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Protein

Envelope protein F13

Gene

F13L

Organism
Vaccinia virus (strain IHD-J) (VACV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Envelope protein associated with the inner side of the enveloped virion (EV) membrane.By similarity

Miscellaneous

The mutation in position 280 confers resistance to an inhibitor of virus envelopment and release.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral budding, Viral budding via the host ESCRT complexes, Viral release from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope protein F13
Alternative name(s):
37 kDa protein
Palmitoylated EV membrane protein
p37K
Gene namesi
ORF Names:F13L
OrganismiVaccinia virus (strain IHD-J) (VACV)
Taxonomic identifieri10251 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi280D → Y: Resistance to IMCBH. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000991961 – 372Envelope protein F13Add BLAST372

Post-translational modificationi

Palmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiP26653

Expressioni

Keywords - Developmental stagei

Late protein

Structurei

3D structure databases

ProteinModelPortaliP26653
SMRiP26653
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini307 – 334PLD phosphodiesterasePROSITE-ProRule annotationAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi153 – 156YPPL4

Domaini

Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. F13 contains one L domain: a LYPX(n)L motif, which might interact with PDCD6IP/AIP1 (By similarity).By similarity

Family and domain databases

InterProiView protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF00614 PLDc, 1 hit
PF13918 PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 1 hit

Sequencei

Sequence statusi: Complete.

P26653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPFAPVPAG AKCRLVETLP ENMDFRSDHL TTFECFNEII TLAKKYIYIA
60 70 80 90 100
SFCCNPLSTT RGALIFDKLK EASEKGIKII VLLDERGKRN LGELQSHCPD
110 120 130 140 150
INFITVNIDK KNNVGLLLGC FWVSDDERCY VGNASFTGGS IHTIKTLGVY
160 170 180 190 200
SDYPPLATDL RRRFDTFKAF NSAKNSWLNL CSAACCLPVS TAYHIKNPIG
210 220 230 240 250
GVFFTDSPEH LLGYSRDLDT DVVIDKLKSA KTSIDIEHLA IVPTTRVDGN
260 270 280 290 300
SYYWPDIYNS IIEAAINRGV KIRLLVGNWD KNDVYSMATA RSLDALCVQN
310 320 330 340 350
DLSVKVFTIQ NNTKLLIVDD EYVHITSANF DGTHYQNHGF VSFNSIDKQL
360 370
VSEAKKIFER DWVSSHSKSL KI
Length:372
Mass (Da):41,806
Last modified:August 1, 1992 - v1
Checksum:iA2757EA5C60116A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60412 Genomic DNA Translation: AAA48236.1
M60413 Genomic DNA Translation: AAA48237.1
PIRiA40339 WMVZID

Similar proteinsi

Entry informationi

Entry nameiF13_VACCI
AccessioniPrimary (citable) accession number: P26653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

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