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Protein

Early growth response protein 1

Gene

egr1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri311 – 33525C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • camera-type eye development Source: ZFIN
  • embryonic retina morphogenesis in camera-type eye Source: ZFIN
  • embryonic viscerocranium morphogenesis Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 1
Short name:
EGR-1
Alternative name(s):
Zinc finger protein Krox-24
Gene namesi
Name:egr1
Synonyms:krox24
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-980526-320. egr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Early growth response protein 1PRO_0000047116Add
BLAST

Proteomic databases

PaxDbiP26632.

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiENSDARG00000037421.
ExpressionAtlasiP26632. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000054459.

Structurei

3D structure databases

ProteinModelPortaliP26632.
SMRiP26632. Positions 308-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi146 – 1527Poly-Ser
Compositional biasi155 – 16511Poly-SerAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri311 – 33525C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
InParanoidiP26632.
KOiK09203.
OMAiFATQTGS.
OrthoDBiEOG091G06VX.
PhylomeDBiP26632.
TreeFamiTF318980.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021839. DUF3432.
IPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11914. DUF3432. 1 hit.
PF11928. DUF3446. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKTEMLL PALQISDPLS FPHSPTDNYP KLEEMIMLNS AGTPFLNATA
60 70 80 90 100
PEGAVFGSGE PGEQFDHLAG DTLSEISMEK PLSDQTYSTQ RLPPISYTGR
110 120 130 140 150
FTLEPATNCS NSLWAEPLFS LVSGLVGINP PPASIPSSTS QATHPSSSST
160 170 180 190 200
SSIPSSSSSS TSSASLSCSV HQSEPNPIYS AAPTYSSASP DIFPESGPNF
210 220 230 240 250
STTVGTSLQY SSSTYPSAKT CNPSFSVPMI PDYLFTQQQS EISLVPPDQK
260 270 280 290 300
PIQTQAGQQP ALTPLHTIKA FATQTGSQDL KSVYQSQLIK PSRMRKYPNR
310 320 330 340 350
PSKTPPHERP YACPVETCDR RFSRSDELTR HIRIHTGQKP FQCRICMRNF
360 370 380 390 400
SRSDHLTTHI RTHTGEKPFA CEICGRKFAR SDERKRHTKI HMRQKDKKAE
410 420 430 440 450
KGATAAVQSS VSNISISASS PVSSYPSPIT SYPSPVSSFP SPVNSCYSSP
460 470 480 490 500
VHTSYPSPSI ATTYPSATST FQTQVATSFP TSVASNIYSS PVTTPLPDMQ
510
SALSPRTADI C
Length:511
Mass (Da):55,140
Last modified:February 1, 1996 - v2
Checksum:i411C31E6F4AA10BF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti317 – 3171T → S in AAA50035 (PubMed:1930167).Curated
Sequence conflicti320 – 3201R → S in AAA50035 (PubMed:1930167).Curated
Sequence conflicti351 – 3511S → R in AAA50035 (PubMed:1930167).Curated
Sequence conflicti372 – 3721E → D in AAA50035 (PubMed:1930167).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12895 Genomic DNA. Translation: AAA63651.1.
M81109 Genomic DNA. Translation: AAA50035.1.
PIRiI50114.
PQ0233.
RefSeqiNP_571323.1. NM_131248.1.
UniGeneiDr.144146.

Genome annotation databases

EnsembliENSDART00000054460; ENSDARP00000054459; ENSDARG00000037421.
GeneIDi30498.
KEGGidre:30498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12895 Genomic DNA. Translation: AAA63651.1.
M81109 Genomic DNA. Translation: AAA50035.1.
PIRiI50114.
PQ0233.
RefSeqiNP_571323.1. NM_131248.1.
UniGeneiDr.144146.

3D structure databases

ProteinModelPortaliP26632.
SMRiP26632. Positions 308-394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000054459.

Proteomic databases

PaxDbiP26632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000054460; ENSDARP00000054459; ENSDARG00000037421.
GeneIDi30498.
KEGGidre:30498.

Organism-specific databases

CTDi1958.
ZFINiZDB-GENE-980526-320. egr1.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
InParanoidiP26632.
KOiK09203.
OMAiFATQTGS.
OrthoDBiEOG091G06VX.
PhylomeDBiP26632.
TreeFamiTF318980.

Miscellaneous databases

PROiP26632.

Gene expression databases

BgeeiENSDARG00000037421.
ExpressionAtlasiP26632. differential.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021839. DUF3432.
IPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11914. DUF3432. 1 hit.
PF11928. DUF3446. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEGR1_DANRE
AccessioniPrimary (citable) accession number: P26632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.