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Protein

Beta-2-glycoprotein 1

Gene

Apoh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

GO - Molecular functioni

  • heparin binding Source: UniProtKB-KW
  • lipid binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • blood coagulation Source: RGD
  • negative regulation of respiratory burst Source: RGD
  • organ regeneration Source: RGD
  • positive regulation of triglyceride catabolic process Source: RGD
  • response to triglyceride Source: RGD
  • triglyceride transport Source: BHF-UCL
Complete GO annotation...

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-glycoprotein 1
Alternative name(s):
Apolipoprotein H
Short name:
Apo-H
Beta-2-glycoprotein I
Short name:
B2GPI
Short name:
Beta(2)GPI
Gene namesi
Name:Apoh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310625. Apoh.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • extracellular space Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 297278Beta-2-glycoprotein 1PRO_0000002062Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 76PROSITE-ProRule annotation
Disulfide bondi62 ↔ 89PROSITE-ProRule annotation
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence analysis
Disulfide bondi94 ↔ 140PROSITE-ProRule annotation
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi126 ↔ 152PROSITE-ProRule annotation
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence analysis
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence analysis
Disulfide bondi157 ↔ 200PROSITE-ProRule annotation
Disulfide bondi186 ↔ 212PROSITE-ProRule annotation
Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence analysis
Disulfide bondi216 ↔ 267PROSITE-ProRule annotation
Disulfide bondi252 ↔ 277PROSITE-ProRule annotation
Disulfide bondi259 ↔ 297PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP26644.

PTM databases

iPTMnetiP26644.
PhosphoSiteiP26644.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Structurei

3D structure databases

ProteinModelPortaliP26644.
SMRiP26644. Positions 23-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 3213Sushi 1; incompletePROSITE-ProRule annotationAdd
BLAST
Domaini34 – 9158Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini92 – 15463Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini155 – 21460Sushi 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni215 – 29783Sushi-likeAdd
BLAST

Sequence similaritiesi

Contains 4 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

HOVERGENiHBG004271.
InParanoidiP26644.

Family and domain databases

InterProiIPR015104. Sushi_2.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 3 hits.
PF09014. Sushi_2. 1 hit.
[Graphical view]
ProDomiPD012422. Sushi_2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 4 hits.
PROSITEiPS50923. SUSHI. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISPALIFFS AFLCHVAIAG RRMWPINTLK CTPRVCPFAG ILENGVVRYT
60 70 80 90 100
TFEYPNTIGF ACNPGYYLNG TSSSKCTEEG KWSPELPVCA RITCPPPPIP
110 120 130 140 150
KFAALKEYKT SVGNSSFYQD TVVFKCLPHF AMFGNDTVTC TAHGNWTQLP
160 170 180 190 200
ECREVKCPFP SRPDNGFVNY PAKPVLSYKD KAVFGCHETY KLDGPEEVEC
210 220 230 240 250
TKTGNWSALP SCKASCKLSV KKATVLYQGQ RVKIQDQFKN GMMHGDKVHF
260 270 280 290
YCKNKEKKCS YTEEAQCIDG TIEIPKCFKE HSSLAFWKTD ASDVTPC
Length:297
Mass (Da):33,197
Last modified:February 1, 1996 - v2
Checksum:i911209DA6C119D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15551 mRNA. Translation: CAA33556.1.
PIRiS05310. NBRT.
UniGeneiRn.1824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15551 mRNA. Translation: CAA33556.1.
PIRiS05310. NBRT.
UniGeneiRn.1824.

3D structure databases

ProteinModelPortaliP26644.
SMRiP26644. Positions 23-297.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP26644.
PhosphoSiteiP26644.

Proteomic databases

PRIDEiP26644.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1310625. Apoh.

Phylogenomic databases

HOVERGENiHBG004271.
InParanoidiP26644.

Miscellaneous databases

PROiP26644.

Family and domain databases

InterProiIPR015104. Sushi_2.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 3 hits.
PF09014. Sushi_2. 1 hit.
[Graphical view]
ProDomiPD012422. Sushi_2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 4 hits.
PROSITEiPS50923. SUSHI. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPOH_RAT
AccessioniPrimary (citable) accession number: P26644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1996
Last modified: January 20, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.