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Reviewed, UniProtKB/Swiss-Prot P26640 (SYVC_HUMAN)

Last modified July 7, 2009. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Valyl-tRNA synthetase
    EC=6.1.1.9
Alternative name(s):
    Valine--tRNA ligase
      Short name=ValRS
    Protein G7a
Gene names
Name: VARS
Synonyms: G7A, VARS2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1264 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).

Enzyme regulation

Can be regulated by protein kinase C-dependent phosphorylation.

Subunit structure

Forms high-molecular-mass aggregates with elongation factor 1.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Contains 1 GST C-terminal domain.

Sequence caution

The sequence CAA41990.1 differs from that shown. Reason: Frameshift at positions 620 and 640.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Coding sequence diversityPolymorphism
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processtranslational elongation

Non-traceable author statement. Source: UniProtKB

valyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

valine-tRNA ligase activity Ref.8

Inferred from direct assay. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7
Chain2 – 12641263Valyl-tRNA synthetase
PRO_0000106253

Regions

Domain89 – 219131GST C-terminal
Motif344 – 35411"HIGH" region
Motif862 – 8665"KMSKS" region

Sites

Binding site8651ATP By similarity

Amino acid modifications

Modified residue21N-acetylserine Ref.7
Modified residue3001Phosphotyrosine Ref.9

Natural variations

Natural variant511P → R: dbSNP rs2607015.
VAR_052647
Natural variant1811R → C: dbSNP rs35196751.
VAR_052648
Natural variant6261P → S: dbSNP rs11531.
VAR_052649
Natural variant10081P → L: dbSNP rs1076827.
VAR_052650

Experimental info

Sequence conflict511P → S in CAA41990. Ref.1
Sequence conflict511P → S in AAH12808. Ref.5
Sequence conflict3311A → G in AAA81332. Ref.8
Sequence conflict5901V → G in CAA41990. Ref.1
Sequence conflict7921S → F in CAA41990. Ref.1
Sequence conflict10641M → I in AAA81332. Ref.8
Sequence conflict11691Missing in AAA81332. Ref.8

Sequences

Sequence LengthMass (Da)Tools
P26640-1 [UniParc].

Last modified December 1, 2000. Version 4.
Checksum: 95CCDDBB3AB148AD

FASTA1,264140,476
        10         20         30         40         50         60 
MSTLYVSPHP DAFPSLRALI AARYGEAGEG PGWGGAHPRI CLQPPPTSRT PFPPPRLPAL 

        70         80         90        100        110        120 
EQGPGGLWVW GATAVAQLLW PAGLGGPGGS RAAVLVQQWV SYADTELIPA ACGATLPALG 

       130        140        150        160        170        180 
LRSSAQDPQA VLGALGRALS PLEEWLRLHT YLAGEAPTLA DLAAVTALLL PFRYVLDPPA 

       190        200        210        220        230        240 
RRIWNNVTRW FVTCVRQPEF RAVLGEVVLY SGARPLSHQP GPEAPALPKT AAQLKKEAKK 

       250        260        270        280        290        300 
REKLEKFQQK QKIQQQQPPP GEKKPKPEKR EKRDPGVITY DLPTPPGEKK DVSGPMPDSY 

       310        320        330        340        350        360 
SPRYVEAAWY PWWEQQGFFK PEYGRPNVSA ANPRGVFMMC IPPPNVTGSL HLGHALTNAI 

       370        380        390        400        410        420 
QDSLTRWHRM RGETTLWNPG CDHAGIATQV VVEKKLWREQ GLSRHQLGRE AFLQEVWKWK 

       430        440        450        460        470        480 
EEKGDRIYHQ LKKLGSSLDW DRACFTMDPK LSAAVTEAFV RLHEEGIIYR STRLVNWSCT 

       490        500        510        520        530        540 
LNSAISDIEV DKKELTGRTL LSVPGYKEKV EFGVLVSFAY KVQGSDSDEE VVVATTRIET 

       550        560        570        580        590        600 
MLGDVAVAVH PKDTRYQHLK GKNVIHPFLS RSLPIVFDEF VDMDFGTGAV KITPAHDQND 

       610        620        630        640        650        660 
YEVGQRHGLE AISIMDSRGA LINVPPPFLG LPRFEARKAV LVALKERGLF RGIEDNPMVV 

       670        680        690        700        710        720 
PLCNRSKDVV EPLLRPQWYV RCGEMAQAAS AAVTRGDLRI LPEAHQRTWH AWMDNIREWC 

       730        740        750        760        770        780 
ISRQLWWGHR IPAYFVTVSD PAVPPGEDPD GRYWVSGRNE AEAREKAAKE FGVSPDKISL 

       790        800        810        820        830        840 
QQDEDVLDTW FSSGLFPLSI LGWPNQSEDL SVFYPGTLLE TGHDILFFWV ARMVMLGLKL 

