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P26674

- STE6_SCHPO

UniProt

P26674 - STE6_SCHPO

Protein

Protein ste6

Gene

ste6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Promotes the exchange of RAS-bound GDP by GTP. This protein is essential for mating.

    GO - Molecular functioni

    1. GTPase regulator activity Source: PomBase
    2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. conjugation with cellular fusion Source: PomBase
    2. pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: PomBase
    3. regulation of catalytic activity Source: GOC
    4. regulation of small GTPase mediated signal transduction Source: InterPro
    5. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_188314. PPARA activates gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ste6
    Gene namesi
    Name:ste6
    ORF Names:SPCC1442.01, SPCC1450.17
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC1442.01.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 911911Protein ste6PRO_0000068899Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    BioGridi275308. 15 interactions.
    MINTiMINT-4687960.
    STRINGi4896.SPCC1442.01-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP26674.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6060SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini489 – 623135N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini663 – 894232Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG265981.
    OMAiQFSERIV.
    OrthoDBiEOG78WM2F.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    SMARTiSM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26674-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRFQTTAISD YENSSNPSFL KFSAGDTIIV IEVLEDGWCD GICSEKRGWF    50
    PTSCIDSSKI QNFFSSFHSS NEKDPNAQCC APFHVEAHLQ DSAWFEKHGV 100
    QAINSIPSSE EFLRKNLQND IHHLVKGILT TAAAVSQSIK KEGTQVIVFG 150
    IETVRSMVLS FPLIILSTLD ENFLSEVAQV FSSLNLLPEL SRMGCTYGEL 200
    CIRFTKLLKQ LANKFLFFFR PDVSFPSYFL GSLIAHEIHF LPWDFNMLCS 250
    NSVQSAHTNL QPDITSFVAI LSLSHEAYHC TENEFWNLEA QKLTENTTQK 300
    VLQLVAEDAL EAWKLDILED IDRCIQCCRR FLSANQRINY SSSENNPFSF 350
    TSQDVEALKD ELSSNLCDLY LWSIDLEQIS PSDCLLDNYS LFVDLLVTLK 400
    VSLLRIKSII VQFSERIVFL SLEYKFLTNI QPELNDAEKS QLDGFDLNKT 450
    NWFDSKGLVC YLMKQTSPEP LLIRNLLFSF WSCNGKIEQD GKIKTATLVF 500
    IINYLLRTDI DSTFFTTIFL NTYASMISSS DLFSILGAHF RFICSLNFGK 550
    ISFISHEFYR VSKRFLDILL IWFESYLVEE LDNSKSIFFL FKIYKVFEVF 600
    VVPHFASAEE LLHSLSHLLH HPSTKRSHKM LEGKELSQEL EDLSLHNSPD 650
    PIIYKDELVL LLPPREIAKQ LCILEFQSFS HISRIQFLTK IWDNLNRFSP 700
    KEKTSTFYLS NHLVNFVTET IVQEEEPRRR TNVLAYFIQV CDYLRELNNF 750
    ASLFSIISAL NSSPIHRLRK TWANLNSKTL ASFELLNNLT EARKNFSNYR 800
    DCLENCVLPC VPFLGVYFTD LTFLKTGNKD NFQNMINFDK RTKVTRILNE 850
    IKKFQSVGYM FNPINEVQEL LNEVISRERN TNNIYQRSLT VEPRESEDQA 900
    LQRLLIDSGI F 911
    Length:911
    Mass (Da):105,186
    Last modified:August 1, 1992 - v1
    Checksum:i5F8C12D20C4B753F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53254 Genomic DNA. Translation: CAA37345.1.
    CU329672 Genomic DNA. Translation: CAB40184.1.
    PIRiS28098.
    RefSeqiNP_588316.1. NM_001023306.2.

    Genome annotation databases

    EnsemblFungiiSPCC1442.01.1; SPCC1442.01.1:pep; SPCC1442.01.
    GeneIDi2538724.
    KEGGispo:SPCC1442.01.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53254 Genomic DNA. Translation: CAA37345.1 .
    CU329672 Genomic DNA. Translation: CAB40184.1 .
    PIRi S28098.
    RefSeqi NP_588316.1. NM_001023306.2.

    3D structure databases

    ProteinModelPortali P26674.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275308. 15 interactions.
    MINTi MINT-4687960.
    STRINGi 4896.SPCC1442.01-1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC1442.01.1 ; SPCC1442.01.1:pep ; SPCC1442.01 .
    GeneIDi 2538724.
    KEGGi spo:SPCC1442.01.

    Organism-specific databases

    PomBasei SPCC1442.01.

    Phylogenomic databases

    eggNOGi NOG265981.
    OMAi QFSERIV.
    OrthoDBi EOG78WM2F.

    Enzyme and pathway databases

    Reactomei REACT_188314. PPARA activates gene expression.

    Miscellaneous databases

    NextBioi 20799909.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    InterProi IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    SMARTi SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homologous activators of ras in fission and budding yeast."
      Hughes D.A., Fukui Y., Yamamoto M.
      Nature 344:355-357(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiSTE6_SCHPO
    AccessioniPrimary (citable) accession number: P26674
    Secondary accession number(s): Q9UUM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3