P26654 (VFUS_ORFN2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: 10 kDa fusion protein
Organism	Orf virus (strain NZ2) (OV NZ-2)
Taxonomic identifier	10259 [NCBI]
Taxonomic lineage	Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Parapoxvirus › Orf virus
Virus host	Capra hircus (Goat) [TaxID: 9925] Homo sapiens (Human) [TaxID: 9606] Ovis aries (Sheep) [TaxID: 9940]

Protein attributes

Sequence length	89 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subunit structure	Homotrimer, covalently linked By similarity.
Sequence similarities	Belongs to the poxviruses fusion protein family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral attachment to host cell Virus entry into host cell
Developmental stage	Late protein
PTM	Glycoprotein
Gene Ontology (GO)
Biological_process	viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell via membrane fusion with the plasma membrane Inferred from electronic annotation. Source: InterPro
Cellular_component	viral envelope Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 89	89	10 kDa fusion protein		PRO_0000099216
Amino acid modifications
	Glycosylation	18	1	N-linked (GlcNAc...); by host Potential

Sequences

	Sequence		Length	Mass (Da)
	P26654 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: A0105456AAC8F8E9	FASTA	89	10,050
	10 20 30 40 50 60 MDENDGENLL TQPDDTGNST NGVYAAGAPT KESVEERLVS LLDSYKTITD CCRETGNRLD 70 80 RLERHLESLR KALLDLNRKI DVQTGYSRY

References

[1]	"An orf virus sequence showing homology to the 14K 'fusion' protein of vaccinia virus." Naase M., Nicholson B.H., Fraser K.M., Mercer A.A., Robinson A.J. J. Gen. Virol. 72:1177-1181(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
PIR	WMVZRF. A38711.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003436. Chordopox_Fusion. [Graphical view]
Pfam	PF02346. Vac_Fusion. 1 hit. [Graphical view]
PRINTS	PR01847. VIRALFUSION.
ProtoNet	Search...

Entry information

Entry name

VFUS_ORFN2

Accession

Primary (citable) accession number: P26654

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program