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P26674

- STE6_SCHPO

UniProt

P26674 - STE6_SCHPO

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Protein
Protein ste6
Gene
ste6, SPCC1442.01, SPCC1450.17
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

Promotes the exchange of RAS-bound GDP by GTP. This protein is essential for mating.

GO - Molecular functioni

  1. GTPase regulator activity Source: PomBase
  2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

GO - Biological processi

  1. conjugation with cellular fusion Source: PomBase
  2. pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: PomBase
  3. regulation of catalytic activity Source: GOC
  4. regulation of small GTPase mediated signal transduction Source: InterPro
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_188314. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ste6
Gene namesi
Name:ste6
ORF Names:SPCC1442.01, SPCC1450.17
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC1442.01.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 911911Protein ste6
PRO_0000068899Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi275308. 15 interactions.
MINTiMINT-4687960.
STRINGi4896.SPCC1442.01-1.

Structurei

3D structure databases

ProteinModelPortaliP26674.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6060SH3
Add
BLAST
Domaini489 – 623135N-terminal Ras-GEF
Add
BLAST
Domaini663 – 894232Ras-GEF
Add
BLAST

Sequence similaritiesi

Contains 1 Ras-GEF domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG265981.
OMAiQFSERIV.
OrthoDBiEOG78WM2F.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26674-1 [UniParc]FASTAAdd to Basket

« Hide

MRFQTTAISD YENSSNPSFL KFSAGDTIIV IEVLEDGWCD GICSEKRGWF    50
PTSCIDSSKI QNFFSSFHSS NEKDPNAQCC APFHVEAHLQ DSAWFEKHGV 100
QAINSIPSSE EFLRKNLQND IHHLVKGILT TAAAVSQSIK KEGTQVIVFG 150
IETVRSMVLS FPLIILSTLD ENFLSEVAQV FSSLNLLPEL SRMGCTYGEL 200
CIRFTKLLKQ LANKFLFFFR PDVSFPSYFL GSLIAHEIHF LPWDFNMLCS 250
NSVQSAHTNL QPDITSFVAI LSLSHEAYHC TENEFWNLEA QKLTENTTQK 300
VLQLVAEDAL EAWKLDILED IDRCIQCCRR FLSANQRINY SSSENNPFSF 350
TSQDVEALKD ELSSNLCDLY LWSIDLEQIS PSDCLLDNYS LFVDLLVTLK 400
VSLLRIKSII VQFSERIVFL SLEYKFLTNI QPELNDAEKS QLDGFDLNKT 450
NWFDSKGLVC YLMKQTSPEP LLIRNLLFSF WSCNGKIEQD GKIKTATLVF 500
IINYLLRTDI DSTFFTTIFL NTYASMISSS DLFSILGAHF RFICSLNFGK 550
ISFISHEFYR VSKRFLDILL IWFESYLVEE LDNSKSIFFL FKIYKVFEVF 600
VVPHFASAEE LLHSLSHLLH HPSTKRSHKM LEGKELSQEL EDLSLHNSPD 650
PIIYKDELVL LLPPREIAKQ LCILEFQSFS HISRIQFLTK IWDNLNRFSP 700
KEKTSTFYLS NHLVNFVTET IVQEEEPRRR TNVLAYFIQV CDYLRELNNF 750
ASLFSIISAL NSSPIHRLRK TWANLNSKTL ASFELLNNLT EARKNFSNYR 800
DCLENCVLPC VPFLGVYFTD LTFLKTGNKD NFQNMINFDK RTKVTRILNE 850
IKKFQSVGYM FNPINEVQEL LNEVISRERN TNNIYQRSLT VEPRESEDQA 900
LQRLLIDSGI F 911
Length:911
Mass (Da):105,186
Last modified:August 1, 1992 - v1
Checksum:i5F8C12D20C4B753F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53254 Genomic DNA. Translation: CAA37345.1.
CU329672 Genomic DNA. Translation: CAB40184.1.
PIRiS28098.
RefSeqiNP_588316.1. NM_001023306.2.

Genome annotation databases

EnsemblFungiiSPCC1442.01.1; SPCC1442.01.1:pep; SPCC1442.01.
GeneIDi2538724.
KEGGispo:SPCC1442.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53254 Genomic DNA. Translation: CAA37345.1 .
CU329672 Genomic DNA. Translation: CAB40184.1 .
PIRi S28098.
RefSeqi NP_588316.1. NM_001023306.2.

3D structure databases

ProteinModelPortali P26674.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275308. 15 interactions.
MINTi MINT-4687960.
STRINGi 4896.SPCC1442.01-1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC1442.01.1 ; SPCC1442.01.1:pep ; SPCC1442.01 .
GeneIDi 2538724.
KEGGi spo:SPCC1442.01.

Organism-specific databases

PomBasei SPCC1442.01.

Phylogenomic databases

eggNOGi NOG265981.
OMAi QFSERIV.
OrthoDBi EOG78WM2F.

Enzyme and pathway databases

Reactomei REACT_188314. PPARA activates gene expression.

Miscellaneous databases

NextBioi 20799909.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
InterProi IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homologous activators of ras in fission and budding yeast."
    Hughes D.A., Fukui Y., Yamamoto M.
    Nature 344:355-357(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiSTE6_SCHPO
AccessioniPrimary (citable) accession number: P26674
Secondary accession number(s): Q9UUM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3