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Protein

Protein A46

Gene

VACWR172

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

BCL2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Acts close to the plasma membrane and targets several host TIR-domain containing adaptor proteins including MYD88, TIRAP, TRIF and TICAM2. In turn, blocks the host NF-kappa-B and TRIF-mediated IRF3 activation.2 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein A46
Gene namesi
Ordered Locus Names:VACWR172
ORF Names:A46R
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000993351 – 240Protein A46Add BLAST240

Interactioni

Subunit structurei

Tetramer (PubMed:27973613). Interacts with host MYD88, TRF4, TICAM2 and MAL (PubMed:20802145).2 Publications

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Beta strandi13 – 20Combined sources8
Turni21 – 24Combined sources4
Beta strandi25 – 32Combined sources8
Beta strandi35 – 41Combined sources7
Beta strandi47 – 54Combined sources8
Turni55 – 58Combined sources4
Beta strandi59 – 65Combined sources7
Beta strandi71 – 75Combined sources5
Helixi91 – 101Combined sources11
Turni102 – 104Combined sources3
Helixi108 – 114Combined sources7
Helixi117 – 124Combined sources8
Helixi127 – 132Combined sources6
Turni133 – 135Combined sources3
Helixi142 – 150Combined sources9
Turni151 – 156Combined sources6
Helixi158 – 173Combined sources16
Turni174 – 176Combined sources3
Helixi178 – 191Combined sources14
Helixi194 – 208Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LQKX-ray1.99A/B/C/D87-229[»]
5EZUX-ray1.55A/B1-83[»]
SMRiP26672.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae A46R protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000Q4.

Family and domain databases

InterProiView protein in InterPro
IPR022819. Poxvirus.
PfamiView protein in Pfam
PF06227. Poxvirus. 1 hit.

Sequencei

Sequence statusi: Complete.

P26672-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFDISVNAS KTINALVYFS TQQNKLVIRN EVNDTHYTVE FDRDKVVDTF
60 70 80 90 100
ISYNRHNDTI EIRGVLPEET NIGCAVNTPV SMTYLYNKYS FKLILAEYIR
110 120 130 140 150
HRNTISGNIY SALMTLDDLA IKQYGDIDLL FNEKLKVDSD SGLFDFVNFV
160 170 180 190 200
KDMICCDSRI VVALSSLVSK HWELTNKKYR CMALAEHISD SIPISELSRL
210 220 230 240
RYNLCKYLRG HTESIEDKFD YFEDDDSSTC SAVTDRETDV
Length:240
Mass (Da):27,635
Last modified:August 1, 1992 - v1
Checksum:i0D5F3324E187A665
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M72474 Genomic DNA. Translation: AAA48313.1.
D11079 Genomic DNA. Translation: BAA01820.1.
AY243312 Genomic DNA. Translation: AAO89451.1.
PIRiJQ1784.
RefSeqiYP_233054.1. NC_006998.1.

Genome annotation databases

GeneIDi3707702.
KEGGivg:3707702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M72474 Genomic DNA. Translation: AAA48313.1.
D11079 Genomic DNA. Translation: BAA01820.1.
AY243312 Genomic DNA. Translation: AAO89451.1.
PIRiJQ1784.
RefSeqiYP_233054.1. NC_006998.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LQKX-ray1.99A/B/C/D87-229[»]
5EZUX-ray1.55A/B1-83[»]
SMRiP26672.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707702.
KEGGivg:3707702.

Phylogenomic databases

OrthoDBiVOG090000Q4.

Family and domain databases

InterProiView protein in InterPro
IPR022819. Poxvirus.
PfamiView protein in Pfam
PF06227. Poxvirus. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA46_VACCW
AccessioniPrimary (citable) accession number: P26672
Secondary accession number(s): Q76ZN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 12, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.