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Protein

Paired box protein Pax-6

Gene

pax6a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi229 – 288HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: ZFIN
  • sequence-specific DNA binding Source: ZFIN

GO - Biological processi

  • anterior/posterior pattern specification Source: ZFIN
  • epithalamus development Source: ZFIN
  • forebrain development Source: ZFIN
  • hindbrain development Source: ZFIN
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: ZFIN
  • regulation of gene expression Source: ZFIN
  • retinal cone cell differentiation Source: UniProtKB
  • retinal rod cell differentiation Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-6
Alternative name(s):
Pax[Zf-a]
Gene namesi
Name:pax6a
Synonyms:pax[zf-a], paxzf-a
ORF Names:si:dkeyp-46c10.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 25

Organism-specific databases

ZFINiZDB-GENE-990415-200. pax6a.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ZFIN

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501911 – 437Paired box protein Pax-6Add BLAST437

Proteomic databases

PaxDbiP26630.

PTM databases

iPTMnetiP26630.

Expressioni

Tissue specificityi

Spatially restricted regions of the neural tube.

Gene expression databases

BgeeiENSDARG00000103379.
ExpressionAtlasiP26630. baseline.

Interactioni

Protein-protein interaction databases

ELMiP26630.
STRINGi7955.ENSDARP00000115545.

Structurei

3D structure databases

ProteinModelPortaliP26630.
SMRiP26630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 149PairedPROSITE-ProRule annotationAdd BLAST127

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi298 – 437Pro/Ser/Thr-richAdd BLAST140

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox, Paired box

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230939.
HOVERGENiHBG009115.
InParanoidiP26630.
KOiK08031.
OMAiQTGTWGT.
OrthoDBiEOG091G0S4E.

Family and domain databases

CDDicd00131. PAX. 1 hit.
Gene3Di1.10.10.10. 2 hits.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
PRINTSiPR00027. PAIREDBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Short (identifier: P26630-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQKEYYNRA TWESGVASMM QNSHSGVNQL GGVFVNGRPL PDSTRQKIVE
60 70 80 90 100
LAHSGARPCD ISRILQVSNG CVSKILGRYY ETGSIRPRAI GGSKPRVATP
110 120 130 140 150
EVVGKIAQYK RECPSIFAWE IRDRLLSEGV CTNDNIPSVS SINRVLRNLA
160 170 180 190 200
SEKQQMGADG MYEKLRMLNG QTGTWGTRPG WYPGTSVPGQ PNQDGCQQSD
210 220 230 240 250
GGGENTNSIS SNGEDSDETQ MRLQLKRKLQ RNRTSFTQEQ IEALEKEFER
260 270 280 290 300
THYPDVFARE RLAAKIDLPE ARIQVWFSNR RAKWRREEKL RNQRRQASNS
310 320 330 340 350
SSHIPISSSF STSVYQPIPQ PTTPVSFTSG SMLGRSDTAL TNTYSALPPM
360 370 380 390 400
PSFTMANNLP MQPSQTSSYS CMLPTSPSVN GRSYDTYTPP HMQAHMNSQS
410 420 430
MAASGTTSTG LISPGVSVPV QVPGSEPDMS QYWPRLQ
Length:437
Mass (Da):48,425
Last modified:August 1, 1992 - v1
Checksum:i01D0999EFCA22837
GO
Isoform Long (identifier: P26630-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-66: Q → QTHADAKVQVLDNEN

Show »
Length:451
Mass (Da):49,961
Checksum:i04DFCD94BCCF2433
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00236766Q → QTHADAKVQVLDNEN in isoform Long. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61389 mRNA. Translation: CAA43661.1.
X63183 mRNA. Translation: CAA44867.1.
AL929172 Genomic DNA. Translation: CAM16649.1.
BC066722 mRNA. Translation: AAH66722.1.
PIRiI50108.
RefSeqiNP_571379.1. NM_131304.1. [P26630-2]
XP_009296158.1. XM_009297883.2. [P26630-1]
XP_017209537.1. XM_017354048.1. [P26630-2]
UniGeneiDr.24244.

Genome annotation databases

EnsembliENSDART00000162485; ENSDARP00000139430; ENSDARG00000103379. [P26630-1]
ENSDART00000164384; ENSDARP00000135767; ENSDARG00000103379. [P26630-2]
GeneIDi30567.
KEGGidre:30567.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPAX6_DANRE
AccessioniPrimary (citable) accession number: P26630
Secondary accession number(s): A2AUN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: August 30, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families