 113-232 IN COMPLEX WITH KLRD1, SUBUNIT, DISULFIDE BONDS.
[8]"CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence."
Petrie E.J., Clements C.S., Lin J., Sullivan L.C., Johnson D., Huyton T., Heroux A., Hoare H.L., Beddoe T., Reid H.H., Wilce M.C., Brooks A.G., Rossjohn J.
J. Exp. Med. 205:725-735(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF 113-232 IN COMPLEX WITH KLRD1, SUBUNIT, DISULFIDE BONDS.
[9]"Structural basis for NKG2A/CD94 recognition of HLA-E."
Kaiser B.K., Pizarro J.C., Kerns J., Strong R.K.
Proc. Natl. Acad. Sci. U.S.A. 105:6696-6701(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (4.41 ANGSTROMS) OF 113-232 IN COMPLEX WITH KLRD1, SUBUNIT, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54867 mRNA. Translation: CAA38649.1.
X54868 mRNA. Translation: CAA38650.1.
U54786 expand/collapse EMBL AC list , U54783, U54784, U54785 Genomic DNA. Translation: AAB17133.1.
AF023840 Genomic DNA. Translation: AAC17488.1.
AF461812 mRNA. Translation: AAL65234.1.
AC068775 Genomic DNA. No translation available.
BC012550 mRNA. Translation: AAH12550.1.
BC053840 mRNA. Translation: AAH53840.1.
CCDSCCDS8625.1. [P26715-1]
CCDS8626.1. [P26715-2]
PIRPT0372.
RefSeqNP_002250.1. NM_002259.4.
NP_015567.1. NM_007328.3.
NP_998822.1. NM_213657.2.
NP_998823.1. NM_213658.2.
UniGeneHs.512576.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMXNMR-B1-15[»]
2YU7NMR-B33-47[»]
3BDWX-ray2.50B/D113-232[»]
3CDGX-ray3.40F/K113-232[»]
3CIIX-ray4.41H/J113-232[»]
ProteinModelPortalP26715.
SMRP26715. Positions 113-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110020. 1 interaction.
STRING9606.ENSP00000352064.

PTM databases

PhosphoSiteP26715.

Polymorphism databases

DMDM317373399.

Proteomic databases

PaxDbP26715.
PRIDEP26715.

Protocols and materials databases

DNASU3821.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000347831; ENSP00000256965; ENSG00000134545. [P26715-2]
ENST00000359151; ENSP00000352064; ENSG00000134545. [P26715-1]
ENST00000408006; ENSP00000385304; ENSG00000134545. [P26715-2]
ENST00000544822; ENSP00000438038; ENSG00000134545. [P26715-1]
GeneID3821.
KEGGhsa:3821.
UCSCuc001qyl.3. human. [P26715-1]
uc001qym.3. human. [P26715-2]

Organism-specific databases

CTD3821.
GeneCardsGC12M010598.
HGNCHGNC:6374. KLRC1.
MIM161555. gene.
neXtProtNX_P26715.
PharmGKBPA30163.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146673.
HOGENOMHOG000220925.
HOVERGENHBG077044.
InParanoidP26715.
KOK06541.
OMATEQEIIY.
PhylomeDBP26715.
TreeFamTF336674.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressP26715.
BgeeP26715.
CleanExHS_KLRC1.
GenevestigatorP26715.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP26715.
GenomeRNAi3821.
NextBio15019.
PROP26715.
SOURCESearch...

Entry information

Entry nameNKG2A_HUMAN
AccessionPrimary (citable) accession number: P26715
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries