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P26674 (STE6_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ste6
Gene names
Name:ste6
ORF Names:SPCC1442.01, SPCC1450.17
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length911 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Promotes the exchange of RAS-bound GDP by GTP. This protein is essential for mating.

Sequence similarities

Contains 1 N-terminal Ras-GEF domain.

Contains 1 Ras-GEF domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 911911Protein ste6
PRO_0000068899

Regions

Domain1 – 6060SH3
Domain489 – 623135N-terminal Ras-GEF
Domain663 – 894232Ras-GEF

Sequences

Sequence LengthMass (Da)Tools
P26674 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 5F8C12D20C4B753F

FASTA911105,186
        10         20         30         40         50         60 
MRFQTTAISD YENSSNPSFL KFSAGDTIIV IEVLEDGWCD GICSEKRGWF PTSCIDSSKI 

        70         80         90        100        110        120 
QNFFSSFHSS NEKDPNAQCC APFHVEAHLQ DSAWFEKHGV QAINSIPSSE EFLRKNLQND 

       130        140        150        160        170        180 
IHHLVKGILT TAAAVSQSIK KEGTQVIVFG IETVRSMVLS FPLIILSTLD ENFLSEVAQV 

       190        200        210        220        230        240 
FSSLNLLPEL SRMGCTYGEL CIRFTKLLKQ LANKFLFFFR PDVSFPSYFL GSLIAHEIHF 

       250        260        270        280        290        300 
LPWDFNMLCS NSVQSAHTNL QPDITSFVAI LSLSHEAYHC TENEFWNLEA QKLTENTTQK 

       310        320        330        340        350        360 
VLQLVAEDAL EAWKLDILED IDRCIQCCRR FLSANQRINY SSSENNPFSF TSQDVEALKD 

       370        380        390        400        410        420 
ELSSNLCDLY LWSIDLEQIS PSDCLLDNYS LFVDLLVTLK VSLLRIKSII VQFSERIVFL 

       430        440        450        460        470        480 
SLEYKFLTNI QPELNDAEKS QLDGFDLNKT NWFDSKGLVC YLMKQTSPEP LLIRNLLFSF 

       490        500        510        520        530        540 
WSCNGKIEQD GKIKTATLVF IINYLLRTDI DSTFFTTIFL NTYASMISSS DLFSILGAHF 

       550        560        570        580        590        600 
RFICSLNFGK ISFISHEFYR VSKRFLDILL IWFESYLVEE LDNSKSIFFL FKIYKVFEVF 

       610        620        630        640        650        660 
VVPHFASAEE LLHSLSHLLH HPSTKRSHKM LEGKELSQEL EDLSLHNSPD PIIYKDELVL 

       670        680        690        700        710        720 
LLPPREIAKQ LCILEFQSFS HISRIQFLTK IWDNLNRFSP KEKTSTFYLS NHLVNFVTET 

       730        740        750        760        770        780 
IVQEEEPRRR TNVLAYFIQV CDYLRELNNF ASLFSIISAL NSSPIHRLRK TWANLNSKTL 

       790        800        810        820        830        840 
ASFELLNNLT EARKNFSNYR DCLENCVLPC VPFLGVYFTD LTFLKTGNKD NFQNMINFDK 

       850        860        870        880        890        900 
RTKVTRILNE IKKFQSVGYM FNPINEVQEL LNEVISRERN TNNIYQRSLT VEPRESEDQA 

       910 
LQRLLIDSGI F 

« Hide

References

« Hide 'large scale' references
[1]"Homologous activators of ras in fission and budding yeast."
Hughes D.A., Fukui Y., Yamamoto M.
Nature 344:355-357(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53254 Genomic DNA. Translation: CAA37345.1.
CU329672 Genomic DNA. Translation: CAB40184.1.
PIRS28098.
RefSeqNP_588316.1. NM_001023306.2.

3D structure databases

ProteinModelPortalP26674.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275308. 15 interactions.
MINTMINT-4687960.
STRING4896.SPCC1442.01-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC1442.01.1; SPCC1442.01.1:pep; SPCC1442.01.
GeneID2538724.
KEGGspo:SPCC1442.01.

Organism-specific databases

PomBaseSPCC1442.01.

Phylogenomic databases

eggNOGNOG265981.
OrthoDBEOG78WM2F.

Family and domain databases

Gene3D1.10.840.10. 1 hit.
InterProIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR008937. Ras_GEF.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR001452. SH3_domain.
[Graphical view]
PANTHERPTHR23113. PTHR23113. 1 hit.
PfamPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20799909.

Entry information

Entry nameSTE6_SCHPO
AccessionPrimary (citable) accession number: P26674
Secondary accession number(s): Q9UUM8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names