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Protein

Early growth response protein 1

Gene

egr1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator (PubMed:7945937). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri311 – 335C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri341 – 363C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • camera-type eye development Source: ZFIN
  • embryonic retina morphogenesis in camera-type eye Source: ZFIN
  • embryonic viscerocranium morphogenesis Source: ZFIN
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 1
Short name:
EGR-1
Alternative name(s):
Zinc finger protein Krox-24
Gene namesi
Name:egr1
Synonyms:krox24
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-980526-320 egr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471161 – 511Early growth response protein 1Add BLAST511

Proteomic databases

PaxDbiP26632

Expressioni

Tissue specificityi

Detected in muscle and brain.1 Publication

Gene expression databases

BgeeiENSDARG00000037421
ExpressionAtlasiP26632 baseline and differential

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei309Interaction with DNABy similarity1
Sitei320Interaction with DNABy similarity1
Sitei324Interaction with DNABy similarity1
Sitei330Interaction with DNABy similarity1
Sitei348Interaction with DNABy similarity1
Sitei352Interaction with DNABy similarity1
Sitei376Interaction with DNABy similarity1
Sitei380Interaction with DNABy similarity1
Sitei386Interaction with DNABy similarity1

Protein-protein interaction databases

STRINGi7955.ENSDARP00000054459

Structurei

3D structure databases

ProteinModelPortaliP26632
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi146 – 152Poly-Ser7
Compositional biasi155 – 165Poly-SerAdd BLAST11

Domaini

Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri311 – 335C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri341 – 363C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000036856
HOVERGENiHBG003909
InParanoidiP26632
KOiK09203
OMAiFATQTGS
OrthoDBiEOG091G06VX
PhylomeDBiP26632
TreeFamiTF318980

Family and domain databases

InterProiView protein in InterPro
IPR021849 EGR
IPR021839 EGR1_C
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF11914 DUF3432, 1 hit
PF11928 DUF3446, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

P26632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKTEMLL PALQISDPLS FPHSPTDNYP KLEEMIMLNS AGTPFLNATA
60 70 80 90 100
PEGAVFGSGE PGEQFDHLAG DTLSEISMEK PLSDQTYSTQ RLPPISYTGR
110 120 130 140 150
FTLEPATNCS NSLWAEPLFS LVSGLVGINP PPASIPSSTS QATHPSSSST
160 170 180 190 200
SSIPSSSSSS TSSASLSCSV HQSEPNPIYS AAPTYSSASP DIFPESGPNF
210 220 230 240 250
STTVGTSLQY SSSTYPSAKT CNPSFSVPMI PDYLFTQQQS EISLVPPDQK
260 270 280 290 300
PIQTQAGQQP ALTPLHTIKA FATQTGSQDL KSVYQSQLIK PSRMRKYPNR
310 320 330 340 350
PSKTPPHERP YACPVETCDR RFSRSDELTR HIRIHTGQKP FQCRICMRNF
360 370 380 390 400
SRSDHLTTHI RTHTGEKPFA CEICGRKFAR SDERKRHTKI HMRQKDKKAE
410 420 430 440 450
KGATAAVQSS VSNISISASS PVSSYPSPIT SYPSPVSSFP SPVNSCYSSP
460 470 480 490 500
VHTSYPSPSI ATTYPSATST FQTQVATSFP TSVASNIYSS PVTTPLPDMQ
510
SALSPRTADI C
Length:511
Mass (Da):55,140
Last modified:February 1, 1996 - v2
Checksum:i411C31E6F4AA10BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317T → S in AAA50035 (PubMed:1930167).Curated1
Sequence conflicti320R → S in AAA50035 (PubMed:1930167).Curated1
Sequence conflicti351S → R in AAA50035 (PubMed:1930167).Curated1
Sequence conflicti372E → D in AAA50035 (PubMed:1930167).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12895 Genomic DNA Translation: AAA63651.1
M81109 Genomic DNA Translation: AAA50035.1
PIRiI50114
PQ0233
RefSeqiNP_571323.1, NM_131248.1
UniGeneiDr.144146

Genome annotation databases

EnsembliENSDART00000054460; ENSDARP00000054459; ENSDARG00000037421
GeneIDi30498
KEGGidre:30498

Similar proteinsi

Entry informationi

Entry nameiEGR1_DANRE
AccessioniPrimary (citable) accession number: P26632
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health