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Protein

Endothelin-1 receptor

Gene

Ednra

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

GO - Molecular functioni

  • endothelin receptor activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • endothelin receptor signaling pathway Source: GOC
  • enteric nervous system development Source: InterPro
  • fibroblast proliferation Source: RGD
  • glomerular filtration Source: RGD
  • histamine secretion Source: RGD
  • maternal process involved in parturition Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • penile erection Source: RGD
  • positive regulation of calcium ion transport Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of inflammatory response Source: RGD
  • positive regulation of kidney development Source: RGD
  • positive regulation of neutrophil chemotaxis Source: RGD
  • positive regulation of odontogenesis Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • positive regulation of release of sequestered calcium ion into cytosol Source: RGD
  • protein kinase C-activating G-protein coupled receptor signaling pathway Source: RGD
  • regulation of blood pressure Source: InterPro
  • regulation of epithelial cell proliferation Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to morphine Source: RGD
  • response to organic cyclic compound Source: RGD
  • Rho protein signal transduction Source: RGD
  • sensory perception of pain Source: RGD
  • smooth muscle cell proliferation Source: RGD
  • vasoconstriction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1 receptor
Alternative name(s):
Endothelin A receptor
Short name:
ET-A
Short name:
ET-AR
Gene namesi
Name:Ednra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2535. Ednra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 8060ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10222Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini103 – 11210CytoplasmicSequence analysis
Transmembranei113 – 13220Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini133 – 15927ExtracellularSequence analysisAdd
BLAST
Transmembranei160 – 18122Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini182 – 20524CytoplasmicSequence analysisAdd
BLAST
Transmembranei206 – 22924Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini230 – 25627ExtracellularSequence analysisAdd
BLAST
Transmembranei257 – 27822Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini279 – 30628CytoplasmicSequence analysisAdd
BLAST
Transmembranei307 – 32822Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini329 – 34719ExtracellularSequence analysisAdd
BLAST
Transmembranei348 – 37225Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini373 – 42654CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: RGD
  • nuclear membrane Source: RGD
  • T-tubule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2111453.
GuidetoPHARMACOLOGYi219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 426406Endothelin-1 receptorPRO_0000012724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Disulfide bondi158 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP26684.

PTM databases

PhosphoSiteiP26684.

Expressioni

Tissue specificityi

Predominantly expressed in vascular smooth muscle cells of a variety of issues, bronchial smooth muscle cells, myocardium, and the pituitary gland.

Interactioni

Subunit structurei

Interacts with HDAC7 and KAT5.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054967.

Chemistry

BindingDBiP26684.

Structurei

3D structure databases

ProteinModelPortaliP26684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP26684.
KOiK04197.
OrthoDBiEOG7HHWS4.
PhylomeDBiP26684.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVLCFLASF WLALVGGAIA DNAERYSANL SSHVEDFTPF PGTEFNFLGT
60 70 80 90 100
TLQPPNLALP SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT
110 120 130 140 150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH
160 170 180 190 200
NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL
210 220 230 240 250
ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGEQHRTCM LNATTKFMEF
260 270 280 290 300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
310 320 330 340 350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM
360 370 380 390 400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM
410 420
NGTSIQWKNQ EQNHNTERSS HKDSMN
Length:426
Mass (Da):48,245
Last modified:July 1, 1993 - v2
Checksum:iE8A24683DBB78BB8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461N → D in AAA41114 (PubMed:1849646).Curated
Sequence conflicti53 – 531Q → R in AAA41114 (PubMed:1849646).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60786 mRNA. Translation: AAA41114.1.
PIRiA40440.
RefSeqiNP_036682.1. NM_012550.2.
XP_006255482.1. XM_006255420.2.
XP_008770693.1. XM_008772471.1.
UniGeneiRn.10915.

Genome annotation databases

GeneIDi24326.
KEGGirno:24326.
UCSCiRGD:2535. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60786 mRNA. Translation: AAA41114.1.
PIRiA40440.
RefSeqiNP_036682.1. NM_012550.2.
XP_006255482.1. XM_006255420.2.
XP_008770693.1. XM_008772471.1.
UniGeneiRn.10915.

3D structure databases

ProteinModelPortaliP26684.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054967.

Chemistry

BindingDBiP26684.
ChEMBLiCHEMBL2111453.
GuidetoPHARMACOLOGYi219.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP26684.

Proteomic databases

PaxDbiP26684.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24326.
KEGGirno:24326.
UCSCiRGD:2535. rat.

Organism-specific databases

CTDi1909.
RGDi2535. Ednra.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP26684.
KOiK04197.
OrthoDBiEOG7HHWS4.
PhylomeDBiP26684.
TreeFamiTF331292.

Miscellaneous databases

NextBioi602991.
PROiP26684.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors."
    Hori S., Komatsu Y., Shigemoto R., Mizuno N., Nakanishi S.
    Endocrinology 130:1885-1895(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor."
    Lin H.Y., Kaji E.H., Winkel G.K., Ives H.E., Lodish H.F.
    Proc. Natl. Acad. Sci. U.S.A. 88:3185-3189(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiEDNRA_RAT
AccessioniPrimary (citable) accession number: P26684
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 1, 1993
Last modified: May 11, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.