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P26697

- GSTA3_CHICK

UniProt

P26697 - GSTA3_CHICK

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Protein
Glutathione S-transferase 3
Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Glutathione

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

SABIO-RKP26697.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 3 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha
GST-CL3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 229228Glutathione S-transferase 3
PRO_0000185800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Blocked amino end (Ala)

Proteomic databases

PaxDbiP26697.

Interactioni

Subunit structurei

Homodimer or heterodimer (with a subunit from group CL-4).

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036177.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 94
Turni14 – 163
Helixi17 – 259
Beta strandi31 – 344
Helixi38 – 4710
Beta strandi57 – 604
Beta strandi63 – 675
Helixi68 – 7811
Helixi86 – 10419
Turni105 – 1073
Helixi109 – 1113
Helixi114 – 13017
Helixi132 – 14312
Beta strandi146 – 1494
Helixi155 – 17016
Turni172 – 1776
Helixi179 – 19012
Helixi192 – 1987
Helixi210 – 22011

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VF1X-ray1.77A1-229[»]
1VF2X-ray2.15A/B1-229[»]
1VF3X-ray2.15A/B1-229[»]
1VF4X-ray2.45A1-229[»]
ProteinModelPortaliP26697.
SMRiP26697. Positions 2-228.

Miscellaneous databases

EvolutionaryTraceiP26697.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminal
Add
BLAST
Domaini85 – 207123GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 552Glutathione binding
Regioni67 – 682Glutathione binding

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.

Phylogenomic databases

eggNOGiNOG266414.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiP26697.
KOiK00799.
PhylomeDBiP26697.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26697-1 [UniParc]FASTAAdd to Basket

« Hide

MAAKPVLYYF NGRGKMESIR WLLAAAGVEF EEVFLETREQ YEKLLQSGIL    50
MFQQVPMVEI DGMKLVQTRA ILNYIAGKYN LYGKDLKERA LIDMYVGGTD 100
DLMGFLLSFP FLSAEDKVKQ CAFVVEKATS RYFPAYEKVL KDHGQDFLVG 150
NRLSWADIHL LEAILMVEEK KSDALSGFPL LQAFKKRISS IPTIKKFLAP 200
GSKRKPISDD KYVETVRRVL RMYYDVKPH 229
Length:229
Mass (Da):26,326
Last modified:January 23, 2007 - v2
Checksum:iEA30D949034BD8DB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451L → V.
Natural varianti47 – 471S → A.
Natural varianti49 – 491I → F.
Natural varianti49 – 491I → V.
Natural varianti52 – 521F → R.
Natural varianti129 – 1302TS → AN.
Natural varianti135 – 1362AY → VF.
Natural varianti155 – 1551W → R.
Natural varianti158 – 1592IH → VV.
Natural varianti163 – 1631A → T.
Natural varianti166 – 1661M → A.
Natural varianti168 – 1681E → V.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M38219 mRNA. Translation: AAA62731.1.
PIRiS19734.
RefSeqiNP_990743.1. NM_205412.1.
UniGeneiGga.788.

Genome annotation databases

GeneIDi396380.
KEGGigga:396380.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M38219 mRNA. Translation: AAA62731.1 .
PIRi S19734.
RefSeqi NP_990743.1. NM_205412.1.
UniGenei Gga.788.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VF1 X-ray 1.77 A 1-229 [» ]
1VF2 X-ray 2.15 A/B 1-229 [» ]
1VF3 X-ray 2.15 A/B 1-229 [» ]
1VF4 X-ray 2.45 A 1-229 [» ]
ProteinModelPortali P26697.
SMRi P26697. Positions 2-228.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000036177.

Proteomic databases

PaxDbi P26697.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396380.
KEGGi gga:396380.

Phylogenomic databases

eggNOGi NOG266414.
HOGENOMi HOG000115734.
HOVERGENi HBG053749.
InParanoidi P26697.
KOi K00799.
PhylomeDBi P26697.

Enzyme and pathway databases

SABIO-RK P26697.

Miscellaneous databases

EvolutionaryTracei P26697.
NextBioi 20816422.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of a chick liver glutathione S-transferase CL 3 subunit with the use of a baculovirus expression system."
    Chang L.-H., Fan J.-Y., Liu L.-F., Tsai S.-P., Tam M.F.
    Biochem. J. 281:545-551(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: White leghorn.
    Tissue: Liver.

Entry informationi

Entry nameiGSTA3_CHICK
AccessioniPrimary (citable) accession number: P26697
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The variations were found from AA sequencing and imply there are multiple forms of CL-3.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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