Reviewed, UniProtKB/Swiss-Prot P26651 (TTP_HUMAN)

Names and origin

Protein names

Recommended name:
    Tristetraproline
      Short name=TTP
Alternative name(s):
    Zinc finger protein 36 homolog
      Short name=Zfp-36
    Protein TIS11A
      Short name=TIS11
    Growth factor-inducible nuclear protein NUP475
    G0/G1 switch regulatory protein 24

Gene names

Name:	ZFP36
Synonyms:	G0S24, RNF162A, TIS11A, TTP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Has been experimentally shown to be able to bind zinc.
Subcellular location	Nucleus.
Induction	By stimulation with various mitogens.
Sequence similarities	Contains 2 C3H1-type zinc fingers.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytosol Inferred from direct assay. Source: MGI nucleus Inferred from direct assay. Source: HPA
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA binding Inferred from direct assay. Source: MGI protein binding Inferred from physical interaction. Source: IntAct single-stranded RNA binding Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DCP1A	Q9NPI6	1	EBI-374248,EBI-374238
DCP2	Q8IU60-1	1	EBI-374248,EBI-521586
EDC3	Q96F86	1	EBI-374248,EBI-997311
EXOSC8	Q96B26	1	EBI-374248,EBI-371922
UPF2	Q9HAU5	1	EBI-374248,EBI-372073

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Tristetraproline		PRO_0000089163
Regions
	Repeat	71 – 75	5	P-P-P-P-G
	Repeat	198 – 202	5	P-P-P-P-G
	Repeat	219 – 223	5	P-P-P-P-G
	Zinc finger	103 – 131	29	C3H1-type 1
	Zinc finger	141 – 169	29	C3H1-type 2
Amino acid modifications
	Modified residue	60	1	Phosphoserine By similarity
	Modified residue	88	1	Phosphoserine By similarity
	Modified residue	90	1	Phosphoserine By similarity
	Modified residue	93	1	Phosphoserine By similarity
	Modified residue	186	1	Phosphoserine Ref.5
	Modified residue	257	1	Phosphothreonine By similarity
	Modified residue	323	1	Phosphoserine By similarity
Natural variations
	Natural variant	37	1	P → S: dbSNP rs17878633. Ref.3		VAR_021064
	Natural variant	55	1	P → S: dbSNP rs2229272.		VAR_052324
	Natural variant	259	1	I → F Ref.3		VAR_021065
	Natural variant	324	1	V → F Ref.3		VAR_021066

Sequences

	Sequence		Length	Mass (Da)
	P26651-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: DDD9AD950AF7AF98	FASTA	326	34,003
	10 20 30 40 50 60 MDLTAIYESL LSLSPDVPVP SDHGGTESSP GWGSSGPWSL SPSDSSPSGV TSRLPGRSTS 70 80 90 100 110 120 LVEGRSCGWV PPPPGFAPLA PRLGPELSPS PTSPTATSTT PSRYKTELCR TFSESGRCRY 130 140 150 160 170 180 GAKCQFAHGL GELRQANRHP KYKTELCHKF YLQGRCPYGS RCHFIHNPSE DLAAPGHPPV 190 200 210 220 230 240 LRQSISFSGL PSGRRTSPPP PGLAGPSLSS SSFSPSSSPP PPGDLPLSPS AFSAAPGTPL 250 260 270 280 290 300 ARRDPTPVCC PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE 310 320 AGVFAPPQPV AAPRRLPIFN RISVSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes." Taylor G.A., Lai W.S., Oakey R.J., Seldin M.F., Shows T.B., Eddy R.L. Jr., Blackshear P.J. Nucleic Acids Res. 19:3454-3454(1991) [PubMed: 2062660] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[3]	NIEHS SNPs program Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-37; PHE-259 AND PHE-324.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, MASS SPECTROMETRY.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	M92843 mRNA. Translation: AAA58489.1. M92844 Genomic DNA. Translation: AAC37600.1. M63625 mRNA. Translation: AAA61240.1. AK314042 mRNA. Translation: BAG36751.1. AY771351 Genomic DNA. Translation: AAV28731.1. BC009693 mRNA. Translation: AAH09693.1.
IPI	IPI00000893.
PIR	S34427.
RefSeq	NP_003398.1.
UniGene	Hs.534052 Hs.707878
3D structure databases
HSSP	HSSP built from PDB template 1M9O based on UniProtKB P22893.
SMR	P26651. Positions 102-170.
ModBase	Search...
Protein-protein interaction databases
IntAct	P26651. 8 interactions.
PTM databases
PhosphoSite	P26651.
Proteomic databases
PRIDE	P26651.
Genome annotation databases
Ensembl	ENSG00000128016. Homo sapiens. [Contig view]
GeneID	7538.
KEGG	hsa:7538.
Organism-specific databases
GeneCards	GC19P044589.
HGNC	HGNC:12862. ZFP36.
HPA	HPA006009.
MIM	190700. gene.
PharmGKB	PA37451.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P26651.
HOVERGEN	P26651.
OMA	P26651. NRISVSE.
Gene expression databases
ArrayExpress	P26651.
Bgee	P26651.
CleanEx	HS_ZFP36.
GermOnline	ENSG00000128016. Homo sapiens.
Family and domain databases
InterPro	IPR000571. Znf_CCCH. [Graphical view]
Pfam	PF00642. zf-CCCH. 2 hits. [Graphical view]
SMART	SM00356. ZnF_C3H1. 2 hits. [Graphical view]
PROSITE	PS50103. ZF_C3H1. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	29497.
SOURCE	Search...

Entry information

Entry name

TTP_HUMAN

Accession

Primary (citable) accession number: P26651
Secondary accession number(s): B2RA54

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	June 16, 2009
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)