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Protein

Protein son of sevenless

Gene

Sos

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development.2 Publications

GO - Molecular functioni

  • DNA binding Source: InterPro
  • protein heterodimerization activity Source: InterPro
  • Rac guanyl-nucleotide exchange factor activity Source: FlyBase
  • Ras guanyl-nucleotide exchange factor activity Source: FlyBase

GO - Biological processi

  • anterior/posterior axis specification, embryo Source: FlyBase
  • axon midline choice point recognition Source: FlyBase
  • defense response to virus Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • negative regulation of G1/S transition of mitotic cell cycle Source: FlyBase
  • positive regulation of Rac protein signal transduction Source: FlyBase
  • positive regulation of Ras protein signal transduction Source: FlyBase
  • regulation of Rho protein signal transduction Source: InterPro
  • sevenless signaling pathway Source: FlyBase
  • small GTPase mediated signal transduction Source: InterPro
  • torso signaling pathway Source: FlyBase
  • tracheal outgrowth, open tracheal system Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, Guanine-nucleotide releasing factor
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-DME-112412 SOS-mediated signalling
R-DME-1433557 Signaling by SCF-KIT
R-DME-1433559 Regulation of KIT signaling
R-DME-179812 GRB2 events in EGFR signaling
R-DME-180336 SHC1 events in EGFR signaling
R-DME-193648 NRAGE signals death through JNK
R-DME-194840 Rho GTPase cycle
R-DME-1963640 GRB2 events in ERBB2 signaling
R-DME-210993 Tie2 Signaling
R-DME-2179392 EGFR Transactivation by Gastrin
R-DME-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-DME-375165 NCAM signaling for neurite out-growth
R-DME-416482 G alpha (12/13) signalling events
R-DME-5654693 FRS-mediated FGFR1 signaling
R-DME-5654699 SHC-mediated cascade:FGFR2
R-DME-5654700 FRS-mediated FGFR2 signaling
R-DME-5654704 SHC-mediated cascade:FGFR3
R-DME-5654706 FRS-mediated FGFR3 signaling
R-DME-5654712 FRS-mediated FGFR4 signaling
R-DME-5673001 RAF/MAP kinase cascade
R-DME-74749 Signal attenuation
R-DME-74751 Insulin receptor signalling cascade
SignaLinkiP26675

Names & Taxonomyi

Protein namesi
Recommended name:
Protein son of sevenless
Gene namesi
Name:Sos
ORF Names:CG7793
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001965 Sos

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688981 – 1596Protein son of sevenlessAdd BLAST1596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1550Phosphoserine1 Publication1
Modified residuei1551Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP26675
PRIDEiP26675

PTM databases

iPTMnetiP26675

Expressioni

Gene expression databases

BgeeiFBgn0001965
ExpressionAtlasiP26675 baseline and differential
GenevisibleiP26675 DM

Interactioni

Subunit structurei

May form a complex with sevenless and DRK.

GO - Molecular functioni

  • protein heterodimerization activity Source: InterPro
  • Rac guanyl-nucleotide exchange factor activity Source: FlyBase
  • Ras guanyl-nucleotide exchange factor activity Source: FlyBase

Protein-protein interaction databases

BioGridi60823, 40 interactors
DIPiDIP-22308N
IntActiP26675, 12 interactors
STRINGi7227.FBpp0080118

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AZENMR-B1342-1350[»]
ProteinModelPortaliP26675
SMRiP26675
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26675

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 434DHPROSITE-ProRule annotationAdd BLAST187
Domaini480 – 588PHPROSITE-ProRule annotationAdd BLAST109
Domaini637 – 792N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST156
Domaini829 – 1066Ras-GEFPROSITE-ProRule annotationAdd BLAST238

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 51Gly-richAdd BLAST48
Compositional biasi1110 – 1146Ala-richAdd BLAST37
Compositional biasi1519 – 1542His-richAdd BLAST24

Phylogenomic databases

eggNOGiKOG3417 Eukaryota
ENOG410XR96 LUCA
InParanoidiP26675
KOiK03099
OMAiFQDLNNF
OrthoDBiEOG091G04UL
PhylomeDBiP26675

Family and domain databases

CDDicd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.10.20.10, 1 hit
1.10.840.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF00169 PH, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
SSF48065 SSF48065, 1 hit
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P26675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSGPSGHAH TISYGGGIGL GTGGGGGSGG SGSGSQGGGG GIGIGGGGVA
60 70 80 90 100
GLQDCDGYDF TKCENAARWR GLFTPSLKKV LEQVHPRVTA KEDALLYVEK
110 120 130 140 150
LCLRLLAMLC AKPLPHSVQD VEEKVNKSFP APIDQWALNE AKEVINSKKR
160 170 180 190 200
KSVLPTEKVH TLLQKDVLQY KIDSSVSAFL VAVLEYISAD ILKMAGDYVI
210 220 230 240 250
KIAHCEITKE DIEVVMNADR VLMDMLNQSE AHILPSPLSL PAQRASATYE
260 270 280 290 300
ETVKELIHDE KQYQRDLHMI IRVFREELVK IVSDPRELEP IFSNIMDIYE
310 320 330 340 350
VTVTLLGSLE DVIEMSQEQS APCVGSCFEE LAEAEEFDVY KKYAYDVTSQ
360 370 380 390 400
ASRDALNNLL SKPGASSLTT AGHGFRDAVK YYLPKLLLVP ICHAFVYFDY
410 420 430 440 450
IKHLKDLSSS QDDIESFEQV QGLLHPLHCD LEKVMASLSK ERQVPVSGRV
460 470 480 490 500
RRQLAIERTR ELQMKVEHWE DKDVGQNCNE FIREDSLSKL GSGKRIWSER
510 520 530 540 550
KVFLFDGLMV LCKANTKKQT PSAGATAYDY RLKEKYFMRR VDINDRPDSD
560 570 580 590 600
DLKNSFELAP RMQPPIVLTA KNAQHKHDWM ADLLMVITKS MLDRHLDSIL
610 620 630 640 650
QDIERKHPLR MPSPEIYKFA VPDSGDNIVL EERESAGVPM IKGATLCKLI
660 670 680 690 700
ERLTYHIYAD PTFVRTFLTT YRYFCSPQQL LQLLVERFNI PDPSLVYQDT
710 720 730 740 750
GTAGAGGMGG VGGDKEHKNS HREDWKRYRK EYVQPVQFRV LNVLRHWVDH
760 770 780 790 800
HFYDFEKDPM LLEKLLNFLE HVNGKSMRKW VDSVLKIVQR KNEQEKSNKK
810 820 830 840 850
IVYAYGHDPP PIEHHLSVPN DEITLLTLHP LELARQLTLL EFEMYKNVKP
860 870 880 890 900
SELVGSPWTK KDKEVKSPNL LKIMKHTTNV TRWIEKSITE AENYEERLAI
910 920 930 940 950
MQRAIEVMMV MLELNNFNGI LSIVAAMGTA SVYRLRWTFQ GLPERYRKFL
960 970 980 990 1000
EECRELSDDH LKKYQERLRS INPPCVPFFG RYLTNILHLE EGNPDLLANT
1010 1020 1030 1040 1050
ELINFSKRRK VAEIIGEIQQ YQNQPYCLNE ESTIRQFFEQ LDPFNGLSDK
1060 1070 1080 1090 1100
QMSDYLYNES LRIEPRGCKT VPKFPRKWPH IPLKSPGIKP RRQNQTNSSS
1110 1120 1130 1140 1150
KLSNSTSSVA AAAAASSTAT SIATASAPSL HASSIMDAPT AAAANAGSGT
1160 1170 1180 1190 1200
LAGEQSPQHN PHAFSVFAPV IIPERNTSSW SGTPQHTRTD QNNGEVSVPA
1210 1220 1230 1240 1250
PHLPKKPGAH VWANNNSTLA SASAMDVVFS PALPEHLPPQ SLPDSNPFAS
1260 1270 1280 1290 1300
DTEAPPSPLP KLVVSPRHET GNRSPFHGRM QNSPTHSTAS TVTLTGMSTS
1310 1320 1330 1340 1350
GGEEFCAGGF YFNSAHQGQP GAVPISPHVN VPMATNMEYR AVPPPLPPRR
1360 1370 1380 1390 1400
KERTESCADM AQKRQAPDAP TLPPRDGELS PPPIPPRLNH STGISYLRQS
1410 1420 1430 1440 1450
HGKSKEFVGN SSLLLPNTSS IMIRRNSAIE KRAAATSQPN QAAAGPISTT
1460 1470 1480 1490 1500
LVTVSQAVAT DEPLPLPISP AASSSTTTSP LTPAMSPMSP NIPSHPVEST
1510 1520 1530 1540 1550
SSSYAHQLRM RQQQQQQTHP AIYSQHHQHH ATHLPHHPHQ HHSNPTQSRS
1560 1570 1580 1590
SPKEFFPIAT SLEGTPKLPP KPSLSANFYN NPDKGTMFLY PSTNEE
Length:1,596
Mass (Da):177,934
Last modified:September 27, 2005 - v2
Checksum:i08DB85B59213B964
GO

Sequence cautioni

The sequence AAL13978 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15G → W in AAT94523 (Ref. 6) Curated1
Sequence conflicti232 – 244HILPS…LPAQR → TSCPVPCHFPRS (PubMed:1736363).CuratedAdd BLAST13
Sequence conflicti523A → T in AAT94523 (Ref. 6) Curated1
Sequence conflicti1463P → V in AAB04680 (PubMed:1736363).Curated1
Sequence conflicti1468I → V in AAT94523 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti1256P → L in strain: St_L028 and St_L033. 1
Natural varianti1322A → S in strain: In_L019. 1
Natural varianti1503S → N in strain: In_L019. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83931 mRNA Translation: AAB04680.1
M77501 Genomic DNA Translation: AAA28904.1
AE014134 Genomic DNA Translation: AAF53336.2
BT015294 mRNA Translation: AAT94523.1
AY058749 mRNA Translation: AAL13978.1 Different initiation.
AF459566 Genomic DNA Translation: AAN61382.1
AF459567 Genomic DNA Translation: AAN61383.1
AF459568 Genomic DNA Translation: AAN61384.1
AF459569 Genomic DNA Translation: AAN61385.1
AF459570 Genomic DNA Translation: AAN61386.1
AF459571 Genomic DNA Translation: AAN61387.1
AF459572 Genomic DNA Translation: AAN61388.1
AF459573 Genomic DNA Translation: AAN61389.1
AF459574 Genomic DNA Translation: AAN61390.1
AF459575 Genomic DNA Translation: AAN61391.1
AF459576 Genomic DNA Translation: AAN61392.1
AF459577 Genomic DNA Translation: AAN61393.1
AF459578 Genomic DNA Translation: AAN61394.1
AF459579 Genomic DNA Translation: AAN61395.1
AF459580 Genomic DNA Translation: AAN61396.1
AF459581 Genomic DNA Translation: AAN61397.1
AF459582 Genomic DNA Translation: AAN61398.1
AF459583 Genomic DNA Translation: AAN61399.1
AF459584 Genomic DNA Translation: AAN61400.1
AF459585 Genomic DNA Translation: AAN61401.1
PIRiA41216
RefSeqiNP_476597.2, NM_057249.6

Genome annotation databases

EnsemblMetazoaiFBtr0080541; FBpp0080118; FBgn0001965
GeneIDi34790
KEGGidme:Dmel_CG7793

Similar proteinsi

Entry informationi

Entry nameiSOS_DROME
AccessioniPrimary (citable) accession number: P26675
Secondary accession number(s): Q6AWF4
, Q8I067, Q8I0F7, Q8ITK2, Q95TI8, Q969D6, Q9VJV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 27, 2005
Last modified: May 23, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health