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Protein

Elongation factor 1-gamma

Gene

EEF1G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably plays a role in anchoring the complex to other cellular components.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • response to virus Source: UniProtKB
  • translational elongation Source: Reactome

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-156842 Eukaryotic Translation Elongation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-gamma
Short name:
EF-1-gamma
Alternative name(s):
eEF-1B gamma
Gene namesi
Name:EEF1G
Synonyms:EF1G
ORF Names:PRO1608
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000254772.9
HGNCiHGNC:3213 EEF1G
MIMi130593 gene
neXtProtiNX_P26641

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1937
OpenTargetsiENSG00000254772
PharmGKBiPA27649

Polymorphism and mutation databases

BioMutaiEEF1G
DMDMi119165

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00002088132 – 437Elongation factor 1-gammaAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei147N6-acetyllysineCombined sources1
Modified residuei212N6-acetyllysineBy similarity1
Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei401N6-acetyllysineBy similarity1
Modified residuei434N6-acetyllysine; alternateCombined sources1
Modified residuei434N6-malonyllysine; alternate1 Publication1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP26641
PaxDbiP26641
PeptideAtlasiP26641
PRIDEiP26641
ProteomicsDBi54359
TopDownProteomicsiP26641-1 [P26641-1]

2D gel databases

OGPiP26641

PTM databases

iPTMnetiP26641
PhosphoSitePlusiP26641
SwissPalmiP26641

Expressioni

Tissue specificityi

Highly expressed in pancreatic tumor tissue and to a lesser extent in normal kidney, intestine, pancreas, stomach, lung, brain, spleen and liver.

Inductioni

Down-regulated in response to enterovirus 71 (EV71) infection.1 Publication

Gene expression databases

BgeeiENSG00000254772
CleanExiHS_EEF1G
ExpressionAtlasiP26641 baseline and differential
GenevisibleiP26641 HS

Organism-specific databases

HPAiHPA040688
HPA055316

Interactioni

Subunit structurei

EF-1 is composed of four subunits: alpha, beta, delta, and gamma.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108257, 181 interactors
CORUMiP26641
DIPiDIP-32516N
IntActiP26641, 149 interactors
MINTiP26641
STRINGi9606.ENSP00000331901

Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi13 – 25Combined sources13
Beta strandi28 – 32Combined sources5
Turni35 – 37Combined sources3
Turni40 – 42Combined sources3
Helixi43 – 45Combined sources3
Helixi47 – 52Combined sources6
Beta strandi58 – 63Combined sources6
Helixi72 – 78Combined sources7
Helixi82 – 85Combined sources4
Helixi89 – 105Combined sources17
Helixi107 – 117Combined sources11
Helixi125 – 145Combined sources21
Turni146 – 148Combined sources3
Beta strandi150 – 153Combined sources4
Helixi159 – 174Combined sources16
Helixi178 – 181Combined sources4
Helixi185 – 195Combined sources11
Helixi198 – 204Combined sources7
Helixi279 – 281Combined sources3
Helixi290 – 299Combined sources10
Helixi302 – 304Combined sources3
Helixi306 – 311Combined sources6
Turni316 – 318Combined sources3
Beta strandi320 – 324Combined sources5
Helixi329 – 331Combined sources3
Helixi338 – 348Combined sources11
Helixi349 – 351Combined sources3
Helixi353 – 355Combined sources3
Beta strandi356 – 358Combined sources3
Beta strandi361 – 364Combined sources4
Beta strandi370 – 381Combined sources12
Helixi384 – 386Combined sources3
Helixi388 – 390Combined sources3
Helixi394 – 396Combined sources3
Helixi408 – 418Combined sources11
Turni424 – 426Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PBUNMR-A276-437[»]
5DQSX-ray2.10A2-218[»]
5JPOX-ray2.00A/B/C/D1-218[»]
ProteinModelPortaliP26641
SMRiP26641
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26641

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 87GST N-terminalAdd BLAST86
Domaini88 – 216GST C-terminalAdd BLAST129
Domaini276 – 437EF-1-gamma C-terminalPROSITE-ProRule annotationAdd BLAST162