       850        860        870        880        890        900 
TGRLPFREVY LHAIVRDAHG RKMSKSLGNV IDPLDVIYGI SLQGLHNQLL NSNLDPSEVE 

       910        920        930        940        950        960 
KAKEGQKADF PAGIPECGTD ALRFGLCAYM SQGRDINLDV NRILGYRHFC NKLWNATKFA 

       970        980        990       1000       1010       1020 
LRGLGKGFVP SPTSQPGGHE SLVDRWIRSR LTEAVRLSNQ GFQAYDFPAV TTAQYSFWLY 

      1030       1040       1050       1060       1070       1080 
ELCDVYLECL KPVLNGVDQV AAECARQTLY TCLDVGLRLL SPFMPFVTEE LFQRLPRRMP 

      1090       1100       1110       1120       1130       1140 
QAPPSLCVTP YPEPSECSWK DPEAEAALEL ALSITRAVRS LRADYNLTRI RPDCFLEVAD 

      1150       1160       1170       1180       1190       1200 
EATGALASAV SGYVQALASA GVVAVLALGA PAPQGCAVAL ASDRCSIHLQ LQGLVDPARE 

      1210       1220       1230       1240       1250       1260 
LGKLQAKRVE AQRQAQRLRE RRAASGYPVK VPLEVQEADE AKLQQTEAEL RKVDEAIALF 


QKML 

« Hide

References

« Hide 'large scale' references
[1]"Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase."
Hsieh H.-L., Campbell R.D.
Biochem. J. 278:809-816(1991) [PubMed: 1898367] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Erratum
Hsieh S.-L., Campbell R.D.
Biochem. J. 281:879-879(1992)
[3]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed: 14656967] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[7]Bienvenut W.V., Dhillon A.S., Kolch W.
Submitted (FEB-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-17; 123-147; 451-461; 592-606; 619-633; 935-942; 1120-1129 AND 1252-1262, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY.
Tissue: Hepatoma.
[8]"Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase."
Vilalta A., Donovan D., Wood L., Vogeli G., Yang D.C.H.
Gene 123:181-186(1993) [PubMed: 8428657] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 201-1263.
[9]"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer."
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. expand/collapse author list , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.
Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-300, MASS SPECTROMETRY.
[10]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

X59303 mRNA. Translation: CAA41990.1. Frameshift.
AF134726 Genomic DNA. Translation: AAD21819.1.
BA000025 Genomic DNA. Translation: BAB63303.1.
AL671762, AL662899 Genomic DNA. Translation: CAI18211.1.
AL662899, AL671762 Genomic DNA. Translation: CAI18384.1.
AL662834 Genomic DNA. Translation: CAI17732.1.
BC012808 mRNA. Translation: AAH12808.1.
M98326 mRNA. Translation: AAA81332.1.
IPIIPI00000873.
PIRS17675.
RefSeqNP_006286.1.
UniGeneHs.520026

3D structure databases

HSSPHSSP built from PDB template 1IVS based on UniProtKB P96142.
ModBaseSearch...

Protein-protein interaction databases

IntActP26640. 10 interactions.

PTM databases

PhosphoSiteP26640.

Proteomic databases

PRIDEP26640.

Genome annotation databases

EnsemblENSG00000096171. Homo sapiens. [Contig view]
ENSG00000204394. Homo sapiens. [Contig view]
GeneID7407.
KEGGhsa:7407.
UCSCuc003nxe.1. human.

Organism-specific databases

GeneCardsGC06M031855.
H-InvDBHIX0005731.
HIX0057947.
HIX0058259.
HGNCHGNC:12651. VARS.
MIM192150. gene.
PharmGKBPA37275.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP26640.
HOVERGENP26640.
OMAP26640. WPDETPE.

Enzyme and pathway databases

BRENDA6.1.1.9. 247.
ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressP26640.
BgeeP26640.
CleanExHS_VARS.
HS_VARS2.
GermOnlineENSG00000204394. Homo sapiens.

Family and domain databases

InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017933. Glutathione_S_Trfase/Cl_chnl_C.
IPR004046. GST_C.
IPR014729. Rossmann-like_a/b/a_fold.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR002303. Val-tRNA_synth_Ia.
IPR019754. Val-tRNA_synth_Ia_N.
[Graphical view]
Gene3DG3DSA:1.20.1050.10. GST_C_like. 1 hit.
G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHERPTHR11946:SF5. tRNA-synt_val. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSPR00986. TRNASYNTHVAL.
TIGRFAMsTIGR00422. valS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50405. GST_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00161. L-Valine.
NextBio28996.
SOURCESearch...

Entry information

Entry nameSYVC_HUMAN
AccessionPrimary (citable) accession number: P26640
Secondary accession number(s): Q5JQ90, Q96E77, Q9UQM2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 1, 2000
Last modified: July 7, 2009
This is version 100 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents