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P26674

- STE6_SCHPO

UniProt

P26674 - STE6_SCHPO

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Protein

Protein ste6

Gene

ste6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Promotes the exchange of RAS-bound GDP by GTP. This protein is essential for mating.

GO - Molecular functioni

  1. GTPase regulator activity Source: PomBase
  2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

GO - Biological processi

  1. conjugation with cellular fusion Source: PomBase
  2. pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: PomBase
  3. regulation of catalytic activity Source: GOC
  4. regulation of small GTPase mediated signal transduction Source: InterPro
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_236142. G alpha (12/13) signalling events.
REACT_249602. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ste6
Gene namesi
Name:ste6
ORF Names:SPCC1442.01, SPCC1450.17
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC1442.01.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 911911Protein ste6PRO_0000068899Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi275308. 15 interactions.
MINTiMINT-4687960.
STRINGi4896.SPCC1442.01-1.

Structurei

3D structure databases

ProteinModelPortaliP26674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6060SH3PROSITE-ProRule annotationAdd
BLAST
Domaini489 – 623135N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini663 – 894232Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG265981.
InParanoidiP26674.
OMAiQFSERIV.
OrthoDBiEOG78WM2F.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26674-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRFQTTAISD YENSSNPSFL KFSAGDTIIV IEVLEDGWCD GICSEKRGWF
60 70 80 90 100
PTSCIDSSKI QNFFSSFHSS NEKDPNAQCC APFHVEAHLQ DSAWFEKHGV
110 120 130 140 150
QAINSIPSSE EFLRKNLQND IHHLVKGILT TAAAVSQSIK KEGTQVIVFG
160 170 180 190 200
IETVRSMVLS FPLIILSTLD ENFLSEVAQV FSSLNLLPEL SRMGCTYGEL
210 220 230 240 250
CIRFTKLLKQ LANKFLFFFR PDVSFPSYFL GSLIAHEIHF LPWDFNMLCS
260 270 280 290 300
NSVQSAHTNL QPDITSFVAI LSLSHEAYHC TENEFWNLEA QKLTENTTQK
310 320 330 340 350
VLQLVAEDAL EAWKLDILED IDRCIQCCRR FLSANQRINY SSSENNPFSF
360 370 380 390 400
TSQDVEALKD ELSSNLCDLY LWSIDLEQIS PSDCLLDNYS LFVDLLVTLK
410 420 430 440 450
VSLLRIKSII VQFSERIVFL SLEYKFLTNI QPELNDAEKS QLDGFDLNKT
460 470 480 490 500
NWFDSKGLVC YLMKQTSPEP LLIRNLLFSF WSCNGKIEQD GKIKTATLVF
510 520 530 540 550
IINYLLRTDI DSTFFTTIFL NTYASMISSS DLFSILGAHF RFICSLNFGK
560 570 580 590 600
ISFISHEFYR VSKRFLDILL IWFESYLVEE LDNSKSIFFL FKIYKVFEVF
610 620 630 640 650
VVPHFASAEE LLHSLSHLLH HPSTKRSHKM LEGKELSQEL EDLSLHNSPD
660 670 680 690 700
PIIYKDELVL LLPPREIAKQ LCILEFQSFS HISRIQFLTK IWDNLNRFSP
710 720 730 740 750
KEKTSTFYLS NHLVNFVTET IVQEEEPRRR TNVLAYFIQV CDYLRELNNF
760 770 780 790 800
ASLFSIISAL NSSPIHRLRK TWANLNSKTL ASFELLNNLT EARKNFSNYR
810 820 830 840 850
DCLENCVLPC VPFLGVYFTD LTFLKTGNKD NFQNMINFDK RTKVTRILNE
860 870 880 890 900
IKKFQSVGYM FNPINEVQEL LNEVISRERN TNNIYQRSLT VEPRESEDQA
910
LQRLLIDSGI F
Length:911
Mass (Da):105,186
Last modified:August 1, 1992 - v1
Checksum:i5F8C12D20C4B753F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53254 Genomic DNA. Translation: CAA37345.1.
CU329672 Genomic DNA. Translation: CAB40184.1.
PIRiS28098.
RefSeqiNP_588316.1. NM_001023306.2.

Genome annotation databases

EnsemblFungiiSPCC1442.01.1; SPCC1442.01.1:pep; SPCC1442.01.
GeneIDi2538724.
KEGGispo:SPCC1442.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53254 Genomic DNA. Translation: CAA37345.1 .
CU329672 Genomic DNA. Translation: CAB40184.1 .
PIRi S28098.
RefSeqi NP_588316.1. NM_001023306.2.

3D structure databases

ProteinModelPortali P26674.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275308. 15 interactions.
MINTi MINT-4687960.
STRINGi 4896.SPCC1442.01-1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC1442.01.1 ; SPCC1442.01.1:pep ; SPCC1442.01 .
GeneIDi 2538724.
KEGGi spo:SPCC1442.01.

Organism-specific databases

PomBasei SPCC1442.01.

Phylogenomic databases

eggNOGi NOG265981.
InParanoidi P26674.
OMAi QFSERIV.
OrthoDBi EOG78WM2F.

Enzyme and pathway databases

Reactomei REACT_236142. G alpha (12/13) signalling events.
REACT_249602. Rho GTPase cycle.

Miscellaneous databases

NextBioi 20799909.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
InterProi IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homologous activators of ras in fission and budding yeast."
    Hughes D.A., Fukui Y., Yamamoto M.
    Nature 344:355-357(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiSTE6_SCHPO
AccessioniPrimary (citable) accession number: P26674
Secondary accession number(s): Q9UUM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 26, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3