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Protein

Cell division protein FtsP

Gene

ftsP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell division Source: CACAO
  • FtsZ-dependent cytokinesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciEcoCyc:EG11376-MONOMER.
ECOL316407:JW2985-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsPUniRule annotation
Gene namesi
Name:ftsPUniRule annotation
Synonyms:sufI
Ordered Locus Names:b3017, JW2985
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11376. ftsP.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: UniProtKB-HAMAP
  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene are sensitive to oxidative stress and DNA damage at high temperature. They also exhibit filamentation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Tat-type signalUniRule annotation1 PublicationAdd
BLAST
Chaini28 – 470443Cell division protein FtsPPRO_0000002993Add
BLAST

Post-translational modificationi

Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system.

Proteomic databases

PaxDbiP26648.
PRIDEiP26648.

Interactioni

Protein-protein interaction databases

BioGridi4260932. 56 interactions.
DIPiDIP-10942N.
IntActiP26648. 7 interactions.
STRINGi511145.b3017.

Structurei

Secondary structure

1
470
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi39 – 424Combined sources
Beta strandi43 – 453Combined sources
Beta strandi48 – 547Combined sources
Helixi57 – 593Combined sources
Beta strandi61 – 655Combined sources
Beta strandi68 – 703Combined sources
Beta strandi73 – 753Combined sources
Beta strandi78 – 825Combined sources
Beta strandi86 – 938Combined sources
Beta strandi95 – 973Combined sources
Beta strandi101 – 1044Combined sources
Helixi110 – 1123Combined sources
Helixi116 – 1183Combined sources
Beta strandi129 – 1313Combined sources
Beta strandi136 – 1438Combined sources
Turni146 – 1483Combined sources
Helixi149 – 1546Combined sources
Beta strandi158 – 1647Combined sources
Helixi166 – 1705Combined sources
Beta strandi171 – 1733Combined sources
Turni177 – 1793Combined sources
Beta strandi180 – 19112Combined sources
Beta strandi203 – 2053Combined sources
Beta strandi210 – 2145Combined sources
Beta strandi217 – 2193Combined sources
Beta strandi221 – 2244Combined sources
Beta strandi226 – 23510Combined sources
Beta strandi242 – 2465Combined sources
Beta strandi252 – 2565Combined sources
Beta strandi258 – 27316Combined sources
Beta strandi278 – 2847Combined sources
Beta strandi291 – 2944Combined sources
Beta strandi319 – 3257Combined sources
Beta strandi340 – 3434Combined sources
Beta strandi351 – 3588Combined sources
Beta strandi360 – 3645Combined sources
Beta strandi376 – 3794Combined sources
Beta strandi383 – 39816Combined sources
Beta strandi402 – 4087Combined sources
Helixi415 – 4173Combined sources
Beta strandi421 – 43515Combined sources
Beta strandi446 – 4527Combined sources
Helixi453 – 4575Combined sources
Beta strandi461 – 4677Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2UXTX-ray1.90A/B28-470[»]
2UXVX-ray2.61A/B28-470[»]
ProteinModelPortaliP26648.
SMRiP26648. Positions 30-469.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26648.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 16497Plastocyanin-likeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FtsP family.UniRule annotation
Contains 1 plastocyanin-like domain.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107TZ2. Bacteria.
COG2132. LUCA.
HOGENOMiHOG000096435.
InParanoidiP26648.
KOiK04753.
OMAiPSYEHFP.
PhylomeDBiP26648.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
HAMAPiMF_00915. FtsP. 1 hit.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR008972. Cupredoxin.
IPR026589. FtsP.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSRRQFIQ ASGIALCAGA VPLKASAAGQ QQPLPVPPLL ESRRGQPLFM
60 70 80 90 100
TVQRAHWSFT PGTRASVWGI NGRYLGPTIR VWKGDDVKLI YSNRLTENVS
110 120 130 140 150
MTVAGLQVPG PLMGGPARMM SPNADWAPVL PIRQNAATLW YHANTPNRTA
160 170 180 190 200
QQVYNGLAGM WLVEDEVSKS LPIPNHYGVD DFPVIIQDKR LDNFGTPEYN
210 220 230 240 250
EPGSGGFVGD TLLVNGVQSP YVEVSRGWVR LRLLNASNSR RYQLQMNDGR
260 270 280 290 300
PLHVISGDQG FLPAPVSVKQ LSLAPGERRE ILVDMSNGDE VSITCGEAAS
310 320 330 340 350
IVDRIRGFFE PSSILVSTLV LTLRPTGLLP LVTDSLPMRL LPTEIMAGSP
360 370 380 390 400
IRSRDISLGD DPGINGQLWD VNRIDVTAQQ GTWERWTVRA DEPQAFHIEG
410 420 430 440 450
VMFQIRNVNG AMPFPEDRGW KDTVWVDGQV ELLVYFGQPS WAHFPFYFNS
460 470
QTLEMADRGS IGQLLVNPVP
Length:470
Mass (Da):51,858
Last modified:November 1, 1995 - v2
Checksum:iC843A5A4CB146688
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69185.1.
U00096 Genomic DNA. Translation: AAC76053.1.
AP009048 Genomic DNA. Translation: BAE77073.1.
M63491 Genomic DNA. Translation: AAA24398.1.
PIRiG65088.
RefSeqiNP_417489.1. NC_000913.3.
WP_000059388.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76053; AAC76053; b3017.
BAE77073; BAE77073; BAE77073.
GeneIDi944982.
KEGGiecj:JW2985.
eco:b3017.
PATRICi32121448. VBIEscCol129921_3111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69185.1.
U00096 Genomic DNA. Translation: AAC76053.1.
AP009048 Genomic DNA. Translation: BAE77073.1.
M63491 Genomic DNA. Translation: AAA24398.1.
PIRiG65088.
RefSeqiNP_417489.1. NC_000913.3.
WP_000059388.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2UXTX-ray1.90A/B28-470[»]
2UXVX-ray2.61A/B28-470[»]
ProteinModelPortaliP26648.
SMRiP26648. Positions 30-469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260932. 56 interactions.
DIPiDIP-10942N.
IntActiP26648. 7 interactions.
STRINGi511145.b3017.

Proteomic databases

PaxDbiP26648.
PRIDEiP26648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76053; AAC76053; b3017.
BAE77073; BAE77073; BAE77073.
GeneIDi944982.
KEGGiecj:JW2985.
eco:b3017.
PATRICi32121448. VBIEscCol129921_3111.

Organism-specific databases

EchoBASEiEB1350.
EcoGeneiEG11376. ftsP.

Phylogenomic databases

eggNOGiENOG4107TZ2. Bacteria.
COG2132. LUCA.
HOGENOMiHOG000096435.
InParanoidiP26648.
KOiK04753.
OMAiPSYEHFP.
PhylomeDBiP26648.

Enzyme and pathway databases

BioCyciEcoCyc:EG11376-MONOMER.
ECOL316407:JW2985-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP26648.
PROiP26648.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
HAMAPiMF_00915. FtsP. 1 hit.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR008972. Cupredoxin.
IPR026589. FtsP.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSP_ECOLI
AccessioniPrimary (citable) accession number: P26648
Secondary accession number(s): Q2M9I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Is used as a model substrate in studies of the twin-arginine translocation (Tat) protein transport system.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.