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
KOG1627 Eukaryota
COG0625 LUCA
GeneTreeiENSGT00390000007552
HOGENOMiHOG000235245
HOVERGENiHBG051444
InParanoidiP26641
KOiK03233
OMAiDYEVYDW
OrthoDBiEOG091G06QR
PhylomeDBiP26641
TreeFamiTF314343

Family and domain databases

Gene3Di3.30.70.1010, 1 hit
InterProiView protein in InterPro
IPR001662 EF1B_G_C
IPR036433 EF1B_G_C_sf
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00647 EF1G, 1 hit
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SMARTiView protein in SMART
SM01183 EF1G, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
SSF89942 SSF89942, 1 hit
PROSITEiView protein in PROSITE
PS50040 EF1G_C, 1 hit
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26641-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGTLYTYP ENWRAFKALI AAQYSGAQVR VLSAPPHFHF GQTNRTPEFL
60 70 80 90 100
RKFPAGKVPA FEGDDGFCVF ESNAIAYYVS NEELRGSTPE AAAQVVQWVS
110 120 130 140 150
FADSDIVPPA STWVFPTLGI MHHNKQATEN AKEEVRRILG LLDAYLKTRT
160 170 180 190 200
FLVGERVTLA DITVVCTLLW LYKQVLEPSF RQAFPNTNRW FLTCINQPQF
210 220 230 240 250
RAVLGEVKLC EKMAQFDAKK FAETQPKKDT PRKEKGSREE KQKPQAERKE
260 270 280 290 300
EKKAAAPAPE EEMDECEQAL AAEPKAKDPF AHLPKSTFVL DEFKRKYSNE
310 320 330 340 350
DTLSVALPYF WEHFDKDGWS LWYSEYRFPE ELTQTFMSCN LITGMFQRLD
360 370 380 390 400
KLRKNAFASV ILFGTNNSSS ISGVWVFRGQ ELAFPLSPDW QVDYESYTWR
410 420 430
KLDPGSEETQ TLVREYFSWE GAFQHVGKAF NQGKIFK
Length:437
Mass (Da):50,119
Last modified:January 23, 2007 - v3
Checksum:iA6110663110CF3FC
GO
Isoform 2 (identifier: P26641-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MAAG → MAERWVAPAVLRRARFASTFFLSPQIYAHKDGDLRSAFFILSFKRGEFIPFLNW

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):56,150
Checksum:i3FF3FDCBDAFE1A4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102A → V in AAH13918 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562041 – 4MAAG → MAERWVAPAVLRRARFASTF FLSPQIYAHKDGDLRSAFFI LSFKRGEFIPFLNW in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63526 mRNA Translation: CAA45089.1
Z11531 mRNA Translation: CAA77630.1
AK300203 mRNA Translation: BAG61974.1
AP001363 Genomic DNA No translation available.
AP002990 Genomic DNA No translation available.
BC000384 mRNA Translation: AAH00384.1
BC006509 mRNA Translation: AAH06509.1
BC006520 mRNA Translation: AAH06520.1
BC007949 mRNA Translation: AAH07949.2
BC009865 mRNA Translation: AAH09865.1
BC013918 mRNA Translation: AAH13918.1
BC015813 mRNA Translation: AAH15813.1
BC021974 mRNA Translation: AAH21974.2
BC028179 mRNA Translation: AAH28179.1
BC031012 mRNA Translation: AAH31012.1
BC067738 mRNA Translation: AAH67738.1
M55409 mRNA Translation: AAC18414.1
AF119850 mRNA Translation: AAF69604.1
CCDSiCCDS44626.1 [P26641-1]
PIRiS22655
RefSeqiNP_001395.1, NM_001404.4 [P26641-1]
UniGeneiHs.144835
Hs.444467

Genome annotation databases

EnsembliENST00000329251; ENSP00000331901; ENSG00000254772 [P26641-1]
GeneIDi1937
KEGGihsa:1937

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEF1G_HUMAN
AccessioniPrimary (citable) accession number: P26641
Secondary accession number(s): B4DTG2
, Q6PJ62, Q6PK31, Q96CU2, Q9P196
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 205 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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